Web viewSAFETY DATA SHEET"Dmitrievsky chemical plant – Production", LLCPage 51 of 51n-Butyl...

SAFETY DATA SHEETN-butyl acetate, Grade ADate 11/04/2011

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SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/ UNDERTAKING1.1 Product identifier1.1.1 Commercial Product Name

N-butyl acetate, Grade A1.1.2 Product code

CAS-No.: 123-86-4EINECS-No.: 204-658-1

Common name(s), synonym(s) of the substance: 1-butyl acetate, 1-butyl ethanoate, Acetic acid n-butyl ester

1.2 Relevant identified uses of the substance or mixture and uses advised against1.2.1 Recommended use

Industrial: manufacture, distribution; formulation & (re)packaging; use in coatings and cleaning agents; use in laboratories.Professional: use in coatings and cleaning agents, use in laboratories.

1.3 Details of the supplier of the safety data sheet1.3.3 Identification of the manufacturer

"Dmitrievsky chemical plant – Production", LLC

1, Proizvodstvennaya street155800 Kineshma, Ivanovo regionRussiaTelephone: (49331) 5-72-89, (495) 988-68-42Email: http://www.dhz.ru

1.4 Emergency telephone number1.4.1 Telephone number, name and address

Poison centres, Europe: http://www.who.int/pcs/poisons/centre/directory/euro/en/See SECTION 16.6 for the list of telephone numbers of poison centers in the European Economic Area.

SECTION 2. HAZARDS IDENTIFICATIONIn accordance with Directive 67/548/EEC and Regulation 1272/2008 this substance is classified as hazardous. The substance is a flammable liquid (H226). Exposure to vapours may cause drowsiness or dizziness (H336). Frequent contact can lead to skin dryness of cracking of the skin (EUH066).

2.1 Classification of the substance or mixture67/548/EEC (DSD)R10R66R671272/2008 (CLP)Flam. Liq. 3, H226STOT SE 3, H336



EUH0662.2 Label elements

1272/2008 (CLP)GHS07 - GHS02Signal word WarningHazard StatementsH226 Flammable liquid and vapour.H336 May cause drowsiness or dizziness.EUH066 Repeated exposure may cause skin dryness or cracking.Precautionary StatementsP210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.P233 Keep container tightly closed.P235 Keep cool.P261 Avoid breathing dust/fume/gas/mist/vapours/spray.P280 Wear protective gloves/protective clothing/eye protection/face protection.P303+P361+P353 IF ON SKIN (or hair): Remove/Take off immediately all contaminated

clothing. Rinse skin with water/shower.P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position

comfortable for breathing.P312 Call a POISON CENTER or doctor/physician if you feel unwell.

2.3 Other hazardsVapour is heavier than air and can travel considerable distance to a source ignition and flashback. Vapours may form explosive mixture with air. Components of the product may be absorbed into the body by inhalation.

Seveso substance: Main Seveso Category 6. Flammable

The substance does not fulfil the PBT criteria (not PBT) nor the vPvB criteria (not vPvB), see section 12 for further information.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances

N-butyl acetate is a mono-constituent substance of organic origin.CAS/EC andReg.number

EINECS Chemical name of the substance

Concentration Classification

123-86-4 204-658-1 n-butyl acetate > 99 % DSD: R10; R66; R67CLP: Flam. Liq. 3, H226; STOT SE 3, H336

SECTION 4. FIRST AID MEASURES4.1 Description of first aid measures

Remove contaminated, soaked clothing immediately and dispose of safely. First aider needs to protect himself.

4.1.2 InhalationKeep at rest. Move to fresh air. When symptoms persist or in all cases of doubt seek medical advice.

4.1.3 Skin contactWash off immediately with soap and plenty of water. When symptoms persist or in all cases of doubt seek medical advice.

4.1.4 Eye contactRinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses. Immediate medical attention is required.

4.1.5 IngestionCall a physician immediately. Do not induce vomiting without medical advice.



4.2 Most important symptoms and effects, both acute and delayedExposure to vapours may cause drowsiness or dizziness. Frequent contact can lead to skin dryness of cracking of the skin.

Cough, nausea, vomiting, headache, unconsciousness, shortness of breath, dizziness, narcosis.Special hazard: Lung oedema, central nervous system effects, Prolonged skin contact may defat the skin and produce dermatitis.

4.3 Indication of immediate medical attention and special treatment neededNotes to physician: Treat symptomatically.

SECTION 5. FIREFIGHTING MEASURESThe substance is classified as a flammable liquid cat. 3 (H226). Exposure to vapours may cause drowsiness or dizziness (H336).

Vapour is heavier than air and can travel considerable distance to a source of ignition and flashback. Vapours may form explosive mixtures with air.

5.1 Extinguishing media5.1.1 Suitable extinguishing media

Foam, dry chemical, carbon dioxide (CO2), water spray.5.1.2 Extinguishing media which must not be used for safety reasons

Do not use a solid water stream as it may scatter and spread fire.5.2 Special hazards arising from the substance or mixture

Under conditions giving incomplete combustion, hazardous gases produced may consist of:- carbon monoxide (CO)- carbon dioxide (CO2)Combustion gases of organic materials must in principle be graded as inhalation poisons.Vapour is heavier than air and can travel considerable distance to a source of ignition and flashback. Vapours may form explosive mixtures with air.

5.3 Advice for firefightersFire fighter protection should include a self-contained breathing apparatus (NIOSH-approved or EN 133) and full fire-fighting turn out gear.

5.4 Specific methodsCool containers / tanks with water spray. Dike and collect water used to fight fire. Water run-off can cause environmental damage. Keep people away from and upwind of fire.

SECTION 6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures

Avoid contact with skin and eyes. Avoid breathing vapors or mists. Keep people away from and upwind of spill/leak. Ensure adequate ventilation, especially in confined areas. Keep away from heat and sources of ignition.For emergency responders: Personal protection see section 8.

6.2 Environmental precautionsPrevent further leakage or spillage. Do not discharge product into the aquatic environment without pretreatment(biological treatment plant). See Section 8: Environmental exposure controls.

