Zetterberg plasmatau2013
-
Upload
alzheimer-research-forum -
Category
Health & Medicine
-
view
2.192 -
download
0
Transcript of Zetterberg plasmatau2013
![Page 1: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/1.jpg)
Plasma tau in acute brain injury and Alzheimer’s disease
Henrik Zetterberg, MD, PhDProfessor of Neurochemistry
![Page 2: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/2.jpg)
Plasma tau as a biomarker of neuronal injury – the Simoa technique by Quanterix
AEB ~ 0.1 AEB ~ 0.6 AEB ~ 3.0
Rissin et al., Anal Chem. 2011Randall et al., Resuscitation, 2013AEB = Average number of Enzymes per Bead
HT7
Tau5
BT2 Detection: β-gal
Capture: magnetic beads
![Page 3: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/3.jpg)
Plasma tau in cardiac arrest survivors
Randall et al., Resuscitation, 2013
![Page 4: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/4.jpg)
P=.038P=.030
Plasma tau in boxers
• Study design: 30 amateur (olympic) boxers25 healthy age-matched controls
Plasma samples A) After bout (1-6 days)B) After a rest period (> 2 weeks)
• Study design: 30 amateur (olympic) boxers25 healthy age-matched controls
Plasma samples A) After bout (1-6 days)B) After a rest period (> 2 weeks)
Neselius et al., Brain Injury, 2013
![Page 5: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/5.jpg)
Plasma tau in concussed hockey players of the Swedish NHL
Pre-season vs 1 hrUnpaired 2-tail t test
P=0.0011
Pre-season vs 12 hrUnpaired 2-tail t test
P=0.0717
Randall et al., unpublished
![Page 6: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/6.jpg)
Plasma tau in concussed hockey players – sample series indicate biphasic release
Randall et al., unpublished
![Page 7: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/7.jpg)
Plasma tau in Alzheimer’s disease
Zetterberg et al., Alz Res & Ther. 2013
![Page 8: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/8.jpg)
Plasma tau in Alzheimer’s disease – no correlation to CSF…
![Page 9: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/9.jpg)
Hesse et al., JAD 2000
CSF tau stays elevated for weeks following acute stroke
![Page 10: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/10.jpg)
…but tau changes fast and is rapidly cleared in blood
Interpretation: different clearance rates of tau in CSF and blood may explain lack of correlation and lack of clear plasma tau changes in AD?
![Page 11: Zetterberg plasmatau2013](https://reader034.fdocuments.net/reader034/viewer/2022052602/559ac6bc1a28abd8138b4733/html5/thumbnails/11.jpg)
Clinical Neurochemistry LaboratorySahlgrenska University HospitalMölndal/Gothenburg, Sweden
Acknowledgements
Dave Wilson, Jeff Randall and colleagues at Quanterix Corporation