WATER SOLUBLE VITAMINS

Dr Vijay Marakala MBBS.,MD.Assistant professor

BiochemistrySIMS&RC

WATER SOLUBLE VITAMINS

BIOTIN

BIOTIN - CHEMISTRY

Imidazole ring

Thiophene ring Valeric acid

BIOTIN - SOURCES

It is widely distributed in

the foods

Liver, kidney, vegetables and

egg yolk are important

source

Biotin also synthesized by

intestinal bacteria

BIOTIN - RDA

RDA 20=30µg/day

BIOTIN - ABSORPTION

It is absorbed in the small

intestine and reaches liver

and other tissues through

circulation

BIOTIN - FUNCTIONS

Biotin is a coenzyme of carboxylase

reactions

4 enzymes in the body require

biotin

BIOTIN - FUNCTIONS

Acetyl CoA carboxylase

Propionyl CoA carboxylase

Pyruvate carboxylase

β Methyl crotonyl CoA carboxylase

BIOTIN

BIOTIN DEFICIENCY

Biotin deficiency is rare in humans because it is present in most of the common foods.

However experimentally induced biotin deficiency symptoms in man are dermatitis, alopecia, depression, muscular pain and anemia

BIOTIN - ANTAGONISTS

AVIDIN