6.3 Methods and materials for containment and cleaning upMethods for containmentStop the flow of material, if possible without risk. Dike spilled material, where this is possible.Methods for cleaning upSoak up with inert absorbent material. Keep in suitable, closed containers for disposal. If liquid has been spilt in large quantities clean up promptly by scoop or vacuum. Dispose of in accordance with local regulations. Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapours).



6.4 Reference to other sectionsFor personal protection see section 8.

SECTION 7. HANDLING AND STORAGE7.1 Precautions for safe handling

General industrial hygiene practice. Ensure that eyewash stations and safety showers are close to the workstation location. When using, do not eat, drink or smoke. Take off all contaminated clothing immediately.

Avoid contact with skin, eyes and clothing. Do not breathe vapours or spray mist. Wash hands before breaks and immediately after handling the product. Provide sufficient air exchange and/or exhaust in work rooms. Keep away from sources of ignition - No smoking. Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapours). In case of fire, emergency cooling with water spray should be available. Ground and bond containers when transferring material. Vapour is heavier than air and can travel considerable distance to a source of ignition and flashback. Vapours may form explosive mixture with air.

7.2 Conditions for safe storage, including any incompatibilitiesKeep containers tightly closed in a cool, well-ventilated place. Handle and open container with care.Suitable storage material : stainless steel, mild steel, aluminiumUnsuitable storage material : copper, attacks some forms of plastic and rubber

7.3 Specific end use(s)The quantitative exposure assessment for the substance n-Butyl Acetate was performed using the Chesar tool (version 1.1.2). Only the inhalative exposure route is taken into account (DNELs for dermal route have not been derived). The methodology and all input parameters are described in the Exposure Scenarios (ES) available in the Annexes to this Safety Data Sheet. The following uses are covered by the exposure scenarios:

Industrial:ES1 Manufacture of Butyl acetate; ES2 Distribution of Butyl acetate; ES3 Formulation;ES4 Use in coatings;ES7 Use in cleaning agents;ES10 Use in laboratories.

Professional:ES5 Use in coatings;ES8 Use in cleaning agents;ES11 Use in laboratories.

See further the information provided in the Annexes to this SDS. The technical conditions and measures at process level as well as for controlling dispersion from source towards the workers and environment are also summarized in sections 7 and 8 of this SDS.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters8.1.1 Threshold limits

123-86-4

n-butyl acetate

150 ppm (8 h) 200 ppm (15 min)720 mg/m3 (8 h) 960 mg/m3 (15 min)

8.1.2 Other information on limit valuesno other information available

8.1.3 Limit values in other countries



Germany MAK: 100 ppm, 480 mg/m3 (8h), 960 mg/m3 (short-term); Peak limitation category: I(2); Pregnancy risk group: C; (DFG 2003).NIOSH REL: TWA 150 ppm (710 mg/m3); STEL 200 ppm (950 mg/m3) OSHA PEL: TWA 150 ppm (710 mg/m3); STEL 200 ppm (950 mg/m3)

8.1.4 DNELsBased on available data, the classification criteria are not met for acute toxicity, nor for skin or respiratory irritation. The DNELs for dermal acute exposure (systemic and local) and the DNEL for dermal long-term exposure (systemic and local) are not derived, because no relevant hazards leading to classification have been identified. The German MAK commission determined a scientific OEL for n-butyl acetate of 100 ppm (480 mg/m3), 8 hours of exposure. Regarding the occupational situation, the critical toxic effect of exposure to n- butyl acetate is considered the irritative effect on the eyes and the mucosa of the upper respiratory tract. The MAK value is based on available human data that indicates that the aforementioned effects do not appear at concentrations of 100 ppm or below. In addition, there are no systemic toxic effects expected, even on reproduction and development, if the MAK value will be adhered to. Therefore the German MAK values were adopted for acute and long-term (systemic and local) inhalation limit values.

WorkersAcute exposure - Systemicinhalation: 960 mg/m3 (derived based on MAK short-term limit)Acute exposure - Localinhalation: 960 mg/m3 (derived based on MAK short-term limit)

Long-term exposure - Systemicinhalation: 480 mg/m3 (derived based on MAK long-term limit)Long-term exposure - Localinhalation: 480 mg/m3 (derived based on MAK long-term limit)

8.1.5 PNECsThe PNEC values for the water compartment are derived based on the lowest short-term toxicity test results for freshwater fish ( Pimephales promelas) with LC50 (96h) value of 18 mg/l.The following assessment factors (AF) are used: PNEC aqua (freshwater): 0.18 mg/l (AF=100)PNEC aqua (marine water): 0.018 mg/l (AF=1000) PNEC aqua (intermittent releases): 0.36 mg/l (AF=50)

PNEC sediment: No data for sediment organisms are available. However, the PNEC sediment can also be calculated according to the equilibrium partitioning method and the PNEC aqua. This calculated PNEC was converted to dry weight (conversion factor: 4.6).PNEC sediment (freshwater): 0.981 mg/kg sediment dw (calculated to be 0.213 mg/kg ww; Koc = 18.5; PNECaqua (freshwater) = 0.18 mg/L).PNEC sediment (marine water): 0.0981 mg/kg sediment dw (calculated to be 0.0213 mg/kg ww; Koc = 18.5; PNEC aqua (marine water) = 0.018 mg/L).

PNEC soil: direct and indirect exposure of the soil compartment is unlikely. However, the PNEC soil can also be calculated according to the equilibrium partitioning method and the PNEC aqua. This PNEC was converted to dry weight (conversion factor: 1.13).PNEC soil: 0.0903 mg/kg soil dw (calculated to be 0.0799 mg/kg ww (Henry's Law constant = 28.5 Pa; Koc =18.5; PNEC aqua (freshwater) = 0.18 mg/L).

The PNEC value for sewage treatment plant (STP) is derived based on the growth inhibiting effect of n-butyl acetate on the ciliate ( Tetrahymena pyriformis) with EC50/LC50/40h value of 356 mg/L. The following assessment factor (AF) was applied:



PNEC STP: 35.6 mg/L (AF=10)



8.2 Exposure controls8.2.1 Appropriate engineering controls

General or dilution ventilation is frequently insufficient as the sole means of controlling employee exposure. Local ventilation is usually preferred. Explosion-proof equipment (for example fans, switches, and grounded ducts) should be used in mechanical ventilation systems.

