'World Meeting on Pharmaceutics, Biopharmaceutics ... · Scientific programme M Tuesday,9May1995...
Transcript of 'World Meeting on Pharmaceutics, Biopharmaceutics ... · Scientific programme M Tuesday,9May1995...
1st World Meetingon
Pharmaceutics,Biopharmaceutics andPharmaceutical Technology
Budapest, 9 to 11 May 1995
UB/TIB Hannover 89
114 000 417
Scientific programme
M Tuesday, 9 May 1995
Room A
9.00 h Opening ceremony
9.20 h APV Medal
9.30 h Jean Marie Lehn, College de France, Paris
Supramolecular chemistry, Molecular recognition, self-organization and the
molecular information paradigm
10.30 h Break
11.00 h Oral sessions
Room A
Physicochemicalaspects of formulation
and preformulation
12.40 h Lunch break
14.00 h Poster session
Solid oral dosage forms, Nanoparticles, Liposomes,Transmembranal passage.
Posters will be exhibited from 10.30 h to 16.35 h. However authors are
requested to remain by their poster during this special session.
15.00 h Oral sessions
Room A Room B Room C
Physicochemical Microparticles Emulsions and
aspects of formulation suspensionsand preformulation
16.20 h Break
16.35 h Oral sessions
Room A Room B Room C
Cyclodextrins Delivery through mucosae Pellets
17.35 h End of session
RoomB
MicroparticlesRoomCDermal deliverysystems
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Scientific programme
Wednesday, 10 May 1995
Room A
9.00 h Helmut Ringsdorf, Institut fur Chemie, Mainz
What to learn from Mother Nature for drug delivery and biosensors,
Mimicking of biomembrane processes based on functional
supramolecular systems
10.00 h Break
10.20 h
11.20 h Break
Oral sessions
Room A RoomB RoomC
Solid oral dosage forms Cyclodextrins Pellets
11.30 h Oral sessions
Room ASolid oral dosage forms
12.30 h Lunch break
RoomB
Molecular targetingRoomC
Pellets
14.00 h Poster session
Delivery through mucosae, Pulmonary delivery, Transdermal delivery,
Pharmacolology, pharmacokinetics and biopharmacy, Emulsions and
suspensions, Stability, Sterilization, Lyophilization.
Posters will be exhibited from 10.00 h to 16.35 h. However authors are
requested to remain by their poster during this special session.
15.00 h Oral sessions
Room A Room B
Solid oral dosage forms Liposomes
16.20 h Break
RoomCBioadhesion
16.35 h Oral sessionsRoom A Room B
Solid oral dosage forms Liposomes
17.35 h End of session
RoomC
Bioadhesion
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Scientific programme
Thursday, 11 May 1995
Room A
9.15 h Maurice Marie Janot Lecture, Daan J.A. Crommelin,Universiteit UtrechtInternational Jury President: Professor Trevor M. Jones
10.00 h Break
10.20 h Oral sessionsRoom A
Solid oral dosage forms
11.20 h Break
RoomB
NanoparticlesRoomC
Lyophilization
11.30 h Oral sessions
Room A
Solid oral dosage forms
12.30 h Lunch break
RoomB
NanoparticlesRoomC
Stability
14.00 h Poster session
Microspheres, Pellets, Controlled release, Synthesis and analysis,Bioadhesion, Physicochemistry, Cyclodextrins, Miscellaneous
Posters will be exhibited from 10.00 h to 16.35 h. However authors are
requested to remain by their poster during this special session.
15.00 h Oral sessions
Room A
Solid oral dosage forms
16.20 h Break
Room B
NanoparticlesRoomC
Pharmacology,pharmacokineticsand biopharmacy
16.35 h Oral sessions
Room A
Pulmonary deliveryRoomB
ProdrugsRoom C
Pharmacology,pharmacokineticsand biopharmacy
17.35 h End of session
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Tuesday, 9 May 1995
Room A
09.00 h Opening Ceremony
09.20 h APV Medal
09.30 h Jean-Marie Lehn, College de France, Paris
Supramolecular chemistry, Molecular recognition, self-organizationand the molecular information paradigm
10.30 h Break
Room A
Proceedings page
Physicochemical aspects offormulation and preformulationChairmen, Jelka Smid-Korbar and Praveen Tyle
11.00 h Obtaining new generation drugs on the basis of physically stablemetastable modifications of known substances
N. Leonidov 9
11.20 h The presentation of polymorphic systems by energy/temperature diagramsA. Burger and J.-O. Henck 10
11.40 h Drug of low solubility, Physicochemical characterization and dissolutionR. Alle, J. Berail, C. Boull6, A. Caron, C Condamine
and J.C. Gautier 12
12.00 h Interactions between fenoprofen sodium and hydrophilic polymeric excipientsT. Rades and C.C. Muller-Goymann 14
12.20 h Interactions between Carbopol 980 and additional second
macromolecule in aqueous formulations
M. Oechsner and S. Keipert 16
12.40 h Lunch break
Physicochemical aspects offormulation andpreformulationChairmen, Christel Muller-Goymann and Artur Burger
15.00 h Preformulation studies of a novel HIV protease inhibitor, AG1343
M. Longer, I. Zamansky and P. Tyle 18
15.20 h Influence of mechanical and thermal treatments on the
colloidal/chemical structure of a semisolid mixture
B. Otten and C. Fuhrer 20
15.40 h Partitioning and solubility of the psoralens used in therapyassessed through a spectrofluorimetric analysis
A. Said, P. Muret, S. Makki, J.-C. Rouland and J. Millet 22
16.00 h D-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) as
an absorption enhancerS.H.W. Wu, W. Hopkings and D. Wyatt 24
16.20 BreakProceedings page
CyclodextrinsChairmen, Dominique Duchene and Jose Luis Vila Jato
16.35 h Solution for insolubility problems of base-type drugs,Multi-component cyclodextrin complexation
L. Szente, J. Szejtli, M. Vikmon, J. Szeman, E. Fenyvesi,M. Pasini, E. Redenti and P. Ventura 579
16.55 h Idebenone/8-cyclodextrin inclusion complexes,Characterization and in vitro studies
C.A. Ventura, G. Puglisi, M.A. Vandelli and M.T. Zappala 581
17.15 h Interaction between 8-methoxypsoralen and cyclodextrinsM. Kata, F. Giordano, M. Rillosi, G.P. Bettinetti,A. Gazzaniga and LA. Hadi 583
Tuesday, 9 May 1995
RoomB
MicroparticlesChairmen, James McGinity and Tadeusz W. Hermann
11.00 h PDLLA microspheres containing steroids, Spray-drying and w/o/wemulsification as preparation methods
P. Giunchedi, A. Benvenga, H.O. Alpar and U. Conte 389
11.20 h Preparation of poly (D,L lactide-co-glycolide) microsphereswith narrow size distributions
C. Albayrak, S. Keipert, G. RSBling and R. Schmitz 391
11.40 h Ultrasound-induced degradation of aliphatic polyestersduring microsphere processing, Influence of formulation variables
G. Reich 393
12.00 h Composite swellable polymeric microparticles for improved bioavailabilityF. Carli and P.A. Esposito 395
12.20 h Bone morphogenic protein-2 release from freeze-dried polymer matrices
S. Duggirala and P.P. DeLuca 397
12.40 h Lunch break
MicroparticlesChairmen, Ubaldo Conte and Nicholas Peppas
15.00 h Microencapsulation of tetanus toxoid using poly(lactide-coglycolide)polymers and novel ABA-triblock copolymers for single-shot vaccines
R. Koneberg and T. Kissel 399
15.20 h Malaria antigen in biodegradable PLA/PLGA microspheres,Formulation and quality control aspects
E. Casali, G. Corradin, H.P. Merkle and B. Gander 401
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Proceedings page15.40 h Enhancement of vaccine efficacy by induction of IgA with ricin toxoid
vaccine incorporated into poly(lactide-co-glycolide) (PLG) microspheresM. Kende, C. Yan,W. Rill, R. Malli, H. Naseem,J. Hewetson and R. Tammariello 403
16.00 h Protracted immunity evoked by ricin toxoid vaccine
incorporated into a new carrier systemC. Yan, W. Rill, J. Hewetson, R. Tammariello,R. Malli and M. Kende 405
16.20 h Break
Delivery through various mucosae
Chairmen, Peter Langguth and Gilles Ponchel
16.35 h In vivo buccal delivery of macromolecular drugsA.J. Hoogstraate, J. Verhoef, A.H.G.J. Schrijvers, A. Pijpers,L.A.M.G. van Leengoed, J.H.M. Verheijden, H.E. JungingerandH.E. Bodde 747
16.55 h Experimental anti-thrombotic effect of a low-molecular weight heparinabsorbed through the nasal mucosa, Role of the enhancing effect
of sodium glycocholateM. Buhannic, C. Bardin, F. Chast, C. Busin, L. Bara,M. Samama and J.-C. Chaumeil 749
17.15 h Characterization of the uterus as a site of drug administration
for systemic effect
A. Hoffman, I. Shaked, A. Nyska, A. Avramoff and G. Golomb 751
Tuesday, 9 May 1995
RoomC
Dermal and transdermal delivery systems
Chairmen, Veronique Preat-Haine and Bernhard C. Lippold
11.00 h Cosmetic efficiency assessment on human skin microtopographyS. Makki, P. Agache, P. Muret and J. Millet 679
11.20 h Microemulsion as a topical drug delivery vehicle for
local anaesthetics of the carbamate typeM. Zabka, M. Benkova and E. Racanska 681
11.40 h Universal hydrophilic drug-containing adhesive matrix
for systemic and topical transdermal drug deliveryA.E. Vasiliev, M.M. Feldstein, M.E. Pudel and N.A. Plate 683
12.00 h In vitro percutaneous permeation of a model zwitterion, baclofen
M. Sznitowska and S. Janicki 685
12.20 h Electroperturbation of the human skin barrier in vitro,
Effects on stratum comeum impedance and lipid fine structure
W.H.M. Craane-van Hinsberg, F. Spies, J. vErhoef and G. Gooris 687
12.40 h Lunch break
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Emulsions and suspensionsChairmen, Jacqueline Plaizier-Vercammen and Yasemin Yazan
Proceedings
15.00 h HPMC as emulsifier for submicron emulsions
M. Schulz and R. Daniels 637
15.20 h Positively-charged self-emulsifying oily formulation
for improving oral bioavailability of progesteroneT. Gershanik and S. Benita 639
15.40 h Dry emulsions as a potential drug delivery systemG.P. Pedersen, P. Faldt, B. Bergenstahl and H.G. Kristensen 641
16.00 h Adsorption behaviour of a surfactant (oleic acid) on to salbutamol
base and salbutamol sulphate in non-aqueous suspensionP.M. Blackett and G. Buckton 643
16.20 h Break
Pellets
Chairmen, Luc Delattre and Christina Graffner
16.35 h Structure and pharmaceutical properties of pellets,Effect of the granulation liquid
M. Schroder and P. Kleinebudde 341
16.55 h Homogeneous pellets of binary mixtures,Comparison between extruder/ spheronizer and high-shear mixer
P. Kleinebudde and L. Nymo 343
17.15 h Matrix pellets based on the combination of waxes,
starches and maltodextrinsZ. Fang, C. Vervaet and J.P. Remon 345
Tuesday, 9 May 1995
Posters
Exhibited continuously from 10.30 to 16.35, with special session from 14.00 to 15.00 h.
