Your first mentored grant proposal: The National Institutes of Health F and K proposals Alison K....
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Transcript of Your first mentored grant proposal: The National Institutes of Health F and K proposals Alison K....
Your first mentored grant proposal:
The National Institutes of Health
F and K proposals
Alison K. Hall, Ph.D.
Case School of Medicine
Office of Graduate Education
Committee on National Needs for Biomedical and Behavioral Scientists, a unit of the National Research Council, the operating arm of the National Academy of Sciences.
Estimates that there are some 52,000 postdocs in the country (2001)
3/4 in life sciences, half from foreign countries
Postdoctoral trainess at Case SOM, Spring 2005
Total SOM Male Female
Postdoc Scholar
30 18 12
Postdoc Fellow
81 48 33
Research Associate*
277 160 117
Senior
Research Associate*
57 33 24
Many are planning independent careers
Postdocs are at a critical juncture in training
productive
self-reliant
about to embark on independent careers
Often write a grant to seek financial support and recognition for their research
Why do you want a mentored grant?
1. Makes the relationship with the PI explicit
2. Benefits associated with grant
3. Looks good on your resume
4. Great learning experience
5. Not ready for the R01…
Where do you start?
Communicateyour PI, potential mentors/committeeyour chairpersonthe Office of Research
Are you ready?pilot datatime to focusappointment statusdeadlines
Do you qualify?
Not every Institute has these mechanisms
Restricted to US citizens, permanent residents
The F32 NRSA
individuals seeking posdoctoral research training in the basic and clinical sciences
F32->RO1
set stipend scale and supplement
The F32 NRSA February 4, 2005Stipends for Kirschstein-NRSA awards 2005PostdoctoralYears of Experience:0 $ 35,5681 $ 37,4762 $ 41,7963 $ 43,4284 $ 45,0485 $ 46,9926 $ 48,8527 or more $ 51,036
Program announcements http://grants.nih.gov/training/nrsa.htm
Institutional Allowance $5,500 Research supplies, health insurance, travel to mtgs
2002 Number number total cost success reviewed awarded awarded 1000s rate*
MD 202 91 4,602 45 PHD 1,336 516 20,813 38.6 all 1,538 607 25,415 39.5
Percentage that receive funding in a year (a resubmission is only counted the first time)
http://grants.nih.gov/grants/award/training/F32MDPHD9502.HTM
The F32 NRSA is a reasonable goal:Success rates on Individual Postdoc Fellowship applications
Prepare the Application: read the instructions!!start early, seek internal reviewers
a. Candidate (grades, GREs, etc)a. US citizen or permanent residentb. Doctoral degree (many ok)
b. Sponsor and Training Environment c. Research Proposal
a. Up to 3 yrsc. Training Potentiald. Vertebrate Animals, Human Subjects etc.e. 3 times per year, usu Feb1, June1, Oct 1
The A1 or A2. You may have to resubmit…
http://grants.nih.gov/training/nrsa.htm
http://grants.nih.gov/training/data/tf_trends/sld006.htm
Postdoctoral trainees are funded by many Institutes
1F30NS050913-01 Assistive Device Control With Brain Surface Signals5F30ES011931-03 Initiation of Experimental Colitis by Commensal Flora1F31HD049326-01 Upper Extremity Control Using Reinforcement Learning1F31MH073296-01 Molecular Genetics of the Serotonin System1F31NR009344-01 Dance and Physical Activity in African American Women5F31HD041926-03 PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES1F31MH074241-01 ERK2 Specific Function of the CNS5F31NR007943-04 Kangaroo Care Effects on post/cath stabilization
1F32GM074554-01 Creation of designer biogenic amine receptors1F32AG024031-01A1Mechanisms of Abeta-Stimulated ROS in Microglia 5F32EB003363-02 Group Theory Applied to rf Coil Design
Predoctoral (Graduate Students!)
Postdoctoral
Case has few F awards
http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen
Grantwriting Resources
Grantpersonship: An Instruction Manualhttp://www.pitt.edu/~survival
NIMH Grant Application Processhttp://www.nimh.nih.gov/researchFunding/grantprocess.cfmhttp://www.nimh.nih.gov/researchFunding/training.cfm
FASEB Grantsmanship Training Programhttps://ns2.faseb.org/careerutilities/grantprg.htm
Grant Application Writer’s Handbook, Reif-Lehrer
The K08
For clinically trained persons to pursue research careersin basic or clinical sciences.
Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship)
Mentored Clinical Scientist Development AwardK08->K02-> R01up to $85,000 salary up to $50,000 costs per yearup to five years, non-renewable
The K08
Prepare the Application: read the instructions!!
a. Candidateb. Research Planc. Career Development Plan/ Training Pland. Environment/ Institutional supporte. Mentor*f. Vertebrate Animals, Human Subjects etc.g. The A1 or A2. You may have to resubmit…h. (The summary statement)
The K08
1. Candidate**
2. Basic Science Mentor/co Mentor:
1. Good working relationship
2. Often funded by NIH
3. Expert in this area
4. Experienced trainer
**some Institutes require faculty appointment (eg Instructor)
The K08
3. Career Development Plan (very important)
• Focused and relevant
• New techniques, new area, could be funded
• Present at meetings, review grants, external courses
• Update didactics
• Create an oversight committee familiar with research, career goals, meet six mos for feedback
4. Research Plan
• Provide preliminary data to support rationale, approach. Focus!
• Include study of Research Ethics, animals etc.
The K08
http://grants.nih.gov/grants/guide/pa-files
See supplementary info at each institute
Insure protected time-Do not assume that 75% means anythingexcept 75% of your total working hours
-These estimates are carefully reviewedessential that your chair state thisnot contingent on receipt of the grant
-50% Neurosurgery
What happens to your application after it leaves the mailbox?
Scientific Review Group in Center for Scientific ReviewStudy section review
supplementsScores and percentilesSummary sheet
Inside the NIH Grant Review Process
39 min video NIH Center for Scientific Review
Includes R01/K08/ R03
Download proposals
http://www.drg.nih.gov/Video/video.asp#docs
View the video on the web
http://www.drg.nih.gov/Video/Video.asp
Helpful Hints for an NLHBI K08 Application http://www.nhlbi.nih.gov/funding/training/redbook/hints.htm
1K08HL073240-01A1Medullary GABAergic Neurons in Neonatal Reflex Apnea5K08AI001581-05 CD8+ T CELLS AND MYCOPLASMA TUBERCULOSIS5K08CA084337-06 ERBB2 KINASE SIGNALING IN COLON CARCINOGENESIS5K08DK059488-04 The Role of TGF-alpha in the Pathogenesis of ARPKD5K08DK002699-05 QUANTITATIVE EXPRESSION LIBRARIES TO IDENTIFY ESRD GENES5K08MH068584-02 Youth Subjective Experience of Psychotropic Treatment5K08HL004299-05 PULMONARY IMMUNE DEFENCES AGAINST M. BOVIS-BCG INFECTION5K08AI054652-02 Innate immune responses in lymphatic filariasis1K08HD047431-01 Metabolic Requirements for Oogenesis and Embryogenesis5K08AI051565-03 Immunologic Studies of Endemic Burkitt's Lymphoma5K08NS046486-02 Systemic perinatal insults disrupt neurodevelopment5K08NS041594-03 The Role of PPAR Agonists in Inflammation and stroke
K08 awards at Case
http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen