GENETIC VARIATIONS BETWEEN HAEMOGLOBIN PROTEIN OF HUMAN AND MACACA FASCICULARIS.…..
BY_ANIKET BAGUL
OUTLINE INTRODUCTION DATABASE OF HAEMOGLOBIN PROTEIN FASTA FORMAT SEQUENCE ALIGNMENT GRAPHICAL DISPLAY ALIGNMENT DESCRIPTION PHYLOGENETIC TREES AMINO ACID ANNOTATIONS AND PROPERTIES MAP VIEWER SEQUENCE VIEWER EPIGENOMICS 3D STRUCTURE OF PROTEIN CONCLUSION REFERENCE
DATABASE IN BIOINFORMETICS
NUCLEOTIDE SEQUENCE
PROTEIN SEQUENCE
3D STRUCTURE OF MOLECULE
ALIGNMENT
GENE EXPRESSION
GRAPHICAL DISPLAY
EPIGENOMICS
BIOINFORMETICS-Application of computer science that deals with the study of molecular biology
It deals with coding and decoding of sequence of nucleotides
Branches- ‘Genome , ‘Genomics , ‘Proteome , ‘Proteomics .
Central dogma….DNA-RNA-PROTEIN
HAEMOGLOBIN PROTEIN
HAEMOGLOBIN (HB) IS OXYGEN BINDING PROTEIN
IT CONTAINS 2 PARTS – HEME LIGAND & GLOBIN PROTEIN PART
HEME PART IS SYNTHESIZED IN MITOCHONDRIA AND IMMATURE RBC’s
GLOBIN PROTEIN PART IS SYNTHESIZED BY RIBOSOMES IN CYOTOSOL
DATABASE OF HUMAN HB PROTEIN
DATABASE OF MACACA HB PROTEIN
FASTA FORMAT GTGCACCTGACTCCTGAGGAGAAGTCTGCC
GTTACTGCCCTGTGGGGCAAGGTGAACGTGGATGAAGTTG GTGGTGAGGCCCTGGGCAGGCTGCTGGTGGTCTACCCTTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGA TCTGTCCACTCCTGATGCTGTTATGGGCAACCCTAAGGTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCC TTTAGTGATGGCCTGGCTCACCTGGACAACCTCAAGGGCACCTTTGCCACACTGAGTGAGCTGCACTGTG ACAAGCTGCACGTGGATCCTGAGAACTTCAGGCTCCTGGGCAACGTGCTGGTCTGTGTGCTGGCCCATCA CTTTGGCAAAGAATTCACCCCACCAGTGCAGGCTGCCTATCAGAAAGTGGTGGCTGGTGTGGCTAATGCC CTGGCCCACAAGTATCAC
ACACTTGCTTCTGACACAACTGTGTTCACGAGCAACCTCAAACAGACACCATGGTGCATCTGACTCCTGA GGAGAAGAATGCCGTCACCACCCTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCCCTGGGC AGGCTGCTGGTGGTCTACCCTTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGATCTGTCCTCTCCTGATG CTGTTATGGGCAACCCTAAGGTGAAGGCTCATGGCAAGAAAGTGCTTGGTGCCTTTAGTGATGGCCTGAA TCACCTGGACAACCTCAAGGGTACCTTTGCCCAGCTCAGTGAGCTGCACTGTGACAAGCTGCATGTGGAT CCTGAGAACTTCAAGCTCCTGGGCAACGTGCTGGTGTGTGTGCTGGCCCATCACTTTGGCAAAGAATTCA CCCCGCAAGTGCAGGCTGCCTATCAGAAAGTGGTGGCTGGTGTGGCTAATGCCCTGGCCCACAAGTACCA CTAAGCTCACTTTCTTGCTGTCCAATTTCTACCAAAGGTTCCTTTGTTCCCAAAGTCCAACTACTGAACT GGGGGATATTATGAAGGGCCTTGAGGATCTGGATTCTGCCTAAT
HUMAN HB PROTEIN MACACA HB PROTEIN
SEQUENCE ALIGNMENT
GRAPHICAL DISPLAY
ALIGNMENT DESCRIPTION
PHYLOGENETIC TREE OF HUMAN HB
PHYLOGENETIC TREE OF MACACA HB
ALIGNMENT ANNOTATIONS AND AMINO ACID PROPERTIES
AMINO ACID PROPERTIES
AMINO ACID PROPERTIES
GENE – MAP VIEWER OF HUMAN HB
GENE POSITION AND SIZE
SEQUENCE VIEWER
GENE – MAP VIEWER OF MACACA HB
GENE POSITION AND SIZE
SEQUENCE VIEWER
EPIGENOMICS OF HB PROTEIN
HUMAN HB PROTEIN 3D STRUCTURE
MACACA HB PROTEIN 3D STRUCTURE
HEME PART OF HAEMOGLOBIN
CONCLUSION THE SEQUENCE ALIGNMENT SHOWS MORE THAN 200
SCORE THE IDENTITIES OBSERVED – 419/439…. ABOUT 95% PHYLOGENETIC TREE SHOWS ABOUT 0.85 SEQUENCE
DIFFERENCE IN HUMANS HB SYNTHESIZING GENE IS LOCATED ON
11TH CHROMOSOME AND IN MACACA FASCICULARIS ITS ON 14TH CHROMOSOME
SIZE OF GENE IS ABOUT 1,606BP IN HUMAN AND 1,853BP IN MACACA FASCICULARIS
HEME PART IS PERMANENTLY ATTACHED IN HUMAN HB PROTEIN BUT IN MACAC FASCICULARIS DUE TO ITS PRIMARY STRUCTURE IT IS ATTACHED TEMPARORYLY ONLY DURING OXYGEN TRANSPORTATION
REFERENCE
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