The number indicates the number displayed on the poster panel.
Solid oral dosageforms
1 Influencing the neutralization effect of antacids usingpharmaceutical technological methods
R. Zelko, E. Bihari, E. Balogh and I. Riicz 181
2 Methodological approach of the particle size distribution of
two standard powders by image analysis and light scatteringC. Andres, P. Reginault, B. Chaillot and Y. Pourcelot 183
3 Formulation of dispersible tablets containing 50% of
active ingredient prepared by wet granulationM. Rosovsky, B. Huet de Barochez and A. Cuine 185
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Proceedings page4 Spray-drying as a method to achieve hydrophilization of
sparingly soluble drugsG. Nork, M. Bisrat and H. Nyqvist 187
5 Instrumentation of fluid-bed granulator Niro-Aeromatic Strea-1 ®
for control of critical spray rate and of free humidityT. Abberger, H. Egermann and LA. Raneburger 189
6 Effect of the presence of a lubricant and a binder, respectively,on the compactibility of lactose granulations
G.K. Bolhuis, K. Zuurman and H. Vromans 191
7 Investigation of the mechanical properties of ethylcellulose by the
use of the Fraser-Susuki function and thermal mechanical analysisG. Shlieout, F. Wiese, T. Muller and G. Zessin 193
8 Influence of drying conditions on residual solvent contents in crystalsC. Barthelemy, P. Di Martino and A.-M. Guyot-Hermann 195
9 The effect of moisture content on the volume reduction
behaviour and the compactibility of amorphous lactose
T. Sebhatu, C. Ahlneck and G. Alderborn 197
10 New antiviral compound, Characterization and formulation
of tablet dosage formS. Bogdanova, T. Nikova, D. Sidzhakova and K. Mitikov 199
11 X-ray diffraction to study compression parameters of Compril®A. Mufioz-Ruiz, T. Pay£n, V. Velasco, C. Monedero, A. Justo
and M.R. Jimenez-Castellanos 201
12 The use of gravimetric studies to assess the degreeof crystallinity of predominantly crystalline powders
G. Buckton and P. Darcy 203
13 Investigation of the effect of type and source of microcrystallinecellulose on capsule filling
R. Patel and F. Podczeck 205
14 Influence of the crystallinity of cellulose on its compactibilityand compressibility
H. Gerecke, M. Dittgen, S. Fricke and H. Oelschlager 207
15 Study of flowability and compressibility of microcrystallinecelluloses with different morphological characteristics
P. Szabo-Revesz, K. Pintye-Hodi, P. Kasa Jr and B. Selmeczi 209
16 Behaviour of Vivacel® comprimates during loadingK. Pintye-Hodi, P. Szabo-Revesz, P. Kasa Jr and B. Selmeczi 211
17 Technological comparison of two microcrystalline cellulose brands (c.m.c.)
JJ. Diaz-Esquivel, C.F. Perez-Alvarez, R. Lopez Arellano and
A. Cervantes-Sandoval 213
18 Compactibility curves as a characteristic of technologicalbehaviour of powders
L. Villafuerte Robles 215
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Proceedings page19 Compactibility of the microcrystalline cellulose 102/calcium
phosphate dihydrate systemL. Villafuerte Robles 217
20 Tabletting properties of pellets of varying porosity consistingof dicalcium phosphate and microcrystalline cellulose
B. Johansson, F. Nicklasson and G. Alderborn 219
21 Evaluation of bonding mechanisms of pharmaceutical materials
by compaction and strength characterization of compacts in liquidA. Adolfsson, H. Olsson and C. Nystrom 221
22 Comparison of the compressional behaviour of four batches of spray-driedlactose with the help of a non-instrumented single-punch machine
E. Joiris, S. Tak Tak and J.-C. Guyot 223
23 Ultrasound-assisted compaction of pharmaceutical materials,
(1) Description and preliminary evaluation of the apparatusM.F. Saettone, B. Giannaccini, D. Monti, I. Cabani,L. Rodriguez, M. Cini, C. Cavallari and O. Caputo 225
24 Ultrasound-assisted compaction of pharmaceutical materials,(2) Preparation of matrices for sustained release of theophylline
L. Rodriguez, M. Cini, N. Passerini, O. Caputo, B. Biannaccini,D. Monti and M.F. Saettone 227
25 Formulation, quality control parameters and release rate for clonidine tabletsD. Lupuleasa, A.M. Dumitrescu, V. Hirjau, M. Pana, I. Popovici,V. Dorneanu, M. Stan, G. Tantaru and N. Bibire 229
26 Drug liberation from tablets containing Vitacel®
M. Vitkova, N. Shalan, J. Rak and M. Chalabala 231
27 Investigation on tablet disintegrating power, Application to a
croscaramellose sodium, Primellose®S. Rizk, C. Barthelemy, C. Duru and A.-M. Guyot-Hermann 233
28 New method for disintegration process analysis in pharmaceutical tabletsL. Maggi, G. Massimo, R. Bettini, P.L. Catellani and P. Colombo 235
29 Dissolution enhancement of an insoluble drug by physical mixturewith a superdisintegrant, Optimization with a simplex lattice design
F. Ferrari, M. Bertoni, M.C. Bonferoni, S. Rossi, C. Caramellaand G.K. Bolhuis 237
30 Effect of crospovidone on the physical properties of acetaminophen tabletsM. Sheikh Salem, G.K. Pillai and A.A. Badwan 239
3.1 The influence of the cross-linking degree on drug dissolution,water uptake and swelling profiles of cross-linked amylose matrices
I.S. Moussa and L.H. Cartilier 241
32 In vitro evaluation of molsidomin release from thermallypregelatinized starch matrices
V. Mihailova, V. Andonova and P. Kazanjieva 243
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Proceedings page33 Controlled release of theophylline from hydrophilic matrices based
on modified starches, Capsule and tablet availability studiesC. Barthelemy, P. Degen, B. Frimat, A. Delacourte and H. Robert 245
34 Advantage of the use of an experimental design for determining theinfluence of the manufacturing parameters on the release of an
active ingredient from a hydrophilic matrixE. Le Doeuff, J.L. Avan, J. Bougaret and E. Goutay 247
35 Study of pentoxifylline release from matrix tablets based on cellulose ethersF. Vrecer and A. Kramar 249
36 Alginate as hydrophilic matrix for controlled release tabletsmade by direct compression
T. Grenager and J. Karlsen 251
37 Co-transformed matrices for oral controlled releaseR.TJ. Mutambara, J.N. Staniforth and D.J.G. Davies 253
38 Oral sustained release of nifedipine from tablets prepared with polyacrylatesR. Maraqa and S .E. Leucuta 255
39 Use of an acrylic and metacrylic acid derivative as a sustained release
matrix for theophylline hydrate tablets
S.I. Ofoefule and A. Chukwu 257
40 Sustained release effect of a natural polymer in chlorpheniraminemaleate tablet formulations
A. Chukwu, J.I. Mbanisi and S.L Ofoefule 258
41 An assessment of the performance of matrices containinghydroxypropyl methylcellulose, sodium carboxy methylcelluloseand propranolol hydrochloride
J.L. Ford, M.A. Dabbagh, M.H. Rubinstein and J.E. Hogan 259
42 Formulation of sustained release propranolol hydrochloride tablets
using hydroxypropyl methylcellulose matrices
A. Bodea, A. Bakri, C. Jeannin and S.E. Leucuta 261
43 In vitro evaluation of sustained release matrix tablets prepared with
new modified polymeric carbohydratesM.V. Velasco, I. Castellano, A. Muiioz, I. Goni,M. Gurruchaga and M.R. Jimenez-Castellanos 263
44 Dissolution of diflunisal from controlled release tablets
C. Martinez-Oharriz, C. Martin, M.M. Goni,C. Rodriguez-Espinosa and M. Sanchez 265
45 Process variables affecting performance of modified release dosageforms of nifedipine prepared by the solvent evaporation method
J.M. Khanna, H. Sen, V.K. Arora and K.V. Rangaiah 267
46 Pharmaceutical availability of oxazepam from solid dispersion systemsR. Jachozicz 269
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Proceedings page47 Use of lipid matrices of Gelucire for sustained release
of salbutamolR.M. Hernandez, A. San Vicente, A. Esquisabel, M. Igartua,D. Ilardia and J.L. Pedraz 270
48 Design of diclofenac sodium 100 mg sustained release tablets,In vitro and in vivo studies
E. Sallam, S. Al-Deleq, M. Shubair, S. Zemeili, M. Hasan,N. Najib and T. Arafat 272
49 Pharmaceutical testing of sustained release theophyllineproducts on the Turkish market
O. Coskun, G. Aksoy and I. Agabeyoglu 274
50 A polymeric matrix tablet containing a centralized drug core
exhibiting bimodal release propertiesD.L. Munday 276
51 A delayed delivery system for colonic drug release
M.A. Vandelli, F. Forni and M.T. Bernabei 278
52 Development and scale-up of new film-coated Tisasen A+B
10 and 20 mg tablets
Z.B. Jeko and M. Mit6 280
53 The effect of atomizing air pressure on the aqueous film coatingprocess and on film coat quality
A.M. Twitchell, J.E. Hogan and M.E. Aulton 282
54 Protector effect of some coating agents in fluidized bed,
Comparative study and application to josamycine and paracetamolE. Cauture, P. Prinderre, M. Todorova, P. Piccerelle,R. Boistelle and J. Joachim 284
55 Delayed release system based on retarding low viscosityHPMC coating
A. Gazzaniga, C. Busetti, L. Moro, C. Lombardi
and F. Giordano 286
56 Zero-order release by partial coating ofHPMC matrix tablets with
permeable and semi-permeable films
R. Bettini, G. Massimo, P.L. Catellani, N.A. Peppasand P. Colombo 288
57 Control of drug release by ternary film coatingsP.I. Fekete and I. Antal 290
58 The influence of process parameters on the quality of enteric
polymethacrylate film coatingsB. Brogmann and P. Wolff 292
59 Diffusion/osmotic drug release control by ammonio methacrylate(Eudragit RL/RS) copolymers
P.L Fekete and M. Kiraly 294
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Nanoparticles Proceedings page
60 Influence of the viscosity of the dispersed phase on the mean diameterof nanoparticles prepared by emulsification/solvent evaporation
S. Desgouilles, D. Bazile, L-L. Grossiord, J.-R. Authelin,M. Veillard and P. Couvreur 475
61 Biopharmaceutical studies of poly (methyl glyoxylate) as a potentialdrug carrier
R. Duclos, C.H. Brachais, B. Mac6, C. Bunel
and A.-M. Orecchioni 477
62 Preparation, characterization, toxicity and efficacy ofamphotericin B-loaded poly(caprolactone) nanoparticles
M.S. Espuelas, J.M. Irache, A.-M. Orecchioni, C. Gamazo
and P. Ygartua 479
63 Stability study of poly (D,L-lactide), poly(D,L-lactide-co-glycolide)and poly(e-caprolactone) nanoparticles
D. Lemoine, C. Francois, V. Berlage, F. Kedzierewicz,P. Maincent, M. Hoffman and V. Preat 481
