Welcome!. IRAP? interleukin 1receptor antagonist proteininterleukin 1receptor antagonist protein...
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Transcript of Welcome!. IRAP? interleukin 1receptor antagonist proteininterleukin 1receptor antagonist protein...
Welcome!Welcome!
IRAP?IRAP?
• interleukin interleukin 1receptor 1receptor antagonist proteinantagonist protein
• brandname of brandname of technology used to technology used to obtain obtain Autologous Autologous Conditioned SerumConditioned Serum (ACS)(ACS)
What does Interleukin1(IL-1) do?What does Interleukin1(IL-1) do?
Following joint injury there is up Following joint injury there is up regulation of synthesis of IL-1regulation of synthesis of IL-1
IL-1 drives IL-1 drives • PainPain• InflammationInflammation• DegenerationDegeneration
What's The Big Deal?What's The Big Deal?
100% non chemical 100% non chemical – uses the body‘s – uses the body‘s own treatment own treatment mechanismmechanism
EffectiveEffective SafeSafe
Irap SyringeIrap Syringe
Sterile AcquisitionSterile Acquisition
IRAP syringe is IRAP syringe is used to draw fresh used to draw fresh venous blood from venous blood from the horsethe horse
Mild sedation Mild sedation allows a higher allows a higher yield (proportion of yield (proportion of plazma to red cells plazma to red cells is higher)is higher)
24 hour Incubation24 hour Incubation
WWhite blood cells hite blood cells produce produce therapeutic therapeutic proteinsproteins through through their physical their physical contact with the contact with the glass beads during glass beads during incubation at 37°Cincubation at 37°C
CentrifugationCentrifugation
Sterile ProcessingSterile Processing
Filtering into Syringes & FreezingFiltering into Syringes & Freezing
Injecting into Joint(s)Injecting into Joint(s)
Controlled studiesControlled studies
Benefits of ACSBenefits of ACS
100% autologous100% autologous antiinflammatoryantiinflammatory relieves painrelieves pain regenerativeregenerative all components are in physiological all components are in physiological
concentration onlyconcentration only all components act synergistically -> more all components act synergistically -> more
effectiveeffective safe: so far not a single infectionsafe: so far not a single infection
• Horses which have a well diagnosed arthritis condition with no specific pathology such as osteo-chondral bone fragments, OCD lesions, etc.
• In addition those horses that have had hyaluronic acid (HA) and/or cortico-steroids with little or no improvement.
For what type of problems ?
Post ArthroscopyPost Arthroscopy
Post-Arthroscopy joints with cartilage lesions and scratches but not totally destroyed cartilage areas.
Post SurgeryPost Surgery
Maintenance therapy for those horses with more severe joint disease
German RecommendationsGerman Recommendations
Amount: 2-8 ml depending on size of Amount: 2-8 ml depending on size of jointjoint
Frequency: every 4-8 or 8-16 daysFrequency: every 4-8 or 8-16 days Repetitions: 0- 3X (i.e. 1-4 injections Repetitions: 0- 3X (i.e. 1-4 injections
in a row)in a row) Our experience – stifles require Our experience – stifles require
higher volume – 10-15 mlhigher volume – 10-15 ml
Cost?Cost?
1.1. IRAP syringe, sample acquisition, IRAP syringe, sample acquisition, incubation, centrifugation & filtration incubation, centrifugation & filtration into multiple syringes for immediate into multiple syringes for immediate and future injection.and future injection.
2.2. Injection fee: sterile scrub, filtering Injection fee: sterile scrub, filtering IRAP, sterile joint injection +/-antibiotic, IRAP, sterile joint injection +/-antibiotic, sedation, bandagingsedation, bandaging