8.2.2 Individual protection measures8.2.2.1 Respiratory protection

Respirator with A filter. Full mask with above mentioned filter according to producers using requirements or self-contained breathing apparatus. Equipment should conform to respiratory protection standards EN 136 or EN140 and EN 143.

8.2.2.2 Hand protectionWear protective gloves. Recommendations are listed below. Other protective material may be used, depending on the situation, if adequate degradation and permeation data is available. If other chemicals are used in conjunction with this chemical, material selection should be based on protection for all chemicals present.

Suitable material: butyl-rubberEvaluation according to protective glove standard EN 374: level 3Glove thickness approx 0.3 mmBreak through time approx 60 min

Suitable material: polyvinylchloride / nitrile rubberEvaluation according to protective glove standard EN 374: level 2Glove thickness approx 0.9 mmBreak through time approx 30 min

8.2.2.3 Eye/face protectionTightly fitting safety goggles. In addition to goggles, wear a face shield if there is a reasonable chance for splash to the face. Equipment should conform to eye&face protection standard EN 166.

8.2.2.4 Skin protectionImpervious clothing. Wear face-shield and protective suit for abnormal processing problems.

8.2.3 Environmental exposure controlsIf possible use in closed systems. If leakage cannot be prevented, the substance needs to be sucked off at the emersion point, if possible without danger. Observe the exposure limits, clean exhaust air if needed. If recycling is not practicable, dispose of in compliance with local regulations. Inform the responsible authorities in case of leakage into the atmosphere, or of entry into waterways, soil or drains.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Important Health Safety and Environmental Information9.1.1 Appearance

Clear, colorless liquid.9.1.2 Odour no data available9.1.3 Odour threshold no data available9.1.4 pH no data available



9.1.5 Melting point/freezing point < -90°C (at 1013 hPa) (no test method specified)9.1.6 Initial boiling point and boiling

range126 °C (at 1013 hPa) (no test method specified)

9.1.7 Flash point 27 °C (at 1013 hPa), EU test method A.9: closed-cup9.1.8 Evaporation rate no data available9.1.9 Flammability (solid, gas) Flammable liquid Cat. 3 (based on flash point). No

chemical groups associated with pyrophoric properties or flammability on contact with water.

9.1.10 Explosive properties9.1.10.1 Lower explosion limit 1.2 vol% (no test method specified)



9.1.10.2 Upper explosion limit 7.6 vol% (no test method specified)9.1.11 Vapour pressure 15 hPa at 20 °C (no test method specified)9.1.12 Vapour density no data available9.1.13 Relative density 0.8812 g/cm³ (at 20°C) (no test method specified)9.1.14 Solubility(ies)9.1.14.1 Water solubility 5.3 g/L (at 20 °C) OECD Guideline 105 and EU test method

A.6: flask method

9.1.14.2 Fat solubility (solvent - oil to be specified) no data available9.1.15 Partition coefficient: n-octanol/water Log Kow = 2.3 (at 25 °C) OECD Guideline 117 and

EU test method A.8: HPLC9.1.16 Auto-ignition temperature 415 °C (at 1013 hPa), EU test method A.159.1.17 Decomposition temperature not applicable (see boiling point)9.1.18 Viscosity 0.83 mm²/s (static; at 20°C) OECD Guideline 1149.1.19 Explosive properties non explosive (no chemical groups associated with

explosive properties present in the molecule). Vapours may form explosive mixture with air.

9.1.20 Oxidising properties not applicable (substance is flammable)9.2 Other information

Surface tension of aqueous solution: 61.3 mN/m (at 20°C and 1000 mg/L) OECD Guideline 115 and EU test method A.5: ring method.

SECTION 10. STABILITY AND REACTIVITY10.1 Reactivity

Stable under recommended storage conditions.10.2 Chemical stability

no data available10.3 Possibility of hazardous reactions

Vapours may form explosive mixture with air.10.4 Conditions to avoid

Avoid contact with heat, sparks, open flame, and static discharge. Avoid any source of ignition.10.5 Incompatible materials

Strong acids and strong bases, strong oxidizing agents.10.6 Hazardous decomposition products

No decomposition if stored and applied as directed.

SECTION 11. TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects

Exposure to vapours may cause drowsiness or dizziness (STOT SE 3 - H336). Due to the defatting solvent character of n-butyl acetate it is assumed that frequent contact can lead to skin dryness of cracking of the skin (Additional hazard statement: EUH066).

11.1.1 Acute toxicityBased on available data, the classification criteria are not met. LD50/oral/rat: 10760 mg/kg bw (method similar to OECD Guideline 423) LD50/dermal/rabbit: 14000 mg/kg bw (method similar to OECD Guideline 402)Data on acute toxicity of n-butyl acetate after inhalation exposure are inconsistent. No definite LC50 value can be stated.

11.1.2 Irritation and corrosion


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Based on available data, the classification criteria are not met. Skin irritation (rabbits): not irritating (OECD Guideline 404)Eye irritation (rabbits): not irritating (OECD Guideline 405)Respiratory irritation (human): not irritating (no guideline followed, Iregren et al. (1993))Investigations with human volunteers indicate, that weak irritation of the eyes and respiratory tract occurs after short term inhalation exposure to concentrations of about 200 ppm.

Due to the defatting solvent character of n-butyl acetate it is assumed that frequent contact can lead to skin dryness of cracking of the skin (Additional hazard statement: EUH066 - Repeated exposure may cause skin dryness or cracking).

11.1.3 SensitisationBased on available data, the classification criteria are not met.Animal experiments (Gad et al., 1986; mouse, guinea pig) and investigations with humans (Gad et al., 1986; Roed-Petersen, 1980; Anon., 1989) revealed that n-butyl acetate is not sensitising to skin.

