1
CHEM 452(G)
Forensic Toxicology
Western Illinois University
Spring 2018 Semester
Instructor: Dr. Liguo Song
Tel: (309) 298-1656
E-mail: [email protected]
Office: Currens 324B
Office Hours: M.W.F. 10:00 – 11:20 am
Teaching Assistant: Mr. Terrence Petry
Lecture (Section/001; STAR Number/35997): M.W.F./ 12:00 – 12:50am; Currens 206.
Lab (Section/021; STAR Number/36050): T./11:00 am -1:50 pm; Currens 419. The first hour
will be the case studies and pre-lab lectures in Currens 206.
Course prerequisites: CHEM 332 Organic Chemistry II, CHEM 341 Analytical Techniques.
Course description: This course will survey the principal areas in analytical and forensic
toxicology. The first half of the course covers the main elements of forensic toxicology, including
introduction to forensic toxicology, pharmacokinetics and metabolism, drugs of abuse, workplace
drug testing, postmortem toxicology, drug abuse in sport, drug-facilitated sexual assault, and
driving under the influence of alcohol and drugs. The second half of the course is devoted to the
main elements of analytical toxicology, including sample preparation, spectroscopy, immunoassay,
mass spectrometry, introduction to analytical separations, gas chromatography, high-performance
liquid chromatography, capillary electrophoresis, and QA/QC (quality assurance and quality
control) in the toxicology laboratory.
Couse structure: This course is composed of lectures (including class discussion and video
supplements), laboratory experiments, case studies, homework assignments, quizzes, a research
paper, and examinations. We will meet face-to-face for lectures, laboratory experiments, case
studies, quizzes and examinations. We will also make extensive use of our WesternOnline course
website (http://westernonline.wiu.edu) for homework assignments and a research paper. If you
need technical assistance at any time during the course or to report a problem with WesternOnline
you can:
1. Call uTech support center 309-298-2704
2. Use Desire2Learn Help 10.1
Objectives: 1. Gain knowledge of how to perform meaningful interpretation of data from
analytical/forensic measurements.
2. Gain a fundamental understanding of the types of toxicological evidence and the correct
procedures for their collection, preservation, inventory and transportation.
3. Understand the principles, theories, and application of the appropriate analytical
technologies used for the analysis of toxicological specimens.
2
Materials:
1. Textbook:
1) Clarke’s Analytical Forensic Toxicology, 2nd edition. Editor: Adam Negrusz and
Gail Cooper. Print: ISBN-13 9780857110541. Publishers: Pharmaceutical Press.
2. Supplemental textbooks:
1) Criminalistics: an introduction to forensic science, 11th edition. Author: Richard
Saferstein. Print: ISBN-13 9780133858136. Publisher: Pearson Prentice Hall.
2) Forensic Chemistry, 2nd edition. Author: Suzanne Bell. Print: ISBN-13
9780321765758. Publishers: Pearson Prentice Hall.
3) Quantitative Chemical Analysis, 9th edition, Author: Daniel C. Harris. Print:
ISBN-13 9781464135385. Publisher: W.H. Freeman and Company. 3. Lab Manual: Handouts.
4. Case files (to be provided).
Supplies (required):
1. Protective eyewear (safety goggles) for use in the laboratory experiments
2. Scientific calculator without internet access capability
3. Official lab research notebook-50 pages from the WIU bookstore.
Grade determination
Component % Possible points
Laboratory experiments 18 180
Case studies 8 80
Homework assignments 12 120
Quizzes 12 120
Research paper/presentation 5 50
Three semester exams 30 297
Final exam 15 153
Total points 100 1000
1. Laboratory experiments (18%): A total of 10 laboratory experiments will be performed
during the semester. Labs are given as scheduled in the syllabus (or announced in class in
the unlikely case that it must be rescheduled). Students may work in lab groups of a few
people, but each student must complete his/her own lab reports. No credit will be given to
any student who did not physically complete the lab as instructed or turn in the lab report.
To accommodate absence only your 9 best labs will be counted toward your final grade.
