ASTRI Proprietary

Healthcare Electronics

John Tsang, WM

Optoelectronics 08 July 2016

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Healthcare Electronics

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Source: http://www.gettyimages.com/

• Small Size – Portable – Wearable – implantable – injectable / swallowable

• Real time / Continual Measurement

– Physiology – Environment – Food

• Wireless connectivity / IoT

• Alerts / Tips

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Dream Devices

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Non-invasive Blood Glucose Meter

Source: https://www.youtube.com/watch?v=SxXnjY7jy9g

Food Sensor

Source: http://the-sun.on.cc/cnt/news/20140905/00407_003.html

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Non-invasive Blood Glucose Meter

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Products with CE Mark

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1998 1999 2003 2007 2011 2012 2013

Diasensor 2000 Pendra glucose Watch Glucotrack (糖无忌)

Combo-Glucometer CNOGA

GlucoWatch OrSense NBM 200G C8 MediSensors HypoMon

FDA cleared on Mar 2001

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Products with CE Mark

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1998 1999 2003 2007 2011 2012 2013

Diasensor 2000 Pendra glucose Watch Glucotrack (糖无忌)

Combo-Glucometer CNOGA

GlucoWatch OrSense NBM 200G C8 MediSensors HypoMon

FDA cleared on Mar 2001

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Skin Structure

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DOI: 10.1038/srep07013

Stratum corneum

Epidermis

Dermis

Interstitial fluid

Glucose Molecules

• Human skin is ~2–3 mm thick

• No blood vessels and very little glucose in epidermis

• Interstitial body fluid constitutes ~45% of the volume fraction of human skin (Dermis)

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Glucowatch

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Source: ISBN 0 642 82610 2

• GlucoWatch ( CE mark @ Dec 1999) • FDA cleared on Mar 2001 • Adjunctive medical device • Reverse iontophoresis • Out of business due to skin irritation and

unreliable hypoglycemia detection

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Pendra glucose Watch

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• Pendra glucose Watch (CE Mark @ May 2003) • Adjunctive Type IIb medical device • Impedance Spectroscopy • Withdrawn due to inaccurate and failed to warn of

dangerous blood sugar levels.

Source: www.pendra.narod.ru/downloads/Presentation_Warsaw_110904.pdf

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Non CE Mark Products

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Symphony™ Transdermal Continuous Glucose Monitor

(tCGM) System

Google smart contact lens

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HypoMon, AiMedics

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• 4 electrodes • Change of bodies physiological responses (e.g.

ECG and skin impedance) • Recalled at Aug 2013 and identified that it is not

performing as well as expected

Source: Nguyen HT, Ghevondian N, Jones T (2006): Neural-network Detection of Hypoglycemic Episodes in children with Type 1 Diabetes using Physiological Parameters, 28th Annual Int Conf of the IEEE Eng in Med and Biol Society, New York, 6053-6056.

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Glucotrack (糖无忌)

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Glucotrack (CE mark @ Jun 2013) • Multi-sensors technology: ultrasonic,

electromagnetic, and thermal • Calibration valid for 6 months • Zones A & B: 95.9% Zone A: 41.3%;

Source: http://www.integrity-app.com/the-glucotrack/

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Combo-Glucometer, CNOGA

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• Combo-Glucometer, CNOGA (CE Mark @ Mar 2011)

• Skin pigment tone • Optical: 300 nm to 1200 nm • Diabetics Type 2 only • Initial individual calibration (65 -100

invasive measurements in less than 2 weeks time)

Source: http://cnogacare.co/

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Optical Method

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DOI: 10.1038/srep07013

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OrSense NBM 200G

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• OrSense NBM 200G (Jun 2007)

• Tested on over 450 diabetic subjects

• Occlusion Spectroscopy

• Red/near-infrared (R/NIR)

• Unavailable for the market yet

https://www.youtube.com/watch?v=uGbhElP-UUc

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C8 MediSensors

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• Raman • Out of business

Source: J Diabetes Sci Technol Vol 3, Issue 2, March 2009

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Food Sensor

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Food Sensor (Optical Method)

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Ref: Chem. Soc. Rev., 2012, 41, 5706–5727

Sowoidnich New Food. 2013. p. 14.

