XT-2000i™ and XT-1800i™

Automated Hematology Analyzers

Mid Volume Laboratory Solution

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Advanced Technology SolutionstoMeet your Lab’s Needs

Today’s LaboratoryChallenges

Laboratories continue to facea number of challenges.

These include clinical, operationaland financial issues such as:

• Demand for clinically relevant information• Medical technologist labor shortage• Increased workload• Need for faster turnaround time• Requirement for high reliability• Limited laboratory budgets

Fluorescent Flow CytometryYields Optimized Productivity

The Sysmex XT Automated Hematology Systemsutilize the power of fluorescent flow cytometry andhydrodynamic focusing technologies. Using a unique,state-of-the-art, diode laser bench, Sysmex fluorescentflow cytometry provides the sensitivity needed formeasuring and differentiating cell types in whole bloodand body fluid samples. Fluorescent technology andhydrodynamic focusing enable the analyzers toconsistently classify normal WBC, RBC, and PLTpopulations from abnormal populations, therebydecreasing the number of manual interventions.

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Even with these challenges, the need for hematology testinghas remained steady or continued to grow. Laboratoriesare searching for hematology analyzers that can improveproductivity and efficiency while providing enhancedclinical information. Designed to be reliable and efficient,the Sysmex XT-2000i and XT-1800i (XT) offers mediumvolume labs an automated hematology system that cantruly meet and exceed their expectations. The XT streamlinesyour workflow by providing testing for up to 80 samplesper hour, enabling rapid turnaround time.

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Clinically Relevant Information

High Quality Hemoglobin(HGB) Analysis

The XT utilizes the cyanide-freereagent, Sodium Laurel SulfateHemoglobin (SLS). The end productis a colored compound that is measuredspectrophotometrically. Since hemoglobindeterminations are performed from adilution and in its own separate chamber,there is no interference from high WBCcounts, lipemia or abnormal proteins.

Direct Hematocrit (HCT)Measurement

The cumulative pulse heights of all theRBC counts yield the HCT. This is basedon the principle that the pulse height(voltage change) produced by cellspassing through the aperture isproportional to cell volume.

RBCs and PLTs

RBCs and PLTs are counted in adedicated channel using Impedance orDirect Current (DC) detection methodcombined with hydrodynamic focusingtechnology. Challenges to cell countingsuch as coincidence or recirculationare circumvented and automaticdiscriminators separate the twocell populations.

Even with samples at extremelylow or unusually high concentrations,the Sysmex Systems analyze RBCs andPLTs with uncompromised precisionand accuracy.

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Hydrodynamic Focused Cell Counting

Effective Red CellDisorder Screening andTherapy Monitoring

The XT Systems provide the panelof standard parameters for basicand reliable anemia screeningand monitoring.

WBC, A Clear Differentiation

The combination of side scatter(cell complexity), forward scatter(cell size) and fluorescence (DNA &RNA concentration) of nucleated cellsprovides a concise and precise imageof each detected peripheral blood cell.

This 3-dimensional blood cell analysisprovides unique accuracy and precision.Fluorescence labeling of peripheralblood cells is a milestone for theroutine leukocyte differential.

Fluorescent technology enablesthe XT to reliably differentiate normalWBC populations from abnormal WBCpopulations. The sensitivity of theunique application of fluorescent flowcytometry gives the lab a high level ofconfidence in reporting accurate WBCdifferentials, even on critical patientsamples when the WBC count is low.

Non-Cyanide HGB

WBC Differential Scattergram

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Advanced Clinical Parameters

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Fluorescent Optical Platelet

Fluorescent Optical Platelet*

The XT-2000i offers both aFluorescent Optical Platelet (PLT-O)in addition to the traditional impedancePLT count. Flagging associated withatypical or abnormal platelets, due toincreased size or fragmentation isminimized by use of the opticalplatelet count. Accuracy in reportingis supported by the availability of bothtechnologies.

Fluorescent Optical Platelet is acomplementary, reportable parameterto the impedance platelet count.

The PLT-O parameter provides:

• Improved accuracy on lowplatelet counts

• Accurate counts when interferencesare present, thus reducing manualintervention

• Automated judgment for reportingPLT-O or impedance PLT throughinstrument settings, eliminatingtech-to-tech decision variability

*XT-2000i only

Body Fluids

The XT analyzers include measurementfor body fluids. These analyzers providereportable WBC and RBC countsfor all common body fluid samples(CSF, synovial and serous).

The analyzers apply provenimpedance and fluorescent flowcytometry technology ensuringan accurate body fluid count froma single sample analysis.