Also, should you miss two labs due to a medically required absence, military commitment,
or other excused reason, and provide acceptable documentation, a make-up lab will be
given after all the labs are completed to replace the missed lab score. It is the instructor’s
decision as to whether an absence shall be excused. Should you miss more than two labs,
no further make-up lab will be given. Each lab will be worth 20 points. Your total
number of points possible from labs will be 180 points. You must score a minimum of
100 points in the laboratory experiments to pass this course. There is a penalty for
turning in a lab report late: 10% will be deducted for each day. Assignments of lab
3
reports over a week late will not be accepted and will receive zero point. There will be
also a final exam of case studies and labs, which will be worth a total of 30 points.
To participate in the laboratory experiments, students must pay $35 charge and sign
the Chemistry Laboratory Safety Agreement.
To prepare for the lab, students must read through each lab in advance and also attend the
pre-lab lecture.
Safety is the first concern in a chemistry laboratory experiment. Material Safety Data
Sheets (MSDS) information on all chemicals utilized in the laboratory can be found at the
following web site, http://hazard.com/msds/. Proper handling of chemicals is expected. The
following rules must be observed while working in the laboratory:
1) Appropriate safety goggles must be worn at all times – the use of contact lenses
is discouraged.
2) Proper dress is required - bare feet, sandals, or opened-toed shoes are not allowed
in the laboratory. It is best not to wear expensive clothing as stains and holes can
result from misplaced chemicals.
3) Behaving appropriately – you must be aware of others around you, so be careful
when carry chemicals and walk through the laboratory.
4) Know the location and operation of the safety equipment – this includes
eyewash facilities, fire extinguishers, fire showers, and fire blankets. In case of fire,
do not panic, clear out of the immediate area, and call your instructor for help.
5) Cleaning up – it is important that you clean your workstation upon completing
your laboratory exercise.
6) Food, drinks and smoking of any kind are not allowed in the laboratory – keep
all objects, such as glassware or plastic tubing, out of your mouth while in the lab.
7) No cell phone calls in the laboratory.
The lab reports are to be typewritten (Font-12 and Times New Roman is preferred,
margins 1 inch). Lab reports must include the cover page, the objective of the experiment,
theory/background relates to the experiment, materials for the lab, and the procedures (in
your own words), experimental results (including calculations), discussions and
conclusions, and reference(s). The report must be completed and submitted electronically
as a single “word file” to the WesternOnline class dropbox by 11:30 pm on the day of the
same week when the next lab starts on the next day (see schedule below). Lab reports
should represent the individual student's work. Discussion with your lab partner and
classmates on the report is fine, but you must not copy the content of the report from your
partner or any other sources. The format and the distribution of lab points per lab report
are listed below:
1) Cover page (5%): Must include the title of the experiment, course number, your
name (bold type), your lab partner’s name, instructor’s name, TA’s name, and date.
2) Objective (5%): State two to three sentences about the objectives of the
experiment. If there is a crime scene, then narrative about the crime scene must be
included.
4
3) Theory/Background information (15%): Require half to a page to summarize the
basics of how the objectives will be realized. This may include important reactions,
techniques or instrumental methods. It should not include procedures.
4) Materials (5%): List chemicals, reagents and their concentration, instruments
being used.
5) Procedures (15%): The details should be sufficient so that your fellow students
can read your report without any guessing. Any last minute change in procedures
or concentration during lab session must be recorded. Use your own words to write
up a lab procedure; do not directly copy the procedure from lab manual/handout.
You must use past tense and passive voice to write up your lab report (5% will
be deducted with the wrong format).
[Sample examples]
“I collect the samples from the crime scene, place them in the bag, seal it, and
have my signature and date on the bag.” The format is wrong because the
present tense is used.
“I collected the samples from the crime scene, placed them in the bag, sealed it,
and had my signature and date on the bag.” The format is wrong even though
the past tense is used because it is not a passive voice.
“Samples from the crime scene were collected, placed in the bag and sealed,
and signed and dated by me.” This is the right format.