11.1.4 Subacute, subchronic and prolonged toxicityRepeated dose toxicity: Based on available data, the classification criteria are not met. NOAEC (inhalation/rat): 2400 mg/m³ (subchronic), test method EPA OTS 798.2450Mutagenicity: Based on available data, the classification criteria are not met. Used test methods in vitro:similar to OECD Guideline 471, OECD Guideline 476; in vivo: OECD Guideline 474, EU Method B.12, EPA OTS798.5395. Test substance: n-butyl acetate and butan-1-ol (metabolite of n-butyl acetate)Reproductive toxicity: Based on available data, the classification criteria are not met:- - Effects on fertility: NOAEC (inhalation/rat): 9640 mg/m³, test methods OECD Guideline 416, EPA OPPTS870.3800- - Developmental toxicity: LOAEC (inhalation/rabbit): 7230 mg/m³, test method similar to OECD Guideline414Carcinogen: Based on available data, the classification criteria are not met.

11.1.5 STOT-single exposureClassified as STOT SE 3 - H336 - May cause drowsiness or dizziness. Route: inhalation.N-Butyl acetate induced neurotoxicity (mainly sedatory effects) in rats exposed to 1500 ppm (7.2 mg/L) test item for a single 6 hour period or subchronically. Effects occurred only transiently during exposure, no effects were detectable shortly after stop of exposure. No neurotoxicity could be detected in rats exposed subchronically to500 ppm (2.4 mg/L) n-butyl acetate, whereas transient sedation was seen at 1500 ppm and above.

NOAEC (inhalation/rats): 2410 mg/m³, test methods EPA OTS 798.6050, EPA OTS 798.6200, EPA OTS798.6500, 40 CFR Part 798.2450.

11.1.6 STOT-repeated exposureBased on available data, the classification criteria are not met.

11.1.7 Aspiration hazardBased on available data, the classification criteria are not met.

11.1.8 Other information on acute toxicityno data available

SECTION 12. ECOLOGICAL INFORMATION12.1 Toxicity12.1.1 Aquatic toxicity



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Based on available data, the classification criteria are not met (Acute toxicity is >10 mg/L, the substance is readily biodegradable and does not bioaccumulate significantly (experimentally determined log Kow <= 4). Moreover, the chronic toxicity is > 1 mg/L).

Short-term aquatic toxicity:LC50/96h/freshwater fish ( Pimephales promelas) = 18 mg/l (similar to OECD Guideline 203).

EC50/48h/freshwater invertebrates ( Daphnia Sp.) = 44 mg/l (similar to OECD Guideline 202).

NOEC/72h/freshwater algae ( Desmodesmus subspicatus) = 200 mg/l (Method according to

Umweltbundesamt(German Federal Environment Agency) proposal/draft, version February 1984).

Long-term aquatic toxicity:NOEC/21d/freshwater invertebrates ( Daphnia Magna) = 23 mg/l (OECD Guideline 211). Test substance:isobutyl acetate

12.1.2 Toxicity to other organismsAquatic micro-organisms:EC50/LC50/40h for ciliate ( Tetrahymena pyriformis): 356 mg/L (TETRATOX assay; Schultz, 2006) NOEC/28d for domestic activated sewage sludge : >10 mg/L (OECD Guideline 301 D, Waggy et al., 1994)

Terrestrial plants:EC50/14d for lettuce ( Lactuca sativa) : > 1000 mg/kg soil dry weight (similar to OECD Guideline 208)

12.2 Persistence and degradability12.2.1 Biodegradation

n-Butyl acetate is readily biodegradable according to OECD criteria in the Closed Bottle test (OECD Guideline 301D: 83 % in 28 d, 10-d window met; Waggy et al., 1994).

12.2.2 Chemical degradationn-Butyl acetate will hydrolyze slowly in contact with water. The hydrolytic half-life was estimated by calculation(HYDROWIN v2.00) to be 78 d at pH 8 and 2 years at pH 7 (ECT, 2009).The substance will also degrade in contact with air by reaction with OH-radicals. The overall OH rate constantwas determined to be 4.9 -12 cm3/molecule*sec. The half-life was calculated to be 3.3 days (24 -h d; 0.5 E+06OH/cm3). These values were determined experimentally (Kwok & Atkinson, 1994; cited in AOP v1.92).

12.3 Bioaccumulative potentialThe substance has a low potential for bioaccumulation.The log Kow of 2.3 for n-butyl acetate indicates a low potential for bioaccumulation. In addition, the substance is readily biodegradable. Based on a measured log Pow of 2.3, the bioconcentration factor (BCF) of n-butyl acetate was estimated to be 15 by using the BCFBAF program (v3.00). This estimate refers to the uncharged molecule. According to the BCF, n-butyl acetate has a low potential for bioaccumulation in aquatic organisms.

12.4 Mobility in soilThe substance is readily biodegradable and has a low potential for adsorption due to a low octanol-water partition coefficient (log Kow=2.3) and estimated adsorption coefficient (log Koc < 3). The determined Henry's Law constant indicated that low volatilisation is expected. Therefore, adsorption to soil is not expected and the substance may be mobile in soil. It is also not expected that the substance will contaminate ground waters since it is readily biodegradable in water.

The adsorption coefficient (log Koc) was estimated by calculation (KOCWIN v2.00) to be less than 3 (MCI



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method: 1.3; Kow method: 1.8).Koc: 18.54 - 69.84; log Koc: 1.268 - 1.844

The Henry's Law constant (HLC) of n-butyl acetate was experimental determined to be 28.5 Pa*m³/mol (Kieckbusch and King, 1976, as cited in ECT, 2009). The calculated value lies slightly above this value (HENRYWIN v3.20 41.6 Pa*m³/mol at 25 °C).



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12.5 Results of PBT and vPvB assessmentThe substance is not persistent (not P) and not very persistent (not vP) in the environment. The substance is not bioaccumulative (not B) and not very bioaccumulative (not vB). The substance is not toxic (not T). Taking into account all available data on biotic and abiotic degradation, bioaccumulation and toxicity it can be stated that the substance does not fulfil the PBT criteria (not PBT) nor the vPvB criteria (not vPvB).

