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Walter Reed National Military Medical CenterDirectorate for Professional Education
Department of Research Programs
Introduction to Research at WRNMMC
Marina Borovok, PhDHead of Research Education,
Department of Research Programs, WRNMMC
September 2011
Research Course 2Research Course 2
Disclosure Statement :
This CE/CME activity
does not have commercial support,
and has no conflicts of interest.
2011
Research Course 3Research Course 3
Learning Objectives
1. Describe clinical research and the research process steps
2. Discus research at WRNMMC and it’s unique opportunities.
3. Know about research support available at WRNMMC.
4. Recognize IT tools that support research collaboration and communication from anywhere at any time.
2011
LO 1: Describe clinical research and the research process steps
Before you start your research at WRNMMC, you need to do the following THREE steps:
Step 1: Obtaining a DKO/AKO account
Step 2: Registering with IRBNet, e-portal for publications and protocol submission.
Step 3: Completion of CITI training
2011 Research Course 4
5
Research Cue Card
2011 Research Course
Step 1: Obtaining a DKO/AKO accountAKO/DKO platform for research purposes
What is AKO?
Army Knowledge Online (AKO) is the world's largest and secure electronic platform.
AKO is currently serving over 2.26 million users.
What is DKO?
Defense Knowledge Online (DKO) is an information sharing network required by the Department of Defense to support secure access to information (portal).
DKO is using AKO as a platform.
2011 Research Course 6
7
MANY Benefits of DKO1. Universal Email in the .mil environment.
2. Virtual workspace (telework) any time especially in times of national disaster (Sept 11, Pandemic, etc) or exercises (example: DCO)
3. Virus and Spam scanning for over 3 Billion messages per year.
4. Provides access to over 2K free training courses via JKO, etc.
5. Use AKO/DKO credentials to access MyPay, Tricare Online and over 1,200 other DOD applications that use AKO/DKO SSO services.
6. If you have Internet access, you can access AKO/DKO securely from anywhere at any time
7. Centralized Helpdesk (open 24/7) supporting 2.26M users and over 1,200 DoD applications.
8. Use AKO/DKO Portal as a Virtual Thumb Drive ensuring files and folders needed are available regardless of location.
9. Social capabilities such as milSUITE allow you to find new people working on similar projects or with similar interests.
10. Communicate with anyone in DoD via IM, eMail, video messaging.
11. Over 50K deployed US Armed Forces members use AKO/DKO while deployed to many places worldwide.
2011 Research Course
AKO/DKO platform for research purposes The Defense Medical Research Network (DMRN)
For better management of research processes, The Defense Medical Research Network (DMRN) was created. It is a DoD-wide web-based networking solution for all your research management, compliance and oversight needs. Located on AKO/DKO platform at: https://www.us.army.mil/suite/page/596540
IRBNet
IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols.
IRBNet entry is available through DMRN page that located on AKO/DKO site.
2011 Research Course 8
Step 1: Obtaining a DKO/AKO account
Go to the Defense Medical Research Network (DMRN)page on DKO/AKO website at https://www.us.army.mil/suite/page/596540
Cue Card Reference:
2011 Research Course 9
Step 1: Obtaining a DKO/AKO account(cont.)
Login using your AKO/DKO username and password
Research Course 102011
Step 1: Obtaining a DKO/AKO account(cont.)
Research Course 11
You are at the DMRN site at https://www.us.army.mil/suite/page/596540
Click on the IRBNet Entry button
2011
Step 1: Obtaining a DKO/AKO account(cont.)
Research Course 12
Instructions are at the RCRS websitehttps://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx.
Questions? Contact Ms. Dale Gregory 301 295-8239 [email protected]
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Step 2: Registering with IRBNet, e-portal for publications and protocol submission.
Cue Card Reference:
Instructions are at the RCRS websitehttps://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx.
2011 Research Course 13
Step 2: Registering with IRBNet, e-portal
for publications and protocol submission (cont.)
Questions?
Please contact Mr. Luis Calvo
301 295-2269.
2011 Research Course 14
Step 3: Completion of CITI trainingCue Card
Reference:
Principal Investigators, Associate Investigators, Research Staff, as well as anyone coming into contact with Human Subjects or involved with the consent process or study design are required to complete this course.
Research Course 152011
Step 3: Completion of CITI training
The course is available at https://www.citiprogram.org
First Time Users need to register athttps://www.citiprogram.org/enroll/courseregistration1.asp?language=english.
Questions?
Contact Dr. Marina Borovok 301 295-2876
[email protected] Course 162011
Now you are done with the registrations and training.
What is next?
