Population

Characteristics # %

Gender

Male 91 25,6%

Female 165 64,4%

Age

�55 30 11,7%

55-65 36 17,9%

66-75 118 46,09%

76-85 57 22,2%

>86 13 5,07%

Scholarity

< 5 years 19 7,4%

5-11 yrs 97 37,89

12-15 yrs 51 19%

>16 yrs 97 37,98%

Diagnostic

Healthy 118 46%

DCL 44 36,7%

Dementia 94 44,1%

Total 256 100%

Poster Presentations: P2 P453

(p <0.0001). A sensitivity of 75% was established to detect MCI and of

94.4% for MD and the value of specificity was 79% with a cutting point

� 24. The relationship between the sensitivity and specificity was optimized

with cutoff point of�24, was established a p ositive predictive value of 83%

and a negative predictive value of 90%. Conclusions: The translation of

MoCA test is valid for application in Colombiawith fine psychometric prop-

erties such as internal consistency, interrater reliability and convergent val-

idity. The cutting point� 24 reaches 89% sensitivity and 79% specificity for

the detection of DCL and DL. The sensitivity for detecting DCL is 75% and

95.4% for DL.

P2-258 WITHDRAWN

P2-259 NEUROPSYCHOLOGICAL PROFILE AND

NEUROPSYCHOLOGICAL MARKERS OF

DEMENTIA IN OLDER PEOPLE IN RIO DE

JANEIRO CITY, BRAZIL

Helenice Charchat-Fichman1, Camila Faria1, Conceic~ao Fernandes2,

Luciana Brooking2, Daniele Lima3, Regina Novaes3, 1PUC-Rio, Rio de

Janeiro, Rio de Janeiro, Brazil; 2UERJ, Rio de Janeiro, Rio de Janeiro,

Brazil; 3HFSE, Rio de Janeiro, Rio de Janeiro, Brazil. Contact e-mail:

camila_psic@yahoo.com.br

Background: The identification of preclinical stages of dementia is impor-

tant for early intervention and prevention. Many studies analyze the predic-

tive biomarkers of dementia process before the manifestation of the disease,

but few studies investigating the clinical and cognitive factors involved in

the same process. Methods: The sample consisted of 43 older patients

with MCI (15 male and 28 female) between 66 and 89 years old, four years

period. All patients were submitted to clinical evaluation. 17 older people

were reassessed after two years. The instruments used were: Pfeffer, De-

mentia Rating Scale (DRS), Digits Forward and Backward, Spatial Span

Forward and Backward, Phonemic Verbal Fluency (PVF), Categorical Ver-

bal Fluency, Animal Naming, Memory Figures, RAVLT, Rey complex fig-

ure, Trail A and B, Codes, Cubes and Clock Drawing. Results: Most

participants received a MCIamnestic diagnosis 68.6%, mean age 76.9 (65.2) and mean education level 4.9 (6 4.5) years. 31.4% of participants

had a MCInon amnestic diagnosis, mean age 73.3 (6 5.2) and mean educa-

tion level 5.1 (6 4.1) years. More than half of participants showed impair-

ment in executive functions (55.6%) and instrumental activities of daily

living (51.4%) andmuch of the sample showed impairment in delayed recall

(44.4%) and global cognitive functioning (44.1%). After two years, 29.4%

of participants reassessed changed the diagnosis for dementia. 64.7% of re-

assessed participants showed decline in the recognition process and others

64.7% showed decline in delayed recall. 58.8% showed a decline in learning

process and 50%, in attention. The neuropsychological tests considered

markers of preclinical dementia were: delayed recall and recognition of

Memory Figures test; learning score and recognition of RAVLT and Digits

Forward and Backward. Conclusions: The results show that delayed recall,

learning, recognition and working memory tests are important markers of

conversion to dementia, confirming the literature data. The neuropsycholog-

ical markers identification is important for early intervention and prevention

of dementia.

P2-260 DISEASE PROGRESSION MARKERS FROM

CONNECTED SPEECH

Samrah Ahmed1, Celeste de Jager2, Anne-Marie Haigh2, Peter Garrard3,1St George’s University of London, London, England, United Kingdom;2University of Oxford, Oxford, England, United Kingdom; 3St George’s,

University of London, London, England, United Kingdom. Contact e-mail:

sahmed-a@sgul.ac.uk

Background:Our group recently described syntactic simplification and im-

pairments in lexico-semantic processing in samples of connected speech

samples obtained at the time of diagnosis from patients in whom AD was

subsequently confirmed at post mortem. In this study we set out to identify

features of connected speech that: i) had been abnormal during the MCI

phase of these patients’ illness; and ii) showed consistently greater deviation

from normal performance with disease progression.Methods:Members of

the OPTIMA cohort, in whom diagnoses of both MCI and probable AD had

been made during longitudinal evaluation, were selected for the study. Tran-

scripts of the Cookie Theft picture description task were subjected to anal-

ysis using the Quantitative Production Analysis (QPA) approach. QPA

produces a series of measurements and error counts that can be grouped un-

der four broad descriptive domains: syntactic complexity, lexical content,

speech production and fluency. Semantic content was quantified by identi-

fying and counting semantic units. Variables on which the majority of cases

showed a linear decline between the MCI and early AD stages and were

taken as potential markers of progression. These were then applied to tran-

scripts obtained from the same patients at a uniform stage of moderate dis-

ease severity. Results: There were significant linear trends over the three

stages of the disease (MCI, early and moderate AD) for: syntactic complex-

ity (F(1,8)¼12.304, p<0.01), semantic content (F(1,8)¼8.627, p<0.05),

and lexical content (F(1,8)¼9.273, p<0.05), but not for speech production

(F(1,8)¼0.031, p>0.05) or fluency errors (F(1,8)¼2.735, p>0.05).Conclu-

sions: The study found that subtle changes in language function typical of

AD are evident during the preclinical stage, and that a number of these in-

dices showed a progressive decline through later clinical stages of the dis-

ease. Translation of these striking observations into simple and specific

markers, of language change in AD could have far-reaching clinical conse-

quences.

P2-261 PREDICTING DEMENTIA IN DOWN SYNDROME:

STUDY OFA PORTUGUESE COHORT

Paula Breia1, Ros�ario Mendes1, Ana Silvestre1, Maria Jo~ao Goncalves2,

Maria Jo~ao Figueira2, Regina Bispo3, 1Hospital Garcia de Orta, Almada,

Portugal; 2Cercizimbra, Sesimbra, Portugal; 3ISPA - Instituto Universit�ario

de Ciencias Psicol�ogicas, Sociais e da Vida, Lisboa, Portugal. Contact

e-mail: apaulabreia@hotmail.com

Background: Adults with Down syndrome (DS) may frequently present

cognitive deterioration, personality, mood and behavior changes, which

are often related to early signs of dementia.Methods: The aim of this study

is to determine the presence of early signs of dementia in a Portuguese sam-

ple of institutionalized DS patients. The sample comprises 16 adults with

DS, aged between 26 and 50 years. They were initially assessed using the

Plymouth Dementia Screening Checklist (PDSC) and the Global Deteriora-

tion Scale (GDS) with follow-up 12 months later. Collected data were sta-

tistically analyzed. Results: The results of the initial assessment show