PATENTABILITY SEARCH-Quick(Basic Report)

SAMPLE REPORT

Client Ref. No.: XXXXXXXXXX TPSF Ref. No: XXXXXXXXXX

For: Client

May 11, 20XX

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Client Logo

Thank you for allowing us to conduct your search!

Your search fell into one of the categories highlighted below. Please read the description of the category before taking (or not taking) any further steps.

Category 1: A thorough search was conducted, but no relevant patents were found. No further recommendations are made.

Category 2: A thorough search was conducted, and a few close references were found. These are categorized in three primary groups. The “Relevant” group discloses all the features explicitly, the “Related” group appears to disclose some of the features but not all, and the “Interesting” group that appear to be related in some way but are mostly provided to illustrate surrounding technologies. (Note that the “Related” group may also include some “Relevant” group patents. Category 3: A thorough search was conducted, and a few references were found. These are categorized in three primary groups. The “Related” group appears to disclose some of the features but not all, and the “Interesting” group that appear to be related in some way but are mostly provided to illustrate surrounding technologies. (Note that the “Related” group may also include some “Relevant” group patents). The references in this category should be reviewed carefully by the client for relevance, as the inference drawn by us is subjective to our understanding and is done to provide the best case scenario, the client may interpret the references in a different way.

Category 4: A thorough search was conducted and a few references were also identified but a further search in a different jurisdiction is recommended for potentially better results..

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Table of Content

1 SEARCH OVERVIEW & BACKGROUND.................................................................................42 SEARCH SCOPE....................................................................................................................5

2.1 Objective of the Search................................................................................................5

2.2 Assumptions.................................................................................................................5

2.3 Data Sources................................................................................................................ 5

3 METHODOLOGY..................................................................................................................64 SEARCH STRATEGY..............................................................................................................7

4.1 Term Set.......................................................................................................................7

4.2 Search Strings...............................................................................................................9

4.3 Relevant Classes Identified.........................................................................................10

4.4 Glossary of Specific Search Operators Used...............................................................10

5 RELEVANCE CRITERIA........................................................................................................115.1 Relevant Results.........................................................................................................11

5.2 Related Results...........................................................................................................11

5.3 Interesting Results......................................................................................................11

6 SEARCH RESULTS...............................................................................................................126.1 Key Features to be mapped.......................................................................................12

6.2 Details of Search Results............................................................................................13

6.2.1 Relevant Patent Results....................................................................................13

6.2.2 Related Patent Results......................................................................................16

6.2.3 Relevant Non-Patent Results............................................................................17

6.2.4 Interesting Results............................................................................................18

7 NON-DISCLOSURE.............................................................................................................198 DISCLAIMER......................................................................................................................19

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1 SEARCH OVERVIEW & BACKGROUND

Client asked TPSF to conduct a Prior Art Search to identify patent and non-patent references that could affect the patentability of the invention related to Camel Antibodies.

TPSF has gone through the invention and developed the following understanding:

A Phage-displayed library of dromedary camel single heavy domain antibodies (sdAbs) which selectively bind to Helicobacter pylori urease (HPU).

From the said library, four highly reactive sdAbs were selected, sequenced and grafted into a heavy chain antibody Fc region sequence of IgG2 isotype. The full heavy chain antibodies are active against gastritis and are resistant to stomach acidity and temperature.

The product is intended to be used in oral therapy of human gastritis caused by Helicobacter pylori in different dosage formulas.

TPSF carried out the search as per the following variant chosen by the client:

VARIANT COVERAGE SEARCH LANGUAGE

QuickPatent Search in US, EP and WO [All Full Text]

EnglishNon-Patent Search

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2 SEARCH SCOPE

2.1 Objective of the Search

The objective of our search was to identify reference(s) disclosing:

Production of recombinant Heavy Chain Antibodies; wherein, the process comprises selecting, sequencing and grafting of dromedary camel derived sdAbs into heavy chain antibody Fc region sequence of IgG2 isotype.

