Welcome to Retreat 2010
description
Transcript of Welcome to Retreat 2010
![Page 1: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/1.jpg)
Welcome to
Retreat 2010
Center of Biomedical Research Excellence inIntegrated Nutrition and Metabolic Processes
![Page 2: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/2.jpg)
Introduction toThe Center of Biomedical Research Excellence in
Integrated Nutrition and Metabolic Processes
Concetta C. DiRusso, Ph.D.Department of Nutrition and Health Science
Department of BiochemistryUniversity of Nebraska - Lincoln
![Page 3: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/3.jpg)
Why has food been villanized?
“Our menu is divided into three sections: Cancer causing foods, artery clogging foods,
and foods that are being boycotted for political reasons.”
![Page 4: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/4.jpg)
Why has fat been villanized?
![Page 5: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/5.jpg)
(*BMI 30)
Hispanic
State-specific Prevalence of Obesity* Among U.S. Adults, by Race/Ethnicity, 2006-2008
White non-Hispanic
Black non-Hispanic
![Page 6: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/6.jpg)
![Page 7: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/7.jpg)
NAFLD, Nonalcoholic fatty liver disease
![Page 8: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/8.jpg)
Health Consequences of Obesity
* Coronary heart disease and Stroke * Type 2 diabetes * Cancers (endometrial, breast, and colon) * Hypertension * Dyslipidemia (high total cholesterol or triglycerides) * Liver and Gallbladder disease * Sleep apnea and respiratory problems * Osteoarthritis * Immune dysfunction
![Page 9: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/9.jpg)
![Page 10: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/10.jpg)
?
?
Genetics
Nutrition
Activity
Behavior
Economics
![Page 11: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/11.jpg)
Adipose tissue doesn't respond to insulinSends out toxic compounds:
High levels of fatty acidsSignals of inflammation, “Adipokines”
1Obesity
5Atherosclerosis
Muscle
Muscle doesn't respond to insulinBurns fatty acids but also stores fat Blood glucose levels rise
2
Pancreas
Pancreas tries to make more insulin but is confused by both high glucose and high free fatty acids in blood. Cells begin to die from toxic fat and “adipokines”
4Liver responds to high blood glucose levels
Makes more fatMakes more cholesterolStops clearing cholesterolMakes blood clotting factors
3Liver
![Page 12: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/12.jpg)
*
Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications. Stickel and Hellerbrand Online version Gut 2010;59:1303-1307
Cancer
![Page 13: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/13.jpg)
The “thrifty genotype” hypothesis
According to the "thrifty genotype" hypothesis, the same genes that helped our ancestors survive occasional famines are now being challenged by environments in which food is plentiful year round.
Genetics
![Page 14: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/14.jpg)
Yourka, et al PNAS October 19, 2010 vol. 107 pp. 18226-18231
Normal Weight Obese
Gastric Bypass
Observed shifts in gut microbial populations with obesity
![Page 15: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/15.jpg)
and also….Tame your gut microbial community
![Page 16: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/16.jpg)
![Page 17: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/17.jpg)
Biomedical research
Metabolic engineering, production
and marketing of food
Education, behavioral
science, epidemiology
Improved health
outcomes and quality
of life
A New Paradigm for Nutrition-related Disease Research
Integrate Collaborate Translate
![Page 18: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/18.jpg)
“Strengthening and diversifying the pool of researchers who are dedicated to understanding and ameliorating obesity and its many adverse outcomes is a priority for NIH.
This commitment includes attracting and training a cadre of researchers with a wide range of knowledge and skills, such as expertise in the basic, clinical, behavioral, and social sciences...”
NIH Obesity Research Task Forcestrategic plan:
![Page 19: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/19.jpg)
[1] Expand the biomedical infrastructure to link research on nutrition, biofortification of foods, and healthy eating practices;
[2] Increase the research profile
[3] Build research infrastructure
[4] Mentor talented young faculty to become prominent members of the scientific community
The objectives of the CINMP for NU
![Page 20: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/20.jpg)
Acquisition of independent NIH or other major federal funding
Publication of manuscripts in prominent peer-reviewed journals
Active participation in professional societies Service on peer-review panels and editorial
boards Speaking at national and international scientific
conferences Mentoring students and post-doctoral fellows
The objective of mentoring is to guide success in tenure track faculty line particularly in research
![Page 21: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/21.jpg)
Support within the CINMP
[1] Strong mentorship team composed of internationally recognized NU faculty led by a dedicated director
[2] External advisory board made up of outstanding leaders in the fields of biomedical, nutrition, and behavioral research
[3] Robust institutional commitment and support
“I'm a great believer in luck, and I find the harder I work the more I have of it.” Thomas Jefferson
![Page 22: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/22.jpg)
Gut microbiology and immunologyHepatic and gastrointestinal
metabolism and metabolic regulationBiofortification of foods through
breeding and genetic engineeringPopulation based interventions in
nutritional practices
CINMP Phase I Focus Areas
![Page 23: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/23.jpg)
Possible CINMP Phase II Focus Area Expansion Nutrient-to-Neuronal signaling and regulation
[gut-hypothalamic axis] Dietary influences on cardiovascular fitness
and performance Genetics/epigenetics of obesity and
comorbidities microRNAs in regulation of nutrient-dependent
gene expression Nutritional enhancement for improved
digestion and absorption Population based interventions in nutritional
practices
![Page 24: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/24.jpg)
Formulating a Budget Total budget cannot exceed $1.5 Million per year
for 5 years Core facilities [Computational and Translational] Administrative core Projects Mentor Stipends External Advisory Board Members travel and
honorarium Symposia, website, outreach Seed Grants
![Page 25: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/25.jpg)
We are here!
![Page 26: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/26.jpg)
Vice Chancellor for Research,
Prem Paul
CINMP Director, Concetta DiRusso
Terry T-K Huang,
Co-investigator
Edgar Cahoon, Co-investigator
Melanie Simpson
Andrew Benson
Paul N. Black
Jennifer Larsen
Thomas Clemente
External Advisory
Board
Mentoring TeamLeadership Team Project Investigators
DeansChairs
Project 1Edward Harris
Project 2Jens Walter
Project 3Daniel Peterson
Project 4Phyllis Nsiah-Kumi
Project 5[Biofortification of food
crops]
CINMP Human Resources
![Page 27: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/27.jpg)
Peterson
Walter
HarrisHire 1
Nsaih-Kumi
Team 1 New Investigators
Immunology
Microbiology
BiochemistryMetabolism
AgriEngineering
Behavioral Science
![Page 28: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/28.jpg)
ACTION PLAN
![Page 29: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/29.jpg)
ACTION PLAN
![Page 30: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/30.jpg)
CINMP: Broadening and Integrating Its Impact
Innovation Campus
Public Policy
Educ
ation
Extension
Basic Science
Business and
Marketing
Education and
Outreach
Public Private Partnerships
Translational Research
![Page 31: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/31.jpg)
AFRI CoBRE
REUT32
IGERT
RO1, P01NSF, USDA,
others
Biomedical and
epidemiological research
Plant metabolic
engineering
Education, production
and marketing
Improved health
outcomes
CINMP: Research expansion and longevity of the Center
![Page 32: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/32.jpg)
CINMPUNL/UNMCNational Public Health PolicyGlobal Health
Center’s Ultimate Impact
![Page 33: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/33.jpg)
![Page 34: Welcome to Retreat 2010](https://reader030.fdocuments.net/reader030/viewer/2022012902/5681638c550346895dd47cfd/html5/thumbnails/34.jpg)
MOVE EAT FOOD