Steven Dubinett, MDDirector, Clinical and Translational Science Institute Associate Vice Chancellor and Senior Associate Dean, Translational Research

NIH/ Career Development Award WorkshopJuly 25, 2013

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UCLA CTSI Clinical and Translational Science Institute

www.ctsi.ucla.edu

Create an academic home for translational science

Advance team science

Train the next generation of translational scientists

Build bi-directional community partnerships

Promote inter-institutional collaborations

UCLA CTSI Goals

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NIH CTSA Consortium

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UCLA translational investigation extends from molecules to society

Translating knowledge gained from laboratory science into clinical practice to improve health.

The aim of translational research is to produce new:

• therapeutics• medical devices• tools for diagnosing disease• avenues for community engagement research

What is translational research?

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1) Clinical and Community Research Resources (CCRR)

2) Biomedical Informatics Program (BIP)

3) Community Engagement in Research Program (CERP)

4) Pilot and Collaborative Translational and Clinical Studies Programs (Pilot)

5) Research Education, Training and Career Development Program (CTSI-ED)

Program Areas (1-5)

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6) Biostatistics and Computational Biology Program

7) Center for Translational Technologies (CTT)

8) Maternal, Child and Adolescent Health (MCAH)

9) Regulatory Knowledge, Industry Relations and Research Ethics Program (Regulatory)

10) Evaluation & Tracking

Program Areas (6-10)

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Opportunity Funds Grant Amount

Duration of Award (Years)

Award Cycle

Application Due Date

KL2 Awards: to pursue interdisciplinary, mentored research with training

Up to $125,000 in salary and

research support

1 year at 75% effort(renewable for up to 3

years)

July 1 RFA to be released in

Jan 2014

Full application: late Feb 2014

TL1 Translational Science Fellowship: PhD candidates in the Department of Health Policy and Management in the UCLA Fielding School of Public Health receive mentored training to ensure the translational nature of their dissertation projects

Annual stipend plus funding for

health insurance,

tuition/fees, and training-related

travel

Renewable for up to 4

years

Annual UCLA School of Public Health application deadline is Dec 1, 2014

TL1 Summer Program for Professional Students: provides professional students (medical, nursing and dental) early exposure to interdisciplinary, community-partnered translational or health services research

Summer stipend plus funding for training-related

expenses

The summer between

student’s first and second

year (8 weeks)

June 1 March 28, 2014

Early Career Awards

Assistant Professor, CDU

“ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice”

Amira Brown, MS, PhDAmira Brown, MS, PhD

Assistant Professor, Pediatric Nephrology, UCLA

“ Hepcidin and the Anemia of Chronic Kidney Disease”

Joshua Zaritsky, MD, PhDJoshua Zaritsky, MD, PhD

Assistant Professor of Medicine, UCLA/VA

“ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults”

Gelareh Gabayan, MD, MSHSGelareh Gabayan, MD, MSHS

KL2 Y1 Awardees

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Assistant Professor, UCLA-Harbor / LA-BioMed

“Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization”

James McKinnell, MDJames McKinnell, MD

Assistant Professor, UCLA

“Modeling of EMT/MET transitions in breast cancer stem cells”

Mary Sehl, MD, PhDMary Sehl, MD, PhD

Assistant Professor, UCLA

“Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer”

David Shackelford, PhDDavid Shackelford, PhD

KL2 Y2 Awardees

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Assistant Professor, UCLA

“Understanding the relationship between adolescent identity and substance use”

Rebecca Dudovitz, MD, MSHSRebecca Dudovitz, MD, MSHS

Assistant Clinical Professor, Cedars-Sinai Medical Center

“Role of IL1-ß and the NLRP3 inflammasome in the development of hypoxemia in acute lung injury”

Heather Jones, MDHeather Jones, MD

Assistant Professor, UCLA

“Single fraction vs. multiple fraction radiation for patients with advanced cancer and painful bone metastases”

Anne Walling, MD, PhDAnne Walling, MD, PhD

KL2 Y3 Awardees

Clinical Instructor, UCLA

“Mechanisms Of Allograft Injury And The Development Of Bronchiolitis Obliterans Syndrome After Lung Transplantation”

