What is dose painting?

download What is dose painting?

of 37

  • date post

    15-Jan-2016
  • Category

    Documents

  • view

    46
  • download

    0

Embed Size (px)

description

What is dose painting?. Barbara Vanderstraeten Ghent University Hospital 19 January 2008. Outline. Introduction Technical solution Planning studies Conclusions. I. Introduction. Imaging for RT. From V Grégoire. Anatomical imaging. CT MRI. Biological imaging. PET SPECT fMRI MRSI. - PowerPoint PPT Presentation

Transcript of What is dose painting?

  • What is dose painting?Barbara VanderstraetenGhent University Hospital19 January 2008

  • OutlineIntroductionTechnical solutionPlanning studiesConclusions

  • I. Introduction

  • Imaging for RTFrom V Grgoire

  • Anatomical imaging

    CTMRI

  • Biological imaging

    PETSPECTfMRIMRSIBrainTumor

  • Tumor biology characterizationS Apisarnthanarax and KSC Chao. Radiat Res 2005;163:1-25.

  • Biological imaging for RTImprovement of diagnostic and staging accuracyGuidance of target volume definition and dose prescriptionEvaluation of therapeutic response

  • Target volume definitionGross tumor volume (GTV)Clinical target volume (CTV)Planning target volume (PTV)

  • Biological target volume (BTV)CC Ling, J Humm, S Larson et al. Int J Radiat Oncol Biol Phys 2000;47:551-60.

  • Dose painting

  • Dose painting by contours

  • Dose painting by contoursKSC Chao, WR Bosch, S Mutic et al. Int J Radiat Oncol Biol Phys 2001;49:1171-82.

  • Dose painting by contoursKSC Chao, WR Bosch, S Mutic et al. Int J Radiat Oncol Biol Phys 2001;49:1171-82.

  • Dose painting by contours18F-FDG-PET-guided dose painting in head and neck cancer: phase I clinical trial (41 patients)I Madani, W Duthoy, C Derie et al. Int J Radiat Oncol Biol Phys 2007;68:126-35.

  • Dose painting by numbers

  • Dose painting by numbersBiologically Conformal Radiation Therapy

  • II. Technical solution

  • Relationship between signal intensity and radiation dose

  • Treatment plan optimizationB Vanderstraeten et al. Phys Med Biol 2006;51:N277-86

  • Treatment plan evaluationQVH

  • Example: 18F-FDG-PET-guided BCRT for oropharyngeal cancer

  • Example: 18F-FDG-PET-guided BCRT for oropharyngeal cancer

    Data

    2.5 Gy/fx3 Gy/fx

    PTV_69_whbu_0.6cmspinal_cord_exp_5mmparotid_rightQVHPTV_69_whbu_0.6cmspinal_cord_exp_5mmparotid_rightQVH1565

    010001000100010001000100010001008450

    2.5558811002.5558811002.5558811000.0053391003.1306611003.1306611003.1306611000.005833100

    5.1117611005.1117611005.1117611000.0106781006.2613221006.2613221006.2613221000.011665100

    7.6676421007.6676421007.66764298.70.0160171009.3919821009.3919821009.39198296.80.017498100

    10.22352210010.22352210010.223522980.02135510012.52264310012.52264310012.52264392.40.023331100

    12.77940310012.77940310012.77940395.30.02669410015.65330410015.65330410015.65330488.20.029164100

    15.33528310015.33528310015.33528391.50.03203310018.78396510018.78396510018.78396584.90.034996100

    17.89116410017.89116410017.89116488.40.03737210021.91462510021.91462510021.91462580.90.040829100

    20.44704410020.44704410020.44704485.70.04271110025.04528610025.04528610025.04528678.50.046662100

    23.00292510023.00292510023.00292582.30.0480510028.17594710028.17594710028.17594774.30.052494100

    25.55880510025.55880510025.55880579.60.05338910031.30660810031.30660810031.30660871.60.058327100

    28.11468610028.11468610028.11468678.20.05872810034.43726810034.43726810034.43726869.30.06416100

    30.67056710030.67056710030.670567750.06406610037.56792910037.56792910037.56792967.20.069993100

    33.22644710033.22644710033.22644772.40.06940510040.6985910040.6985910040.6985965.70.075825100

    35.78232810035.78232810035.78232869.90.07474410043.82925110043.82925110043.82925163.60.081658100

    38.33820810038.33820810038.33820867.90.08008310046.95991210046.95991210046.95991261.70.087491100

    40.89408910040.89408910040.89408966.70.08542210050.09057210050.09057299.950.09057259.40.093323100

    43.44996910043.44996910043.44996964.70.09076110053.22123310053.22123399.853.22123357.30.099156100

    46.0058510046.0058510046.0058563.20.096110056.35189410056.35189499.756.35189455.60.104989100

    48.5617310048.5617310048.5617360.90.10143910059.48255510059.48255599.759.48255553.20.110821100

    51.11761110051.11761110051.11761158.60.10677710062.61321510062.61321599.762.613215520.116654100

    53.67349110053.67349199.953.67349157.20.11211610065.74387610065.74387699.665.743876500.122487100

    56.22937210056.22937299.856.22937255.50.11745510068.87453710068.87453799.668.87453748.30.12832100

    58.78525310058.78525399.858.78525354.20.12279410072.00519810072.00519899.572.00519847.20.134152100

    61.34113310061.34113399.861.34113352.90.12813310075.13585910075.13585999.575.13585945.60.139985100

    63.89701410063.89701499.763.89701451.20.13347210078.26651910078.26651999.278.26651944.10.145818100

