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Akt signalingpathway
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128_12_KB AKT BioChem Card Side01:Layout 1 21/02/2012 12:23 Page 1
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Akt signaling related products in the Abcam Biochemicals range:
Discover more at abcam.com/biochemicals
*Sold under exclusive licence from Children’s Medical Research Institute and Newcastle Innovation Ltd. Dynole-34-2™, Dynole-31-2™, MiTMAB™, OcTMAB™, Iminodyn-22™ and Iminodyn-17™ are trademarks of Children’s Medical Research Institute and Newcastle Innovation Ltd.”
Product Biological description Purity Product code
Adenosine 3’,5’-cyclic monophosphate Second messenger. PKA activator >98% ab120493
HA-1077 ROCK2 inhibitor >98% ab120306
Honokiol Anti-inflammatory and chemotherapeutic agent > 98% ab120647
Genistein Protein tyrosine kinase inhibitor. Anticancer agent. >99% ab120112
Luteolin Antioxidant, anti-inflammatory, anti-cancer flavonoid >99% ab120662
LY 294002 PI-3 kinase inhibitor >99% ab120243
2-Methoxyestradiol Potent antitumor and antiangiogenic agent >98% ab120653
Myricetin Potent anti-neoplastic, anti-oxidant and anti-inflammatory agent >97% ab120721
NG-Monomethyl-L-arginine, monoacetate salt NOS inhibitor >99% ab120137
Nω-Nitro-L-arginine Methyl Ester hydrochloride NOS inhibitor >98% ab120136
Okadaic acid PP1 and PP2A inhibitor >98% ab120375
Phospho-Glycogen Synthase Peptide-2 GSK substrate >99% ab120079
Piceatannol Syk tyrosine kinase inhibitor >99% ab120722
Pifithrin-α-HBr p53 inhibitor >98% ab120478
PP2 Src and RIP2 kinase inhibitor >98% ab120308
PP3 Negative control for the Src kinase inhibitor PP2 >98% ab120617
Resveratrol Antioxidant polyphenol with a multitude of biological activities >98% ab120726
SB 203580 hydrochloride p38 MAP kinase inhibitor; water soluble >99% ab120235
SB 216763 Potent selective GSK-3 inhibitor >98% ab120202
Sodium salicylate Cell permeable anti-inflammatory agent >99% ab120746
SP600125 JNK inhibitor >98% ab120065
Spermidine hydrochloride Endogenous polyamine. nNOS inhibitor. >99% ab120057
Sulindac sulfide Active metabolite of Sulindac. COX-1/ 2 inhibitor. >98% ab120650
Triptolide from Tripterygium wilfordii Anti-inflammatory agent with multiple biological activities >99% ab120720
1400W Selective iNOS inhibitor >99% ab120165
Wortmannin PI3-kinase inhibitor >98% ab120148
Y-27632 dihydrochloride Selective Rho kinase inhibitor >99% ab120129
Z-D(OMe)E(OMe)VD(OMe)-FMK Cell permeable caspase-3 inhibitor >90% ab120488
ZM 336372 Potent, selective c-Raf inhibitor >98% ab120428
Z-VAD-FMK Irreversible general caspase inhibitor >98% ab120382
Dynamin inhibitors*
Dyngo-4a™ Novel, highly potent dynamin inhibitor - ab120689
Dynole-31-2™ Negative control for Dynole 34-2™ >98% ab120464
Dynole-34-2™ Potent dynamin I and dynamin II inhibitor >98% ab120463
Iminodyn-17™ Negative control for Iminodyn-22™ >98% ab120462
Iminodyn-22™ Potent, broad spectrum dynamin inhibitor >98% ab120461
OcTMAB™ Cell permeable dynamin I and dynamin II inhibitor >98% ab120467
Pro-Myristic Acid Negative control for MiTMAB™ and OcTMAB™ - ab120476
RTIL-13™ Potent dynamin I and II inhibitor >98% ab120465
GTPase
GTP GDP
Stalk AD PRDPH
Structural domains of dynamin, their function and the target sites of action of the MiTMAB™, Dynole™ and Iminodyn™ chemical series collections
GTPBinding
LipidBinding
Domain
InhibitorInteraction
• MiTMAB™• OcTMAB™• RTIL-13™
• Dynole-34-2™• Iminodyn-22™
RingAssembly
Phos/DephosProtein-Protein
World Exclusive!
Pitstop 2™ Clathrin inhibitor
Novel, selective, cell membrane permeable clathrin inhibitor.
Competitively inhibits clathrin terminal domain to selectively inhibit
clathrin mediated endocytosis (CME) (IC50 = 12 µM for inhibition
of amphiphysin association of clathrin TD). Interferes with
receptor mediated endocytosis (RME), entry of HIV and synaptic
vesicle recycling. (ab120687)
World Exclusive!
Dynamin inhibitors toolbox
The Dynamin Inhibitors Toolbox (ab120468) is a unique collection
of small molecule, potent and cell permeable dynamin inhibitors,
enabling characterization of dynamin and endocytosis. The
inhibitors have different mechanisms of action, target different
domains of dynamin, and are based on differing chemical scaffolds.
Negative controls for each chemical series are included.
Featured products
Product Biological description Purity Product code
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