A

Rel

ativ

e fo

ld c

hang

eR

elat

ive

fold

cha

nge

D

-1 0 1 2

ScAS

O1

ScAS

O2

ASO

1.1

ASO

1.2

ASO

1.3

ASO

2.1

ASO

2.2

ASO

2.3

ASO

2.D

Krt73Prr9Bpifb9aDsc14732456N10RikKrt16CnfnLipmCol10a1SptbKcnk5Malat1Pdzd2PaplnB4galnt3St6galnac6Itpr2FurinMansc1Dusp14Myh14Gse1Iffo2Mkl2Cdc7Fhl1Gm2237Eid2Nr1i2Tnni2Ccl7GypcMylpfLrrn4clMyh4Myl1CkmPvalbTnnt3Cyp2e1Acta1Pdx1Scgb1b27RetnCfdAdipoqPipCidecCsn1s2aCar3Csn2Glycam1

B

C

Figure S5

Csn1s2aCsn2

csn3Wap Pip

02468

1020

30

40 ScASOScASOASO1ASO1ASO2ASO2

Csn1s2aCsn2

csn3Wap Pip

02468

1020

30

40 PyMT;Malat+/+

PyMT;Malat-/-