Slide 1

Robert JerajAssociate Professor of Medical Physics, Human Oncology,Radiology and Biomedical EngineeringDirector of Wisconsin Oncology Network of Imaging eXcellenceUniversity of Wisconsin Carbone Cancer Center, Madison, WI

Wisconsin Oncology NetworkAspirus Regional Cancer Center, WausauAurora Cancer CareAurora HealthCare NetworkBellin Memorial Hospital, Green BayColumbia-St. Marys, MilwaukeeDean Clinic Heme/OncFerguson Cancer Center, Freeport, ILFox Valley Heme/OncGundersen Lutheran, La CrosseHoly Family Cancer Center, ManitowocMarshfield ClinicMedical College of Wisconsin, MilwaukeeMercy Health System, JanesvilleProHealth Care, Waukesha and OconomowocSt. Vincent Hospital, Green BaySwedishAmerican Hospital/SAH Regional Cancer Center, Rockford, ILUWCCCUWCCC Partners, Johnson Creek, Wisconsin RapidsVucurevich Cancer Center, Rapid City, SD

Wisconsin Oncology Network of Imaging Excellence (WONIX)

WONIX organizational structure

Molecular Imaging Agents Working GroupTo develop molecular imaging agents and make them available to the WONIX sites. It includes development of necessary distribution infrastructure and necessary regulatory documentation for obtaining Investigator New Drug (IND) approvals.

Chairs:Scott Perlman, Co-ChairRebecca Marnocha, Co-Chair

Members: John Centanni, Scott Knishka, Yongjun Yan, Todd Barnhart, Robert Jeraj, Anne Traynor, Dona Alberti

Imaging quality assurance Working GroupTo establish harmonized imaging quality assurance program across the WONIX sites.

Chairs:Chihwa Song, Co-ChairMatt La Fontaine, Co-chair

Members: Robert Pyzalski, Karl Vigen, Frank Ranallo, Frank Korosec, Sean Fain, Guanghong Chen, Ed Jackson, Robert Jeraj, Nagesh Adluru, Chris Jaskowiak, Cheryl Gain

Informatics Working GroupTo enable automated workflows, data collection and integration, and processes that enable scalable clinical trials within WONIX

Chairs:Richard Bruce, Co-chairSean Fain, Co-Chair

Members: Gary Wendt, Andy Craven, Chihwa Song, Matt La Fontaine, Cheryl Gain, Jonathon Boott

Data Working GroupTo develop common database platform and appropriate tools for data analysis and data mining

Chairs:Umberto Tachinardi (Co-chair)Jonathan Boott (Co-chair)

Members: Stephine Wasielewski, Mary Jane Staab, Jill Kolesar, Richard Bruce, Robert Jeraj, Dona Alberti

Imaging clinical trials Working GroupTo design, coordinate and execute individual imaging clinical trial projects through the WONIX network.

Chairs:Robert Jeraj, Co-ChairGlenn Liu, Co-chair

Members: George Wilding, Anne Traynor, Ryan Mattison, Kari Wisinski, Scott Perlman, Jill Kolesar, Dona Alberti, Jennifer Heideman

Clinical trialsRetrospective analysis of FDG PET/CT in NSCLCCurrent UW pilot (20 pts) will be extended (200 pts) through WONIX

MITOS: FDG PET/CT in NSCLCComprehensive genomic analysis and CTCsEarly and late FDG PET/CT response assessmentPiloted (3 pts) at UWCCC; WONIX amendmentsSoon to be activated through WONIX

NaF PET/CT in mCRPCFDG PET/CT in lymphomaFLT PET/CT in AML

Next stepsWONIX working groups:Molecular imaging agents: cGMP facility (Q1 2015)Imaging QA: Automated QA/QC monitoring (Q3 2015)Informatics: XDS data exchange platform (Q2 2015)Data: Common databased established (Q3 2015)

WONIX site activation (Q4 2014/Q1 2015)Gundersen, La Crosse (Q4 2014)St. Vincent, Green Bay (Q1 2015)Others to follow

WONIX clinical trial activation (Q1/Q2 2015)Retrospective FDG PET/CT analysis (Q1 2015)MITOS trial (Q2 2015)Others to follow

WONIX Site Visit with Gundersen Health System, La Crosse

Monthly newsletter

Monthly update at the TIR meeting

WONIX Website

UW Health Main Page15

WONIX Wiki

WIKI Org Page16

Questionswonix@lists.wisc.edu