Finola Delamere,Finola Delamere,Managing Editor Managing Editor
Cochrane Skin GroupCochrane Skin Group
Centre of Evidence Based Dermatology Centre of Evidence Based Dermatology (CEBD)(CEBD)
Nottingham, UKNottingham, UK
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An introduction to theAn introduction to the
Cochrane Collaboration & the Cochrane Collaboration & the Cochrane Skin GroupCochrane Skin Group
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Rationale for Cochrane CollaborationRationale for Cochrane Collaboration
Collective ignorance about effects of healthcare Collective ignorance about effects of healthcare
Overwhelming amount of clinical informationOverwhelming amount of clinical information
A systematic approach needed to organising A systematic approach needed to organising and evaluating clinical trial dataand evaluating clinical trial data
The Cochrane systematic reviewThe Cochrane systematic review
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What is the Cochrane What is the Cochrane Collaboration?Collaboration?
An international organisationAn international organisation
It prepares and maintains the Cochrane Library It prepares and maintains the Cochrane Library which is published onlinewhich is published online
The principle source of The principle source of up-to-dateup-to-date high quality high quality evidence on the effects of healthcare interventionsevidence on the effects of healthcare interventions
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Cochrane Centres
South African
Australasian
Chinese
Brazilian
Nordic
German
ItalianIberoamerican
Dutch
UK
Canadian
US
South Asian
French
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Cochrane Collaboration - structureCochrane Collaboration - structure
Collaborative Review Groups
Fields
The Consumer Network
Centres
Methods Groups
Steering Group
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Why the ‘Cochrane’ Collaboration?Why the ‘Cochrane’ Collaboration?
Archie Cochrane, a British epidemiologist, pointed out the Archie Cochrane, a British epidemiologist, pointed out the deficiencies of current reviews of the medical literature in deficiencies of current reviews of the medical literature in Cochrane AL (1972). 'Effectiveness and Efficiency: random Cochrane AL (1972). 'Effectiveness and Efficiency: random reflections on health services'.reflections on health services'.
Iain Chalmers -an obstetrician in Cardiff,UK. The first Iain Chalmers -an obstetrician in Cardiff,UK. The first ‘Cochrane Centre’ opened in Oxford 1992.‘Cochrane Centre’ opened in Oxford 1992.
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What makes a Cochrane review?What makes a Cochrane review?
Structured process involving several stepsStructured process involving several steps
Well formulated questionWell formulated question Team effortTeam effort Comprehensive data searchComprehensive data search Unbiased selection and abstraction processUnbiased selection and abstraction process Critical appraisal of dataCritical appraisal of data Synthesis of dataSynthesis of data
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Why is a Cochrane review different Why is a Cochrane review different from any other review?from any other review?
Rigorous, open, published research methodsRigorous, open, published research methods
More exhaustive search for trials than a conventional More exhaustive search for trials than a conventional reviewreview
Two stages - protocol and full review - both peer reviewedTwo stages - protocol and full review - both peer reviewed
Highlights both implications for practice and for researchHighlights both implications for practice and for research
Only systematic review to be updated regularly.Only systematic review to be updated regularly.
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Stages of a Cochrane ReviewStages of a Cochrane Review
Submit a title-the ideaSubmit a title-the idea
Write the protocol-the planWrite the protocol-the plan
Write the review-the productWrite the review-the product
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Cochrane Skin GroupCochrane Skin Group
Currently we have published 48 reviews-which we Currently we have published 48 reviews-which we aim to update every 2 yearsaim to update every 2 years
Currently we have published 40 protocols- which Currently we have published 40 protocols- which are under development to reviewsare under development to reviews
Currently 20 registered titles under development to Currently 20 registered titles under development to published protocolspublished protocols
Cochrane Skin GroupCochrane Skin Group Some of the reviews & updated reviews we haveSome of the reviews & updated reviews we have
published in The Cochrane Library in 2010published in The Cochrane Library in 2010
Interventions for vitiligo (updated review) by Whitton ME, Pinart Interventions for vitiligo (updated review) by Whitton ME, Pinart M, Batchelor J, Lushey C, Leonardi-Bee J, González UM, Batchelor J, Lushey C, Leonardi-Bee J, González U
Interventions for bullous pemphigoid (updated review) by Interventions for bullous pemphigoid (updated review) by Kirtschig G, Middleton P, Bennett C, Murrell DF, Wojnarowska Kirtschig G, Middleton P, Bennett C, Murrell DF, Wojnarowska F, Khumalo NPF, Khumalo NP
Interventions for melasma (new review) by Rajaratnam R, Interventions for melasma (new review) by Rajaratnam R, Halpern J, Salim A, Emmett CHalpern J, Salim A, Emmett C
