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sCD 14-ST Presepsin
sCD14
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( D) sCD14 c ( ) sCD14-ST -
Meisner M. J Lab Med. 1999 23(5):263-272 Nakamura M, et al. Crit Care 2008, 12(Suppl 2):P194
-
-6
-10
-
Shozushima T, Takahashi G, Matsumoto N et al. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother. 2011;17(6):764-9.
Liu B, Chen YX, Yin Q et al, Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department. Crit Care. 2013 Oct 20;17(5):R244.
APACHE II SOFA
APACHE II SOFA
Kojika M, Takahashi G, Matsumoto N, et al: Serum levels of soluble CD14 subtype reflect the APACHE II and SOFA scores. Med Postgrad. 2010; 48: 46-50.
SOFA -
APACHE II -
+ -
2 881 437 2 641 370
% 95,5% 77,8%
-
, 600
,
IL-6, 100
% - % - % -
+ 95,5 21/22 95,5 21/22 100 22/22
- 77,8 28/36 86,1 31/36 88,9 32/36
+/- 94,7 18/19 94,7 18/19 89,5 17/19
-
100 1/1 100 1/1 100 1/1
89,2 33/37 75,7 28/37 67,6 25/37
87,8 101/115 86,1 99/115 84,3 97/115
Endo S et al., Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemother. 2012 Jun 13.
600 pg/mL 0.5 ng/mL
Ratio n Ratio n
- 100% 19/19 68.4% 13/19
95.0% 19/20 50.0% 10/20
100% 4/4 50.0% 2/4
97.6% 42/43 58.1% 25/43
2857 (n=19)
1488 (n=20)
1464 (n=4) 0.961
(n=19) 0.670 (n=20)
0.424 (n=4)
(n=43),
.
Fukui Y, et al. Poster of Sepsis 2013
- -
+
Sample: EDTA plasma sample collected before or after blood culture positive
-
Reference: LSI medience in-house evaluation result
Liu B, Chen YX, Yin Q et al, Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department. Crit Care. 2013 Oct 20;17(5):R244.
APACHE II
630 100% 98% 0,494 87% 97%
.
Vodnik T et al., Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis . Clin Chem Lab Med. 2013 Jun 5:1-10.
,
-
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- 20%».
1 -
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38
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.
Shozushima T, Takahashi G, Matsumoto N et al. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother. 2011;17(6):764-9.
Shozushima T, Takahashi G, Matsumoto N et al. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity
of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother. 2011;17(6):764-9.
26 (70%)
11 (30%).
et al. Evaluation of soluble CD14 subtype (presepsin) in burn sepsis.
Burns. 2013 Sep 26. [Epub ahead of print]
.
20-
30- 63%
-
:
- , ,
-
(AUC~ 0.9)
647 47%
899 55%
. Ishikura H et al, New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study. Crit Care. 2014 Jan 20;18(1):R19.
Chiesa C et al. C reactive protein and procalcitonin: Reference intervals for preterm and term newborns during the early neonatal period Clinica Chimica Acta 412 (2011) 1053 1059
26
643,1 SD 303,8
578
-
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.
Mussap M. et al. Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges. J Matern Fetal Neonatal Med. 2012 ;25(Suppl 5):51-3.
18 -
- 556 ± 158
- 1772 ± 1009
presepsin concentration in neonatal whole blood
may be usefulness in diagnosis of early-
Kwiatkowska-Gruca M et al. Presepsyna (rozpuszczalny podtyp CD14-ST) jako diagnostyczny biomarker
posocznicy u noworodków. Pediatria Polska 88, 5 , 392-397, September 2013
AUC ROC
1- 0,97 0,90 0,68
2- 0,98 0,92 0,75
3- 0,98 0,93 0,77
- 781 ; 0,5 ,
.
-
,
-
.
18 1-167 .), ,
38 , 30
PRESEPSIN (sCD14-ST) MEASURED IN CEREBROSPINAL FLUID IN CHILDREN WITH SUSPECTED BACTERIAL VENTRICULITIS/MENINGITIS WITH INSTALLED EXTERNAL VENTRICULAR DRAINAGE TO REDUCE RAISED INTRACRANIAL PRESSURE. A.N. Kopitar et al., 2014, in press.
- :
- - 25-
Shirakawa K. Diagnosis of Respiratory Tract Infectious Disease using urine specimens.
European Patent Application EP 2 711 710 A1
,
15 . 15 .
28 . 28 .
-
.
».
Novelli G et al., Pathfast Presepsin Assay for Early Diagnosis of Bacterial Infections in Surgical Patients: Preliminary Study. Transplant Proc. 2013 Sep;45(7):2750-3
100
1000
10000
100000
48hr 96hr 144hr 15day
Pres
epsi
n (p
g/m
L)
Day100
1000
10000
100000
48hr 96hr 144hr 15day
Pres
epsin
(pg/
mL)
Day
A) Patient group administrated
with optimal antibiotics (n=34)
B) patient group changed Antibiotics n=16
Transplant Proc. 2013 Sep;45(7):2750-3.
Presepsin values decreased by the appropriate use of antibiotic.
500 500
28 day non-survivor
*
* *
*
Changing antibiotic
Subject: Transplant and abdominal surgery patients who confirmed infection (positive blood culture) The transition of presepsin levels with patient group administrated with optimal antibiotic and changed antibiotic were shown in the following.
Useful to monitor antibiotic application
Patient died after 96hr (48hr: 1245pg/mL, 96hr: 1845pg/mL)
- (n=27) (n=26)
SOFA
-6
-
-
-
-
-
-
-
-
103
SOFA APACHE II
-
Endo S et al Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis: A multicenter prospective study. J Infect Chemother. 2013 Dec 1
Masson S et al. , Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care. 2014 Jan
50
-
- - 2269 (1171-4300) 18,5 (3,4-45,2)
- - 1184 ( 875-2113) - 10,8 (2,7-41,9)
Masson S et al. , Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care. 2014 Jan
Trial registration. ClinicalTrials.gov NCT01535534. Registered 14 February 2012.
AUC ROC - 0,72 0,84. sepsis, cutoff = 600 pg/ml;
AUC 0,64 0,71. -
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Sargentini V et al. Presepsin as a potential marker for bacterial infection relapse in critical care patients. A preliminary study.[Clin Chem Lab Med 2014;
Sargentini V et al. Presepsin as a potential marker for bacterial infection relapse in critical care patients.
A preliminary study. Clin Chem Lab Med 2014
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17.02 199 24 355 9,67 13,3 11 093
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19.02 233 1 875 16,1 1 253
24.02 456 1 361 202
27.02 350 992 8,3 353
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September 21-22, 2014
September 21-22, 2014
Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Klinik für Thorax- und Herz-Gefäßchirurgie
62
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Mitsubishi Chemical Medience Corporation,
PATHFAST®
www.presepsintest.ru
\ : (495) 980 6679
-78-10, 975-78-11
\ : (495) 975-78-12
[email protected] www.diakonlab.ru
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