CHAPTER 19 Reconstitution of Solutions 437
Copyright © 2014 by Mosby, an imprint of Elsevier Inc. All rights reserved.
CHAPTER REVIEW
Use the labels where provided to obtain the necessary information; shade the dosage onsyringes where provided. Round the answers to the nearest tenth where indicated.
1. Order: Kefzol 250 mg IM q4h.
Available:
a. How much diluent must be added to the vial for IM administration? ___________________________________
b. What is the final concentration of the solution prepared for IM administration? ________________________________
c. How many milliliters will you administer to provide the ordered dosage? __________________________________
d. Shade the dosage calculated on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
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2. Order: methylprednisolone sodium succinate 165 mg IV daily.
Available:
a. How many milliliters will you administer? ______________________________
b. Shade the dosage calculated on the syringe provided.
3. Order: Ampicillin 375 mg IM q6h
Available:
a. How much diluent must be added to the vial for IM administration? ___________________________________
b. What is the final concentration of the solution prepared for IM administration? ________________________________
11/ 2
21 /
2
1 /2
1 2 3 mL
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CHAPTER 19 Reconstitution of Solutions 439
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c. How many milliliters will you administer? ______________________________
d. Shade the dosage calculated on the syringe provided.
4. Order: Doxycycline 100 mg IVPB q12h.
Available:
How many milliliters will you administer? _________________________________
5. Order: Amoxicillin 0.4 g p.o. q8h.
Available:
a. How much diluent must be added to prepare the solution? _________________
b. What diluent is recommended for reconstitution? _________________________
c. What is the dosage strength of the reconstituted solution? __________________
d. How many milliliters will you administer? ______________________________
e. How long will the medication maintain its potency? ______________________
11/ 2
21 /
2
1 /2
1 2 3 mL
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440 UNIT FOUR Oral and Parenteral Dosage Forms and Insulin
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6. Order: penicillin G potassium 275,000 units IM q6h.
Available:
a. Which dosage strength would be best to choose? _________________________
b. How many milliliters of diluent would beneeded to make the dosage strength? ___________________________________
c. How many milliliters will you administer? ______________________________
d. Shade the dosage calculated on the syringe provided.
7. Order: Cytarabine 200 mg IV daily for 1 week.
Available:
a. What is the concentration of the reconstituted material? ___________________________________
b. How many milliliters will you add to the IV? ___________________________________
c. Shade the dosage calculated on the syringe provided.
11 / 2
21 /
2
1 /2
1 2 3 mL
11/ 2
21 /
2
1 /2
1 2 3 mL
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8. Order: Methylprednisolone Sodium Succinate 175 mg IV q6h.
Available:
a. What is the total dosage strength of Methylprednisolone Sodium Succinate in this vial? ___________________________________
b. What diluent is recommended for reconstitution? ___________________________________
c. How many milliliters will you add to the IV? ___________________________________
d. Shade the dosage calculated on the syringe provided.
9. Order: Amoxicillin/clavulanate 0.5 g p.o. q12h (calculation based on Amoxicillin).
Available:
a. How many milliliters of diluent must be added? ___________________________________
b. What is the dosage strength after reconstitution? ___________________________________
c. How many milliliters are needed to administer the required dosage? ___________________________________
32 541 mL
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10. Order: Cefotan 1.2 g IM q12h.
Available: Read the medication label and portion of the package insert.
a. How many milliliters will you administer? ______________________________
b. Shade the dosage calculated on the syringe provided.
11. Order: Nafcillin 0.5 g IM q6h.
Available:
a. What is the dosage strength of the reconstituted Nafcillin? __________________
b. How many milliliters will you administer? ______________________________
c. Shade the dosage calculated on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
11/ 2
21 /
2
1 /2
1 2 3 mL
Vial Size
1 gram
2 gram
Amount of DiluentAdded (mL)
2
3
ApproximateWithdrawable Vol (mL)
2.5
4
Approximate AverageConcentration (mg/mL)
400
500
442 UNIT FOUR Oral and Parenteral Dosage Forms and Insulin
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CHAPTER 19 Reconstitution of Solutions 443
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12. Order: Biaxin 350 mg p.o. q12h for 10 days.
Available:
a. How many milliliters of diluent must be added? __________________________
b. What is the dosage strength after reconstituion? __________________________
c. How many milliliters will you administer? ___________________________________
13. Order: Claforan 1 g IV q8h.
Available:
a. How much diluent must be added to the vial for IV administration? ___________________________________
b. What is the dosage strength of the solution prepared for IV administration? ___________________________________
c. How many milliliters will you add to the IV? ___________________________________
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444 UNIT FOUR Oral and Parenteral Dosage Forms and Insulin
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14. Order: Penicillin G potassium 400,000 units IM q4h.
Available:
a. How many milliliters will you administer? ___________________________________
b. Shade the dosage calculated on the syringe provided.
15. Order: Ceftazidime 250 mg IM q12h.
Available:
a. How many milliliters will you administer? ___________________________________
b. Shade the dosage calculated on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
11/ 2
21 /
2
1 /2
1 2 3 mL
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16. Order: Ticar 0.5 g IM q6h.
Available:
a. How many milliliters will you administer? ___________________________________
b. Shade the dosage calculated on the syringe provided.
17. Order: Cytarabine 150 mg IV daily for 7 days.
Available:
a. How many milliliters will you administer? __________________________________
b. Shade the dosage calculated on the syringe provided.
32 541 mL
11/ 2
21 /
2
1 /2
1 2 3 mL
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446 UNIT FOUR Oral and Parenteral Dosage Forms and Insulin
Copyright © 2014 by Mosby, an imprint of Elsevier Inc. All rights reserved.
18. Order: Vancomycin 0.45 g IV q8h.
Use the directions from the insert below.