64 Polyethyl-2-cyanoacrylate nanocapsules, Influence of preparationconditions on the mechanisms of formation
M. Fresta, G. Puglisi, G. Giammona, C.A. Ventura and
G. Cavallaro 483
65 Sterilization of drug-free and tetracaine-loaded solid lipidnanoparticles
C. Schwarz and W. Mehnert 485
66 In vivo photodynamic activity of hexadecafluoro zinc phthalocyaninloaded in PEG-coated nanoparticles
E. Allemann, S. Kudrevich, K. Lewis, R. Gurnyand J.E. van Lier 487
67 Solid lipid nanoparticles, Determination of in vivo toxicityH. Weyhers, S. Ehlers, W. Mehnert, H. Hahn nd R.H. Miiller 489
68 Nanosuspensions, A novel formulation for the intravenous
administration of poorly soluble drugsR.H. Miiller, K. Peters, R. Becker and B. Kruss 491
69 Effect of storage conditions on long-term stability of solid lipidnanoparticles in aqueous dispersion
C. Freitas, J.S. Lucks and R.H. Miiller 493
70 Comparison of drug-loaded and drug-free physiological low-densitylipoproteins and artificial lipid particles
A. Gerke, K. Westesen and M.H.J. Koch 495
71 Complex fats as matrix constituents in lipid nanoparticlesH. Bunjes, K. Westesen and M.H.J. Koch 497
72 Stability studies of the doxorubicin association to new colloidal
carriers made of amphiphilic cyclodextrinsF. Leroy-Lechat, D. Wouessidjewe, D. Duchene and F. Puisieux 499
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Proceedings page73 Physicochemical characterization of vicilin coacervates
and small-sized particlesI. Ezpeleta, LM. Irache, S. Staimesse and A.-M. Orecchioni 501
74 Legumin nanoparticles, In vitro response of human skin fibroblasts
and immunological behaviour in rats
T. Mirshahi, LM. Irache and A.-M. Orecchioni 503
75 Comparative study on encapsulation of an azole compound within
colloidal drug carrier systemsS. de Chasteigner, H. Fessi, J.-P. Devissaguet and F. Puisieux 505
76 Estimation of hydrodynamic sizes of dextran coated iron oxide
nanoparticles by size exclusion chromatographyM. Kresse, D. Pfefferer, K. Thode, R.H. Miiller and W. Semmler 507
77 Mini-HIC for the determination of the surface hydrophobicityof magnetite dispersions
K. Thode, M. Kresse, D. Pfefferer, W. Semmler and R.H. Muller 509
78 Development of a quantitative PAGE analysis using a multi-channel
radioactivity counter for oligonucleotide drug carrier evaluationI. Aynid, M. Foulquier, E. Fattal, F. Puisieux, P. Couvreur
and C. Vauthier 511
79 Characterization of microspheres loaded with a cholecystokininderivative peptide
MJ. Blanco Prieto, E. Fattal, F. Delie, V. Dauge, B.P. Roquesand P. Couvreur 513
80 Protection against muscular side effects of diclofenac byencapsulation in poly(D,L-lactide) nanocapsules
S. Guterres, H. Fessi, G. Barratt, F. Puisieux and J.-P. Devissaguet 515
81 Poly(D,L-lactide) nanocapsules containing non-steroidal anti¬
inflammatory drugs, Gastro-intestinal tolerance followingintravenous and oral administration
S. Guterres, H. Fessi, G. Barratt, F. Puisieux and J.-P. Devissaguet 517
82 Effects of mononuclear phagocyte system of acute administration of
polymeric nanoparticlesR. Fernandez-Urrusuno, LM. Rodrigues Jr, E. Fattal,P. Bedossa and P. Couvreur 519
83 Induction of macrophage nitric oxide synthase by an immunomodulator
entrapped within polymeric nanocapsulesI. Seyler, G. Barratt, M. Appel, J.-P. Devissaguet and F. Puisieux 521
84 Uptake and localization of fluorescent polystyrene nanoparticlesin the spleen
M. Demoy, J.P. Andreux, C. Weingarten, S. Gibaud and P. Couvreur 523
85 Phagocytic uptake of polymeric particles in vitro, Effect of surface
hydrophobicity and fluorescent labellingD. Riihl, B.-R. Paulke, H.R. Maurer and R.H. Muller 525
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Proceedings page86 Influence of nanoparticles on the body distribution of
azidothymidin (AZT)R. Lobenberg, L. Araujo and J. Kreuter 527
87 Nanoparticles as a carrier system for an HIV-protease inhibitorA. Bender, H. von Briesen, H. Riibsamen-Waigmannand J. Kreuter 529
88 Influence of polyethylene oxide chains on protein adsorptionon nanoparticles for drug targeting
T. Blunk, M. Luck, B.W. Muller and R.H. Muller 531
89 Drug targeting in leishmaniasis, Factors affecting the fate of
colloidal carriers in Leishmania donovani-infectcd miceLM. Rodriguez Jr, H. Fessi, R. Fernandez-Urrussuno,C. Bories and J.-P. Devissaguet 533
Liposomes
90 Physical stability studies on different liposome preparationsA. Memoli, L.G. Palermiti, V. Travagli and F. Alhaique 551
91 Prediction of physical stability of liposomes by the EPR method
K. Gregorc, J. Kristl, V. Gabrijelcic, M. Sentjurcand J. Smid-Korbar 553
92 Particle size analysis of liposomes in hydrogels by photoncorrelation spectroscopy (PCS)
J. Herbort, J.E. Diederichs and R.H. Muller 555
93 Design and characterization of a liposome dispersion in poloxamer 407
A. Bochot, E. Fattal, J.-L. Grossiord, F. Puisieux and
P. Couvreur 557
94 The use of pressurized aerosols for the topical delivery of
liposomes/phospholipidsA. Sasse, D.Q.M. Craig, K.M.G. Taylor and D. Gregory 559
95 In vivo studies on radio-opaque liposomes containing iopromideS. Erdogan, A.Y. Ozer, M.T. Ercan and A.A. Hincal 561
96 Lipophilic amide derivatives of methotrexate, DSC studies on their
interaction with DPPC liposomes as a membrane model
R. Pignatello, M. Fresta and G. Puglisi 563
97 Drug/phospholipid interaction evidence by fluorescence measurements
A. Doisy, J.-L. Dubois and LC. Brochon 565
98 Liposomes for oral immunization
S. Ouadahi, G. Barratt, I. Genin, C. Andre, T. Tran Xuan,J.-P. Devissaguet, F. Puisieux and M. Paternostre 567
99 Amphotericin B release from liposomes and its action againstfungal and mammalian cells
P. Legrand, M. Cheron, H. Fessi, J.-P. Devissaguet and J. Bolard 569
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Proceedings page100 Interleukin-2 and dipalmitoyl phosphatidylcholine liposomes,
Evidence for a specific interaction
L. Fleury, M. Ollivon, J.-L. Dubois, F. Puisieux and G. Barratt 571
101 Characterization of liposome uptake by macrophagesM. Macchluf, I. Likhman and S. Cohen 573
102 Establishment of the endocytic capability of platelets and determination
of the feasibility of carrier-mediated drug delivery to plateletsP. Bandyopadhyay, G.H. Rao and Y.E. Rayman 575
Transmembranal passage
103 Raman spectroscopy and differential scanning calorimetry for
characterizing structure and function of the stratum corneum ceramides
M. Wegener, R. Neubert, W. Rettig and S. Wartewig 851
104 Mathematical assessment of different penetration mechanisms
from vehicles with propylene glycolS. Huth, R. Neubert and L. Boltze 853
105 Comparative study of the release of a model compound using two
types of artificial membrane
A.M. Rodriguez Bayon and A.M. Ariza Osorio 854
106 Comparative study of ISDN transport through biological and
artificial membranes
N. Cvetkovic, M. Rosic, M. Nesic, B. Vujovic and T. Nedeljkovic 856
107 NADH, Evaluation of the possibilities for permeation throughbiological membranes
C. Mattern, R. Hacker and H.-H. Borchert 858
108 Bisphosphonates increase tight junction permeability in the
human intestinal epithelial (Caco-2) model
X. Boulenc, C. Roque and Y. Berger 860
109 Paracellular transport and other mechanisms involved in intestinal
peptide absorptionV. Bohner, B. Rothen-Rutishauser, LC. Perriard, C. Ottiger,H. Wunderli-AUenspach, H.P. Merkle and P. Langguth 862
110 Blood/brain barrier in vitro, Rapid evaluation of strategies for
achieving drug targeting to the central nervous systemM.P. Dehouck, B. Dehouck, E. Teissier and R. Cecchelli 864
20
Wednesday, 10 May 1995
Room A
09.00 h Helmut Ringsdorf, Institut fur Chemie, MainzWhat to learn from Mother Nature for drug delivery and biosensors,Mimicking of biomembrane processes based on functional
supramolecular systems
10.00 h Break
Room A
Solid oral dosage formsChairmen, James L. Ford and Istvan Racz
Proceedings page
10.20 h Flow properties of two pharmaceutical powders, Assessment byJenike's shear test and by air permeability
G. Mortha and C. Jeannin 135
10.40 h Characterization of wetting behaviour of pharmaceutical powdersby contact angle measurement using capillary rise technology
H. Lechner 137
11.00 h Power wettability and agglomeration in the granulation processS. Kiortsis and S. Malamataris 139
11.20h Break
Solid oral dosageformsChairmen, Gerad K. Bolhuis and Stavros Malamataris
11.30 h Differential scanning calorimetry, An alternative for compatibilitystudies of complete mixtures for fabricating tablets
R.M. Cruz-Hernandez and F. Mijangos-Santiago 141
11.50 h A new maltodextrin as filler/binder for direct compressionK.-L Steffens 143
12.10 h Binding performance of pregelatinized starchesC.W. Symecko and C.T. Rhodes 145
12.30 h Lunch break
Solid oral dosage formsChairmen, Paolo Colombo and Jan Karlsen
15.00 h Disintegration efficiency of sodium starch glycolate preparedfrom enset starch
T. Gebre-Mariam and P.C. Schmidt 147
15.20 h Image analysis for the study of water penetration and polymerswelling in cross-linked amylose
I.S. Moussa and L.H. Cartilier 149
21
Proceedings page15.40 h Growth kinetics of granulation in a high-shear mixer
H.G. Kristensen and T. Schaefer 151
16.00 h Compressive elastic modulus and strength isotropy of tabletted
pharmaceutical powdersS. Malamataris, T. Hatjichristos and LE. Rees 153
16.20 h Break
Solid oral dosageformsChairmen, David LG. Davies and Fritz Stanislaus
16.35 h NIR spectroscopy as a tool for in-process control in pharmaceuticalproduction, An example
K.-J. Steffens and K. List 155
16.55 h Instrumented punch for rotary tablet machines
A. Gullatz and K.-L Steffens 157
17.15 h Use ofpercolation theory to interpret the deformation hardness,the tensile strength and the modified Young's modulus of tablets
consisting of Sta-RX 1500®, a-monohydrous lactose, either as
powder or as granulesL. Ineichen and H. Leuenberger 159
Wednesday, 10 May 1995
RoomB
CyclodextrinsChairmen, Bernd W. Muller and Jozsef Szejtli
10.20 h Characterization and dissolution rate of tolbutamide/6-cyclodextrincomplexes prepared by different methods
F. Veiga, J.J. Teixeira-Dias and A. Sousa 585
10.40 h Preparation and properties of a physiologically active nitric oxide
