8/2/2015 [Effectofnewpotentialpsychotropicdrug,8(trifluoromethyl)1,2,3,4,5benzopentathiepin6aminehydrochloride,ontheexpressionofserotoninr...PubMedNCBI

http://www.ncbi.nlm.nih.gov/pubmed/21634115 1/2

MolBiol(Mosk).2011MarApr45(2):2828.

[Effectofnewpotentialpsychotropicdrug,8(trifluoromethyl)1,2,3,4,5benzopentathiepin6aminehydrochloride,ontheexpressionofserotoninrelatedgenesinmousebrain].[ArticleinRussian]KulikovAV,TikhonovaMA,KulikovaEA,KhomenkoTM,KorchaginaDV,VolchoKP,SalachutdinovHF,PopovaNK.

AbstractStudyofmolecularmechanismsofpsychotropicdrugactionisthemainaimofmolecularpsychopharmacology.Newsyntheticanalogofvariacin8(Trifluoromethyl)1,2,3,4,5benzopentathiepin6amine(TX2153)wasshowntoproduceanxiolyticandanticonvulsanteffectsonmice.HeretheeffectofchronicadministrationofTX2153onexpressionofsomeserotoninrelatedgenesinmousebrainwasinvestigated.Thedrug(10mg/kg,peros,16days)wasadministeredtoadultmalesofASC(AntidepressantSensitiveCatalepsy)mousestraincharacterizingbyalterationsinbehaviorandbrainserotoninsystem.Theexpressionofgenesencoding1)thekeyenzymeofserotoninsynthesis,tryptophanhydroxylase2(TPH2),2)mainenzymeofserotonindegradation,monoamineoxydaseA(MAOA),3)5HTtransporter(SERT)and4)5HT(1A)receptorwasstudiedusingquantitativeRTPCR.TX2153significantlyreducedmRNAlevelof5HT(1A)receptorandMAOAgenesinthemidbrainwithoutanyeffectonexpressionofthesegenesinthefrontalcortexandhippocampus.ThedrugfailedtoaffectexpressionofTPH2andSERTgenesinthemidbrain.Theresultindicatesinvolvementofthebrain5HTsysteminthemolecularmechanismunderlyingtheeffectofTX2153.

PMID:21634115[PubMedindexedforMEDLINE]

Abstract

PublicationTypes,MeSHTerms,Substances

LinkOutmoreresources

PubMed

8/2/2015 [Effectofnewpotentialpsychotropicdrug,8(trifluoromethyl)1,2,3,4,5benzopentathiepin6aminehydrochloride,ontheexpressionofserotoninr...PubMedNCBI

http://www.ncbi.nlm.nih.gov/pubmed/21634115 2/2

HowtojoinPubMedCommons

PubMedCommonshomePubMedCommons

0comments