Young Investigator Awards Early Career Award Symposium October 29, 2010 Jeanne Hardy University of...
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Transcript of Young Investigator Awards Early Career Award Symposium October 29, 2010 Jeanne Hardy University of...
Young Investigator Awards
Early Career Award Symposium
October 29, 2010
Jeanne Hardy
University of Massachusetts Amherst Department of Chemistry
Projects in the Hardy Lab
• Caspase-7
• Caspase-6
• CA-GFP
• Caspase-9
• Dengue Virus Protease
Protein engineering to make protein therapeutics
Drugs for neurodegeneration
Building an apoptosis reporting mouse to screen for drug toxicity
New class of allosteric inhibitors
New allosteric sites for treating a global health threat.
90’s helix
130’s helix
10 Å
PDB ID: 3K7E
Unique structural features of apo caspase-6Casp-7Casp-6
Sravanti Vaidya
Real-time imaging of single cells
FUTURE:
• Other colors CA-FP• Other proteases• CA-IRFP for whole mice & zebrafish
+ Apoptosis Inducer - Apoptosis Inducer
Table compiled during my first week here:Grant Due Date
Alliance for Cancer Gene Therapy (ACGT) 15-Sep
Beckman Foundation Young Investigator Award 1-Oct-06
Pew Scholars Program in the Biomedical Sciences 1-Nov
The Robert Leet & Clara Guthrie Patterson Trust 1-Nov
Kimmel Foundation Scholar Award Dec 2005?
Juvenile Diabetes Foundation Career Development Awards 16-Jan-06
Rita Allen Foundation Scholars 12-Jan-05
American Diabetes Association Career Development award 15-Jan-06
American Diabetes Association Career Development award 15-Jan-06
March of Dimes Basil O’Connor Starter Scholar Award 1-Feb
Concert for the Cure Boston Symphony - must be in first three years of faculty position - HMS only?
1-Apr-06
The David & Lucile Packard Foundation Fellowships 19-Apr-06
Damon Runyon 1-Jul-06
NSF Career Award 18-Jul-06
American Heart Association Scientist Development Grant 12-Jul-06
W. M. Keck Foundation- must have been faculty one but no more than 4 years.
Invitation
http://www.brandeis.edu/givingto/cfr/award-programs.pdf
Awards: Received1. The Medical
Foundation Smith New Investigator Award
2. The Beckman Foundation Young Investigator Award
3. Cottrell Scholar From Research Corporation
Awards: Received1. The Medical
Foundation Smith New Investigator Award
2. The Beckman Foundation Young Investigator Award
3. Cottrell Scholar From Research Corporation
Attempted1. The Medical Foundation Smith New
Investigator Award (Sept 2005)
2. The Beckman Foundation Young Investigator Award (June 2006)
3. Cottrell Scholar From Research Corporation (June 2008)
4. Did not make it through on-campus nomination for Packard 2006
5. NSF CAREER* (July 2007)
NIH R01 in Dec 2007
6. Packard Foundation Fellowship (July 2008)
7. HHMI Early Career Award (Jun 2008)
8. DreyfusTeacher-Scholar Award (Jan 2009)
Contributions to winning a “beauty contest”• Letters of recommendation are very important
– My Post Doc Advisor• Well-loved and well-respected, member of NAS
– Letter writers from Penn, Princeton & UCSF
• Pedigree was good• Unusual background academic/ Industrial
• UC Berkeley / Sunesis Pharmaceuticals
• Turned down jobs at Princeton, Georgia Tech and U. Illinois: the dept head could say that in his letter– I wrote a draft of the department head’s letter.
• Good Proposal
Elements of a Good YI Proposal• Unique idea within my expertise
– Some preliminary data, although not required
• Wrote to the audience
• Good collaborator– Full Professor at UCSD
• my prof when I was a grad student
• Good images
• I followed all the rules applications
An early proposal• Smith
• Can you talk to foundation donors.
Thanks!
The Beckman Foundation Young Investigator Award
NIH R01 GM080532
NSF FTF CCI CHE-0739227
American Cancer Society IRG
Research Corporation Cottrell Scholar Award
Center of Excellence in Apoptosis Research Co-PI: K.D. Tremblay
NSF IGERT in Cellular Engineering DGE-0654128
Genevieve Abbruzzese Jun Chu Lindsay Dawson Dan Fowler Sumana Ghosh Amanda Hogan Kristen Huber Joachim Moch Samantha NIcholls Daniel Seeman Sravanti Vaidya
Elih Velazquez Witold Witkowski Muslum Yildiz
http://people.chem.umass.edu/jhardy/