Recombinant Full Camel Heavy Chain Antibodies with selective binding to Helicobacter pylori urease.

Use of Recombinant Full Camel Heavy Chain Antibodies for the treatment of gastritis in human by oral administration.

2.2 Assumptions

Assumptions1. Questel Orbit database was used for conducting Patent searches.2. Google, Scholar, Science-Direct, PubMed and PubChem were used for conducting non-patent searches.3. The term 'Patent' has been used as a collective term for Patents and Published Applications.4. The comprehensiveness of this search has been governed by the upper cap on the effort to be invested.5. This search has been carried out as per our Quick Variant and covers US, EP and WO jurisdictions using keywords in English language.

2.3 Data Sources

Patent Sources Non-patent SourcesFor Bibliographic Data (including title, abstract):Questel OrbitEspacenetGoogle Patents

For Non-Patent Searches:Google ScholarScience-DirectPubMedPubChem

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3 METHODOLOGY

The following methodology was adopted for performing the Patentability Search:

Methodology

Task Details OutputStep I Understanding

TPSF developed a thorough understanding of the technology area and client’s requirements to prepare a strategy for the search.

A preliminary strategy for the search was prepared including keyword-based search, citations search, assignee/inventor name search

Step II aKeyword-based Patent Searching

TPSF generated a list of keywords to be used for conducting the patent and non-patent search, as per the preliminary search strategy. Further, the list of search strategy was used to perform patent searches on Questel Orbit patent databases. The patents obtained from the search were analysed to identify relevant/related patents.

A set of relevant/related patents

Step II bClass-based Searching

TPSF conducted searches using relevant classes, such as IPC/CPC/ECLA etc., with broad keywords to identify additional patents relevant to the domain.

A set of relevant/related patents

Step II cPatent Citations Searching

TPSF conducted Spider citation analysis for relevant/related patents obtained from the steps II a & b.

A set of relevant/related patents

Step IIIAssignee Based Searching

TPSF conducted searches using potential assignees in the field of the study.

A set of relevant/related patents

Step IVNon-Patent Searching

The search strings prepared for the patent search were modified to adapt to syntax of non-patent searches. Searches were carried out on different non-patent databases to obtain a list of non-patent references matching the keyword criteria. These non-patent references were screened on the basis of free-information (mostly abstract).

A set of relevant/related non-patent references

Step VReport Preparation

An MS Word document containing the project overview, search strategy, relevance criteria and the results was prepared.

MS Word Report

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4 SEARCH STRATEGY

The following search strings, some combinations and/or some syntactical variations of them were used to conduct searches on Questel Orbit to extract patents for analysis or extract other relevant information to assist in searching.

Similarly, syntactical variations of these strings were run on non-patent databases as well.

4.1 Term Set

Keyword Based Search

Term Set Keywords

Single Heavy Domain Antibody Term Set

(Single D heavy D domain D (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR (single D domain 3D (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR sdAbs OR Nanobody OR ((antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+)) 5D (single W monomeric W variable W antibody+ W domain+)) OR (Camel+ W Single 2W Domain W Antibod+) OR (camel+ W antibod+) OR (camel+ W heavy 2W chain W variable 2W domain W (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR (heavy W chain W (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR ((“VHH” OR VHsquare+) 2D (fragment+ OR antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR (single W domain W heavy W chain W (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+)))

Full Size Heavy Chain Antibody Term Set

((immuno OR immune) W globulin+) OR (HcAb) OR (full W size W heavy W chain W (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR (heavy W chain W (antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+))) OR Antibod+ OR ((recombinant OR engineer+) D (Antibod+ OR immunoglobulin OR ((immuno OR immune) W globulin+)))

Gastritis Term Set

Gastritis OR ((inflammat+ OR irritat+ OR erosion OR acid+ OR burn+ OR damag+) 5D (stomach OR (gastric W mucosa) OR (gastrointestinal W tract) OR GIT OR abdomen+ OR abdomin+)) OR gastroenteritis OR ((abdomen+ OR abdomin+ OR stomach OR belly) 2D (pain OR upset)) OR indigestion OR dyspepsia OR ((Peptic OR gastric OR stomach OR duodenal) 2D ulcer+)