Research Course 172011
Next steps: 4-5The entire research writing process can be divided
into easily manageable and clear steps:
STEP 4: Develop a Research Question
Select a topic
Discuss Research Ideas
Find Sources to support your ideas
STEP 5: Submit your proposal via
Proposal Approval
Funding (if needed)
18Research Course
Step 4: Develop Research Question Good research question: could the "FINER" criteria be applied to it?
F- Feasible. Is the question answerable? Do you have access to all the materials you will need to do the study?
Do you have access to enough subjects? Will you have enough time and money? Do you have the expertise to do this study or can you collaborate with
someone who does?
I- Interesting. The question has to be interesting to the investigator, but should also be interesting to others.
N- Novel. Has this study been done before? Does it add to the current body of medical knowledge?
E- Ethical. Risk/benefit ratio? Can the study be done with a minimal risk? Will an IRB approve the study?
R- Relevant. Will it further medical science? Will the results change clinical practice, health policy or point towards further avenues of research?
If your question fails on any one of these 5 criteria, it is probably not worth putting much effort into.
STEP 4: Good research question (cont.)
Readings: • Designing clinical research: an epidemiologic approach,
3rd ed., by Stephen B. Hulley, et.al.Lippincott Williams & Wilkins, 2007ISBN: 07-8178210-4;
• Research begins with the question.http://familymed.uthscsa.edu/facultydevelopment/elearning/ResearchQuestions.swf
2011 Research Course 20
Step 4: Research topic selection
Cue Card
Reference:
In order to do that you need to consult with your Department Chair/Supervisor/Mentor.
Need help to choose your Mentor?
Please contact Dr. Marina Borovok
at [email protected], 301 295-2876.
2011 Research Course 21
Step 4: Research topic selection (cont.)In case if you need HELP
2011 Research Course 22
Choose your mentor, and ask him/her to help. INTERNET Web resource :
http://nnmcresearch.wikispaces.com/NNMC-USUHS+Mentorship+Project
Step 4: Research topic selection (cont.) New: Protocol Outreach Program
• Protocol Outreach Program to discuss research ideas and roadmap:– Clinician, statistician, regulatory reviewer, laboratory scientist– 45 min appointments for research ideas and roadmap. More information will be provided by Dr. Klote (Module 6), and Dr. Bernstein (Module 7).
• To schedule an appointment please contact Ms. Dale Gregory at
301 295-8239, or [email protected]
2011 Research Course 23
Step 5: Protocol submission via
2011 Research Course 24
Submission instructions are available on the IRBNet portal, under Forms and Templates.
Questions? Contact DRP 301 295-8239 [email protected]
Cue Card Reference:
Next steps are: Proposal Approval (SRP,IRB approval),
Funding (if needed).
These steps will be successful if you worked on the Research Protocol with help of the WRNMMC specialists
(Step 4)
2011 Research Course 25
Research Funding
Information on Research Funding is provided
By Dr. Kaminsky (Day 2, Module 9).
2011 Research Course 26
IMPORTANT TO REMEMBER !!!
Cue Card Reference:
You may not begin your research until
you have received
an IRB Approval and Approval Letter
from the Commander, WRNMMC.
2011 Research Course 27
The National Capital Region Military Medical Centers POCs:
Walter Reed National Military Medical Center DRP
(WRNMMC) ,
301 295-8239
Malcolm Grow Medical Center (MGMC),
IRB Office Cheryl James 240-857-8216
The Uniformed Services University (USU),
Research Office Maggie Pickerel 301-295-0819
2011 Research Course 28
Questions?
2011 Research Course 29
LO 2: Discus research at WRNMMC and it’s unique opportunities
Research at WRNMMC
WRNMMC’s goal remains to promote excellence in health care and militarily relevant research and human subject protection.
Department of Research Programs (DRP)
Human subject protection, research compliance and integrity; research administration, support, funding, publication and education.
https://nnmcintra/SiteDirectory/RCRS/default.aspx
2011 Research Course 30
Research Course 31Research Course 31
Research at WRNMMC
Current research efforts at WRNMMC are ongoing:
head injury/TBI, stroke,
colon, breast cancer, leukemia and lymphoma,
investigational chemotherapy,
virtual colonoscopy,
diabetes management,
infectious disease,
dental imaging.
2011
Open Protocols at WRNMMCList is available on the Intranet at:https://nnmcintra/SiteDirectory/RCRS/Lists/Open%20Protocols/AllItems.aspx?View=%7b40123BB7%2dBE3A%2d4899%2d9423%2dB28C17B522E1%7d
Go to the Department of Research programs (DRP)) Intranet site at https://nnmcintra/SiteDirectory/RCRS/default.aspx
and click on Open Protocols
2011 Research Course 32
Questions?