    66.45289410066.45289499.766.45289449.50.13881110081.3971810081.3971898.981.39718430.15165100

    69.00877510069.00877599.669.00877548.20.14414910084.52784110084.52784193.184.52784141.80.157483100

    71.56465510071.56465599.671.56465547.40.14948810087.65850210087.65850285.187.65850240.70.163316100

    74.12053610074.12053699.674.12053646.50.15482710090.78916210090.78916278.290.78916239.60.169149100

    76.67641610076.67641699.576.67641645.20.16016610093.91982310093.91982372.493.91982339.10.174981100

    79.23229710079.23229799.579.23229744.20.16550510097.05048410097.0504846897.05048438.70.180814100

    81.78817710081.78817799.481.78817742.80.170844100100.181145100100.18114564.3100.18114537.30.186647100

    84.34405810084.34405899.384.34405841.70.176183100103.311805100103.31180559.6103.31180536.40.192479100

    86.89993910086.89993999.286.89993940.90.181522100106.442466100106.44246655106.44246635.30.198312100

    89.45581910089.45581998.889.45581940.20.18686100109.573127100109.57312750.2109.57312733.90.204145100

    92.011710092.011798.692.011739.60.192199100112.703788100112.70378845112.70378832.50.209978100

    94.5675810094.5675898.494.5675839.20.197538100115.834449100115.83444937.8115.83444930.90.21581100

    97.12346110097.12346198.397.12346138.40.202877100118.965109100118.96510930118.96510929.40.221643100

    99.67934110099.67934198.399.67934137.60.208216100122.09577100122.0957723.2122.09577280.227476100

    102.235222100102.23522298.3102.235222370.213555100125.226431100125.22643118.2125.22643126.80.233308100

    104.791102100104.79110295.8104.79110236.10.218894100128.357092100128.35709213.1128.35709225.70.239141100

    107.346983100107.34698386.5107.34698335.50.224232100131.487752100131.4877529.2131.48775224.90.244974100

    109.902864100109.90286477.2109.90286434.40.229571100134.618413100134.6184135.7134.61841323.50.250807100

    112.458744100112.45874470112.45874433.10.23491100137.749074100137.7490743.9137.749074220.256639100

    115.014625100115.01462565.8115.01462531.80.240249100140.879735100140.8797352140.87973520.90.262472100

    117.570505100117.57050560.4117.57050530.40.245588100144.010396100144.0103961.3144.01039618.60.268305100

    120.126386100120.12638653.8120.12638629.40.250927100147.141056100147.1410560.3147.141056170.274137100

    122.682266100122.68226648.3122.68226628.20.256266100150.271717100150.2717170.1150.27171715.90.27997100

    125.238147100125.23814742.2125.23814727.20.261605100153.402378100153.4023780153.40237814.40.285803100

    127.794027100127.79402738.1127.79402726.40.266943100156.533039100156.5330390156.53303912.60.291636100

    130.349908100130.34990831.4130.34990825.90.272282100159.663699100159.6636990159.66369910.30.297468100

    132.905788100132.90578825.4132.90578824.90.277621100162.79436100162.794360162.794368.30.303301100

    135.461669100135.46166919.4135.46166924.10.28296100165.925021100165.9250210165.9250216.40.309134100

    138.01755100138.0175514.6138.0175523.20.288299100169.055682100169.0556820169.0556825.10.314966100

    140.57343100140.5734311140.5734322.30.293638100172.186342100172.1863420172.1863423.90.320799100

    143.129311100143.1293117.2143.12931120.70.298977100175.317003100175.3170030175.3170033.30.326632100

    145.685191100145.6851915.1145.68519119.40.304316100178.447664100178.4476640178.4476642.60.332464100

    148.241072100148.2410723.2148.24107218.20.309654100181.578325100181.5783250181.5783252.10.338297100

    150.796952100150.7969521.7150.79695217.10.314993100184.708986100184.7089860184.7089861.80.34413100

    153.352833100153.3528330.8153.352833160.320332100187.839646100187.8396460187.8396461.70.349963100

    155.908713100155.9087130.3155.908713140.325671100190.970307100190.9703070190.9703071.20.355795100

    158.464594100158.4645940158.46459412.20.33101100194.10096899.8194.1009680194.10096810.361628100

    161.020474100161.0204740161.0204749.60.336349100197.23162999.5197.2316290197.2316290.80.367461100

    163.576355100163.5763550163.57635580.341688100200.36228999.2200.3622890200.3622890.40.373293100

    166.132236100166.1322360166.1322366.50.347026100203.4929598203.492950203.492950.20.379126100

    168.688116100168.6881160168.6881165.50.352365100206.62361196206.6236110206.6236110.10.384959100

    171.243997100171.2439970171.2439975.30.357704100209.75427293.5209.7542720209.7542720.10.390792100

    173.799877100173.7998770173.7998774.80.363043100212.88493387.7212.8849330212.88493300.396624100

    176.355758100176.3557580176.3557584.10.368382100216.01559376.9216.0155930216.01559300.402457100

    178.911638100178.9116380178.9116383.90.373721100219.14625462.5219.1462540219.14625400.40829100

    181.467519100181.4675190181.4675193.60.37906100222.27691550.3222.2769150222.27691500.414122100

    184.023399100184.0233990184.0233993.20.384399100225.40757640225.4075760225.40757600.419955100

    186.57928100186.579280186.579282.80.389737100228.53823633.6228.5382360228.53823600.425788100

    189.13516100189.135160189.1351620.395076100231.66889727.4231.6688970231.66889700.431621100

    191.691041100191.6910410191.6910411.80.400415100234.79955823.7234.7995580234.79955800.437453100