Available:
a. How many milliliters of diluent must be added to the vial? ___________________________________
b. What is the final concentration of the prepared solution? ___________________________________
c. How many milliliters will you add to the IV? ___________________________________
d. Shade the dosage calculated on the syringe provided.
PREPARATION AND STABILITYAt the time of use, reconstitute by adding either 10 mL ofSterile Water for Injection to the 500-mg vial or 20 mL of Sterile Water for Injection to the 1-g vial of dry, sterile van-comycin powder. Vials reconstituted in this manner will givea solution of 50 mg/mL. FURTHER DILUTION IS RE-QUIRED.After reconstitution, the vials may be stored in a refrigeratorfor 14 days without significant loss of potency. Reconstituted solutions containing 500 mg of vancomycin must be dilutedwith at least 100 mL of diluent. Reconstituted solutions con-taining 1 g of vancomycin must be diluted with at least 200mL of diluent. The desired dose, diluted in this manner,should be administered by intermittent intravenous infusion over a period of at least 60 minutes.
10 mL
2 41 3 6 8 95 7
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19. Order: Levothyroxine sodium 0.05 mg IV daily.
Available:
a. How many milliliters will you add to the IV? ____________________________
b. Shade the dosage calculated on the syringe provided.
20. Order: Acyclovir 0.25 g IV q8h for 5 days.
Use the directions from the insert below.
Available:
a. How many milliliters will you add to the IV? ____________________________
b. Shade the dosage calculated on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
10 mL
2 41 3 6 8 95 7
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21. Order: Vantin 200 mg p.o. q12h.
Available:
How many milliliters will you administer using an oral syringe? ___________________________________
22. Order: Cefazolin 0.5 g IM q8h.
Available:
a. How many milliliters will you administer? ___________________________________
b. Shade the dosage on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
448 UNIT FOUR Oral and Parenteral Dosage Forms and Insulin
Copyright © 2014 by Mosby, an imprint of Elsevier Inc. All rights reserved.
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23. Order: Maxipime (Cefepime Hydrochloride) 1.5 g IV q12h.
Available:
a. How many milliliters will you add to the IV? ___________________________________
b. Shade the dosage on the syringe provided.
24. Order: Penicillin G Sodium 425,000 units IV daily.
Available:
a. Which dosage strength would be best to choose? ___________________________________
b. How many mL of diluent would be needed to make the dosage strength __________________________________
10 mL
2 41 3 6 8 95 7
Single-Dose Vials forIntravenous/IntramuscularAdministration
Amount ofDiluent to beadded (mL)
ApproximateAvailable
Volume (mL)
ApproximateCefepime
Concentration(mg/mL)
cefepime vial content
1 g (IV) 10 11.3 100
1 g (IM) 2.4 3.6 280
2 g (IV) 10 12.5 160
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c. How many milliters will you add to the IV? __________________________________
d. Shade the dosage calculated on the syringe provided.
25. Order: Vfend 200 mg IV q12h.
Available:
a. How many milliliters of diluent must be added to the vial? __________________________________
b. How many milliliters will you add to the IV? ___________________________________
26. Order: Cefprozil 500 mg p.o. q12h for 10 days.
Available:
a. How many milliliters of diluent are recommended for reconstitution? ___________________________________
b. How many milliliters will the bottle contain after reconstitution? ___________________________________
c. How many milliliters will youadminister? ___________________________________
11/ 2
21 /
2
1 /2
1 2 3 mL
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27. Order: Zosyn 2.25 g q8h IV.
Available:
a. How many milliliters of diluent are recommended for reconstitution? ___________________________________
b. What is the dosage strength of the vial? _________________________________
c. How many milliliters will you add to the IV? ___________________________________
28. Order: Zithromax 500 mg p.o. stat for 1 dose.
Available:
How many milliliters will you administer? ___________________________________
29. Order: Cefobid 1 g IM q12h for 5 days.
Available: Cefobid 1 g with directions to add 1.4 mL of sterile water for injection.Each 2 mL yields 1 g.
a. How many milliliters will you administer? ___________________________________
b. Shade the dosage on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
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30. Order: Unasyn 1.5 g IV q6h.
Available:
Refer to portion of package insert.
How many milliliters will you add to the IV? ___________________________________
31. Order: Pepcid 20 mg p.o. b.i.d.
Available:
How many milliliters will you administer using an oral syringe? ___________________________________
Unasyn Vial Size Volume of Diluent to Be Added Withdrawal Volume
1.5 g 3.2 mL
6.4 mL
4 mL
3 g 8 mL
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32. Order: Rocephin 125 mg IM stat.
Available:
a. How many milliliters will you administer? ___________________________________
b. Shade the dosage on the syringe provided.
11/ 2
21 /
2
1 /2
1 2 3 mL
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33. Order: Amphotericin B 45.5 mg IV every day.
Available:
Use the information from the partial package insert to answer the questions and cal-culate the number of milliliters you will administer.
a. How many milliliters of diluent must be added for the initial concentration? ___________________________________
b. What is the recommended diluent? ___________________________________
c. What is the final concentration of the prepared solution per milliliter? ___________________________________
d. How many milliliters will you administer? ___________________________________
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34. Order: Omnicef 300 mg p.o. q12h for 5 days.
Available:
a. How many milliliters of diluent must be added to the bottle for reconstitution? ___________________________________
b. What is the final concentration of the prepared solution? ___________________________________
c. How many milliliters will you administer? ___________________________________
35. Order: Zithromax 250 mg p.o. daily.
Available:
a. How many milliliters of diluent must be added to the bottle? ___________________________________
b. What is the final concentration of the prepared solution? ___________________________________
c. How many milliliters will you administer? ___________________________________
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