2011 Research Course 33
LO 3: Know about research support available at WRNMMC.
WRNMMC Research Resources
Research Integrity Resources
Department of Research Programs (DRP),
Darnall Biomedical Learning Resource Center
Research Protocol/Publication Help,
Education/Mentoring Resources,
Protocol Outreach Program
ICEBERG,
IT tools.
2011 Research Course 34
Research Integrity Resources It is a policy of WRNMMC that all personnel will uphold highest principles of ethics
promoting research integrity and the responsible conduct of research (RCR).
RCR RESOURCES (web links):
TEXT
On Being A Scientist, National Academy of Sciences Committee on the Conduct of Science, 3rd Ed.,
Also available on the web at http://www.nap.edu/openbook.php?isbn=0309119707
DVD “THE LAB”
an interactive educational DVD has been developed by ORI for education regarding research misconduct.
Also available on the web at http://ori.dhhs.gov/TheLab,
RCRS site at https://nnmcintra/SiteDirectory/RCRS/default.aspx (under the RCRS links),
WEB RESOURCES PROVIDED ON THE DRP WEBSITE (INTRANET) at:https://nnmcintra/SiteDirectory/RCRS/default.aspx (under DRPLinks):
RESEARCH INTEGRITY
THE LAB: Interactive Movie on Research Misconduct
AVOID PLAGIARISM: 26 Guidelines at a glance
Research Ethics Resources provided by The Navy Medicine Institute
On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition (2009)
35
Research Integrity Resources (cont.)
ANTI-PLAGIARISM SOFTWARE TURNITIN
Web-based, http://turnitin.com/static/index.php
Free access available to the WRNMMC researchers.
Ask Ann Holman to help with Turnitin registration:
301-319-8411, [email protected]
Example of report : slide # 64
RESEARCH INTEGRITY DISCUSSIONS
ETHICS ROUNDTABLE: FRIDAYS (once/month, 1200-1300)
By Darnall Biomedical Learning Resource Center (Formerly Stitt Library)
https://nnmcintra/SiteDirectory/Darnall/Lists/Calendar/calendar.aspx
2011 Research Course 36
Department of Research Programs (DRP)
Cue Card Reference:
2011 Research Course 37
DRP information• DEPARTMENT OF RESEARCH PROGRAMS (DRP)
Bldg. 17, 3rd floor, suite 3C
DRP Chief LTC Klote, MD, MC [email protected]
301 295-8271 (no voicemail)
Questions: 301 295-8239,
or e-mail [email protected]
DRP Intranet https://nnmcintra/SiteDirectory/RCRS/default.aspx
2011 Research Course 38
Darnall Biomedical Learning Resource Center (DBLRC)
Bldg. 1, 3 rd floor, room 3458, ph. 301-295-1184
• Hours Monday-Thursday 0700-1730Friday 0700-1600
• Online Access is available via Athens.
Athens Registration : https://register.athensams.net/nnmc/
Ask Ann Holman to help with Athens registration
301-319-8411, [email protected]
• After Hours Access is availableContact Ann Holman at [email protected],
or visit the Circulation Desk to sign up for an access account,
and we'll contact you when your card is ready.
Library Access Card
2011 39Research Course
Darnall Biomedical Learning Resource Center (DBLRC)
Intranet
https://nnmcintra/SiteDirectory/Darnall/default.aspx
Stitt Internet
http://www.bethesda.med.navy.mil/professional/stitt_library
Questions: 301 295-1184
2011 Research Course 40
Research Protocol/Publication Help*Literature Search:
Comprehensive DB specialist: Mr. Fredric Simms, MLS
[email protected] 301 295-0080
Reference Librarian:
Kimberly D. Adams, M.A., M.S., M.L.S.
[email protected] 202-782-6547
*Statistical Data Analysis:
Audrey Chang, PhD 301-295-8263, [email protected]
Robin Howard, MA 301-295-8235 [email protected]
Francois O. Tuamokumo, PhD
301 319-8788 [email protected]
*These specialists provide hands-on workshops.
2011 Research Course 41
Education/Mentoring Resources
Head of Research Education: Marina Borovok, PhD
[email protected] 301 295-2876
Cue Card Reference:
2011 Research Course 42
Educational Resources
Research Course: 9 CME/CE, 2 days (0700-1200)
Next 2011 Research Course: November 8-9, 2011
Course PP slide show is available at: https://nnmcintra/SiteDirectory/RCRS/default.aspx
(under DRP Research School)
2011 Research Course 43
Educational Resources
Hands-on Research Preparation CourseApril-December, 2011, once/month, noon-1400.