Helicobacter Pylori Urease Term Set

(((Helicobacter W pylori+) OR (“H” D Pylori+)) D urease) OR ((Helicobacter OR Campylobacter) W pylori+) OR (“H” D Pylori+) OR Helicobacter+ OR (Helicobacter W urease) OR (((Gram W negative) OR microaerophilic) D bacteri+) OR Helicobacteraceae OR Proteobacteria OR Epsilonproteobacteria OR Campylobacterales OR urease

Oral Route Term Set((oral+ OR mouth OR buccal+ OR sublingual+) 2D (route OR administer+ OR administr+ OR dose OR therap+ OR treat+ OR deliver+)) OR Pill+ OR tablet+ OR capsule+

IgG2 Term Set IgG2 OR (“Ig” W “G2”) OR ((immunoglobulin+ OR ( immun+ W

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globulin+)) W (“G2” OR (gamma OR Angebot OR gamme ))) OR (recombinant W "IgG") OR (Immunoglobulin+ W “G” W “2” ) OR (gamma 2D immunoglobulin+) OR (("IgG" W “2”) W (isotype W antibod+)) OR igG

Dromedary Term Set

dromedar+ OR ((Arabian OR Indian) W camel+) OR (Camelus W dromedar+) OR camel+ OR Camelidae OR Camelus OR (Camelus W aegyptiacus W Kolenati) OR (africanus W Gloger) OR (arabicus W Desmoulins) OR (dromas W Pallas) OR (dromos W Kerr) OR (ferus W Falk) OR (lukius W Kolenati) OR (polytrichus W Kolenati) OR (turcomanichus) OR (vulgaris W Kolenati)

Grafting Term SetGraft+ OR insert+ OR fus+ OR combin+ OR integrat+ OR transplant OR implant+ OR transfer+ OR join+ OR attach+ OR engraft+ OR fix+ OR conjoin+ OR hybrid+

Antibody Term Set

+protein+ OR +peptid+ OR antibod+ OR immunoglobulin+ OR ((immuno OR immune) W globulin+) OR monoclonal OR polyclonal OR ((mono OR poly) W clonal) Or Ig OR ab OR abs OR mab OR mabs OR iga OR igg OR iggs Or igd OR igds OR ige OR iges OR igm OR igms OR Fab OR Fabs OR Fv OR Fvs OR scFv OR scFVs Or “VH” OR “VL” OR (variable W (heavy OR light)) OR (single W chain W variable) Or ((heavy OR light) W chain+) OR HcAB OR HcABs OR (antigen W (bind+ OR specifi+)) OR CDR OR CDRs OR (complement+ W determin+ W region+ ) OR CDR1 OR CDR2 OR CDR3 OR CDR1s OR CDR2s OR CDR3s OR ((variable OR hypervariable) W region+) OR slg OR mlg OR slgs OR mlgs OR ((gamma OR mu OR alpha OR epsilon OR delta Or kappa OR lambda) W chain+)

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4.2 Search Strings

S. No. Search String

1Title, Abstract, Claims(Single Heavy Domain Antibody P Full Size Heavy Chain Antibody) AND (Gastritis) AND (Helicobacter Pylori Urease)

2Title, Abstract, Claims(Single Heavy Domain Antibody P Full Size Heavy Chain Antibody) AND (Grafting) AND (IgG2)

3Title, Abstract, Claims(Single Heavy Domain Antibody P Full Size Heavy Chain Antibody) AND (Gastritis) AND (Oral Route)

4Title, Abstract, Claims(Single Heavy Domain Antibody P Full Size Heavy Chain Antibody) AND (Dromedary)

5Title, Abstract, Claims (Single Heavy Domain Antibody) AND (Full Size Heavy Chain Antibody) AND (Helicobacter Pylori Urease)

6Full Patent Specification(Antibody) AND (Dromedary) AND (Helicobacter Pylori Urease)

