本章大綱 :1. B-Cell Maturation
2. B-Cell Activation and Proliferation
3. The Humoral Response
4. In Vivo Studies for Induction of Humoral Response
5. Germinal Centers and Antigen-Induced B-Cell Differentiation
6. Regulation of B-Cell Development
7. Regulation of the Immune Effector Response
Overview of B-cell Development
Sites of B-cell maturation – before birth: yolk sac fetal liver fetal bone marrow after birth: bone marrow
Bone-Marrow Stromal Cells Are Required for Maturation of Progenitor B Cells into Precursor B Cells
Direct contact is required
Sequential Expression of Membrane Ig and Surrogate Light Chain at Different Stages of
B-Cell Differentiation in the Bone Marrow
Experimental Evidence for Negative Selection of Self-Reactive B Cells During Maturation in the Bone Marrow
Clonal Anergy in Mature Peripheral B Cells
Production of double-transgenic mice carrying transgenes encoding HEL and anti-HEL Ab:
Clonal Deletion of Self-Reactive Mature Peripheral B Cells
Production of double-transgenic mice expressing the class I Kb molecule and anti-Kb Ab:
Concentration and Isotype of Serum Ab Following Primary (1° ) and Secondary (2 ° ) Immunization with Ag
Interactions of Numerous Cytokines with B Cells Generate Signals Required for proliferation and Class Switching During the Differentiation of B Cells into Plasma Cells
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