12.6 Other adverse effectsNo other adverse effects identified for this substance.

SECTION 13. DISPOSAL CONSIDERATIONSThe choice of the appropriate disposal method depends on the product composition by the time of disposal as well as the local statutes and possibilities for disposal. Waste codes in accordance with the list of European Waste Catalogue (EWC) should be assigned by the user prior to final disposal. Dispose of product residue in accordance with the instructions of the person responsible for waste disposal. Refer to local and national waste management regulations and dispose of in accordance with selected waste classification.

13.1 Waste treatment methodsDispose of in accordance with waste classification. The primary waste management option for unused substance and contaminated packaging is hazardous waste incineration. Refer to local or national waste management regulations.Waste from residues / unused productsContaminated packaging should be emptied as far as possible and after appropriate cleansing may be taken for reuse. Disposal as hazardous waste.

SECTION 14. TRANSPORT INFORMATION14.1 UN number 112314.2 UN proper shipping name Butyl acetates14.3 Transport hazard class(es) Class 3; Classification code F114.4 Packing group III14.5 Environmental hazards

Not classified as hazardous to the environment. See Section 8 for environmental exposure controls.

14.6 Special precautions for usersIMDG Marine trasport EmS number: F-E; S-D Not a marine pollutant.

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC CodeIBC-CodeProduct name Butyl acetateShip type 3Pollution category Y

SECTION 15. REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

n-Butyl Acetate is classified in Main Seveso Category 6. Flammable according to Annex I of Council Directive96/82/EC of 9 December 1996 on the control of major-accident hazards involving dangerous substances (OJ L10, 14.1.1997, p. 13).

15.2 Chemical safety assessmentIn accordance with REACH Article 14, a Chemical Safety Assessment has been carried out for



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this substance.



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SECTION 16. OTHER INFORMATION16.1 Additions, Deletions, Revisions

Version 3.0, The Lead Registrant has adapted the DNEL values to the German MAK values. Consequently the Chemical Safety Report was updated, and Exposure Assessment and Risk Characterisation was corrected. All sections of this SDS are aligned with the updated REACH Chemical Safety Report.This safety data sheet is drawn up to comply with the requirements of Regulation (EC) No. 1907/2006 (REACH), as amended by Annex I to Commission Regulation (EU) No 453/2010 of 20 May 2010.

16.2 Key or legend to abbreviations and acronyms-AF - Assessment factor-BCF - Bioconcentration factor-CAS - Registry Numbers assigned by the "Chemical Abstracts Service"-CLP - Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006-DNEL - Derived no-effect level-DSD - Council Directive 67/548/EEC (Dangerous Substances Directive)-dw - dry weight-EC50 - Concentration of the substance that causes 50 % reduction of a certain effect on test organisms-EINECS - Registry number in the European Inventory of Existing Commercial Chemical Substances-EPA OPPTS - Environmental Protection Agency, Office for Prevention, Pesticides & Toxic Substances (USA)-EPA OTS - Environmental Protection Agency, Office for Toxic Substances (USA)-ES - Exposure scenario-EU - European Union-Koc - Soil adsorption coefficient-LC50 -Lethal concentration of the substance that causes 50 % mortality of the test population-LOAEC - Lowest observed adverse effect concentration-MAK - Maximale Arbeitsplatzkonzentrationen (Germany): maximum concentration of a chemical substance in the workplace, expressed as daily 8-hour time-weighed average values and apply to healthy adults.-NIOSH - NAtional Institute for Occupational Safety and Health (USA)-NOAEC - No observed adverse effect concentration-NOAEL- No observed adverse effect level-NOEC - No observed effect concentration-OECD - Organisation for Economic Co-operation and Development-OEL - Occupational exposure



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limit-OSHA - Occupational Safety and Health Administration (USA)-PBT/vPvB - Persistent, bioaccumulative and toxic/ very persistent and very bioaccumulative-PEL - Permissible exposure limit-PNEC - Predicted no-effect concentration-REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals-REL - Recommended exposure limit-STEL - Short term exposure limit-STP - Sewage treatment plant-TWA - Time weighted average

16.3 Key literature references and sources for dataREACH Chemical Safety Report Part B for n-butyl acetate.All referenced studies within this safety data sheet can be found from the original Chemical Safety Report.

16.4 Classification procedureThis substance has a harmonized classification according to Annex VI to Regulation (EC) No 1272/2008 (CLP).

16.5 List of relevant R phrases, hazard statements, safety phrases and/or precautionary statements

R10 Flammable.R66 Repeated exposure may cause skin dryness or cracking.R67 Vapours may cause drowsiness and dizziness.



Production", LLC

16.6 Emergency telephone numberEurope-wide emergency number: 112

Con t act a pois o n con t rol cen t re. List of Teleph o ne Nu m bers :AUSTRIA (Vienna Wien) +43 1 406 43 43; BELGIUM (Brussels Bruxelles) +32 70 245 245; BULGARIA (Sofia) +359 2 9154 409; CZECH REPUBLIC (Prague Praha) +420 224 919 293; DENMARK (Copenhagen) 82 12 12 12; ESTONIA (Tallinn) 112; FINLAND (Helsinki) +358 9 471 977; FRANCE (Paris) +33 1 40 0548 48; GERMANY (Berlin) +49 30 19240; GREECE (Athens Athinai) +30 10 779 3777; HUNGARY (Budapest) 06 80 20 11 99; ICELAND (Reykjavik) +354 525 111, +354 543 2222; IRELAND (Dublin) +353 1 8379964; ITALY (Rome) +3906 305 4343; LATVIA (Riga) +371 704 2468; LITHUANIA (Vilnius) +370 5 236 20 52 or +370 687 53378; MALTA (Valletta) 2425 0000; NETHERLANDS (Bilthoven) +31 30 274 88 88; NORWAY (Oslo) 22 591300; POLAND (Gdansk) +48 58301 65 16 or +48 58 349 2831; PORTUGAL (Lisbon Lisboa) 808 250 143; ROMANIA (Bucharest) +40 21 3183606 SLOVAKIA (Bratislava) +421 2 54 77 4166; SLOVENIA (Ljubljana) + 386 41 650500; SPAIN (Barcelona) +34 93 227 98 33 or +34 93 227 54 00 bleep 190; SWEDEN (Stockholm) 112 or +46 833 12 31 (mon-fri 9.00-17.00); UNITED KINGDOM (London) 112 or 0845 4647 (NHS Direct).