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Full Patent Specification(Antibody) AND (Gastritis)ANDAny Classification C07K-016/12

8 Any Classification C07K-2317/00

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Full Patent Specification(Full Size Heavy Chain Antibody) AND (Helicobacter Pylori Urease) AND (Dromedary)ANDAny Classification C07K-016/00

10 Citation Searching

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4.3 Relevant Classes Identified

The following Classes were used in combination with the term sets provided above:

Class Definitions

C07K 16/12 CHEMISTRY; METALLURGY --> Immunoglobulins, e.g. monoclonal or polyclonal antibodies --> against material from bacteria

C07K 2317/00 CHEMISTRY; METALLURGY --> PEPTIDES-->Immunoglobulins specific feautures

C07K-016/00CHEMISTRY; METALLURGY --> Immunoglobulins, e.g. monoclonal or polyclonal antibodies

4.4 Glossary of Specific Search Operators Used

Operators Definitions

+ Any number of characters

nW Search for words in the same sentence and appearing within n words of one another, in the written order. If n is omitted, the number defaults to one

nD Search for words in the same sentence and appearing within n words of one another, but in either order. If n is omitted, the number defaults to one

S Search terms occur in the same sentence

P Search for words in the same paragraph

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5 RELEVANCE CRITERIA

References identified from the search were manually analyzed and tagged as relevant, related and interesting. Provided below is the description of each category:

5.1 Relevant Results

Those patent and non-patent references were considered as Relevant that disclosed: The production of recombinant Heavy Chain Antibodies; wherein, the process comprises

selecting, sequencing and grafting of dromedary camel derived sdAbs into heavy chain antibody Fc region sequence of IgG2 isotype.

Use of recombinant Full Camel Heavy Chain Antibodies with selective binding to Helicobacter pylori urease for the treatment of gastritis in human by oral administration.

5.2 Related Results

Those non-patent references were considered as Related that disclosed: The single domain antibodies or nanobodies derived from camelid that are linked to Fc

portion of IgG2. Delivery of the single domain antibodies or nanobodies prepared to the gastrointestinal

tract by oral administration.

5.3 Interesting Results

Those patents and Non patent references that appeared to be potentially related; however, these could not be categorized as relevant or related and thus were marked as Interesting Results. Note that this list has just been provided to give you an idea of what else exists in the art and is not meant to be comprehensive.

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6 SEARCH RESULTS

6.1 Key Features to be mapped

The following pointers have been identified based on the features of the client disclosure. All the relevant and/or related results identified in the search are mapped on these key features to properly depict their significance.

1. Process for producing recombinant Heavy Chain Antibodies; wherein, the process comprises selecting, sequencing and grafting of dromedary camel derived sdAbs into heavy chain antibody Fc region sequence of IgG2 isotype.

2. Said Recombinant Full Camel Heavy Chain Antibodies have selective binding to Helicobacter pylori urease.

3. Use of said Recombinant Full Camel Heavy Chain Antibodies for the treatment of gastritis in human by oral administration.

For Summary of Search Results, please click here.

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6.2 Details of Search Results

6.2.1 Relevant Patent ResultsThis is the list of most relevant hits available in the art for the given invention identified in the search. Please note that the focus was on identifying the closest hits and not on identifying all the hits comprehensively. Accordingly, the list might not be comprehensive and there might be more documents that are similar (i.e., having the equal or slightly lower relevance) to the documents listed below. Also, the search is restricted to English language and US, EP and WO jurisdictions.