releasing agentM. Vikmon, J. Szemdn, J. Szejtli and J. Geczy 587
11.00 h Diclofenac/6-cyclodextrin inclusion compounds,Characterization and dissolution studies
B. Cappello, F. Barbato, M.I. La Rotonda and A. Miro 589
11.20 h Break
Molecular targetingChairmen, Joseph R. Robinson and Alan S. Rudolph
11.30 h PK1/PK2 lyophilized formulations, HPMA/doxorubicin conjugateswith potentially improved anti-tumour activity
A. Cavallo, M. Adami, R. Magrini and G. Colombo 843
11.50 h Enhanced site-specific tumor therapy with monoclonal antibodies
V.P. Torchilin and L.Z. Iakoubov 845
22
Proceedings page12.10 h Polysialylated catalase, In vitro characterization
A.I. Fernandes and G. Gregoriadis 847
12.30 Lunch break
LiposomesChairmen, Rainer H. Muller and Smadar Cohen
15.00 h Importance of zeta potential and hydrophobicity of liposomalpolymyxin B for macrophage uptake and the implications for
lung deliveryS .M. McAllister, H.O. Alpar and M.R.W. Brown 537
15.20 h Site-specific delivery of liposomes to the heart
V.P. Torchilin, J. Narula and B .A. Khaw 539
15.40 h Imrnunoliposomes as carriers of enzymes for site-specificactivation of anti-cancer prodrugs
G. Storm, M.H. Vingerhoeds, H.J. Haisma and D.J.A. Crommelin 541
16.00 h Biological effectiveness of CDP-choline loaded long-circulatingliposomes on in vivo rat ischaemia model
M. Fresta, E. Wehrli and G. Puglisi 543
16.20 h Break
LiposomesChairmen, Daan LA. Crommelin and Ayla Giirsoy
16.35 h Optimized liposomal amikacin for the treatment of disseminated
mycobacterial infections
W.E. Bucke, S. Ehlers, S. Leitzke, LE. Diederichs,H. Hahn and R.H. Muller 545
16.55 h Binding of LPS and phagocytosis of liposome-encapsulatedhaemoglobin attenuates tumor necrosis factor production in
ex vivo murine splenocytes and RAW264.7 cells
A.S. Rudolph, R.O. Cliff, V. Kwasiborski, H. Spielbeg,L. Neville, F. Abdullah and R. Rabinovici 547
17.15 h Activation of rat complement by the red cell substitute,
liposome-encapsulated haemoglobinJ. Szebeni, N.M. Wassef, H. Spielberg, A.S. Rudolphand C.R. Alving 549
Wednesday, 10 May 1996
Room C
Pellets
Chairmen, Henning G.Kristensen and Tor Waaler
10.20 h Dipyridamole coated pellets prepared by fluidized-bed coatingD.B. Beten, K. Amighi and A.J. Moes 347
23
Proceedings10.40 h The influence of the properties of drug on the preparation of
spherical pellets by extrusion/spheronizationC. Lustig, F. Podczeck and LM. Newton 349
11.00 h The use of a two- and a three-dimensional shape factor to
characterize the sphericity of pelletsF. Podczeck, R. Chopra and LM. Newton 351
11.20 h Lunch break
Pellets
Chairmen, John Newton and Andre Moes
11.30 h Ion exchange resin complex with S(+)-ibuprofen for oral dosageforms with improved dissolution behaviour
K. Cremer, W. Muller and D. Scherer 353
11.50 h The influence of five selected processing and formulation variables
on the release of riboflavin from pellets produced in a rotary processorJ. Vertommen and R. Kinget 355
12.10 h Some technological factors influencing drug release fromB-blocker containing polymer-coated particles
S. Marton, E. Bihari, A. Orban, D. Greskovits and I. R&cz 357
12.30 h Lunch break
Bioadhesion
Chairmen, Pierre Buri and Carla Caramella
15.00 h Oral mucosa enhanced delivery of gonadotropin-releasing hormone,(1) Development of mucoadhesive device
Y.W. Chien, Y. Lee, S. Nakane and K. Yukimatsu 811
15.20 h Oral mucosa enhanced delivery of gonadotropin-releasing hormone,
(2) In vivo evaluations of GnRH-mucoadhesive devices
Y.W. Chien, S. Nakane, Y. Lee, M. Kakumoto and K. Yukimatsu 813
15.40 h Bioadhesive interactions of lectin/latex conjugates with rat
intestinal mucosa
G. Ponchel, J.M. Irache, C. Durrer, F. Puisieux and D. Duchene 815
16.00 h Bioadhesive polyvinyl alcohol) as a carrier for controlled release
of growth factors and proteinsN.A. Peppas, N. Mongia and A.S. Luttrell 817
16.20 h Break
Bioadhesion
Chairmen, Hans E. Junginger and Sorin E. Leucuta
16.35 h Control of acid neutralization and bioadhesion of aluminium and
magnesium containing antacid preparationsI. Antal, J. Plachy, Z. Muskath, M. Gyorffi and I. Racz 819
24
Proceedings page16.55 h Obtention of bioadhesive pellets by extrusion/spheronization
J.L. Vila Jato, J. Blanco-Mendez, F.L Otero-Espinar,S. Anguiano-Igea and J. Amela 821
17.15 h Release and 'washability' properties of mucoadhesive gelsS. Rossi, M.C. Bonferoni, F. Ferrari, M. Bertoniand C. Caramella 823
Wednesday, 10 May 1995
Posters
Exhibited continuously from 10.00 to 16.35, with special session from 14.00 to 15.00 h.The number indicates the number displayed on the poster panel.
Delivery through various mucosae
111 Bucco-adhesive two-layer tablet for topical delivery of AcitretinP. Minghetti and L. Montanari 753
112 Absorption studies in vivo after nasal administration of propiomazineC. Bjerre, E. Bjork and O. Camber 755
113 Nasal administration of the 5-HTia receptor antagonist(S)-5-fluoro-8-hydroxy-2-(dipropylamino) tetralin
M. Dahlin, C. Bogentoft and E. Bjork 757
114 Formulation and in vitro study of anti-malarial rectal suppositoriesG. Regdon Jr, I. Schirm, B. Selmeczi and G. Regdon 759
115 Recrystallization studies on indomethacin suppositoriesL. Albertin and M. Rillosi 761
Pulmonary delivery
116 Depression of glass transition temperature of amorphous spray-driedsalbutamol sulphate
G. Venthoye, K.M.G. Taylor, J.M. Newton and M.C.R. Johnson 771
117 Nebulization of fluids with different surface tensions
O.N.M. McCallion, K.M.G. Taylor, M. Thomas and A.J. Taylor 773
118 Formulation and characterization of aerosol suspensions for inhalationS. Tzolova, L. Stanoeva, P. Kazandjieva, L. Naumova,F. Michailova and V. Zidarova 775
119 Comparative study of the in vitro availability of aerosol emitted
by various jet nebulizers
M.-P. Flament, P. Leterme, T. Burnouf and A.T. Gayot 777
120 In vitro performance of Jago's dry powder inhaler (Prototype No.9),Glaxo's Diskhaler® and Astra's Turbuhaler® using the
twin impinger BP 93 as the test deviceE. Trachslin, M. Keller and U. Gaibrois 779
25
Proceedings page
121 Effect of various actuators/nozzles on the in vitro depositionpattern of liquid metered dose inhalers powered byhydrofluorocarbons
M. Keller, E. Trachslin and H. Kraus 780
122 Evaluation of effective cut-off diameters of a multi-stage liquid impingerG. Wamke, D. Konig, K.H. Bauer and M. Brandl 782
Ophthalmic delivery
123 Determination of the influence of a series of excipients on the irritation
potential of a local anaesthetic on the murine cornea
P. Kalin, LC. Etter and LM. Mayer 787
124 Rheological and surface tension measurements on commercial
tear substitutes
S. Keipert and M. Oechsner 789
125 Fungicidal activity of benzalkonium chloride in acidic
ophthalmic solutionsG. Chastaing, A. Rozier and B. Plazonnet 791
126 Stability of amphotericin B eye-drops as lipidic emulsionT. Cohen, D. Brossard, H. Sauvageon-Martre, F. Chastand J.-C. Chaumeil 793
127 Enhancementsof the bioavailability of pilocarpine in aqueouseye-drops by means of cyclodextrins
J. Fedder and S. Keipert 795
128 Gelrite® in ophthalmic formulations, Evaluations of rheologicalproperties and in vz'frorelease from pilocarpine/Gelrite® preparations
V. Hartmann and S. Keipert 797
129 Evaluation of niosomes as carriers for ophthalmic drugs,(1) Tests with cyclopentolate
G. Perini, M.F. Saettone, M. Carafa, E. Santucci and F. Alhaique 799
130 Evaluation in vitro/in vivo of colloidal lipospheres containingpilocarpine as ion pair
R. Cavalli, S. Morel, M.R. Gasco, P. Chetoni, M.F. Saettone
and L. Mariotti Bianchi 801
131 Spray-dried microspheres for ocular administration of piroxicam,In vitro/in vivo evaluation
P. Giunchedi, M.F. Saettone, P. Chetoni, L. Fusi and U. Conte 803
132 Ophthalmic mini-tablets for controlled release of timolol
M.F. Saettone, P. Chetoni, L. Mariotti Bianchi, B. Giannaccini,U. Conte and M.E. Sangalli 805
133 Formulation of ocular inserts with reticulated collagenE. Gafitanu, S. Braha, V. Trandafir and O. Coman 807
26
Dermal and transdermal deliveryProceedings page
134 Psoralen percutaneous absorption in respect of their molecular
polarities, An in vitro studyJ. Millet, P. Muret, S. Makki and P. Bassignot 689
135 Permeation kinetics of oestradiol in Transcutol® solution and its
relationship to water absorptionA. Ganem, M. De Carvalho, F. Falson-Rieg and P. Buri 691
136 A study of micronized zinc oxide powders for topical applicationsA. Martini, M.-F. Bobin, A. Revillon and M.-C. Martini 693
137 An investigation into the dielectric and rheological behaviour of
cream bases
G. Vuleta, S. Tamburic and D.Q.M. Craig 695
138 Evaluation of rational contents of pentacaine and heptacaine in hydrogelsK. Gardavska, Z. Vitkova, J. Cizmarik and J. Rak 697
139 Cutaneous gels, Rheological behaviour and FTIR studies
P. Piccerelle, M. Bohor, G. Joachim, LP. Reynier,G. Kalantzis and J. Joachim 699
140 A new transdermal in vitro model for human skin, Comparison of the
transdermal in vitro permeability of excised bovine udder skin with
human skin
K. Ahrens, M. Dittgen, H. Oelschlager and C. Volkel 701
141 Investigation of the influence of polyethylene glycol bases of various
average molecular masses on nitroglycerol release
M. Zivkovic and S. Mihaijlovic 703
142 Dermatological pharmaceutical form based on non-steroid
anti-inflammatory agentA. Nedeva, F. Michailova and L. Maksimova 705
143 Enhancement of piroxicam permeation through rat skin
S. Santoyo, A. Arellano, P. Ygartua and C. Martin 707
144 Enhancing effect of terpenes on the percutaneous absorption of
diclofenac sodium
A. Arellano, S. Santoyo, C. Martin and P. Ygartua 709
145 The optimization of anti-burn ointments containing essential oils
E. Diug, V. Prisacari, V. Rudic, A. Taran, M. BodrugandE. Revenco 711
146 A new formulation approach for the treatment of psoriasisM.K. Youssef, LA. Attia and M.A. Fouda 713
147 In vitro studies on ketoprofen transdermal preparations based on
carrageenanP. Caybasi and T. Tuncel 715
27
Proceedings page
148 Cutaneous distribution of a new anti-androgen from liposomes andsolution in a hairless rat model
E. Bernard, J.-L. Dubois, P. Becourt and J. Wepierre 717