16.7 Recommended restrictionsDISCLAIMER OF LIABILITY: The information in this SDS was obtained from recent Chemical Safety Report of this substance from REACH registration 2010. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This SDS was prepared and is to be used only for this product. If the product is used as a component in another product, this SDS information may not be applicable.

SAFETY DATA SHEET "Dmitrievsky chemical plant – Production", LLC Page 1 of 51n-Butyl acetateDate: 11/04/2011Previous date: 03/03/2010

Annex to extended safety data sheet (eSDS)

ES 1 - Manufacture of Butyl Acetate

Manufacture of Butyl AcetateEnvironment: ERC 1WorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesUse as laboratory reagent PROC 15

Operational conditions and risk management measuresControl of environmental exposure: Manufacture of Butyl AcetateProduct characteristicsAmounts usedDaily use at a site <= 400 tonnes/dayAnnual use at a site <= 1.2E5 tonnes/yearPercentage of tonnage used at regional scale = 100 %Frequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 3.456E6 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2.88E4 m3/dApplication of the STP sludge on agricultural soil NoConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk management



Other given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed process, no likelihood of L

exposureTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure" [PROC 2]

Inhal*) Derm*)Loc Sys Loc Sys

Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed, continuous process with L

occasional controlled exposureTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent release



Level of containment Use in closed batch process (synthesis or Lformulation)

Technical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for exposure arises" [PROC 4]


Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in batch and other process (synthesis) L

where opportunity for exposure arisesTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non-dedicated facilities" [PROC 8a]


Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No L



Organisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities" [PROC 8b]


Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Use as laboratory reagent" [PROC 15]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which the determinant has been used for exposure estimation are reported.



Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not required (DNEL was not derived as no respective hazard was observed).According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14 (Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to represent conservative 90th percentiles of the distribution of exposure concentrations. According to the Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional factor of 2. No information is available from the use and practical experience with the substance, which would require a higher factor.Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC TRA, that also potential peak exposures would not give rise to increased risks.

PROC

DNEL inhalation long-term systemic =3480 mg/m (100 ppm)

DNEL dermal = Not derived RCR TOTAL

(inhalation + dermal)Estimated

exposure (mg/m3) RCR Estimated exposure RCR

PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 48.4 0.101 NA NA 0.101PROC 3 121 0.252 NA NA 0.252PROC 4 96.8 0.202 NA NA 0.202PROC 8a 242 0.504 NA NA 0.504PROC 8b 242 0.504 NA NA 0.504PROC 15 48.4 0.101 NA NA 0.101Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation

The values for the parameters river flow and effluent discharge rate have been refined to reflect a realistic dilution rate (river). Furthermore it is taken into account that the sludge from STP is not discharged to soil. The RCR values for marine compartments are not considered as relevant for the manufacturing scenario as the production site is located in a sufficient distance from sea (*).

Environment type PNEC PEC/Local RCRWater: Fresh Water(Pelagic) 0.18 mg/l 0.048 mg/l 0.267

Water: Fresh Water(Sediment) 0.981 mg/kgdwt 0.963 mg/kgdwt 0.982

Water: Marine Water(Pelagic) 0.018 mg/l 0.058 mg/l 3.2 (*)

Water: Marine Water(Sediment) 0.0981 mg/kgdwt 1.15 mg/kgdwt 11.72 (*)

Water: SewageTreatment Plant(Effluent)

35.6 mg/l 5.75 mg/l 0.162

Soil: Agricultural Soil 0.0903 mg/kgdwt 0.07 mg/kgdwt 0.78



ES 2 – Distribution of Butyl Acetate

Distribution of Butyl AcetateEnvironment: ERC 1WorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesTransfer of substance or preparation into small containers (dedicated filling line, PROC 9 including weighing)Use as laboratory reagent PROC 15Operational conditions and risk management measuresControl of environmental exposure: Distribution of Butyl AcetateProduct characteristicsAmounts usedDaily use at a site <= 400 tonnes/dayAnnual use at a site <= 1.2E5 tonnes/yearPercentage of tonnage used at regional scale = 100 %Frequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSA


Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposure



Duration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed process, no likelihood of L







Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposure



Place of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed batch process (synthesis or L

formulation)Technical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA







Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent release







Control of workers exposure for "Transfer of substance or preparation into small containers (dedicated filling line, including weighing) " [PROC 9]





Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is notrequired (DNEL was not derived as no respective hazard was observed).According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14 (Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to represent conservative 90th percentiles of the distribution of exposure concentrations. According to the Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional factor of 2. No information is available from the use and practical experience with the substance, which would require a higher factor.Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC TRA, that also potential peak exposures would not give rise to increased risks.

PROC





PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 48.4 0.101 NA NA 0.101PROC 3 121 0.252 NA NA 0.252PROC 4 96.8 0.202 NA NA 0.202PROC 8a 242 0.504 NA NA 0.504PROC 8b 242 0.504 NA NA 0.504PROC 15 48.4 0.101 NA NA 0.101Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation



Water: Marine Water(Pelagic) 0.018 mg/l 0.002 mg/l 0.123

Water: Marine Water(Sediment) 0.0981 mg/kgdwt 0.044 mg/kgdwt 0.454


35.6 mg/l 0.218 mg/l 0.006




ES 3 - Formulation

FormulationMarket sector:Environment: ERC 2WorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Mixing or blending in batch processes for formulation of preparations and articles PROC 5 (multistage and/or significant contact)Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesTransfer of substance or preparation into small containers (dedicated filling line, PROC 9 including weighing)Production of preparations or articles by tabletting, compression, extrusion, PROC 14 pelletisationUse as laboratory reagent PROC 15Operational conditions and risk management measuresControl of environmental exposure: FormulationProduct characteristicsAmounts usedDaily use at a site <= 13.33 tonnes/dayAnnual use at a site <= 4E3 tonnes/yearPercentage of tonnage used at regional scale = 100 %Frequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSAControl of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]