[Note] Avoid placing Arabic numerals at the beginning of each sentence.
For instance, “0.6 g glycine was weighed out and put into a 100 mL volumetric
flask” is not a correct format.
“Point six gram of glycine was weighed out and put into a 100-mL volumetric
flask” or “Glycine (0.6 g) was weighed out and put into a 100-mL volumetric
flask,” which is the correct format.
6) Results (30%): The accuracy/quality of your data will be graded.
These should include tables, graphs and calculations, if any
Tables and graphs should have self-explanatory titles
Numbers should have appropriate units
X and Y axes should be labeled
All calculations should be included with appropriate units
7) Discussions and Conclusions (20%) You recorded data and did some analysis
during the lab session and did further analysis and wrote a lab report in a week after
the experiment(s). What have you learned from the experiment(s) and what is (are)
the conclusion(s)?
8) References (5%): List cited references.
If you take information from chem 440 Westernonline handouts, then cite
the URL address. For instance:
Huang, Jenq-Kuen (2015). Density of glass by flotation.
https://westernonline.wiu.edu/d2l/le/content/66439/viewContent/971288/
View?ou=66439
If you cite any journal article you have to follow this format:
Thogmartin, Jon R., Wilson, Christopher I., Palma, Noel A., Ignacio,
Susan S., Mark, J. Shuman., and Flannagan, Lisa M. (2011). Sickle Cell
5
Trait-Associated Deaths: A Case Series with a Review of the Literature.
Journal of Forensic Sciences, 56 (5): 1352–1360.
2. Case studies (8%): There will be approximately 10 case files to be presented before every
pre-lab lecture. The presentation of each case file will last approximately 20 minutes.
Students are required to answer specific questions about each case and submit the answers
in the dropbox on WesternOnline. In order to receive a grade of each case study, the
answers must be submitted electronically as a single “word file” in the WesternOnline
class dropbox by 11:30 pm on the day of the same week when the next lab starts on
the next day (see schedule below). Each case study will be worth 5 points. There will
also be a final exam of case studies and labs, which will be worth a total of 30 points. The
case files can also be watched after class. To watch them, please download this syllabus,
open this syllabus in Microsoft Word, right click the corresponding case file name which
is listed in the table of tentative class schedule at the end of this syllabus, copy the hyperlink,
and then paste it on Google Chrome.
3. Homework assignments (12%): There will be approximately eight homework
assignments periodically during the semester. The homework assignments will appear in
the WesternOnline as online quizzes. Each homework assignment will consist of
approximately 20 questions. Each question will be worth 1 point. You will be allowed to
have two attempts with unlimited time to solve the questions. At the end of each attempt,
the questions answered incorrectly will be shown to you. After you finish, your highest
attempt will be automatically graded. In order to receive a grade of each homework,
you must do it within the available time window, which is usually a couple of days. In
order to accommodate absence only your six best homework assignments will be used to
determine your final grades. Your total number of points possible from the homework
assignments will be 120 points.
5. Quizzes (12%): There will be approximately eight online quizzes periodically during the
semester. A quiz usually follow a homework assignment. Each quiz will consist of
approximately 20 questions. Each question will be worth 1 points. You will have 30
minutes to complete each quiz which will be automatically graded. In order to receive a
grade of each quiz, you must do it within the available time window, which is usually
a couple of day. To accommodate absence only your six best quizzes will be used to
determine your final grades. Your total number of points possible from the quizzes will be
120 points.
6. Regular Semester Exams (30%): There will be four regular semester exams. Each exam
will consist of approximately 33 questions and each question will be worth 3 points. To
accommodate absences only your best three of four lecture exams will be counted for your
semester grade. Also, should you miss two exams due to a medically required absence,
military commitment, or other excused reason, and provide acceptable
documentation, a comprehensive make-up examination will be given near the end of
the semester to replace the missed exam score. The make-up exam will be
comprehensive over all materials. It is the instructor’s decision as to whether an absence
shall be excused. Your total number of points possible from the regular semester exams
6
will be 297 points. Exams should be given approximately at the date as scheduled in the
syllabus, but the exact date will be announced in class.