Interventions for cellulitis and erysipelas (new review) by Interventions for cellulitis and erysipelas (new review) by Kilburn SA, Featherstone P, Higgins B, Brindle RKilburn SA, Featherstone P, Higgins B, Brindle R
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Cochrane Skin GroupCochrane Skin GroupSome of the protocols we have published in Some of the protocols we have published in
The Cochrane Library in 2010The Cochrane Library in 2010
Specific allergen immunotherapy for the treatment of atopic Specific allergen immunotherapy for the treatment of atopic eczema by Calderon MA, Boyle RJ, Nankervis H, García eczema by Calderon MA, Boyle RJ, Nankervis H, García Núñez I, Williams HC, Durham S Núñez I, Williams HC, Durham S
Interventions for preventing and managing radiation-induced Interventions for preventing and managing radiation-induced skin reactions in cancer patients by Chan R, Webster J, skin reactions in cancer patients by Chan R, Webster J, Battistutta D, Chung B, Brooks L Battistutta D, Chung B, Brooks L
Topical interventions for genital lichen sclerosus by Chi C-C, Topical interventions for genital lichen sclerosus by Chi C-C, Baldo M, Kirtschig G, Brackenbury F, Lewis F, Wojnarowska FBaldo M, Kirtschig G, Brackenbury F, Lewis F, Wojnarowska F
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Cochrane Skin GroupCochrane Skin GroupSome of the reviews currently in the editorial processSome of the reviews currently in the editorial process
Interventions for ingrowing toenails (U) Interventions for impetigo (U) Interventions for nail psoriasis (R) Interventions for infantile haemangiomas (R) Venom immunotherapy for preventing allergic reactions to
insect stings (P) Balneophototherapy for chronic plaque type psoriasis (P) Interferon alpha for the adjuvant treatment of cutaneous
melanoma (P) Interventions for mycosis fungoides (P)
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Impact of Skin Group reviewsImpact of Skin Group reviews
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About half of our reviews make recommendations to help clinical practice by for example being used in guidelines:
Interventions for vitiligo –Clinical Knowledge Summary
Topical treatments for chronic plaque psoriasis – the subject of a publication to help clinicians put evidence into practice
Interventions for American cutaneous and mucocutaneous leishmaniasis- 1st prize from Pan American Health Organisation for its relevance to a neglected disease in the Americas
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Other skin reviews highlight research gaps:Other skin reviews highlight research gaps:
Interventions for basal cell carcinoma – Interventions for basal cell carcinoma – SINS trial SINS trial
(Surgery vs Imiquimod for Nodular & Superficial BCC)(Surgery vs Imiquimod for Nodular & Superficial BCC)
RCT of excisional surgery vs imiquimod 5% cream for nodular and RCT of excisional surgery vs imiquimod 5% cream for nodular and superficial basal cell carcinoma (SINS)superficial basal cell carcinoma (SINS)
Patient 3 year follow up has been completed, analysis due to start on Patient 3 year follow up has been completed, analysis due to start on primary outcomesprimary outcomes
Interventions for bullous pemphigoid – BLISTER trial Interventions for bullous pemphigoid – BLISTER trial
(The Bullous Pemphigoid Steroids and Tetracyclines Study)(The Bullous Pemphigoid Steroids and Tetracyclines Study)
RCT to compare the safety & effectiveness of doxycycline (200 mg/day) with RCT to compare the safety & effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for the initial treatment of bullous pemphigoid.prednisolone (0.5 mg/kg/day) for the initial treatment of bullous pemphigoid.
64 of 256 bullous pemphigoid participants currently recruited64 of 256 bullous pemphigoid participants currently recruited
Cochrane Skin GroupCochrane Skin Group
www.skin.cochrane.orgwww.skin.cochrane.org
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How you can get involvedHow you can get involved
Read our reviewsRead our reviews
Comment on published reviews via the Comment on published reviews via the feedback facility on the Cochrane Libraryfeedback facility on the Cochrane Library
Be a peer referee for usBe a peer referee for us
Become a Skin Group review author!Become a Skin Group review author!
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The Cochrane LibraryThe Cochrane Library
www.thecochranelibrary.orgwww.thecochranelibrary.org
Electronic publication published onlineElectronic publication published online Issued monthlyIssued monthly Database called ‘Cochrane Reviews’Database called ‘Cochrane Reviews’ Database called ‘Clinical Trials’Database called ‘Clinical Trials’
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Rationale for Cochrane CollaborationRationale for Cochrane Collaboration
Collective ignorance about effects of healthcare Collective ignorance about effects of healthcare
Overwhelming amount of clinical informationOverwhelming amount of clinical information
A systematic approach needed to organising A systematic approach needed to organising and evaluating clinical trial dataand evaluating clinical trial data
The Cochrane systematic reviewThe Cochrane systematic review
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