96.10.26
?
(199923)(Center for Disease Control)
() ://://://://://
I
II
III
(National Health Commend Center)-----
- - - - - -
-----
-----
- ------
-1015,0007,500-(1)(2)(3)(4)(5)(6)(7)(8)
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() () (TB)960920 ()
Sheet1
8887
66
3228
5461
(,,,)14
181186
Sheet2
Sheet3
BSL-3
92-94 95-99 94-97
96/09/13
Sheet1
96
39223.0
(C)(D=F/C)(E=(G+H)/C)(F)(G)
0361,100,00099.04%16.11%60,515,6359,841,431
05-148,192,00098.62%33.85%47,524,8145,860,183
05-284,006,000102.33%20.37%85,961,96017,111,703
0613,468,00091.91%27.86%12,378,7543,751,759
0123,249,50426.85%14.36%6,241,4783,337,499
230,015,50492.44%17.35%212,622,64139,902,575
(C)(D=F/C)(E=G/C)(F)(G)
0324,800,00089.92%0.79%22,300,296196,560
05-133,360,00089.64%2.64%29,902,725880,700
05-217,640,00038.38%0.95%6,770,800167,200
061,900,00080.56%41.06%1,530,650780,150
011,511,30064.26%7.46%971,200112,800
79,211,30077.61%2.70%61,475,6712,137,410
Sheet2
20062007
154,27196,591
15,11513,672
5234
12()
Sheet3
Two virology Laboratories
1. Viral Enteric and Emerging Diseases Laboratory2. Viral Respiratory Diseases Laboratory Being responsible for research and diagnoses on influenza, SARS, measles, mumps, VZV, rubella, parovovirus B19, RSV, adenovirus, hMPV, enteroviruses, rotavirus, norovirus, astrovirus, HAV, HBV, HCV, HDV, HEV, HIV-1/HIV-2, and EID (rabies, ebola, nipah, and smallpox).Current research projects:Surveillance on diagnostic quality of HIV and hepatitis B/CMonitoring AFP syndromeSetting up a surveillance network for enterovirus infectionsDeveloping a swift molecular biological diagnostic system for viral respiratory track infections
Two Bacterial Laboratories
1. Bacterial Respiratory Diseases Laboratory 2. Bacterial Enteric and Emerging Diseases Laboratory
Diagnoses of notifiable bacterial communicable diseases, including Cholera, Plague, Anthrax, Diphtheria, Meningococcal meningitis, Typhoid fever, Paratyphoid fever, Bacillary dysentery, Enterohemorrhagic Escherichia coli infection, Pertussis, Scarlet fever, Legionellosis, Haemophilus influenzae type B infection.Diagnoses of non-notifiable bacterial communicable diseases, including Salmonellosis, Melioidosis, Yersiniosis, Lyme disease, Leptospirosis, cat scratch disease, and diseases caused by Campylobacter spp., Vibrio parahaemolyticus, Staphyolcoccus aureus, Bacillus cereus.Researches related to the above bacterial pathogens.
Vector-Borne Viral and Rickettsial Diseases LaboratoryResponsible for diagnoses and related research of yellow fever, Dengue, Japanese encephalitis, other flaviviruses (WNV, etc.), Hantavirus, scrub typhus (mite-borne), typhus fever (louse-borne), Q fever, and others (spotted fever, etc.).Ongoing research projects:Establishing a flaviviruse reference laboratory for Asian-Pacific region.Dengue fever sero-epidemiological survey in southern part of Taiwan.Setting up a fluorescence quantitative molecular diagnostic system for rickettsial infectious diseases.Setting up a serological diagnostic system for rickettsia.
Mycotic Diseases Laboratory Diagnoses and research of Pathogenic fungi Chlamydia and Mycoplasma. Parasitic Diseases Laboratory Diagnoses and research of malaria andamebic dysentery.
Mycobacterial Diseases Laboratory Diagnoses, identification and research of mycobacteria.External quality control of contract laboratory diagnoses.Vector Biology Laboratory Identification, classification, and survey of disease vector insects. Research in pesticides and their application forbest maintaining environment hygiene. Studying the influence of aerosol size on the effectiveness of killing mosquitoes by the pesticide.
WHO - National Influenza Centres(National Influenza Centre, NIC) WHO(WHO global influenza surveillance network, GISN)1948WHO- GISN118 NIC( 89)4WHO (Collaborating centres, CCs)
NICWHO
NIC
Taiwan NIC
11
Taiwan NIC
* ** ***()(),
5*34113O8522966041761,928488***0116 ***0604A11,0962966621762,23073201740906A21,0962966621762,2301,0962966621762,230B3,090531 **1,464 **2644,704
WHO 1979WHO1986A/Taiwan/1/86 WHO
2005NIIDWHO2006-07A/Taiwan/567/2005
(Biohazard)(Laboratory Biosafety) (Biosecurity)
-() (Aerosol)
RG = Risk Group
BSL = Biosafety Level
(Primary containment)()(Secondary containment)()
(BSC)Class IClass IIClass III
94 9 26 0940000614 19 95 3 26 95 4 11 0950000194 2 1 19
23,4 16,1712567811910,131415 192.1181
3 4 7 15 10 13 3 11 12 3
7
()
13
&&
BSL-3 RG3 BSL-3 BSL-3
SARS
SARS 92 12 SARS RT-PCR SARS BSL-3 SARS CDC NIID BSL-3
93 4 Real-time RT-PCR ()
Dengue I 5NCR-C-prM-M-E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5-3NCR (10735 bp)Structural gene Non-structural gene
NS5 (154 bp) C-prM (435 bp) Virus strain used in the lab100%100%Virus strain isolated from Mainland China in 1980 (n=1)100%99.5%Virus isolated from Kao-Ping area in 1987~1988 (n=10)100%99.3~100%Virus isolated from Kaohsung County in 1991 (n=3)100%99.1~99.3%
95 8 (Pulsed-Field Gel Electrophoresis, PFGE) DNA
vs. vs. vs.
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