7. Final Exam (15%): The final exam is comprehensive. It will consist of approximately 51
questions and each question will be worth 3 points. The final exam will be worth 153 points.
No incomplete grade will be given to a student without documented evidence of an
emergency that requires that the student be away from the university or requires that
the student miss the final examination. Students shall notify the instructor of the
emergency as soon as possible and prior to the final examination.
8. Research paper/presentation (5%): While a research paper is required for students who
take this course as CHEM 452, a research presentation is required for students who take
this course as CHEM 452(G).
Your research paper/presentation will be based on a journal research article describing
the analysis of a drug/poison. A list of drug/poison will be shared with you. You are
required to put your signature by the drug/poison that you choose. The same drug/poison
is not allowed to be chosen twice or by two students. You have to make your choice by
11:30 pm on February 28. Copies of two pertinent journal research articles must be
submitted for the instructor’s approval to the Western Online class dropbox by 11:30 pm
on March 31. Students are required to use Science Citation Index Expanded (via Web of
Science) through the WIU library to choose the two pertinent journal articles. Students are
advised to browse the journal articles and make sure that you will be able to understand
them before your final selection. After the instructor has selected one of the two pertinent
journal articles for each student to read, the student must study the drug/poison and relevant
instrumental technique(s) thoroughly which are usually not the main focus of the selected
article, but are crucial to understand the results described by the journal article.
Your research paper should be about seven pages (Times New Roman Font-12 and double
spaced). The first page should be the cover page which include the title of the article, course
number, your name (bold type), instructor’s name, and date. The last page should be the
reference page. In the middle, there should be about five pages describing the research in
the journal article. There will be 10 points deduction for every page off the mark. While
you can use tables and graphics during the description of the research in the journal article,
the total number of tables and graphics cannot exceed three; and the size of the tables and
graphics cannot be larger than the originals in the journal article. The description should
include five sections: introduction (including toxicology and/or pharmacokinetics, 10
points), sample preparation (5 points), analytical method (5 points), results (20 points) and
discussion (10 points). Your total number of points possible from the research paper will
be 50 points. The final version of the research paper must be completed and submitter to
the Western Online class dropbox by 11:30 pm on April 30.
The PowerPoint slides of your research presentation should include at least five parts:
introduction such as toxicology and/or pharmacokinetics (5 points), sample preparation
(2.5 points), analytical method (2.5 points), results (10 points) and discussion (5 points).
Your total number of points possible from your PowerPoint slides will be 25 points. The
7
final version of your PowerPoint slides must be completed and submitted to the Western
Online class dropbox by 11:30 pm the day before your presentation. Your research
presentation will be approximately 20 minutes. There will be 25% deduction for every
more than 5 minutes off the mark. Your total number of points possible from your research
presentation will be 25 points.
The research paper/presentation is meant to be the original work of the individual student;
plagiarism is not acceptable and will result in a score of zero. If the student is not familiar
with the concept of plagiarism they should contact the University Writing Center for
clarification. "The University Writing Center is available to assist you with general and
specific questions on writing assigned in any discipline and at any academic level. The
one-on-one assistance available at the Writing Center is valuable for generating ideas,
talking about global-level issues such as organization, and even working through
grammatical problems. The University Writing Center is located in the Malpass Library,
third floor, west side. Call for an appointment (298-2815) and be sure to bring a copy of
your assignment."
Grading scale for CHEM 452:
90.00% and above A
86.70 - 89.99% A-
83.40 - 86.69% B+
80.00 - 83.39% B
76.70 - 79.99% B-
73.40 - 76.69% C+
70.00 - 73.39% C
66.70 - 69.99% C-
63.40 - 66.69% D+
60.00 - 63.39% D
56.70 - 59.99% D-
56.66% and below F
Grading scale for CHEM 452(G):
90.00% and above A
80.00 - 89.99% B
70.00 - 79.99% C
60.00 - 69.99% D
59.99% and below F
Course polices - to earn a passing grade in this course the student must:
1. Keep up with textbook reading, including supplemental textbook reading when required.
2. Complete laboratory experiments, case studies, homework assignments, the research paper,
quizzes and exams as assigned.