Michael Shino, MDMichael Shino, MD

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Assistant Clinical Professor, UCLA

“Relationship of physical activity to hippocampal structure and memory in MCI”

David Merrill, MD, PhDDavid Merrill, MD, PhD

Assistant Professor, UCLA

“Gene expression profiles of ECT response in major depressive disorder”

Eliza Congdon, PhDEliza Congdon, PhD

Assistant Professor, Cedars-Sinai Medical Center

“Minimizing errors in medication histories obtained at hospital admission”

Joshua Pevnick, MD, MSHSJoshua Pevnick, MD, MSHS

KL2 Y3 Awardees

Assistant Professor, Charles Drew University of Medicine and Science

“Sensitization of castration-resistant prostate tumors to docetaxel treatment by green tea and quercetin”

Piwen Wang, MD, PhD, MSPiwen Wang, MD, PhD, MS

Ambulatory Clinical Research Facilities at Westwood

•7 private rooms, infusion rooms, 2 procedure rooms

•>20,000 sq ft outpatient area

•Clinical and Research Sleep Center

•Interview and conference rooms

•Scatter Specialty Unit

•Service center with pharmacy and sample processing

•23 hour capacity

CTSI-Wide Accomplishments

•Clinical support for existing research projects

•119 new protocols

•8,137 out-patient & 744 in-patient stays across the CTSI

•Implemented cost-sharing model with waivers or reduced rates for new investigators

Clinical and Translational Research Center (CTRC)

Biostatistical Consults · Core Services · Pilot Funding · CTSI Activities

13banner “Cite It” card

posters newsletters

Quarterly publication

awards

Biostatistical Consults•1267 projects for 611 investigators

Vouchers•Awarded 230 proposals ($2.2 M)

Pilot funding•Awarded 195 pilot grants for total of $6.45 M($3.65 M in CTSI funds; $2.8 M institutional funds)•Return of $26 M

CTSI Activities• 20 proposals funded for total of $80 M ($88 M pending)• Rapid Response Team: supported 23 collaborations• Office of Investigator Services: 744 consults

More than 430 publications prior to January 2013

University of California, Los Angeles

CTSA Regional Consortia

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• A committee of the CTSA PIs at UC Davis, San Diego, San Francisco, Irvine and Los Angeles

• Initial focus on contracting, informatics and IRBs

• Drug discovery and development

• Biobanking and global consent

• Future inclusion of UCLA CTSI partner institutions including LA county health system

UC Biomedical Research Acceleration Integration and Development (UC-BRAID)

16banner “Cite It” card

newsletters

UCLA

UC Davis

UC San Francisco

UC Irvine

UC San Diego

Los Angeles

UCLA xData Repository · Los Angeles Data Repository · UC Research Exchange

UC Research Exchange (UC-ReX)

Los Angeles Data Repository (LADR)

UCLA xData Repository (xDR)

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UC Research Exchange (UC-ReX)UC Research Exchange (UC-ReX)

UC Biomedical Research Acceleration Integration and Development (UC-BRAID)

fact

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Adapted from W. Stead et al, Academic Medicine, Vol. 84, No. 4 / April 2011

1990 2000 2010 2020

Clinical data

Human cognitive capacity

Genetics and proteomics10

100

1000

Augmenting human cognitive capacity in translational research

imagingimaging

pathologypathology

activities of daily livingactivities of daily living

clinical outcomesclinical outcomes

DNADNA

RNARNA

epigeneticsepigenetics

proteinsproteins

computational computational medicinemedicine

universe of universe of clinical dataclinical data

computationalcomputationalbiologybiology

symptomssymptoms

clinical laboratoryclinical laboratory

monitored datamonitored data

A model of computational medicine

behaviorsbehaviors

time

predictionmedicine

data

Investigations in Prediction Medicine

population based

evaluations

Katzan and Rudick. Time to integrate clinical and research informatics. Science Transl Med 2012

UC Research Exchange (UC-ReX)UC Research Exchange (UC-ReX)