Identifying genes that spread
killer cancer
Luke Zappia@_lazappi_
Cancer is BAD
21% of deaths worldwide(WHO Mortality Database, 2010)
30% of deaths in Australia(ABS Causes of Death, Australia, 2012)
COLORECTAL Cancer is
REALLY BadSecond worst cancer
Seventh biggest cause of death(ABS Causes of Death, Australia, 2012)
LATE STAGE Colorectal Cancer is really, REALLY bad
5 year survival
Early stage: 90% Mid Stage: 70%
Late Stage: 13%!(ACS, Cancer Facts and Figures 2014)
Why?
Colorectal Cancer: Tumor SizesFor the National Cancer Institute ©2005 Terese Winslow, U.S. Govt. has certain rights
How?
Labwork by Fanny Grillet, Jean-Marc Pascussi, Julie Pannequin
(CNRS Institute of Functional Genomics, Montpellier)
Our Data
Our Data
RNA-Seq
ALIGNMENT
COUNTING
EXPRESSION
PATHWAYS
Millions of short reads
- Where?
- How Many?
- On/off?
- Effects?
Colorectal cancer is bad
Metastasis is the killer
How do cancer cells spread?
AcknowledgementsSupervisorsArthur Hsu, Fred HollandeMembers of the Taylor lab and Department of Pathology
CollaboratorsFanny Grillet, Jean-Marc Pascussi, Julie PannequinCNRS Institute of Functional Genomics, Montpellier
ImagesHepatocellular Carcinoma, FNA Pathological and histological images courtesy of Ed Uthman at flickr, via Wikimedia Commons
Micrograph showing tumour budding in colorectal carcinoma, H&E stain By Nephron (Own work), via Wikimedia Commons
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