3. Attend class regularly and punctually. You are responsible for all information and materials
in classes whether you are present or not. Students who are present for all the classes
and labs will receive 20 bonus points at the end of the course. While students who
have excused absences may still qualify for 20 bonus points, students who receive
8
more than five excused absences do not qualify. In order to qualify for excused absence,
you have to hand in necessary paperwork. In addition, please make an official request
through the WIU online absence reporting system (OARS). While student are also
allowed to have unexcused absences, after a maximum of five unexcused absences
students will receive 50 point deduction for every additional unexcused absence. Any
student arriving more than ten minutes late for any exam, lecture or lab may not be allowed
to take or complete the exam, lecture or lab at the instructor’s discretion. Leaving the
classroom prior to completion of an exam is prohibited. When a student leaves the
classroom, the exam is complete. If the student leaves the classroom with an exam without
submitting the exam for grading, the value of the exam is zero.
4. Participate in a professional manner. Listen (do not have conversations) while the
instructor is speaking. If you have questions, raise your hand and/or politely say “excuse
me” to get the instructor’s attention. Phrase your questions using professional, respectful
words and tone of voice. Turn your cellphone ringer off, and put it away. Your instructor
should not be able to see your cell phone at any time during class. Laptops and tablets may
only be used with special permission. Use the restroom before class. Leaving the classroom
during class should only happen in very rare circumstances of dire emergency. Failure to
follow these rules may result in being required to leave the classroom for the remainder of
the class period.
5. Email correspondence must also be professional. This means that messages should be
written clearly, using proper spelling, punctuation, and grammar. Address the instructor
using the appropriate title (i.e., Dr. or Professor). Before sending an email, check to see
whether the answer to your question is in the syllabus or other document on WesternOnline.
Unprofessional messages may not receive a response from the instructor.
6. Study regularly for the exams—do not wait until just before. For best results, read the
material according to the schedule in advance, and then review the material and your notes
after lecture and lab the same week.
7. Check WesternOnline to stay apprised of any changes--the student is responsible for
keeping up with class. WIU policy on student rights and responsibilities can be found at
http://www.wiu.edu/provost/students.php.
8. Each student must complete their own individual course assignments and take their own
exams. All exams and the assignments are the responsibility of the individual student. If it
can be demonstrated that two students have collaborated in an assignment, they will both
lose the opportunity to earn a grade for that assignment. (This does not exclude students
from group study). Academic dishonesty in any form, including cheating and
plagiarism, will not be tolerated. Potential penalties will be decided on an individual case
basis. Please see the WIU Academic Policy for Undergraduate Students for further
information: http://www.wiu.edu/policies/acintegrity.php.
9. In accordance with University values and disability law, students with disabilities may
request academic accommodations where there are aspects of a course that result in
barriers to inclusion or accurate assessment of achievement. To file an official request for
disability-related accommodations, please contact the Disability Resource Center at 309-
298-2512, [email protected] or in 143 Memorial Hall. Please notify the instructor as
soon as possible to ensure that this course is accessible to you in a timely manner.
10. University values, Title IX, and other federal and state laws prohibit sex discrimination,
including sexual assault/misconduct, dating/domestic violence, and stalking. If you, or
9
someone you know, has been the victim of any of these offenses, we encourage you to report
this to the Title IX Coordinator at 309-298-1977 or anonymously online at:
http://www.wiu.edu/equal_opportunity_and_access/request_form/index.php. If you
disclose an incident to a faculty member, the faculty member must notify the Title IX
Coordinator. The complete Title IX policy is available
at: http://www.wiu.edu/vpas/policies/titleIX.php.
11. The WIU Office of Risk Management and Emergency Preparedness provides resources
on how to respond to emergency situations. Please view the video resources at
www.wiu.edu/rmep (click “Resources” on the right side of the page). If the fire alarms
sound and/or students are asked to evacuate the building all students should proceed
immediately to the nearest exit and gather at the southwest corner of the Higgins parking
lot (near the fence) until the “all clear” is given. 12. Web address for student rights and responsibilities: http://www.wiu.edu/provost/students.php.
