Whats new in Colon Cancer and Pancreatic cancer in 2021
Transcript of Whats new in Colon Cancer and Pancreatic cancer in 2021
![Page 1: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/1.jpg)
Whats new in Colon
Cancer and Pancreatic
cancer in 2021Warren Brenner M.D
![Page 2: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/2.jpg)
![Page 3: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/3.jpg)
![Page 4: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/4.jpg)
![Page 5: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/5.jpg)
![Page 6: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/6.jpg)
![Page 7: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/7.jpg)
![Page 8: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/8.jpg)
![Page 9: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/9.jpg)
![Page 10: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/10.jpg)
![Page 11: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/11.jpg)
![Page 12: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/12.jpg)
![Page 13: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/13.jpg)
![Page 14: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/14.jpg)
Molecular Subtypes
• BRAF V600E - 7% of CRC- more aggressive - FDA
approved options that target BRAF
• Her2 - about 3% of CRC - numerous agents in clinical
trials testing anti Her2 agents
• KRAS - early clinical trials looking at drugs targeting KRAS
- preliminary testing in CRC
![Page 15: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/15.jpg)
![Page 16: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/16.jpg)
![Page 17: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/17.jpg)
![Page 18: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/18.jpg)
![Page 19: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/19.jpg)
![Page 20: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/20.jpg)
Treatment
• If disease resectable - surgery
• Folfirinox chemotherapy is standard of care following surgical resection
• If high risk disease usually chemotherapy +- radiation followed by
possible surgery
• Metastatic disease - folfirinox and gemcitabine/abraxane are standard
frontline options
• 5FU + liposomal irinotecan approved for second line if failed prior
gemcitabine based regimen
• Multiple trials ongoing looking at different agents usually in combination
with chemotherapy
![Page 21: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/21.jpg)
![Page 22: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/22.jpg)
![Page 23: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/23.jpg)
![Page 24: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/24.jpg)
![Page 25: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/25.jpg)
![Page 26: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/26.jpg)
![Page 27: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/27.jpg)
![Page 28: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/28.jpg)
![Page 29: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/29.jpg)
![Page 30: Whats new in Colon Cancer and Pancreatic cancer in 2021](https://reader033.fdocuments.net/reader033/viewer/2022061414/629e4610956d050629154d58/html5/thumbnails/30.jpg)