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Fundamental of Biomedic Science 2
CO Intoxication
Ayu Insafi M
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Mr.A 27 y.o, presented to emergency unit falling
fall, 4 hour after he took a dinner with his friends.
He had been smoking shisha with three other
friends and had neck stiffness after a fall. Those
three other friends experience dizziness, nause
and vomiting without falling. He had retrograde
amesia. He complained dizziness
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Physical examination
Temperature : 38oC
Pulse : 110 bpm
Laboratory finding
CoHb : 27,8%
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asic sciences
oRedox
Definition
Example redox reaction
oOxidative phosporylation
Structure of mitochondria
Transfer electron and OP mechanismInhibitors in mitochondrias complex
CO binding
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Topic discussionCase review
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asic sciences
oBioenergetics
Thermodynamics law I
Thermodynamics law II
Example
oFree radical
DefinitionExamples
Mechanism
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Topic discussionCase review
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asic sciences
oCO
Source (endogen and exogen)
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Topic discussionCase review
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oBHP and IIMC
oPathomechanism
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Topic discussionCase review
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redoks
Redoks adalah istilah yang menjelaskan
berubahnya bilangan oksidasi atom-atom dalam
sebuah reaksi kimia
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Reduksi Oksidasi
Melepas O2 Menerima O2
Menerima H+ Melepas H+
Menerima e-
Melepas e-
Endergonik Eksergonik
Free radicalBioenergeticsOxidative phosporylationRedox
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redoks
Example
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Free radicalBioenergeticsOxidative phosporylationRedox
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redoks
NAD+ reduction on glycolysis
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Free radicalBioenergeticsOxidative phosporylationRedox
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redoks
NAD+ oxidation on electron transfers
NADH + 5H++ QNAD++ QH2 +
4H+
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Free radicalBioenergeticsOxidative phosporylationRedox
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Transfer elektron
redox reaction on electron transfer
NADH + H++ O2+NAD++ H2O
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Free radicalBioenergeticsOxidative phosporylationRedox
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Nadh dan fadh
10 NADH dan 2 FADH
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2NADH, 2 ATP
Glikolisis
2 NADH, 2 CO2
Dekarboksilasi oksidatif
2 ATP, 6 NADH, 2 FADH, 4 CO2
TCA
FO
Free radicalBioenergeticsOxidative phosporylationRedox
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mitokondria
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Radikal bebasBioenergeticsFosforilasi oksidatifRedoks
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Transfer elektron
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Free radicalBioenergeticsOxidative phosporylationRedox
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Sintesis atp
ADP + Pi + H+PATP + H2O + H+N
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Free radicalBioenergeticsOxidative phosporylationRedox
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inhibitor
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Golongan barbiturat : piercidin,rotenone, amytal
KompleksI
Carboxin dan TTFA
Malonate
Kompleks
II
Antimycin
Dimecarpol
KompleksIII
CO
Sianida
H2S
KompleksIV
Radikal bebasBioenergeticsFosforilasi oksidatifRedoks
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CO binding
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CO binds to cytochrome aa3
Disrupting oxidativemetabolism
Free radicals (peroxynitrite)
Impaired electron transport
ATP
Free radicalBioenergeticsOxidative phosporylationRedox
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Thermodynamics law
e.g
ADP + Pi + H+
PATP + H2O + H+N
ADPHeat
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Energy can be changedfrom one form to another,but it cannot be created or
destroyed.
Free radicalBioenergeticsOxidative phosporylationRedox
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Thermodynamics law
G (< 0) : exergonic. spontanG (> 0) : endergonic
G (= 0) : equilibrium
e.g : Glucose + ATPglucose-6-phosphate
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G = HT. S
Free radicalBioenergeticsOxidative phosporylationRedox
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Free radical
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Free radicalBioenergeticsOxidative phosporylationRedox
Unpaired electron
Reactive
Denaturation ofcell
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examples
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Free radicalBioenergeticsOxidative phosporylationRedox
H2O2O2
.Endogen
UV
NO, SOExogen
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examples
Superoxide
Hydroxyl
Peroxide
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Free radicalBioenergeticsOxidative phosporylationRedox
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Mechanism of action
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Free radicalBioenergeticsOxidative phosporylationRedox
Initation
Propagation
Termination
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Mechanism of action
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Free radicalBioenergeticsOxidative phosporylationRedox
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antioxidant
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Free radicalBioenergeticsOxidative phosporylationRedox
Preventive
Chain breaking
Vitamins
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Sources of CO
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Free radicalBioenergeticsOxidative phosporylationRedox
Endogen
Polution
CigaratteEksogen
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pathomechanism
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CO poisioning
NO Cytochrome
binding
Hemeglobin,myoglobin
binding
POdisturbance
ATP -
ADP kalorFebris
Hipoksia
anaerob
ATP -
Fall
Suplai keotak
takikardi
Amnesia
retrograde
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HP
Pengelolaan informasi :
Bahaya merokok
Bahaya sisha
Konseling :
Menyarankan untuk mengurangi merokok
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IIMC
Dan Kami tidaklah menganiaya mereka tetapi
merekalah yang menganiaya diri mereka
sendiri, karena itu tiadalah bermanfaat
sedikitpun kepada mereka sembahan-sembahan yang mereka seru selain Allah, di
waktu azab Tuhanmu datang. Dan
sembahan-sembahan itu tidaklah menambahkepada mereka kecuali kebinasaan
belaka.(QS. Huud : 101 )
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