Tentative class schedule*:
Week Date Chap/Lab
1 Monday, January 15, 2018 Dr. Martin Luther King Day
1 Tuesday, January 16, 2018 Chap 1 Syllabus, Introduction to forensic
toxicology
1 Wednesday, January 17, 2018 Chap 1 Introduction to forensic toxicology
1 Friday, January 19, 2018 Chap 1 Introduction to forensic toxicology
2 Monday, January 22, 2018 Chap 3 Forensic drug analysis: selected
drug classes
2 Tuesday, January 23, 2018 Chap 3 Forensic drug analysis: selected
drug classes
2 Wednesday, January 24, 2018 Chap 13 Sampling, storage and stability
2 Friday, January 26, 2018 Chap 13 Sampling, storage and stability
3 Monday, January 29, 2018 Chap 7 Postmortem toxicology
3 Tuesday, January 30, 2018 Chap 7 Postmortem toxicology
3 Wednesday, January 31, 2018 Chap 7 Postmortem toxicology
3 Friday, February 02, 2018 Chap 2 Pharmacokinetics and metabolism
4 Monday, February 05, 2018 Chap 2 Pharmacokinetics and metabolism
4 Tuesday, February 06, 2018 Case Study 1 Writer’s block
4 Tuesday, February 06, 2018 Lab 1
1a. Excel laboratory; 1b. Separation
of drugs using thin-layer
chromatography
4 Wednesday, February 07, 2018 Exam 1 (Chapters 1, 3, 13 & 7)
4 Friday, February 09, 2018 Chap 2 Pharmacokinetics and metabolism
5 Monday, February 12, 2018 Lincoln's Birthday
5 Tuesday, February 13, 2018 Case Study 2 Sunday’s wake
5 Tuesday, February 13, 2018 Lab 2 Discovery of internal standard for
GC analysis
5 Wednesday, February 14, 2018 Chap 2 Pharmacokinetics and metabolism
10
5 Friday, February 16, 2018 Chap 10 Drug-facilitated sexual assault
6 Monday, February 19, 2018 No class AAFS Conference
6 Tuesday, February 20, 2018 Case Study 3 Bitter potion
6 Tuesday, February 20, 2018 Lab 3
External versus internal standard
calibration in GC analysis (Part 1
sample preparation)
6 Wednesday, February 21, 2018 No class AAFS Conference
6 Friday, February 23, 2018 No class AAFS Conference
7 Monday, February 26, 2018 Chap 11 Alcohol, drugs and driving
7 Tuesday, February 27, 2018 Case Study 4 Something’s Fishy
7 Tuesday, February 27, 2018 Lab 4
External versus internal standard
calibration in GC analysis (Part 2
GC analysis)
7 Wednesday, February 28, 2018 Chap 11 Alcohol, drugs and driving
7 Friday, March 02, 2018 Chap 11 Alcohol, drugs and driving
8 Monday, March 05, 2018 Chap 5 Work place drug testing
8 Tuesday, March 06, 2018 Case Study 5 Cold hearted
8 Tuesday, March 06, 2018 Lab 5
Salicylates in blood by visible
spectroscopy with external standard
calibration
8 Wednesday, March 07, 2018 Chap 5 Work place drug testing
8 Friday, March 09, 2018 Exam 2 (Chapters 2, 10, & 11)
9 Monday, March 12, 2018 Spring Break
9 Tuesday, March 13, 2018 Spring Break
9 Tuesday, March 13, 2018 Spring Break
9 Wednesday, March 14, 2018 Spring Break
9 Friday, March 16, 2018 Spring Break
10 Monday, March 19, 2018 Chap 16 Immunoassays
10 Tuesday, March 20, 2018 Case Study 6 Without a trace
10 Tuesday, March 20, 2018 Lab 6 Salicylates in blood by visible
spectroscopy with standard addition
10 Wednesday, March 21, 2018 Chap 16 Immunoassays
10 Friday, March 23, 2018 Chap 17 Introduction to analytical
separations
11 Monday, March 26, 2018 Chap 17 Introduction to analytical