149 Multi-component surfactant systems as potential carriers for non¬
steroidal anti-inflammatory agentsK. Stein and S. Keipert 719
150 Influence of a microemulsion containing diclofenac diethylamine onthe permeability of human stratum corneum
I. Eder and C.C. Muller-Goymann 721
151 Influence of microemulsions on the lipid barrier of human skin
U. SchmalfuB, R. Neubert and W. Wohlrab 723
152 In vitro permeation of B-blockers from microemulsions
F. Pattarino, M.E. Carlotti, M. Trotta and M.R. Gasco 725
153 In vitro permeation of pentacaine from microemulsion and
microemulsion gelM. Zabka, F. Skoviera, V. Koprda and L. Bohacik 727
154 Some results of preclinical and clinical evaluation of topicalpreparations containing glucan
K. Duckova, J. Kucera, L. Kuniak and J. Augustin 729
155 The treatment of Acne vulgaris by phosphatidylcholine-boundlinoleic acid
J. GareiB, M. Ghyczy and H.P. Nissen 731
156 Influence of the adhesive layer on the liberation rate of nitroglycerinfrom TDS matrices
K. Duckova, J. Kucera, D. Haddzimova and H. Hanzclova 732
157 A comparison between newly-developed and existing methods for
determining the in vitro drug release profile of 17-B-oestradiol from a
transdermal delivery systemA. Willi, E. Marti, G. Imanidis and H. Leuenberger 734
158 Influence of ethanol and propylene glycol on iontophoresis efficiencyA. Jadoul, D. Skrzypczak and V. Preat 736
159 Bandages with immobilized indomethacin, Preparation, toxicology,application
A.M. Tsatsakis, E. Kurumali, A. Katahanakis, V. Filatov,V. Riltsev, R. Virnik, M. Selala and M.I. Shtilman 738
160 The effects of elevated and ambient temperature dilutions of fluocinolone
acetonide ointment assessed using the human skin blanching assay
J.M. Haigh and E.W. Smith 740
161 Wound healing effectiveness of rHuGM-CSF from different topicalformulations
E. Memisoglu, F. Oner, I. Basaran and A.A. Hincal 742
28
Proceedings pagePharmacology, pharmacokinetics and biopharmacy
162 Synthesis, physical properties and toxicological studies of
L-pyroglutamic and L-glutamic acid esters of acetaminophen as
potentially useful prodrugsE. Bousquet, S. Tirendi, A. Spadaro, A. Marrazzo and G. Puglisi 883
163 Effect of 'Cerosel' preparation on rat organsF. Ryszka, B. Szulc and B. Dolinska 885
164 The influence of magnesium ascorbate on selected biochemical and
haematological blood indices in rats
F. Ryszka and B. Szulc 887
165 Gelisept, Medicinal gum jellyV. Tamas, D. Stavri and R. Dobos 889
166 Mistletoe extract-induced proliferation and cytokine release in cultures
of lymphocytes from untreated individuals in vitro
G. Stein and P.A. Berg 891
167 Estimation of the apparent volume of distribution of drug in plasmafor a process governed by Michaelis-Menten kinetics
G. Dimitriu, I. Popovici, R. Cuciureanu and G.N. Macovei 893
168 Disposition of quinidine and its distribution in plasma liproproteinsin human with hyperlipidemia
J. Masiakowski, M. Wierzchowiecki, E. Szymanskaand B. Michalowicz 895
169 Antihistaminic activity of flavonoid glycosides of Scutellaria
galericulata from RomaniaV. Stefan, M. Georgescu and N. Teoteoi 897
170 A study in non-patient volunteers to assess technology to achieve
colonic delivery of ibuprofenG.R. Howling, A.B. Jones, N. Washington and M.A. Hayward 899
171 Pharmacokinetics of tolfenamic acid in children after single oral dose
I. Niopas, M. Georgarakis, V. Cidi-Frangandrea,C. Chrisanthopoulos and E. Liara 901
172 Investigations on some pharmacokinetic properties of metronidazole
bound on polymeric supportE. Teslariu, M. Nechifor, V. Domeanu, A. Carpov, A. Spac,C. Filip and A. Negru 903
173 Dog pharmacokinetics of zidovudine and a zidovudine chemical
delivery systemM. Brewster, W. Anderson, E. Pop, N. Bodor and A. Webb 905
174 Glucagon-induced changes of adenylate cyclase activity in rat
reticulocytesM.R. Petronijevic and M.M. Kostic 907
29
Proceedings page175 Methyl iodide-induced neurotoxicity in primary neuronal culture,
A useful pharmacological test model
E. Lapis and E. K£rpati 909
176 Minoxidil and protein synthesis in isolated cardiac myocytesM. Strzalkowska 911
177 Some aspects of planning per os pharmaceutical preparationsP. Miskolczi, D. Greskovits, J. Greskovits, I. Klebovich
and A. David 913
178 Bioequivalence study of two tablet formulations of omeprazoleN.M. Najib, G.K. Pillai, M. Sheikh Salem, M.M. Hassan,F. Ghanem, E. Sallam, M.S. Shubair and S. Al-Delq 915
179 Bioavailability of ketotifen from a Pozitan® tablet and inhalation aerosolJ. Masiakowski, E. Szymanska and S. Dyderski 917
180 Bioavailability of clonidine as an oral pharmaceutical formI. Popovici, R. Cuciureanu, D. Lupuleasa, G. Dimitriu,A. Hriscu, L. Agoroaie and E.A. Popovici 919
181 HPLC analysis for the determination of miconazole in human plasmausing solid-phase extraction
M. Kobylinska, K. Kobylinska and B. Sobik 921
182 Pharmacokinetic study of orally-administered ketoconazole and its
multi-component complex on rabbitsA. Gerloczy, J. Szem&n, K. Csabai, M. Vikmon, J. Szejtli,P. Ventura and M. Pasini 923
183 The influence of dimensions on the gastric emptying of tablets infasted and fed volunteers
C.L. Mitchell, LM. Newton, D.F. Evans, M.B. Short and A. Bye 925
184 Evaluation of the correlation between in vitro and in vivo release ofsulfamethazine from a long-acting ovine bolus
B. Evrard and L. Delattre 927
185 Prolongation of drug absorption from hard gelatin capsules usingdifferent viscosity grades of sodium alginate as diluent
P. Veski, I. Lepist, H. Jurjenson and M. Marvola 929
186 Influence of cellulose ethers on the effect of local anaesthetic drug,Heptacaine
Z. Vitkova, K. Gardavska, J. Cizmarik and J. Rak 931
Emulsions and suspensions
187 Some physicochemical properties of micelle benzalkonium chloride
(BAC) adduct on phase limit in selected eye-dropsE. Zawadzka and M.M. Zgoda 645
188 Application of experimental methodology to emulsion formulationD. Notte, M.-F. Bobin and M.-C. Martini 647
30
ion r> i r xtProceedings page
189 Relevance of pH values to phospholipid stabilized fat emulsionsT.K. Bock and B.W. Muller 649
190 Effect of oil content on the properties of emulsions containingHPMCas polymeric emulsifier
S. Rimpler and R. Daniels 651
191 Emulsifying properties of Gelrite®/Veegum® combinationsM.U. Adikwu 653
192 Investigation of the emulsifying properties of Pemulen TR-1 ®, an
acryl acid alkyl methacrylate colpolymerM. Brisaert, H. De Broyer and J.A. Plaizier-Vercammen 654
193 The influence of water/oil phase ratio on the rheological behaviourof microemulsions
M. Primorac, M. Stupar, D. Vasiljevic and J. Milic-Askrabic 656
194 Rheological properties of a semisolid w/o emulsion system withsilicone emulsifiers
L Milic, G. Vuleta, D. Vasiljevic and M. Primorac 658
195 Analytical approach to determine the effect of azo dyes on the
physical stability of sterically stabilized o/w emulsionsB. Eckstein, J.E. Diederichs, J.J. Burger, E.A. Slootand R.G. Muller 660
196 Physical characterization and stability of microemulsions that
enhance intestinal uptakeA. Owen, A. Sarkahian, S. Sturgis, A. Tustian, P. Dentlingerand S. Yiv 662
197 Kinetics of oxidation of keratinic cystine in a w/o microemulsion
M.P. Savelli, C. Solans, P. Erra, G. Cave" and M. Clausse 664
198 Incorporation of the L-ascorbic acid and the N-acetyl L-cystein in
the inner aqueous phase of a w/o/w multiple emulsion,
Stability, characterization and ageing studies
N.S. Tokgoz, A.E. Fructus, P. Prognon, M. Seiller and
J.-L. Grossiord 666
199 In vivo evaluation of a new amphotericin B emulsion
E.S. Tabosa do Egito, M. Appel, H. Fessi, G. Barratt,F. Puisieux and J.-P. Devissaguet 668
200 In-line filtration of a parenteral emulsion using three filters,
Comparison and assessment
M. Faber, G. Mortha, L. Foroni, C. Jeannin and J. Calop 670
201 The influence of hormone/metal gram/molar relationship on selected
properties of peptide/GnRH analogue suspensionsB. Dolinska and F. Ryszka 672
202 Formulation of some nematocides as suspensionsY. Yazan, I. Isikdag and U. Ucucu 674
31
Proceedings pageStability
203 Stability of sulphadimidine in veterinary pharmaceutical specialitiesJ. Bernabeu, M.E. Gil, V. Ruz, O. Pedaez and A.L Torres 941
204 Photo-instability and degradation kinetics of medazepamY. Topaloglu and G. Yener 943
205 Kinetic study of Romener® in aqueous solution, using third-
derivative ultraviolet spectrometryM. Surmeian, G. Ciohodaru and S. Cilianu 945
206 Possibilities for the application of regression analysis and analysisof variance, (2) Stability determination of pharmaceuticalpreparations, Diclofenac sodium injections
M.B. Arambasic and D. Majkic 947
207 Study of the influence of auxiliary substances on the stability of
new anti-arrhythmic drugH+BZ. Vitkovd, K. Gardavska\ J. Cizmarik and J. Rak 949
208 Influence of metal ions, chelator and anti-oxidants on tiagabinestability in solutions
H. Weibel and H.M. Nielsen 951
209 Stability of ranitidine hydrochloride in aqueous solutionsM.K. Youssef, LA. Attia, S. El Gizawy, M.A. Foudaand G. El Maghraby 953
210 Purity and stability assessment of a semi-solid poly(ortho ester)used in drug delivery systems
M. Zignani, A. Merkli, J. Heller, C. Tabatabay and R. Gurny 955
211 Investigation of the'
anti-oxygen' action of acexamic acid on vegetal oils
R. Cuciureanu, I. Dumistracel, I. Popovici and G. Dimitriu 957
Sterilization and aseptic products
212 Stability of gamma-irradiated diltiazem
E. Ciranni Signoretti, L. Valvo, S. Alimonti and C. Lucia 961
213 Developments in pharmaceutical closure technologyW. Van de Poel 963
214 Validation of filter sterilization in autoclaves
J. Voorspoels, J.P. Remon and G. Vandenbossche 965
215 New clean area designed for the manufacturing of asepticpharmaceuticals integrated into an existing R&D facility
R. Anders 967
216 Viresolve, a membrane-based system for the removal of viral
contaminants from biopharmaceuticalsM. Kalyanpur 968
217 Applications, controlling and open questions in sterile filtrationG. Stampf 970
32
. Proceedings page218 Drug delivery systems, Pre-fillable disposable syringesH. Worder 972
Lyophilization (freeze-drying)
219 The use of maltodextrins as lyoprotectants in the lyophilizationof a model protein, LDH
