Why Study Skeletal Problems
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Why Study Skeletal Problems • Skeletal disease reduce the mass and quality of bone • They cause millions of fractures/year and costs tens of billions of dollars in therapy and rehabilitation • A 25% mortality rate within a year in older subjects who experience a hip fracture due to secondary ailments • A 50-year old Caucasian female has a higher chance of dying due to a fracture than due to breast cancer! • Although many new therapies have been developed, they often have serious side effects • Require reliable, non-invasive diagnostic tools to determine the need for and duration of therapy
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Why Study Skeletal Problems. Skeletal disease reduce the mass and quality of bone They cause millions of fractures/year and costs tens of billions of dollars in therapy and rehabilitation - PowerPoint PPT Presentation
Transcript of Why Study Skeletal Problems
Why Study Skeletal Problems• Skeletal disease reduce the mass and quality of bone• They cause millions of fractures/year and costs tens of
billions of dollars in therapy and rehabilitation• A 25% mortality rate within a year in older subjects who
experience a hip fracture due to secondary ailments• A 50-year old Caucasian female has a higher chance of dying
due to a fracture than due to breast cancer!• Although many new therapies have been developed, they
often have serious side effects• Require reliable, non-invasive diagnostic tools to determine
the need for and duration of therapy
Structure of Bone
Damage to Bone
Vibrational Assessment
How to do Physics I
How to do Physics II
How to do Physics III
Modeling
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Computations
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Experiments
Figure 5: Dynamic analysis of bone samples at various stages of bone loss indicated by amount of BMD.
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Normal BoneOsteopenic Bone
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Fig u r e 7 : Dy n a mi c A n a l y si s of bo n e c ub e s a t
f our s t ag e s o f b o ne l o s s . P hy si ca l m ode ls o f th e
mi c r o- C T s can s we r e b u il t us in g r ap i d
p r ot o t y p i ng .
Summary
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0 200 400 600 800 1000 1200Frequency [Hz]Acceleration [m/sec^2]
Normal BoneOsteopenic Bone
QuickTime™ and aGraphics decompressor
are needed to see this picture.QuickTime™ and a
Graphics decompressorare needed to see this picture.
Fig u r e 7 : Dy n a mi c A n a l y si s of bo n e c ub e s a t
f our s t ag e s o f b o ne l o s s . P hy si ca l m ode ls o f th e
mi c r o- C T s can s we r e b u il t us in g r ap i d
p r ot o t y p i ng .