• Raman /NIR is an optical technique to probe

molecular vibration states thus it can show

the chemical fingerprints of the foodstuffs,

non-invasively

• Optical spectroscopic method can be used

for many food safety and quality (FSQ)

applications in food industry such as:

– pesticides residue on vegetables & fruits

– meat spoilage / freshness detection

– authentication for oil and may others

– Cheese protein quality

– adulterant in milk (Melamine)

– ... etc

Meat Spoilage Detection

0

1

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Industry Application

http://www.stemilt.com/our-stories/history-innovation/

• Non-destructive sweetness testing based on near-infrared technology (NIR) is put on Stemilt fruit packing lines.

• provide information about the sugar levels and overall quality of the fruit being packed

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SCiO (NIR)

SCiO (KickSTARTER) •Price: $299 / unit •Target: $200,000 ($2,241,170@ 3 June 2014) •Period: 29 Apr – 16 Jun 2014 •Sensitive: major components of foods (i.e. with typical concentration of 1% or more • Collaboration with ADI to develop a sensor-to-cloud personal and industrial IoT platform that analyzes liquids and solids

https://www.kickstarter.com/projects/903107259/scio-your-sixth-sense-a-pocket-molecular-sensor-fo https://www.youtube.com/watch?v=9Xa-uy9fLEE

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MS-technologies Israel

http://www.ms-technologies.com/products/foodscan/

Hand-held food contamination detector using HF-QCM sensor technology to detect the contamination caused by common pathogens such as Salmonella, E.coli O157:H7, Listeria and others.

• Contact or non-contact analysis • Real-time analysis in 6 seconds • Pre-emptive food poisoning • Wireless and/or GPS data transmission • 850 g with 8-hr battery

FOODSCAN (Electronic Noise)

− High-Frequency Quartz Crystal Microbalance (HF-QCM) Technologies

− A large bank of thin chemical coatings that can be applied on the active surface of HF-QCM sensors.

− Each of these coatings has a specific affinity to different target molecules.

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Market Analysis (Crowdfunding activities)

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200

400

600

800

1000

1200

1400

1600

Nov 13' Mar 14' May 14' Jun 14'

com

ple

tio

n r

ate

[%

]

Time

US$ 386K

US$ 40K US$ 78K

US$ 2.7M + 4M from VC

MyDx

Tellspec

PERES

SCiO

The funding raising completion rate for all these projects are > 100%

Optical Spectroscopy

Electronic Nose

$250 / unit

$89/ unit

$499 / unit

$299 / unit

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How do spectrometer work?

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Filtering Disperse Interference

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Conventional Technical Approaches

Linear Variable Filter (LVF) based Spectrometer Tunable filter spectrometer

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Interference pattern in the temporal domain by moving

mirror

Detector

FT spectrometer (Michelson Interferometer)

• Robustness is limited by moving mirror

𝐼 𝑡 = 1

2𝐿 𝑘 1 + cos 2𝜋 ∙ 𝑘 ∙ 𝛿𝑙 𝑑𝑘

∞

−∞

x

𝑘 =1

𝜆

L(k): Intensity at a particular k

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Conventional Dispersive Spectrometer

s d

• Resolution is limited by the grating ( 1/d)

and slit (1/s)

• Throughput is limited by the slit ( s)