S. Corveleyn and LP. Remon 983
220 Dependence of quality of freeze-dried diazepam/mannitol on some
manufacturing conditionsK.-H. Fromming, M. Bergmann and W. Mehnert 985
Synthesis and analysis
221 Synthesis of new l-l3-(4-phenylpiperazinyl-l)propyll-imidazolidone derivatives
T. Kulinski and T. Tkaczynski 103
222 Synthesis of new l-aryl-2-imino-3-arylsulfonyl-imidazolidinederivatives
M. Rzadkowska and T. Tkaczynski 105
223 Synthesis of new derivatives of 3,8-diphenyl-7,8-di-hydro-6H-imidazo[2,1 -cj-1,2,4-triazin-4-one
K. Sztanke and T. Tkaczynski 107
224 Synthesis and some selected properties of new polyethylenepolyamine/epichlorohydrin copolymers
M.M. Zgoda, K. Rogiewicz and R. Glinka 109
225 Preformulation study of naltrexone, Analytical and thermalcharacterization
J. Alvarez-Fuentes, I. Caraballo, A. Boza, M.A. Holgado andM. Fernandez-Arevalo 111
226 Binding of amino acids and peptides to cyclodextrins, A comparativeelectrospray ionization mass spectrometric and molecular modellingstudy
L. Prokai and R. Ramanathan 113
227 TLC study of nimodipine and degradation productsLL. Lastres, E.M. Garcia, M.P. Ballesteros and P. Frutos 115
228 Ginger extracts, Characterization by analytical determination of
their compositionC. Mattern, P. Eichler, F. Gaedcke and R. Hacker 117
229 A colorimetric method for the assay of pyrimethamine and its dosageforms by charge transfer complexation with chloranilic acid
M/U.Adikwu 119
230 A colorimetric method for the assay of quinine in pharmaceuticalformulations using chloranilic acid as the titrant in non-aqueous medium
M.U. Adikwu 120
33
Proceedings page231 Capillary electrophoresis for the chiral separation of salbutamol
A. Esquisabel, P.F. Goyenaga, A. San Vicente, M.B. Calvo
and J.L. Pedraz 121
232 Rapid spectrophotometric determination of aluminium using colour
complex formation with eriochrome cyanineC. Amezcua, A. Ganem and D. Quintanar 123
Miscellaneous
233 Recent developments in compendial dissolution standards
B.B. Hubert and L.T. Grady 989
234 Mathematical statistical revision of 'uniformity of mass requirementsof single-dose preparations' of different Pharmacopoeias
T.A. Nagy 990
235 Determination of free iodine as a function of dilution in two
different povidone/iodine formulations
D.A. Marroyen, G.R. Bultinck, LM. Haenen and
J.A. Plaizier-Vercammen 992
236 Consequences of the presence of pesticides in medicinal plantsM. Voitcu, V. Nastase, R. Cuciureanu and M. Leanca 994
237 The influence of some excipients on the characteristics of herbal troches
D. Sekulovic, V. Sekesan andL. Tasic 996
238 Isolation, purification and characteruzation of an extracellular
endoglucanase of Aspergillus ochraceusG. Dediu, F. Israel-Roming, M. Milescu and C.G. Tanase 998
239 Aesthetics in scienceK. Lancos, M. Balint and I. Peter 1000
34
Thursday, 11 May 1995
Room A
09.15 h Maurice-Marie Janot Lecture, Daan J.A. Crommelin, Universiteit UtrechtInternational Jury President: Professor Trevor M. Jones
10.00 h Break
Room A
Solid oral dosage formsChairmen, Marco Fabrizio Saettone and Klaus-Jiirgen Steffens
Proceedings page
10.20 h Effect of moisture on tensile strength of tablets based on
microcrystalline cellulose and polyvinyl pyrrolidoneL. Stubberud, H.G. Arwidsson and C. Graffner 161
10.40 h Compaction data bank, (1) Batch-to-batch, plant-to-plant, and
manufacture-to-manufacture consistency of microcrystalline cellulose
and dicalcium phosphateM. Celik and E. Okutgen 163
11.00 h The effect of compaction speed on capping of tablets compressed from
viscoelastic pharmaceutical materials, A quantitative approachK. Van der Voort Maarschalk, H. Vromans, G.K. Bolhuis
and C.F. Lerk 165
11.20h Break
Solid oral dosage formsChairmen, John E. Rees and Metin Celik
11.30 h Investigations into the moisture barrier properties of polyvinylalcohol(PVA) tablet film coatings
M.P. Jordan, M.G. Easterbrook and LE. Hogan 167
11.30 h Comparative study on xanthan gum and hydroxypropyl methylcellulose(HPMC) for sustained release formulation
M.M. Talukdar and R. Kinget 169
12.10 h A novel technique to study the physical properties of beads and film-
coated soft gelatin capsulesL. Felton, C. Wang, G. Zhang, N.H. Shah, M.H. Infeld,A.W. Malick and LW. McGinity 171
12.30 h Lunch break
Solid oral dosage formsChairmen, Renaat Kinget and Gyorgy Stampf
15.00 h The effects of viscosity grade of sodium carboxy methylcelluloseon drug release from matrix tablets 173
15.20 h In vivo performance of quick/slow Geomatrix® technologyL. Maggi, S. Morgenthaler, R. Zimmer, T. Shepard and U. Conte 175
35
Proceedings page15.40 h Polymer particle erosion, A new release mechanism of
hydrocolloid embeddingsB.C. Lippold and W.D. Lindner 177
16.00 h Bioavailability of testosterone using a bioadhesive tablet with
penetration enhancers in dogsJ. Voorspoels, W. De Sy and J.P. Remon 179
16.20 Break
Pulmonary deliveryChairmen, Robert Gurny and Gyorgy Szasz
16.35 h Particle size determination of metered dose inhalers by laser
diffraction, cascade impaction and liquid impingementP.M. Holzner and B.W. Muller 765
16.55 h Effect of drug/carrier ratio on the mixing and dispersion of drypowder inhalations of nedocromil sodium
D.Y.T. Wong, P. Wright and M.E. Aulton 767
17.15 h Delivery performances of three dry powder inhalers
G. Ponchel and A. Blattmann 769
Thursday, 11 May 1995
RoomB
NanoparticlesChairmen, Francis Puisieux and J6rg Kreuter
10.20 h Drug incorporation and delivery of prednisolone-loaded solid
lipid nanoparticlesA. zur Muhlen and W. Mehnert 455
10.40 h Comparison of tripalmitate nanoparticles prepared by melt
homogenization and solvent emulsificationB. Siekmann and K. Westesen 457
11.00 h Recrystallization tendency and polymorphic transitions in
triglyceride nanoparticlesH. Bunjes, K. Westesen and M.H.J. Koch 459
11.20 Break
NanoparticlesChairmen, Patrick Couvreur and A. Atilla Hincal
11.30 h Encapsulation of oligonucleotides in Stealth Me.PEG-PLA50
nanoparticles by complexation with structured oligopeptidesC. Emile, D. Bazile, F. Herman, C. Helene and M. Veillard 461
11.50 h Potential of solid lipid nanoparticles (SLN) for controlled drug deliveryR.H. Muller and W. Mehnert 463
36
Proceedings page
12.10 h Influence of different physicochemical conditions on the release of
indium oxine from nanocapsulesP. Maincent, F. Kedzierewicz, P. Thouvenot, I. Monot and
M. Hoffman 465
12.30 Lunch break
NanoparticlesChairmen, Michel Veillard and Kirsten Westesen
15.00 h Microparticulate drug carriers, Control of biodistribution by surface
modification with hydrophilic polymersV.P. Torchilin and V.S. Trubetskoy 467
15.20 h Polymethacrylic delivery system with NSAID propertiesP.A. Liso, M. Rebuelta, L San Roman, A. Gallardo and A.M. Villar 469
15.40 h Modification of the body distribution of polymethacrylate nanoparticlesby coating with different concentrations of non-ionic surfactants
J. Kreuter and L. Araujo 471
16.00 h Mechanism of action of polyalkylcyanoacrylate doxorubicin-loaded
nanoparticles in the reversion of resistance of P388/ADR
C. Dubernet, F. Nemati, A. Colin de Verdiere, M.-F. Poupon,F. Puisieux and P. Couvreur 473
16.20 h Break
ProdrugsChairmen, Vladimir P. Torchilin and Michael E. Aulton
16.35 h Water-soluble prodrugs and congeners of dexanabinol
E. Pop, M.E. Brewster, Z.Z. Liu, F. Soti, S. Rachwal, A. Dinculescu,
V. Nadler, Y. Barenholz, R. Mechoulam and A. Biegon 127
16.55 h Supramolecular organization and thermal analysis of a prodrug of
timolol, Palmitoyl timolol malonate
B. Pech, Y. Bouligand, J.-E. Proust and J.-P. Benoit 129
17.15 h Biocatalysed N-terminal deprotection of a dipeptide ester
I. Lupescu, D.M. Petrea and G. Radulescu 131
Thursday, 11 May 1995
RoomC
Lyophilization (freeze-drying)Chairmen, Patrick P. DeLuca and Szabolcs Nyiredy
10.20 h Use of statistical experimental design in optimizinginterleukin-2 (RU 49637) freeze-drying
J.-J. Le Fur, B. Voncken, M. Eyraud, N. Gayraud,B. Maneglier and P. Becourt 977
10.40 h Crystal ice size as a critical parameter in freezing of a dispersed system
Y. Bensouda and A. Laatiris 979
37
Proceedings page
11.00 h Freeze-drying plants with modern refrigerants including liquid nitrogenH. Willemer 981
11.20 h Break
StabilityChairmen, Karl-Heinz FrQmming and Svetla Bogdanova
11.30 h Investigation on the chemical stability of erythromycin in lotions
using an optimization systemM. Brisaert, M. Heylen and LA. Plaizier-Vercammen 935
11.50 h Optimization of TLC methods for densitometric determination and
separation of artemisin, arteether and artemether and their isomers
M. Gabriels and LA. Plaizier-Vercammen 937
12.10 h Stability of co-trimoxazole preparations for injectablesF. Giordano, G.P. Bettinetti, A. Gazzaniga, R. Cursano,M. Rillosi and A. La Manna 939
12.30 h Lunch break
Pharmacology, pharmacokinetics and biopharmacyChairmen, Emil Pop and Meir Bialer
15.00 Comparative studies on cellular effects of insulin and vanadate on
cultivated rat hepatocytesR. Albulescu, M. Albulescu, M. Apetroae and D. Gruita 869
15.20 h Effects of aminophylline on ADP-induced biphasic humanplatelet aggregation
M.M. Kostic, M.R. Petronijevic, D.L. Brkovic, M. Avramovic,A. Stajn and R.V. Zikic 871
15.40 h Synergisms between lectins and vesicles of Viscum album L.,(2) Direct cytotoxic effects
R. Scheer, H.H. Fiebig and A. Scheffler 873
16.00 h Some biopharmaceutical aspects of benzyl-iso-quinoline derivatives
S. Marton, P. Szentmiklosi and I. Ricz 875
16.20 Break
Pharmacology, pharmacokinetics and biopharmacyChairmen, Clive G. Wilson and Sylvia Marton
16.35 h Determination of transport rates for ISDN, theophylline and
propranolol across the rabbit colon epitheliumM.A. Rosic, M. Nesic, N. Cvetkovic and G.L. Rosic 877
16.55 h Least-squares deconvolution results in improved estimation ofthe mean input time as a measure of bioavailability
M. Bagli, R. Stiverkriip, M.L. Rao and H. Bode 879
17.15 h Criteria to assess in vivo performance of sustained release products,Application to diltiazem sustained release formulations
M. Bialer 881
38
Thursday, 11 May 1995
Posters
Exhibited continuously from 10.00 to 16.35, with special session from 14.00 to 15.00 h.The number indicates the number displayed on the poster panel.