The XT Body Fluid Count Provides

• No sample pre-treatment• No additional reagents or

additional quality control materialrequirements

• An automatic background checkprior to analyzing a sample

The XT Body Fluid Count Benefits• Improved productivity• Decreased turnaround time (TAT)• Decrease manual technical

intervention

Immature Granulocytes(IG) Determination

• Cells included in the IG countare metamyelocytes, myelocytes,and promyelocytes

• The IG parameter is providedfrom the DIFF channel

• The IG software applies a flexiblegating algorithm tailored toindividual samples, thus providingreliable IG counts

The IG Parameter provides:

Improved accuracy and sensitivity• Reduced false positive and

false negative rates• Result consistency by reducing

tech-to-tech variation in reportingmanual differentials

Improved workflow• Fewer manual differentials means

faster turnaround time (TAT)

Labor savings• Fewer manual slide reviews improves

laboratory efficiency and supportshigher laboratory output

Body FluidImmature Granulocyte Count

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One Comprehensive System

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With the use of fluorescent technology, the reticulocyte count assures:

• Accurate reticulocyte % and #• Improved immature reticulocyte fraction (IRF) information for earlier diagnosis

and treatment by clinicians• Elimination of common interferences from Howell-Jolly bodies,

Pappenheimer bodies and immature reticulocytes to avoid manual counts

In addition, the Reticulocyte Hemoglobin (RET-He), is a parameter measuredin the reticulocyte channel which is used to measure the incorporation of ironinto erythrocyte hemoglobin.

The RET-He parameter supports:

• Rapid, direct analysis of an earlier stage of RBC development forprompt clinical follow-up

• Assessment of anemia. RET-He is an established parameter used inKDOQI (Kidney Disease Outcomes Quality Initiative) guidelines for assessingthe initial iron status of patients

• Accuracy and sensitivity in measurement of red cell production that aidsthe clinician in effective monitoring of costly drug protocols for cell stimulation

*XT-2000i only

Fluorescent Reticulocyte Count

Reticulocyte Analysis*

Known as the “Gold Standard”reticulocyte testing parameter, thefluorescent reticulocyte count isavailable on the XT-2000i. Sysmexwas one of the first companies toprovide on-board retic testing ina dedicated channel, which improvedefficiencies in reticulocyte counting.

Positive PatientSample withRetic Analysis

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Improved Productivity & Efficiency

e-Tools: Assuring Qualityand Optimizing Performance

SNCSTM, Sysmex NetworkCommunications System, is proprietarysoftware which enables fast, securecommunication from your analyzer toSysmex servers using a high-speed,outbound internet connection. Thispowerful tool is the instrument datalink feeding a variety of innovativetools and services.

InsightTM

Insight is a web-based InterlaboratoryQuality Assessment Program (IQAP)which allows on-demand qualitycontrol reporting with access anytime,anywhere. Insight meets therequirements to document peercomparison data for your analyzerwhile eliminating manual steps.

Remote Monitoring

Continuous collection andmonitoring of instrument performancedata is linked to our tracking anddispatch system. We monitor yourinstrument performance, instrumentconfiguration settings and back-upsettings continuously.

Make your lab more efficient with:

• Unobtrusive, remote andreal-time monitoring

• Proactive identification andfollow-up of potential issues

• Enhanced first-time field fixes,if needed

e-Supply – ReagentInventory Management

The e-Supply program offers onlinereagent monitoring that simplifiesboth ordering and inventory processes.

This innovative program helps you:

• Track reagent usage and inventory• Maintain appropriate inventory levels• Reduce your shipping cost

Sysmex WAM™

The XT can be used in conjunctionwith Sysmex WAM DecisionSupport Software for the ClinicalLaboratory, which enhances sampleand data workflow and improvesturnaround time (TAT).

For the Mid VolumeLaboratory

The XT offers comprehensiveclinical testing menus for wholeblood and body fluids, providingaccurate, precise and sensitiveresults. Your clinicians receive qualityresults to assist in the diagnosis,management and therapeuticmonitoring of disease states.

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Principles & Technologies Fluorescent Flow Cytometry:WBC-Diff

DC-Sheath-Flow:RBC, HCT, PLT

Cyanide-free SLS-Method:HGB

21 Whole Blood Reportable WBC, RBC, HGB, HCT, MCV, MCH, MCHC,Parameters PLT (Impedance and Fluorescent Optical)

NEUT%, LYMPH%, MONO%, EO%, BASO%,NEUT#, LYMPH#, MONO#, EO#, BASO#,RDW-SD, RDW-CV, MPV

Additional Parameters

IG XT-2000i StandardXT-1800i Optional

RET-He XT-2000i Optional

2 Body Fluid Reportable Parameters WBC-BF, RBC-BF

Linearity WBC: 0.00 – 440.0 x 103/µLRBC: 0.00 – 8.00 x 106/µLPLT: 0 – 5,000 x 103/µL

Throughput Whole Blood: 80 samples/hourBody Fluid: 30 samples/hour

Sample Volumes Automated Mode 150μLClosed Mode 85μLCapillary Mode 40μL

Data Storage 10,000 samples (including graphics)(IPU: Information Processing Unit)

Quality Control Comprehensive QC files including(Total QC Management) “current” and “new” lot feature

Levey-Jennings control chartX-barM fileOnline Quality Assurance

Program – InsightTM

Interfaces ASTMSysmex WAMTM (HL7 & ASTM)

Dimensions / Weight Main unit (including sampler):w x h x d [in] / [lbs] 20.9" x 24.8" x 28.3" / 129.8 lbs.

SysmexXT-2000i™ and XT-1800i™

Specifications

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Sysmex UK, Ltd.Sysmex House, Garamond Drive, WymbushMilton Keynes, Buckinghamshire, Mk8 8DF, U.K.Tel. +44 (870) 9029270Fax +44 (870) 9029211www.sysmex.co.uk

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© 2011 Sysmex America, Inc.Document Number MKT-10-1136 04/2011 1M

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