1. WO2013166594A1

Title Publication Date

Filing Date Priority Date

Inventor/ Author

Assignee

HETEROMULTIMER CONSTRUCTS OF IMMUNOGLOBULIN HEAVY CHAINS WITH MUTATIONS IN THE FC DOMAIN

14 NOV, 13 10 MAY, 13 10 MAY, 12 SPRETER ET AL.

ZYMEWORKS INC

Abstract:Provided herein are isolated heteromultimers comprising: at least one single domain antigen-binding construct attached to at least one monomer of a heterodimer fc region; wherein the heterodimer fc region comprises a variant ch3 domain comprising amino acid mutations that promote the formation of said heterodimer with stability comparable to that of a native fc homodimer; and wherein said isolated heteromultimer is devoid of immunoglobulin light chains and optionally devoid of immunoglobulin ch1 region. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

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2. WO2006056306A2

TitlePublication Date Filing Date

Priority Date

Inventor/ Author Assignee

HEAVY CHAIN AND DOMAIN ANTIBODIES

01 JUN, 06 03 NOV, 05 25 NOV, 04 FRENKEN ET AL

UNILEVER NV,

Abstract:The present invention relates to heavy chain immunoglobulins or fragments thereof of the vhh or vnar type, or domain antibodies (dabs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the vhh or vnar type, or domain antibodies (dabs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the vhh or vnar type, or domain antibodies (dabs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.

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3. WO2004041867A2

Title Publication Date

Filing Date Priority Date

Inventor/ Author

Assignee

METHOD OF ADMINISTERING THERAPEUTIC POLYPEPTIDES, AND POLYPEPTIDES THEREFOR

21 MAY, 04 07 NOV, 03 10 JAN, 03 SILENCE ET AL

VAN BERGEN EN HENEGOUWEN PAUL,ABLYNX

Abstract:The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using vhh polypeptides derived from camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention furthers a method for delivering therapeutic molecules to the interior of cells. The invention further relates to anti-IgE therapeutic molecules.

4. US2013136744A1

TitlePublication Date

Filing Date

Priority Date

Inventor/ Author Assignee

METHOD OF ADMINISTERING THERAPEUTIC POLYPEPTIDES, AND POLYPEPTIDES THEREFORCAMELIDAE ANTIBODIES AGAINST IMMINOGLOBULIN E AND USE THEREOF FOR THE TREATMENT OF ALLERGIC DISORDERS

30 MAY, 13 7 FEB, 2013

8 NOV, 02

SILENCE ET AL

VAN BERGEN EN HENEGOUWEN PAUL ,ABLYNX

Abstract:In one aspect, the invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention further relates to anti-IgE therapeutic molecules.In one aspect, the present invention relates to a method wherein an immunoglobulin single variable domain (such as a Nanobody) and/or construct thereof are absorbed in pulmonary tissue. More particularly, the invention provides systemic delivery of an immunoglobulin single variable domain and/or construct thereof via the pulmonary route.

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6.2.2 Related Patent Results

This is the list of most related hits available in the art for the given invention identified in the search. Please note that the focus was on identifying the closest hits and not on identifying all the hits comprehensively. Accordingly, the list might not be comprehensive and there might be more documents that are similar (i.e., having the equal or slightly lower relevance) to the documents listed below. Also, the search is restricted to English language and US, EP and WO jurisdictions.

5. US20100136018A1

Title Publication Date

Filing Date Priority Date

Inventor/ Author

Assignee

ANTI-FC-RECEPTOR SINGLE DOMAIN ANTIBODIES (NANOBODIES-TM) AND THERAPEUTIC USE

3 JUN, 10 20 DEC, 07 20 DEC, 06 DOLK EDWARD, ET

AL

ABLYNX

Abstract:The present invention relates to amino acid sequences that are directed against (as defined herein) receptors for proteins with an immunoglobulin fold (Fc receptors), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.

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6.2.3 Relevant Non-Patent Results

This is the list of most relevant hits available in the art for the given invention. Please note that the focus was on identifying the closest hits and not on identifying all the hits comprehensively. Accordingly, the list might not be comprehensive and there might be more documents that are similar (i.e., having the equal or slightly lower relevance) to the documents listed below. Also, the search is restricted to English language and US, EP and WO jurisdictions.

6. Non-Patent Result 1

TitlePublication Date

Journal Details (publication volume, page number etc.)

Inventor/ Author

Affiliation

A NOVEL NANOBODY AGAINST UREASE ACTIVITY OF HELICOBACTER PYLORI.