Microspheres
240 Stability evaluation of PDLLA microspheres loaded with
anti-inflammatory drugF. Castelli, B. Conti, M. Fresta, U. Conte and G. Puglisi 407
241 Influence of the preparation method on residual solvents in
biodegradable microspheresC. Bitz and E. Doelker 409
242 Preparation and in vitro release of thymopentin PLGA microspheresB. Conti, A.M. Panico, C.A. Ventura, P. Giunchedi,V. Cardile and G. Puglisi 411
243 In vitro and in vivo evaluation of nifedipine-loaded PLGA microspheresP. Sansdrap, J. Fontaine and A.J. Moes 413
244 Biodegradable PLGA implants for in vivo sustained delivery of
carboplatin and etoposide to the brainT.L. Whateley, P.A. Fallon, L. Robertson and R. Rampling 415
245 New system for the microencapsulation of water-soluble drugsM.-A. Asin, E. Ferret, P. Tarin, R. Arola and A. Perez 417
246 Analysis of microspheres of poly(lactic/glycoiic acid) containingsalcatonin
P. Tarin, R. Arola, M.-A. Asm, E. Ferret and A. Perez 419
247 In vitro ciprofloxacin release from poly(lactide-co-glycolide)microspheres
M.C. Nacucchio, M. Pena, F. Lairion, P. Di Rocco and B. Martinez 421
248 Factors influencing the release of albumin from biodegradablemicroparticulate systems
LL. Pedraz, M. Igartua, A.G. Goicoechea and R.M, Hernandez 423
249 In vitro evaluation of albumin-loaded poly(D,L-lactide-c<?-glycolide)microspheres
M. Igartua, A. Esquisabel, R.M. Hernandez, A.R. Gascon,A.G. Goicoechea and LL. Pedraz 425
250 NSAJD-loaded polylactic acid microspheres, Preparation andin vitro characterization
D.J. Armstrong, P.N.C. Elliott, J.L. Ford, B. Guiziou,G.P. McCarthy and C. Rostron 427
251 Spray-dried biodegradable microparticles containing antigen as
oral vaccineM.-A. Benoit, B. Baras and J. Gillard 429
39
Proceedings page252 Potential of polyester microparticles for the sustained release of
oral vaccine
M.-A. Benoit, B.C. Youan and J. Gillard 431
253 In vitro/in vivo evaluation of diclofenac sodium/alginate beads
containing aqueous polymer dispersionsA. Giirsoy, M. Tiirkoglu, L. Eroglu, S. Aygin and I. Okar 433
254 Gelatin microspheres as carriers for anticancer drug doxorubicin,In vitro studies
M. Achim and S.E. Leucuta 435
255 Preparation of Eudragit RS 100 microspheres in different pH media,
(1) Morphology, surface and internal microsphere structure
M.K. Youssef, W. Korsatko, I. Attia, V. Ribitsch and O.Y. Mady 437
256 Eudragit microparticles prepared by spray-drying, Effect of
microparticle structure on diltiazem release
T. Kristmundsdottir, O.S. Gudmundsson and K. Ingvarsdottir 439
257 Liquid controlled-release formulations of microencapsulatedterbutalene/resin complexes
D. Torres, M. Curia, L. Boado and LL. Vila Jato 441
258 The effect of viscosity on the micromeritic properties of ethylcellulose-walled theophylline microspheres
G. Zessin and A. Dashevsky 443
259 An improved solvent evaporation method for manufacturingethylcellulose microspheres using phospholipids, Influence of
experimental parameters on particle size and release rate profilesG. Evers and T. Kissel 445
260 Investigation of residual methylene chloride in microparticlesproduced by means of the ASES process
F. Ruchatz, J. Thies and B.W. Muller 447
261 Hyaluronidase injectable microparticles for extravasation and
extravasation injury treatment
T. Modena, F. Pavanetto, I. Genta, M.E. Tira, P. Sini,B. Conti and A. Gazzaniga 449
262 Microencapsulated thiophosphonic acid ester (TPE), A new, highlyeffective insecticide formulation with a low environmental impact
S. Schult, R. L6hr and K. Mrusek 451
Pellets
263 Production of microgranules for multiparticulate dosage forms
O. W0rts 359
264 Influence of the nature of the excipients on the feasibility and the
release characteristics of granules made by a thermoplasticpelletization method
C. Peerboom and L. Delattre 361
40
Proceedings page265 Process study and optimization of pellet manufacture by rotary
granulationP. Delmas, F. Andre, G.A. Lewis, L Montel and D. Wouessidjewe 363
266 Influence of the impeller design, the method of screen perforation and the
perforation geometry on pellet quality made by extrusion/spheronizationC. Vervaet and LP. Remon 365
267 Properties of extruded pellets made from binary mixturesL. Nymo, M. Schroder, P. Schultz, B.W. Muller, T. Waalerand P. Kleinebudde 367
268 Preparation of neutral and ketoprofen pellets byextrusion/spheronization technology
J. Sirca, J. Kerc, S. Srcic and B. Kofler 369
269 Evaluation of beta-cyclodextrin as a pelletization agentA. Gazzaniga, M.E. Sangalli, M. Rillosi, G. Bruni, C. Vecchio
and F. Giordano 371
270 Effect of water solubility of drugs on the extrasio/spheronization processJ.A.C. Elbers, L.H.J. Bouwman and E.M.G. van Bommel 373
271 Comparison of two extruders by means of experimental designsE. Le Doeuff, M. Vanhoeve, A.T. Gayot and P. Becourt 375
272 Spherical preparations of bead cellulose, polyethylene glycol and
griseofulvin for controlled releaseB. Wolf, I. Finke and W. Schmitz 377
273 Beads of cross-linked carboxymethylcellulose, Effect of the viscositygrade and concentration of the polymer
V. Iannuccelli, G. Coppi and R. Cameroni 379
274 Coating of pellets, Comparison between aqueous dispersion andalcoholic solution of ethylcellulose
C. Mathieu, B. Huet de Barochez and A. Cuine 381
275 The effect of dispersion concentration and curing temperature on drugrelease of pellets coated with Eudragit NE 30 D
T.C. Wagner and S. Keitel 383
276 Influence of the pellet coating on drug release from ketoprofenslow-release capsules
M. Dittgen, A. Bauer, C. Timpe and H. Osterwald 385
Controlled release
277 Development of fluid compositions for the critical test of dissolution
sensitivity of oral extended release systemsR. Aloul, K. Gjellan, M. Sjolund, M. Sarkela and C. Graffner 299
278 Diffusion coefficients of ketoprofen sodium in ternary systems with
hydroxypropylcelluloseG.E. Hildebrand and C.C. Muller-Goymann 301
41
Proceedings page
279 Effective surface in inert matrix systems, Reactive dimension
M.J. Fernandez-Hervas, M.T. Vela, M.J. Arias and A.M. Rabasco 303
280 Control of the erosion rate of semi-solid poly(ortho ester), Case studyof 5-fluorouracil and mitomycin C
M.B. Sintzel, A. Merkli, J. Heller, C. Tabatabay and R. Gurny 305
281 Equilibrium swelling behaviour of pH-sensitive anionic vinylalcohol copolymers
N.M. Ranjha and E. Doelker 307
282 Non-ionizable, pH-sensitive hydrogels for controlled release, Swellingbehaviour of poly(ethoxy-triethyleneglycol monomethacrylate) films
B. Vasquez, I. Goni, M. Gurruchaga and J. San Roman 309
283 Release study of acebutolol immobilized on y-irradiated PEO-based
hydrogelsN. Lambov, S. Tsankov and E. Minkov 311
284 Preparation and characterization of hydrogel delivery system,
Application to gentamicin and methotrexate
C. Bregni, E. Beyssac, S. Aiache and L-M. Aiache 313
285 Hydrogel implant controlled delivery system for methotrexate
obtained by ionized radiation
E. Beyssac, C. Bregni and J.-M. Aiache 315
286 Floating minitablets for the sustained release of low-solubility drugsN. Rouge, P. Buri, E. Doelker and E.T. Cole 317
287 Polysaccharides and controlled drug release, Gellan for the
formulation of gel capsulesE. Murtas, M. Carafa, T. Coviello and F. Alhaique 319
288 Simultaneous in vitro controlled release of levodopa and carbidopa from
biocompatible polymeric core-in-cup implantsM.P. Danckwerts and J.G. van der Watt 321
289 Use of methyl polymethacrylate (PMMA) as a drug supportS. El Meski, E. Beyssac and J.-M. Aiache 323
290 Preparation of gelatin sponges as sustained release drug carriers
K. Oungbho and B.W. Muller 325
291 Chitosan cross-linked films as vehicles for controlled drug deliveryC. Remunan-Lopez, M.J. Alonso and R. Bodmeier 327
292 In vitro bacterial degradability of inulinHP incorporated in
Eudragit RS films
L. Vervoort and R. Kinget 329
293 Development of a new controlled-release dosage form, Influence of
coating thickness and gamma sterilization on release kinetics
J.-M. Aiache, S. El Meski, E. Beyssac and G. Serpin 331
42
Proceedings page294 pH- and vehicle-dependence of salbutamol release rate through
a polypropylene control membrane
R. Imboden, G. Imanidis and H. Leuenberger 333
295 Proposal of antimoulding delivery device for the stability improvementof cosmetic formulations
A. Gazzaniga, M.E. Sangalli, F. Giordano, U. Conte,A. Semenzato and A. Bettero 335
296 Evaluation of the release of drug from medicated chewing-gumL. Gyldenvang and M.R. Rassing 337
Bioadhesion
297 Use of scintigraphy to measure bioadhesion in an isolated porcineperitoneal sheet model
Y.P. Zhu, C.G. Wilson, I. Hayter and LD. Smart 825
298 Interaction analyses between purified vaginal mucus and Carbopol 934Pby differential scanning calorimetry and scanning electron microscope
S. Galindo, D. Quintanar and E. Aguilera 827
299 Bioadhesive polymers as platforms for oral Barrett's oesophagustreatment, Formulation and evaluation of various water-solublebioadhesive polymers
P. Iooss, A. Gouyette, A.M. Le Ray, T. Patrice and C. Merle 829
300 Bioadhesive tablets of sodium diclofenacA. Popovici and E. Petrescu 831
301 Aminophylline bioadhesive tablets obtained by wet granulationC. Prudat, P. Arnaud and L-C. Chaumeil 833
302 Effect of technological variables on swelling behaviour of
gelatin/poly(acrylic acid) microspheresS .E. Leucuta, G. Ponchel and D. Duchene 835
303 Influence of a number of technological variables on the propertiesof bioadhesive microspheres loaded with oxprenolol
M. Preda and S.E. Leucuta 837
