WHAT ARE THE MAJOR DRAWBACKS OF CONVENTIONAL CHEMOTHERAPEUTIC AGENTS?
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WHAT ARE THE MAJOR DRAWBACKS OF CONVENTIONAL CHEMOTHERAPEUTIC AGENTS?. 1. 2. 1. POOR SELECTIVITY. LOW THERAPEUTIC INDEX. 2. DRUG RESISTANCE. TARGETED AGENTS IN ANTICANCER CHEMOTHERAPY. ONCOGENE ACTIVATION. ONCOGENE ACTIVATION. TUMOR SUPPRESSOR INACTIVATION. 1) Point mutation. p53. - PowerPoint PPT Presentation
Transcript of WHAT ARE THE MAJOR DRAWBACKS OF CONVENTIONAL CHEMOTHERAPEUTIC AGENTS?
TARGETED AGENTS IN ANTICANCER CHEMOTHERAPY
ONCOGENE ACTIVATION
ONCOGENE ACTIVATION
TUMOR SUPPRESSOR INACTIVATION
p53
TUMOR SUPPRESSOR INACTIVATION
Locus 9p21
TUMOR SUPPRESSOR INACTIVATION
Protein-protein interactions
TUMOR SUPPRESSOR INACTIVATION
Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448–457 10.1038/ncponc0558
Table 1 Examples of oncogene addiction: studies in mice
Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448–457 10.1038/ncponc0558
Table 2 Examples of oncogene addiction: studies in human cancer cell lines
Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448–457 10.1038/ncponc0558
Table 3 Clinical evidence of oncogene addiction
% B inhibition % B inhibition
Cellula normale
Cellula tumorale
PTEN
INIBITORI DI mTOR
effetti lievi
attività PI3K/Akt/mTOR
attività PI3K/Akt/mTORPTEN
Cellula normale
Cellula tumorale
BRCA1riparazione
BRCA1
SSBDSB
BER
HR
riparazioneSSBDSB
BER
HRInstabilità genomica
Cellula normale
Cellula tumorale
BRCA1
riparazione
BRCA1
SSBDSB
BER
HR
SSBDSB
BER
HR
INIBITORI DI PARP
DSB riparazioneHR
INIBITORI DI PARP
DSBHR
Cellula normale
Cellula tumorale
Rb
Rb
attività E2F espressione gene A
espressione gene B
espressione gene topoisomerasi II
espressione gene C
VELENI DELLA TOPO II
SOPRAVVIVENZA
blocco attività E2F
INHIBIT GENE EXPRESSION
INHIBIT PROTEIN FUNCTION
AS-ODN siRNA mAbs Small molecule inhibitors
