Your First Neurotransmitter Reports - Amazon S3 · • B complex, SAMe • Promote GABA levels •...
Transcript of Your First Neurotransmitter Reports - Amazon S3 · • B complex, SAMe • Promote GABA levels •...
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Your First Neurotransmitter
ReportsRuth Hobson, ND
Staff PhysicianLabrix
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Sample NT Test Report
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Adult Reference Ranges
Male 17+Analyte Range Lower
rangeUpper range
Serotonin 42-105 54.6 92.4
GABA 1.4-5.0 2.12 4.28
Dopamine 90-220 116 194
Norepinephrine
12-50 19.6 42.4
Epinephrine
0.9-9.2 2.56 7.54
Glutamate 8-45 15.4 37.6
N/E ratio <10.0 ----- 8.0-10
Female 17+
Analyte Range Lower range
Upper range
Serotonin 52-155 72.6 134.4
GABA 1.6-8.0 2.88 6.72
Dopamine 95-275 131 239
Norepinephrine
15-78 27.6 65.4
Epinephrine 1.0-11.1 3.02 9.08
Glutamate 10-52 18.4 43.6
N/E ratio <11 ----- 8.8-11
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Pediatric Reference RangesAnalyte Ages 0-3 Low range Upper range
Serotonin 130-415 187 358
GABA 2-15 4.6 12.4
Dopamine 200-800 320 680
Norepinephrine 25-126 45.2 105.8
Epinephrine 4.3-36 10.64 29.66
Glutamate 25-150 50 125
Analyte Ages 4-12 Low range Upper range
Serotonin 70-280 112 238
GABA 1.6-12 3.68 9.92
Dopamine 150-600 240 510
Norepinephrine 20-104 36.8 87.2
Epinephrine 1.6-24 6.08 19.52
Glutamate 10-80 24 66
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Pediatric Reference RangesAnalyte Ages 13-16 Low range Upper range
Serotonin 58-200 86.4 171.6
GABA 1.6-10 3.28 8.32
Dopamine 125-450 190 385
Norepinephrine 17-90 31.6 75.4
Epinephrine 1.5-20 5.2 16.3
Glutamate 10-40 16 34
N/E ratio Reference range Upper range
0-12 <12 9.6-12
13-99 F <11 8.8-11
13-99 M <10 8-10
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Creatinine
• Non-diagnostic• Used to normalize concentration of NTs in urine.
Concentration of creatinine directly reflects concentration of NTs; therefore, the NT levels are stated as a function of creatinine (industry standard)
• When doing any urine test that utilizes a creatinine correction, there will be differences between adult males and females, as well as children.
• Since males generally have a higher body mass, their creatinine is higher than females.
• Therefore, when you divide your measured value by creatinine, males will have lower reported levels than females and children, who have lower creatinine levels.
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CASES
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Wendy56 year old postmenopausal femaleCC: • Pronounced fatigue; energy (3/10)• Inability to concentrate (6-8/10)
NeuroAdrenal Panel (Cortisol x 4, DHEA, Serotonin, GABA, Dopamine, Epinephrine, Norepinephrine, Glutamate)
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WendyAdrenal function resultsPhase 3 HPA axis/adrenal dysfunction
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WendyNeurotransmitter results• Serotonin low range. • Acute increase in epi/norepi noted. Contributing to wired and tired
feeling and inability to maintain focus and concentration. • Dopamine levels are low, resulting from increased epi/norepi
production. • Low GABA not sufficient to counterbalance excitability.
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WendyTreatment considerations• Tx for adrenal
cortex• Hydrocortisone• Adaptogenic herbs
and nutrients• DHEA
• Neurotransmitter support• 5 HTP • L-tyrosine and Macuna pruriens• B complex, SAMe• Promote GABA levels
• Glutamine (When giving glutamine for GABA, always give P5P).• L-theanine• Herbal blend containing anxiolytics like valerian, lemon balm, passion flower
• Vitamin D
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Jeffrey28 year old maleCC: • Impulsive • Gaming and food addictions
NeuroBasic panel (Serotonin, GABA, Dopamine, Epinephrine, Norepinephrine, Glutamate)
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JeffreyNeurotransmitter results
• Elevated glutamate is commonly associated with increased impulsivity• Low dopamine is associated with addictive tendency and sense of
discontentment• Inadequate GABA is insufficient to dampen the heightened glutamate
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JeffreyTreatment considerations
• Decrease dietary sources of glutamate (MSG, yeast extract and other hidden sources of free glutamic acid)
• Dampen glutamate activity: • L-theanine• Taurine • NAC
• Increase dopamine levels:• N-acetyl-L-tyrosine• Mucuna pruriens• Vitamin D
• Boost GABA/promote inhibition: • P5P
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Irina49 yo postmenopausal femaleCC: • Very high anxiety QD
• awakens her at night (7/10)
• IBS• Bowel movements coincide with anxiety… 6-10 loose
stools some days…however, then adds that some days, even though anxious, no BM at all
NeuroBasic panel (Serotonin, GABA, Dopamine, Epinephrine, Norepinephrine, Glutamate)
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IrinaNeurotransmitter results
Serotonin is below the reference range • Contributory to anxiety. Alternating diarrhea and constipation is
consistent with the effects of serotonin within the proximal and distal intestinal tract (consider SIBO if further investigation is needed).
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IrinaTreatment considerations• Support serotonin levels
• 5 HTP • B complex• Vitamin D
• Stress reduction techniques • Probiotics and omega 3s
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Neurotransmitter pathways
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Summary Points
• Consider overall balance between excitatory and inhibitory neurotransmitters
• Support low NT levels with precursor amino acids and elevated levels with applicable co-factors for enzyme function and metabolism
• Methylation support is a consideration with upper range or high N/E ratio and/or low monoamines.
• General support in the form of probiotics, omega 3 fatty acids, L-theanine and vitamin D will likely be important for every patient and a great place to start if you’re unsure of treatment
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