中英科技桥

ResearchProfile

SUMMARYOFMYRELEVANTRESEARCHAREAS:Briefsummaryofyourresearchareas,inEnglishjustashortparagraphpleasePolymer processing (natural and synthetic polymers); Biomimetic manufacturing (e.g. melt and solutionspinning;castingtechniques;freeze-drying;bioplotter);Surfacefunctionalisation(e.g.plasmatreatmentandelectrostaticassembly)

Brief summary of your research areas, in Chinese we will translate this for non-Chinese speaking UKparticipantsPrimaryResearchinterests:Afullerdescriptionofyourmainresearchareas.DrPiergiorgioGentileisaBiomedicalEngineergraduatedatthePolitecnicodiTorino(Turin,Italy),withaPhDresearchonbioactivepolymericorcompositescaffoldsforbonetissueregeneration.PiergiorgiojoinedtheSchool of Mechanical and Systems Engineering at Newcastle University in September 2015 as Lecturer.CurrentlyheisalsoCEOofGeltissrl(spin-outcompanyofPolitecnicodiTorino,Italy).Piergiorgio’smissionisbeststatedusinghisexpertiseinbiomedicalengineeringtocreate,disseminateandapplyknowledgeto:(1)improvepeoplehealth,(2)preparestudentsforchangingandchallengedcompanies,and(3)encouragepoliciesthatsupportpeoplehealthydevelopment.Hisresearchisrelatedtothedesign,processing and characterisation of biomedical materials (natural and synthetic polymers, ceramics, &composites), aiming to nano- andmicro-scale design,manufacturing and functionalisation of biomimeticscaffolds for tissueengineering and regenerativemedicine, optimising thephysico-chemical properties toenhancecellgrowthanddifferentiation.Main topics are: (1) processing of natural and synthetic polymers; (2) biomimetic approach to producescaffoldsabletomimicthephysicalandbiologicalpropertiesofthenativetissues,throughvarioustechniques(e.g. melt and solution spinning; freeze-drying; 3D printing); (3) surface functionalisation to obtainnanostructures containing drug(s)/biomolecule(s) to achieve specific biological responses; (4) biologicalevaluationofbioengineeredconstructsusingbasic/advancedskillsincellculture;(5)translationalresearchapproachtoapplybasicresearchtoclinicalapplications.

Topicsinwhichyouwouldliketodevelopcollaborativeresearch:Please indicate here research areas forwhich youwould like to find partners to undertake jointresearch.Nanocompositesorpolymerswithtuneablephysico-chemicalpropertiesforthemanufacturingofimplantablemedicaldevices;Surfacefunctionalisationatthenanoscaleinordertoobtainsuitablebiological activities; Smart scaffolds for Tissue Engineering applications, e.g. bone, cartilage, softtissueregeneration.

Name: PiergiorgioGentilePosition: LecturerInstitute/division: Schoolofmechanicalandsystemsengineering–

NewcastleUniversityEmail: piergiorgio.gentile@ncl.ac.ukTel: +4401912083620

中英科技桥

Relevantexistingcollaborations(academic/clinical/commercial)insideoroutsideChina.IncludehereanyrelevantcollaborationsyouhaveUK:Sheffield,UCL,Leeds,Loughborough,Bradford.Italy:Turin,Milan,ModenaandReggioEmilia,Ancona.Relevantgraphics,figures,pictures:

PublicationsandotheroutputsrelevanttoyourinterestinthisprogrammePleasegivereferencestoyourkeyrecentresearchpublications• Gentile,M.E.Frongia,M.CardellachRedon,C.A.Miller,G.P.Stafford,G.Leggett,P.V.Hatton.

FunctionalisednanoscalecoatingviaLayer-by-LayertechniquetoimpartantibacterialpropertiesofPLGAbiofilms,ActaBiomater.2015,21,35-43.

• P.Gentile,V.K.Nandagiri,R.Pabari,J.Daly,C.Tonda-Turo,G.Ciardelli,Z.Ramtoola.InfluenceofParathyroidHormone-LoadedPLGANanoparticlesinPorousScaffoldsforBoneRegeneration,Int.J.Mol.Sci.2015,16(9),20492-20510.

• P.Gentile,V.K.Nandagiri,J.Daly,V.Chiono,C.Mattu,C.Tonda-Turo,G.Ciardelli,Z.Ramtoola.Localisedcontrolledreleaseofsimvastatinfromporouschitosan-gelatinscaffoldsengraftedwithsimvastatinloadedPLGA-microparticlesforbonetissueengineeringapplication,MaterSciEngC2016,59,249-257.

• P.Gentile,C.Ghione,C.Tonda-Turo,andD.MKalaskar.Peptidefunctionalisationofnanocompositepolymerforbonetissueengineeringusingplasmasurfacepolymerisation,RSCAdvances,2015,5(97),pp.80039-80047

• P.Gentile,I.Carmagnola,T.Nardo,V.Chiono.Layer-by-layerassemblyforbiomedicalapplicationsinthelastdecade,Nanotechnology.2015,26(4),422001.

Fibrousscaffolds

Spongelikescaffolds

Guides

Prototypedscaffolds

CompactfilmsOverviewofthemanufacturedmedicaldevices

Bioactivematerialsabletoinducedepositionofhydroxyapatite

Injectablebiodegradablecement

Antimicrobialsurface Cellsbiocompatibility