304 A novel mucoadhesive buccal drug delivery systemS. Burgalassi, L. Panichi, M.F. Saettone, J. Jacobsenand M.R. Rassing 839
Physicochemistry
305 Reorganization of collagen in the presence of structured (activated) waters
I. Manzatu, V. Trandafir and R. Christof 26
306 Interaction of perfloxacin and ciprofloxacin with antacids
Z. Kokot, H. Bojarowicz, B. Kupcewicz and I. Prawdzik 28
307 Relative lipophilicities of some 1,4-dihydropyridine calcium antagonistsS. Srcic, J. Kerc, M. Pukl, V. Kmetec and O. Planinsek 30
43
Proceedings page
308 Dissolution behaviour of sulphonamides into sodium dodecyl sulphatemicelles, A thermodynamic approach
S. Mall, G. Buckton and D.A. Rawlins 32
309 Comprehensive computer-assisted calculations for pKa, logP and logDvalues of drugs, and their applications to pharmaceutics
A. Papp, F. Csizmadia, F. Darvas and A. DaVid 34
310 Hydration of drug molecules, Cavity inclusion of water in crystals of
loperamide hydrochloride tetrahydrateJ.J. Gerber, M.R. Caira and A.P. Lotter 36
311 Crystal engineering, Solvent effects on glibenclamide crystalsproduced with different crystallization rates
D. Cordes and B.W. Muller 38
312 Phase changes of theophylline crystal forms under different moisture
conditions
U.J. Griesser and A. Burger 40
313 Polymorphism of paracetamolP. Di Martino, A.-M. Guyot-Hermann, P. Conflant, M. Drache,J.-P. Beaufays, J.-P. Huvenne and J.-C. Guyot 42
314 Comparison of physicochemical properties of the polymorphicmodifications and pseudopolymorphic forms of non-steroidal
anti-inflammatory drug substances
A. Burger and J.-O. Henck 44
315 On the solubility of polymorphic modifications of the racemates,
Enantiomers of some 2-arylpropionic acids
A. Burger and K.T. Koller 46
316 Investigations on the melting behaviour, thermotropic mesomorphismand solubility of fenoprofen calcium
T. Rades, Y. Padmadisastra and C.C. Muller-Goymann 48
317 Preparation and characterization of a very stable crystal modification
of H2 antagonist cimetidine
A. Bauer-Brandl 50
318 Determination of thermal properties and film formation characteristics
of different acrylic aqueous dispersions used for film coatingK. Arnighi and A.J. Moes 52
319 Preformulation aspects of hirudin, pH-dependent coprecipitationof hirudin and zinc
U. Gietz, T. Arvinte and H.P. Merkle 54
320 Phase diagram of the carbamazepine/PEG 6000 system and dissolution
rates of eutectic mixture samplesN. Zerrouk, S. Toscani, J. Dugue, R. Ceolin and C. Chemtob 56
321 Preparation, characterization and dissolution performance of
flunnarizine from solid dispersions with PEG 6000
LM. Gines, M.J. Arias, LI. Perez-Martinez, LR. Moyano,M.J. Perez-Barrales, M.D. Veiga, M.T. Faucci and A.M. Rabasco 58
44
Proceedings page322 Solid dispersion systems with nifedipine
S. Michailova, I. Nikolov, A. Pavlova and P. Kazanjieva 60
323 Drug/polymer interactions in coprecipitates with controlled releaseof verapamil hydrochloride
K. Goracinova, A. Simov, L. Klisarova, E. Fredro-Kumbaradzi
and L. Petrusevska-Tozi 62
324 Drug/excipient interaction study of 6-lactame antibiotic usingdifferent techniques
M.A. Hassan, J. Kaloustian, H. Ransis, K.A. Khaled,T.H. El-Faham, S. Shawky-Tous and J. Joachim 64
325 Compatibility study of amonafide hydrochloride with hydrophobicexcipients
M.M. Obregon, M.E. Gil, V. Ruz, J. Bernabeu and M.A. Camacho 66
326 Use of micro DSC III (Setaram) in the study of drug/excipientcompatibility
M. Balint, E. Gondar, I. Peter and S. Sebesi-Siito 68
327 Thermal analysis in pharmaceutical systems using oscillatingdifferential scanning calorimetry (ODSC)
M. Wulff and M. Alden 70
328 Characterization of water uptake by hydrocolloids usingdifferential scanning calorimetry
G. Bhaskar, LL. Ford and D.A. Hollingsbee 72
329 The use of isothermal microcalorimetry in the study of the amorphouscontent of a hydrophobic powder
H. Ahmed, G. Buckton and D. Rawlins 74
330 DSC study of the phase behaviour of an aqueous dextran/mannitol system
during the freezing step of the freeze-drying processJ. Bamba, P. Tchoreloff, G. Cave, F. Puisieux and G. Couarraze 76
331 HLB determination method, Comparison applied to a range of
3-Z-R-1,2-O-isopropylidene-a-D-glucofuranose derivatives
R. Bikanga, P. Gode, D. Postel, G. Ronco, G.-N. Cave,M. Seiller and P. Villa 78
332 Use of the elastic modulus to determine phase transitions of Lutrol F127
gels, Influence of molecular weight and volume fraction of PEG and
PPG on phase transition temperaturesM.E. Voeffray, LM. Mayer and J.-C. Etter 80
333 New gelification method for vegetal oils and rheological study of
oleogels as a function of temperatureP. Gauthier, S. Aiache, E. Beyssac and J.-M. Aiache 82
334 Comparative rheological study of aqueous preparations based on
thickening or gelling agentsC. Montaulieu, P. Michaud, M. Sengelin, E. Leverd and
J. Bougaret 84
45
Proceedings page335 Rheological properties of drug/phospholipid monolayers
A. Doisy, J.-E. Proust, J.C. Chauvin and J.-L. Dubois 86
336 Evaluation of mucin viscoelastic behaviour
J. Kocevar-Nared, J. Kristl and J. Smid-Korbar 88
337 A novel method of dissolution curve processingP. Kaclfk, T. Fazekas, M. Vitkova" and M. Chalabala 90
338 Testing the applicability of the cube root law to the dissolution of
ibuprofen using a particle counterL. Pereira de Almeida, S. Simoes, A. Sousa and M. Figueiredo 92
339 The effect of particle size and shape on the surface specificdissolution rate of suspended, practically insoluble drugs
M. Mosharraf and C. Nystrom 94
340 Influence of particle size variation of a poorly water-soluble
compound on the dissolution behaviour of tablets
A. Bausch, C. Qiao and R. Alex 96
341 Structure/property relationship in the case of PLGA 50/50 copolymersG. Reich 98
Cyclodextrins
342 Microwave drying of a-cyclodextrinG.P. Bettinetti, F. Giordano, M. Rillosi and P. Mura 591
343 Effects of hydrotropic agents on the formation of indomethacin/
B-cyclodextrin inclusion compoundsE. Pioger, D. Wouessidjewe, D. Duchene and S. Bogdanova 593
344 Phase solubility and 13C NMR analysis of the interaction of ketoprofenand ibuprofen with B-cyclodextrins
P. Mura, A. Manderioli, G.P. Bettinetti and G. Bramanti 595
345 Interactions of sulindac with B- and y-cyclodextrinsM.A. Peiia, C. Tros de Ylarduya, C. Martinez-Oharriz,M.M. Goni, C. Martin and M. Sanchez 597
346 Fluorescence study of naproxen/8-cyclodextrin interaction in solution
M. Sanchez, I. Velaz, C. Martin and M.C. Martinez-Oharriz 599
347 Structural characterization of glibenclamide sodium salt inclusion
complex with B-cyclodextrinE. Redenti, M. Pasini, L. Carima, M. Zanol, A. Bacchi,M. Vikmon, J. Szejtli and P. Ventura 601
348 Study of salbutamol/B-cyclodextrin and ethylated B-cyclodextrincomplexes, Determination of stability constant by capillaryelectrophoresis
V. Lemesle-Lamache, M. Taverna, D. Ferrier, D. Duchene
and D. Wouessidjewe 603
46
Proceedings page349 Complexation of the bacteriostat, triclosan, with 7-cyclodextrin
P.M. Ashall, B.M. Kieman and N.R. Russell 605
350 Interaction of triamterene with hydroxypropyl B-cyclodextrin in
ground mixtures, Improvement in the dissolution propertiesM.J. Arias, LM. Gin6s, J.R. Moyano, P.J. Sanchez-Soto,A. Ruiz-Conde, C. Novak and A.M. Rabasco 607
351 Preparation and evaluation of indomethacin/cyclodextrininclusion complexes
D. Lupuleasa, M. Pana, S. Sever, D. Neagu and P. Cracium 609
352 Study of the inclusion complexation of glisentide with B-cyclodextrinJ.R. Moyano, LM. Gines, M.L Arias, LI. Perez-martinez,M.J. Perez-Barrales, M.J. Fernandez-Hervas and A.M. Rabasco 611
353 Inclusion compound of acetazolamide with different cyclodextrinsin liquid and solid state
M.J. P6rez-Barrales, F. Diaz-Estevez, LM. Gines, J.R. Moyano,M.J. Arias and A.M. Rabasco 613
354 Investigation on 2,4-D/DIMEB complexation in aqueous solution
and solid state
LL Perez-Martinez, LM. Gines, M.J. Arias, P.J. Sanchez-Soto,A. Ruiz-Conde, E. Morillo and C. Novak 615
355 Increasing the solubility characteristics of fenofibrate with cyclodextrinZ. Aigner, I. Bencz and M. Kata 617
356 Increasing the solubility and photostability of nifedipine with cyclodextrinsA. Gyeresi, B. Tok6s, G. Regdon and M. Kata 619
357 The influence of 6-cyclodextrin on solubility, stability and inclusion
complexation of a new non-acidic non-steroidal anti-inflammatorydrug (NSA1D) in aqueous solutions
A.M. Le Ray, P. Richomme, J.M.H. Robert and C. Merle 621
358 Improvement in the dissolution properties of ketoconazole throughcomplexation with B- and 2-hydroxypropyl B-cyclodextrin
M.T. Esclusa-Diaz, M. Guimaraens-M6ndez, M. Gayo-Otero,M.B. Perez-Marcos, J.L. Vila Jato and J.J. Torres-Labandeira 623
359 Dissolution studies of mequitazine in several dissolution media
with sodium lauryl sulphate, Tween 20 and B-cyclodextrinM.D. Veiga and F. Ahsan 625
360 Improved oral bioavailability of carbamazepine through the use of
chemically-modified cyclodextrinsM. Brewster, W. Anderson, E. Pop, R. Sawchuk, B. Cheungand A. Webb 627
361 The influence of the method for the preparation of essential oil/
B-cyclodextrin complexes on the stability of selected oil componentsL. Tasic, V. Sekesan, D. Sekulovic and M. Ristic 629
47
Proceedings page362 Photochemical stability of the inclusion complexes formed by
1,4-dihydropyridine derivatives with B-cyclodextrinJ. Mielcarek and J. Pawlaczyk 631
363 A DSC study on the interaction of natural and modified B-cyclodextrinswith liposomes
C.A. Ventura, M. fresta and G. Puglisi 633
48