separations
11 Tuesday, March 27, 2018 Case Study 7 Political thriller
11 Tuesday, March 27, 2018 Lab 7
Presumptive test of urine
adulteration, abused drugs in urine
and alcohol in saliva
11 Wednesday, March 28, 2018 Chap 18 Gas chromatography
11 Friday, March 30, 2018 Chap 18 Gas chromatography
11
12 Monday, April 02, 2018 Chap 18 Gas chromatography
12 Tuesday, April 03, 2018 Case Study 8 Desert served cold
12 Tuesday, April 03, 2018 Lab 8 Optimization of the separation of
NSAIDs by HPLC
12 Wednesday, April 04, 2018 Chap 19 High-performance liquid
chromatography
12 Friday, April 06, 2018 Chap 19 High-performance liquid
chromatography
13 Monday, April 09, 2018 Exam 3 (Chapters 5, 16, 17 & 18)
13 Tuesday, April 10, 2018 Case Study 9 Deadly formula
13 Tuesday, April 10, 2018 Lab 9 SPE of phenylbutazone and internal
standard from equine plasma
13 Wednesday, April 11, 2018 Chap 19 High-performance liquid
chromatography
13 Friday, April 13, 2018 Chap 20 Chromatographic methods and
capillary electrophoresis
14 Monday, April 16, 2018 Chap 20 Chromatographic methods and
capillary electrophoresis
14 Tuesday, April 17, 2018 Case Study 10 Ultimate betrayal
14 Tuesday, April 17, 2018 Lab 10
Phenylbutazone in equine plasma
by HPLC using internal standard
calibration
14 Wednesday, April 18, 2018 Chap 21 Mass spectrometry
14 Friday, April 20, 2018 Chap 21 Mass spectrometry
15 Monday, April 23, 2018 Chap 21 Mass spectrometry
15 Tuesday, April 24, 2018 Make-up lab BAC by UV spectroscopy using an
enzymatic assay
15 Wednesday, April 25, 2018 Chap 22 Quality assurance and control in the
toxicology laboratory
15 Friday, April 27, 2018 Chap 22 Quality assurance and control in the
toxicology laboratory
16 Monday, April 30, 2018 Final exam of case studies and labs
16 Tuesday, May 01, 2018 Research presentation
16 Wednesday, May 02, 2018 Exam 4 (Chapters 19, 20, 21 & 22)
16 Friday, May 04, 2018 Review
17 Monday, May 07, 2018 Final Exam (1 pm)
*This table may not accurately represent the start and end points of each lecture.
Summary of homework assignments, quizzes and exams (not including the final exam):
1/4 1/8 Chap Title
Exam 1 Homework 1;
Quiz 1. 1 Introduction to forensic toxicology
3 Forensic drug analysis: selected drug classes
Homework 2; 13 Sampling, storage and stability
12
Quiz 2. 7 Postmortem toxicology
Exam 2 Homework 3;
Quiz 3. 2 Pharmacokinetics and metabolism
2 Pharmacokinetics and metabolism
Homework 4;
Quiz 4. 10 Drug-facilitated sexual assault
11 Alcohol, drugs and driving
Exam 3 Homework 5;
Quiz 5. 5 Work place drug testing
16 Immunoassays
Homework 6;
Quiz 6. 17 Introduction to analytical separations
18 Gas chromatography
Exam 4 Homework 7;
Quiz 7. 19 High-performance liquid chromatography
20
Chromatographic methods and capillary
electrophoresis
Homework 8;
Quiz 8. 21 Mass Spectrometry
22
Quality assurance and control in the toxicology
laboratory
Note: This syllabus reflects the course policies and planned schedule, and may be amended at the
instructor’s discretion at any time. Any revisions will be announced in class. The most current
version of the syllabus will always be available via the class website on WesternOnline.
Top Related