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MEMS based Spectrometer

Classification: Disperse vs. Interference & Free-field vs. Waveguide

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Disperse

Interference

Free-field Waveguide

e.g. FT spectrometer e.g. AWG based SHS

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Free-field Spectrometer

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Complexity

No

velt

y

Macro-assembly

Micro-assembly

Wafer-scale Integration

Monolithic Integration

MEMS grating and movable slit

e.g. FP spectrometer components on AlN baseplate Pick & Place technology Axsun Technology

e.g. Disperse NIR spectrometer 950 – 1900 nm IMPS, Fraunhofer

e.g. Disperse IR spectrometer Wafer bonding DTU, Netherlands

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Foss 6500

PHAZIR

INSION MicroNIR, JDSU

Neospectra, Si-ware

Technology

Grating Disperse + Grating Light Valve

Waveguide Echelle Grating LIGA Molding / PMMA

Linear Variable Filter

Michelson Interferometer (moving mirror)

Max dimension

43 cm 30 cm

6.7 cm 4.5 cm 8.0 cm

Resolution

2 nm N.A. (10 -12 nm)

< 16 nm 6.5 nm 16 nm

Spectral Range

1000 -2500 nm

1000 -1600 nm

900 – 1700 nm 950 – 1650 nm

1250 – 1700 nm

Competitive Analysis

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Elderly Demand on Portable Healthcare Electronics

• Potential Users: Elderly keen to technology, healthy

elderly living alone & active elderly;

• Chronic diseases elderly concerns most: blood

pressure, heart disease, cardiovascular disease

(stroke), diabetes, dementia.

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Source: ITRI-IEK and OC&C joint study (2010-2011)

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Healthcare Electronics at ASTRI

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Pulse Oximetry Module (15x15x1.7mm)

IP-protected Sensor Module (9x11x1.1mm)

Reflective Pulse Oximeter

Reflective pulse oximetry module Continual measurement of blood oxygen saturation, pulse

rate, breathing rate and heart rate variability Key features:

• Unaffected by nail polish or onychomycosis • Fulfilled FDA standard(Arms <3.5%) • Wireless connectivity • Easy integration with consumer electronics

Pulse Oximetry Dongle (57x27x14.5mm, 15g)

Patent No.: US 2012/0176599

CN 102727220A

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Cardiovascular Monitoring Device

Parameters： • Heart Rate • Arterial Stiffness Index (ASI) • Continual Blood Pressure Measurement

(40 – 180mmHg 8mmHg) Features:

• Compact pressure senor • Cuffless • Continual Measurement • Wireless connectivity

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Cognitive Health Monitoring Device

• Measure pulse oximetry, breathing rate and balance in Autonomous Nervous System (ANS)

• Relieve your stress, and improve your sleeping quality & balance in ANS by controlling your breathing

Physiological &

Cognitive

Measurement Balance in

Autonomous

Nervous System

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Non-Invasive Blood Glucose

• Working Principles: Measurement of

scattered light at different

wavelength in the spectrum

• Applications: pre-screening of pre-

diabetes and diabetes

• Usage: Put your finger on the sensor

Blood glucose level at

different time of a day

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Compact Optical System for Food Safety/Quality

Current Future

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• Portable

• Control environment

• Rapid Detection (~1-2 min)

• Sample Preparation

• Accessory

• Ambient environment

• Real-time detection (< 1 min)

• Direct Measurement

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Miniaturized

High-throughput

Broad range

High resolution

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Disclaimer

The information contained in this presentation is intended solely for your reference

and may be subject to change without further notice.

Such information's truthfulness, accuracy or completeness is not guaranteed and it

may not contain all the material information concerning Hong Kong Applied Science

and Technology Research Institute Company Limited and/or its affiliates

(collectively, "ASTRI"). ASTRI makes no representation or warranty regarding, and

assumes no responsibility or liability for, the truthfulness, accuracy or completeness

of any information contained herein.

In addition, the information may contain projections and forward-looking statements

that may reflect ASTRI’s current views with respect to future events and financial

performance. These views are based on current assumptions which may change

over time. ASTRI makes no assurance that such future events will occur, that such

projections will be achieved, or that ASTRI’s assumptions are correct.

Lastly, this presentation does not constitute an offer made by ASTRI whatsoever

(including an offer relating to ASTRI's technologies and/or services).

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End of Presentation Thank you. Questions are welcome.

Corporate website: www.astri.org

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