03 APR, 13 VOLUME 17, ISSUE 9, PAGES E723-E728.

ARDEKANI ET AL DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCE, SHAHED UNIVERSITY, TEHRAN, IRAN.

Abstract:Background: Helicobacter pylori infection is associated with gastritis and in some cases with gastric and duodenal ulcers and even adenocarcinoma. Antibiotic therapy has significant limitations, such as the high cost and the emergence of antibiotic-resistant strains, generating the need for new treatments. The administration of antibody against H. pylori is a new effective therapeutic strategy. In this study, we successfully developed a single-variable domain of heavy chain antibody against recombinant UreC.Methods: A VHH phagemid library was constructed from immune camel heavy chain antibodies. The nanobodies were displayed on M13 phage. Library selection was performed against UreC recombinant protein. A specific single-variable domain of heavy chain antibody against UreC was screened in five rounds of panning. The nanobody with the highest score in the phage ELISA was selected for soluble expression. The nanobody was purified with a nickel–nitrilotriacetic acid (Ni–NTA) column and confirmed with sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting. Affinity, specificity, and urease inhibitory properties of the nanobody were assayed.Results: Here we showed the isolation and purification of a specific nanobody with high affinity against UreC recombinant protein that can inhibit urease activity.Conclusions: The isolated UreC nanobody can specifically detect and bind to UreC and inhibit urease activity. This nanobody could be a novel class of treatment measure against H. pylori infection.

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6.2.4 Interesting Results

This list is just indicative in nature to give you some idea of what else is available in the art. Note that the list is not meant to be comprehensive.

1. WO2013038203A1

Title Publication Date

Filing Date Priority Date

Inventor/ Author

Assignee

THERMOSTABLE ASSAY REAGENTS

21 MAR, 13 14 SEP, 12 14 SEP, 11

SUTTON, JOHN MARK;

SKIPPER, PHILIP JAMES

ALISTER

HEALTH PROT AGENCY;

SUTTON JOHN MARK;

SKIPPER PHILIP JAMES

ALISTERAbstract:There is provided a single-chain fusion protein comprising :(i)a thermostable kinase and(ii)a single-domain antibody or single-domain antibody fragment. There is also provided a method of preparing a single-domain antibody or single-domain antibody fragment, the method comprising :(i) expressing the single- domain antibody or antibody fragment as a single-chain fusion protein with a thermostable kinase, in a host cell such as E.coli; and (ii)purifying the fusion protein from the cytoplasm of the host cell.

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7 NON-DISCLOSURE

The Patent Search Firm or any subsidiary of The Patent Search Firm (Together, “The Patent Search Firm "), or any of their directors, officers, employees, agents or representatives (Together, "PERSONNEL") promise that all client information shall be treated as confidential material, where no part of your information will be used for any purpose whatsoever outside of the intended purpose of completing the search.  The Patent Search Firm will neither use, nor cause others to use, nor divulge to third parties un-affiliated with The Patent Search Firm, all or any part of your information, in any way, without your express written consent.

8 DISCLAIMER

The novelty search for the invention has been conducted based only on the keywords listed in the document which in turn have been derived from the key features of the invention mentioned in the document. Furthermore, the information contained herein has been obtained from data sources believed to be reliable. The Patent Search Firm disclaims all warranties as to the accuracy, completeness or adequacy of such information. No opinion is expressed or implied. Finally, the search results identified are only up to the date of this report. You should consider the search to be a reasonable expenditure of time and money to determine the patentability of the invention in view of the search results. The Patent Search Firm strives to ensure the accuracy and completeness of our research services. However, because of the subjective nature of such research and possible incomplete data supplied to us, we cannot warrant that our search reports are 100% complete or error-free.

Neither The Patent Search Firm nor any of their PERSONNEL provides legal services or legal advice in any part of the world. Since The Patent Search Firm is not a law firm, it does not and cannot render legal services or legal advice to the general public and is not engaged in the practice of law.

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