Inhal*) Derm*)



Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed process, no likelihood of L







Loc Sys Loc SysProduct characteristicsSubstance in preparation No L



Amounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed batch process (synthesis or L






Control of workers exposure for "Mixing or blending in batch processes for formulation of preparations and articles (multistage and/or significant contact) " [PROC 5]


Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposure



Duration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA






Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the worker



Local Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Transfer of substance or preparation into small containers (dedicated filling line, including weighing) " [PROC 9]



Control of workers exposure for "Production of preparations or articles by tabletting, compression, extrusion, pelletisation" [PROC 14]






PROC





PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 48.4 0.101 NA NA 0.101PROC 3 121 0.252 NA NA 0.252PROC 4 96.8 0.202 NA NA 0.202PROC 5 242 0.504 NA NA 0.504PROC 8a 242 0.504 NA NA 0.504PROC 8b 242 0.504 NA NA 0.504PROC 9 242 0.504 NA NA 0.504PROC 14 242 0.504 NA NA 0.504PROC 15 48.4 0.101 NA NA 0.101Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation






35.6 mg/l 0.145 mg/l 0.004




ES 4 - Use in coatings (industrial)

use in coatings (industrial)Market sector:PC 9a - Coatings and Paints, Thinners, paint removersSector of use:SU 7 - Printing and reproduction of recorded mediaEnvironment: ERC 4WorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Mixing or blending in batch processes for formulation of preparations and articles PROC 5 (multistage and/or significant contact)Industrial spraying PROC 7Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesRoller application or brushing PROC 10Treatment of articles by dipping and pouring PROC 13Use as laboratory reagent PROC 15Operational conditions and risk management measuresControl of environmental exposure: use in coatingsProduct characteristicsAmounts usedDaily use at a site <= 16.66 tonnes/dayAnnual use at a site <= 5E3 tonnes/yearPercentage of tonnage used at regional scale = 100 %Frequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of waste



Additional good practice advice beyond the REACH CSA











Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed batch process (synthesis or L








Product characteristics



Substance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Industrial spraying" [PROC 7]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation Yes LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA



Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposure



Place of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA




Control of workers exposure for "Roller application or brushing" [PROC 10]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluation



Respiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Treatment of articles by dipping and pouring" [PROC 13]Inhal*) Derm*)








PROC





PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 48.4 0.101 NA NA 0.101PROC 3 121 0.252 NA NA 0.252PROC 4 96.8 0.202 NA NA 0.202PROC 5 242 0.504 NA NA 0.504PROC 7 60.5 0.126 NA NA 0.126PROC 8a 242 0.504 NA NA 0.504PROC 8b 242 0.504 NA NA 0.504PROC 10 242 0.504 NA NA 0.504PROC 13 242 0.504 NA NA 0.504PROC 15 48.4 0.101 NA NA 0.101Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation






35.6 mg/l 0.181 mg/l 0.005




ES 5- Use in coatings (professional)

Use in coatings (professional)Market sector:PC 9a - Coatings and Paints, Thinners, paint removersEnvironment: ERC 8aWorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesRoller application or brushing PROC 10Non industrial spraying PROC 11Treatment of articles by dipping and pouring PROC 13Mixing or blending in batch processes for formulation of preparations and articles PROC 5 (multistage and/or significant contact)Use as laboratory reagent PROC 15Hand-mixing with intimate contact and only PPE available PROC 19Operational conditions and risk management measuresControl of environmental exposure: use in coatings (professional)Product characteristicsAmounts usedDaily wide dispersive use = 5.5E-4 tonnes/dayFrequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSA


Loc Sys Loc Sys



Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed process, no likelihood of L







Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts used



Frequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed batch process (synthesis or L








Product characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposure



Duration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA





Loc Sys Loc SysProduct characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent release




Control of workers exposure for "Non industrial spraying" [PROC 11]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection capable offering a L

90% reduction in inhaled concentrations of the substance



Loc Sys Loc SysProduct characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used L






Product characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA



Control of workers exposure for "Hand-mixing with intimate contact and only PPE available" [PROC19]




Product characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA





PROC





PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 96.8 0.202 NA NA 0.202PROC 3 121 0.252 NA NA 0.252PROC 4 242 0.504 NA NA 0.504PROC 5 290.4 0.605 NA NA 0.605PROC 8a 290.4 0.605 NA NA 0.605PROC 8b 242 0.504 NA NA 0.504PROC 10 290.4 0.605 NA NA 0.605PROC 11 242 0.504 NA NA 0.504PROC 13 290.4 0.605 NA NA 0.605PROC 15 48.4 0.101 NA NA 0.101PROC 19 290.4 0.605 NA NA 0.605Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation

Environment type PNEC PEC/Local RCRWater: Fresh Water(Pelagic) 0.18 mg/l 5.37E-4 mg/l 0.003

Water: Fresh Water(Sediment) 0.981 mg/kgdwt 0. 011 mg/kgdwt 0.011

Water: Marine Water(Pelagic) 0.018 mg/l 4.68E-5 mg/l 0.003

Water: Marine Water(Sediment) 0.0981 mg/kgdwt 9.38E-4 mg/kgdwt 0.01


35.6 mg/l 3E-4 mg/l 8.427E-6

Soil: Agricultural Soil 0.0903 mg/kgdwt 1.25E-4 mg/kgdwt 0.002



ES 7 -Use in cleaning agents (industrial)

Use in cleaning agents (industrial)Market sector:PC 35 - Washing and Cleaning Products (including solvent based products)Sector of use:SU 8 - Manufacture of bulk, large scale chemicals (including petroleum products)Environment: ERC 4WorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Industrial spraying PROC 7Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesRoller application or brushing PROC 10Treatment of articles by dipping and pouring PROC 13Operational conditions and risk management measuresControl of environmental exposure: use in cleaning agentsProduct characteristicsAmounts usedDaily use at a site <= 5 tonnes/dayAnnual use at a site <= 100 tonnes/yearPercentage of tonnage used at regional scale = 100 %Frequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSA











