Dr. Vijay Marakala, MBBS, MD.
Assistant professor BIOCHEMISTRY SIMS & RC
CELL AND SUBCELLULAR STRUCTURE
CONTENT
Introduction Cell membrane
Subcellular organelles
Membrane Transport
CELL
Structural and
functional unit of life
Major components
Cell membrane
Cytoplasm with organelles
Nucleus
Animal Cell
Cell wall
Nucleus
Mitochondria
Endoplasmic Reticulum
Plant Cell
PROKARYOTES – NO WELL DEFINED NUCLEUS
CELL MEMBRANE (PLASMA MEMBRANE)
• Chemical composition
Lipids
Phospholipids
Glycolipids
Cholestrol
Proteins
Integral proteins
Peripheral proteins
Carbohydrates
Glycoproteins
Glycolipids
FLUID MOSAIC MODEL OF CELL MEMBRANE
MEMBRANE LIPIDS
Phospholipids
Glycolipids Cholesterol
MOST MEMBRANE LIPIDS ARE AMPHIPATHIC HAVING NONPOLAR END AND POLAR END.
MEMBRANE PROTEINS
Integral proteins
Peripheral protein
MEMBRANE CARBOHYDRATES • Play a key role in cell-cell recognition– ability of a cell to distinguish one cell from
another• antigens
– important in organ & tissue development
– basis for rejection of foreign cells by immune system
CELL MEMBRANE
DISORDER OF MEMBRANE TRANSPORT PROTEIN
Defect in Cystic fibrosis transmembrane regulator (CFTR) protein
A Cl
transporter
Cystic Fibrosis
STUDY QUESTIONS
Describe the Fluid mosaic model of Cell membrane.
Describe the composition of Cell
membrane.
Describe the functions of plasma
membrane.
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