1999 amino acids, peptides

amino acids, peptidesU 0400

12 - 207Chemoenzymatic Synthesis of 4-Amino-2-hydroxy Acids: A Compar-ison of Mutant and Wild-Type Oxidoreductases. — The geneticallyengineered H205Q mutant of oxidoreductase (bio-agent1) is proved to be anideal catalyst for the reduction of all the α-keto acids, which are derived fromthe esters (II) by lipase treatment. In all cases single diastereomers are formed.In contrast, the wild-type lactate dehydrogenases (bio-agent2 and bio-agent3)reduce only the keto acid derived from ester (IIa). — (SUTHERLAND,ANDREW; WILLIS, CHRISTINE L.; J. Org. Chem. 63 (1998) 22, 7764-7769;Sch. Chem., Univ. Bristol, Cantock’s Close, Bristol BS8 1TS, UK; EN)

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