Loc Sys Loc SysProduct characteristicsSubstance in preparation No L



Amounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed batch process (synthesis or L






Control of workers exposure for "Industrial spraying" [PROC 7]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours L



Human factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation Yes LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA






Product characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No L




PROC





PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 48.4 0.101 NA NA 0.101PROC 3 121 0.252 NA NA 0.252PROC 4 96.8 0.202 NA NA 0.202PROC 7 60.5 0.126 NA NA 0.126PROC 8a 242 0.504 NA NA 0.504PROC 8b 242 0.504 NA NA 0.504PROC 10 242 0.605 NA NA 0.605PROC 13 242 0.605 NA NA 0.605Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation


Water: Fresh Water(Sediment) 0.981 mg/kgdwt 0. 065 mg/kgdwt 0.066




35.6 mg/l 0.027 mg/l 7.64E-4




ES 8 - Use in cleaning agents (professional)

Use in cleaning agents (professional)Market sector:PC 35 - Washing and Cleaning Products (including solvent based products)Environment: ERC 8aWorkerUse in closed process, no likelihood of exposure PROC 1Use in closed, continuous process with occasional controlled exposure PROC 2Use in closed batch process (synthesis or formulation) PROC 3Use in batch and other process (synthesis) where opportunity for exposure arises PROC 4Transfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8a containers at non-dedicated facilitiesTransfer of substance or preparation (charging/discharging) from/to vessels/large PROC 8b containers at dedicated facilitiesRoller application or brushing PROC 10Non industrial spraying PROC 11Treatment of articles by dipping and pouring PROC 13Operational conditions and risk management measuresControl of environmental exposure: use in cleaning agents (professional)Product characteristicsAmounts usedDaily wide dispersive use = 2.7E-4 tonnes/dayFrequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSA


Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts used



Frequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed process, no likelihood of L







Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk management



Other given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseLevel of containment Use in closed batch process (synthesis or L








Product characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposure



Place of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA





Loc Sys Loc SysProduct characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposure



Conditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA

Control of workers exposure for "Non industrial spraying" [PROC 11]Inhal*) Derm*)

Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection capable offering a L

90% reduction in inhaled concentrations of the substance



Loc Sys Loc SysProduct characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for whichthe determinant has been used for exposure estimation are reported.




PROC





PROC 1 0.048 1E-4 NA NA 1E-4PROC 2 96.8 0.202 NA NA 0.202PROC 3 121 0.252 NA NA 0.252PROC 4 242 0.504 NA NA 0.504PROC 8a 290.4 0.605 NA NA 0.605PROC 8b 242 0.504 NA NA 0.504PROC 10 290.4 0.605 NA NA 0.605PROC 11 242 0.504 NA NA 0.504PROC 13 290.4 0.605 NA NA 0.605Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation






35.6 mg/l 1.47E-8 mg/l 4.129E-10

Soil: Agricultural Soil 0.0903 mg/kgdwt 3.39E-5 mg/kgdwt 3.754E-4



ES 10 - Use in laboratories (ind)

Use in laboratories (ind)Market sector:PC 21 - Laboratory ChemicalsSector of use:SU 9 - Manufacture of fine chemicalsEnvironment: ERC 4WorkerRoller application or brushing PROC 10Use as laboratory reagent PROC 15Operational conditions and risk management measuresControl of environmental exposure: use in laboratories (ind)Product characteristicsAmounts usedDaily use at a site <= 0.05 tonnes/dayAnnual use at a site <= 1 tonnes/yearPercentage of tonnage used at regional scale = 100 %Frequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSA


Loc Sys Loc SysProduct characteristicsSubstance in preparation No LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors L



Technical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No LOrganisational measures to prevent /limit releases, dispersion and exposureConditions and measures related to personal protection, hygiene and health evaluationRespiratory protection Respiratory protection is not used LAdditional good practice advice beyond the REACH CSA







PROC





PROC 10 242 0.504 NA NA 0.504PROC 15 48.4 0.101 NA NA 0.101Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation






35.6 mg/l 0.054 mg/l 0.002




ES 11 - Use in laboratories (prof)

Use in laboratories (prof)Market sector:PC 21 - Laboratory ChemicalsEnvironment: ERC 8aWorkerRoller application or brushing PROC 10Use as laboratory reagent PROC 15Operational conditions and risk management measuresControl of environmental exposure: use in laboratories (prof)Product characteristicsAmounts usedDaily wide dispersive use = 1.37E-7 tonnes/dayFrequency and duration of useEnvironment factors not influenced by risk managementReceiving surface water flow rate >= 1.8E4 m3/dOther given operational conditions affecting environmental exposureTechnical conditions and measures at process level (source) to prevent releaseTechnical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soilOrganizational measures to prevent/limit release from siteConditions and measures related to municipal sewage treatment plantMunicipal STP Yes [Water: 89.1%] Discharge rate of STP >= 2E3 m3/dApplication of the STP sludge on agricultural soil YesConditions and measures related to external treatment of waste for disposalConditions and measures related to external recovery of wasteAdditional good practice advice beyond the REACH CSAControl of workers exposure for "Roller application or brushing" [PROC 10]


Product characteristicsSubstance in preparation Yes LConcentration of substance in product 5 – 25% LAmounts usedFrequency and duration of use/exposureDuration of activity >4 hours LHuman factors not influenced by risk managementOther given operational conditions affecting workers exposurePlace of use Indoors LTechnical conditions and measures at process level (source) to prevent releaseTechnical conditions and measures to control dispersion from source towards the workerLocal Exhaust Ventilation No L




PROC





PROC 10 290.4 0.605 NA NA 0.605PROC 15 48.4 0.101 NA NA 0.101Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation






35.6 mg/l 3.73E-6 mg/l 1.048E-7

Soil: Agricultural Soil 0.0903 mg/kgdwt 3.53E-5 mg/kgdwt 3.909E-4

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