Next Class is on September 27, 2011(session on IRB registration)
Location: Bldg. 57, ROOM 1214-B
Next Meeting Dates: 9/27, 10/13, 11/17, 12/15
This course provides participants with the practical skills required for writing a research proposal, completing research project, submitting research results to the WRNMMC Research Competition and a peer- reviewed journal in their specialty field.
2011 Research Course 44
Educational resources (cont.) PubMed Search Course
Developed and presented by the National Library of Medicine
2011 DATES: Tentative dates: 10/20, 12/2
TIME: 0900 - 1115
LOCATION: WRNMMC, Bldg 57, room 1214 B
COURSE GOAL
To provide guidelines for PubMed search, and teach researchers how to perform searches on their own.
REGISTRATION: PLEASE CONTACT Ms. Ann Holman: 301-319-8411, or via e-mail [email protected]
Research Course 452011
PubMed LINKS
The PubMed links are posted on the Intranet:
RCRS and Darnall Center websites
DRP website https://nnmcintra/SiteDirectory/RCRS/default.aspx
Darnall Center Website https://nnmcintra/SiteDirectory/Darnall/default.aspx
Research Course 462011
Research Course 47Research Course 47
Hands-on Educational WORKSHOPS
Workshops are offered all year long at WRNMMC on a per-request basis.
Topics:
• Literature Search by Mr. Fredric Simms
• Statistical Analysis by Dr. Tuamokumo, Dr. Chang, and Ms. Howard
Please contact our specialists to schedule a workshop
2011
Protocol Outreach Program
To discuss research ideas and roadmap:– Clinician, statistician, regulatory reviewer, laboratory scientist– 45 min appointments for research ideas and roadmap. More information will be provided by Dr. Klote (Module 6), and Dr. Bernstein (Module 7).
• To schedule an appointment please contact Ms. Dale Gregory at
301 295-8239, or [email protected]
2011 Research Course 48
MENTORSHIP RESOURCESWRNMMC-USUHS mentorship initiative
• USUHSIf you are looking for a mentor in the specific areas of research, clinicalwork, education, professional development, please contact mentorshiprepresentatives at USUHS, and they will help you to find a mentor from theUSUHS mentorship network:
Andrew Waters, Ph.D ([email protected]) Chair of Research Committee
Dr. Jennifer Rusiecki ([email protected]) or Dr. Barbara Knollman ([email protected]) Co-chairs of Faculty Mentoring Committee
• WRNMMCIf you are looking for a mentor in the specific areas of military research,please contact research mentorship representative at WRNMMC:
Marina Borovok, PhD ([email protected])Head of Research Education.
On the web:
http://nnmcresearch.wikispaces.com/NNMC-USUHS+Mentorship+Project
2011 Research Course 49
MENTORSHIP RESOURCESInterdepartmental Collaborative Bethesda
Research Group
2011 Research Course 50
http://nnmcresearch.wikispaces.com/
MISSIONHelp WRNMMC to become a premier research organization in the Department of Defense.
Questions?
2011 Research Course 51
Research Course 52Research Course 52
ResourcesIT tools: Turnitin
Turnitin is a Plagiarism Prevention Software.
Website: http://www.turnitin.com/static/index.html
• Plagiarism Prevention: Instantly identifies papers containing unoriginal material.
• Peer Review: Participants can review and respond to their colleagues' work online.
2011
Research Course 53Research Course 53
Resources: IT toolsTurnitin http://turnitin.com/static/index.php
Example of report
2011
Research Course 54Research Course 54
Resources: IT toolsIRBNet
www.irbnet.org
• IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols.
• IRBNet is secure, web-based, and easy to use.
2011
2011 Research Course 55
LO 4: Recognize IT tools that support research collaboration and communication from anywhere at any time. Collaborative E-applications Defense Connect Online (DCO) - Synchronous
Wikis - Asynchronous
Google Docs - Asynchronous
Best collaborative platform AKO/DKO
www.us.army.mil
2011 Research Course 56
Research Course 57Research Course 57
Virtual meeting room DCO https://www.dco.dod.mil
2011
DCO– Defense Connect Online
• DCO– Defense Connect Online - provides DoD users worldwide with a second option for enterprise collaboration services.
• The DCO meeting room capabilities are: the DCO Portal, webconferencing, instant messaging, screen and file sharing, whiteboard, video and audio capabilities, hosting large meetings, and more.
2011 Research Course 58
Research Course 59Research Course 59
Virtual meeting room DCO
2011 Live Training Schedule is available at:
https://www.dco.dod.mil/public/dsp/liveTraining.cfm
To participate in live training:
Go to
https://connect.dco.dod.mil/dcoliveremotetraining
Enter as a guest
2011
2011 Research Course 60
Wikis http://www.wikispaces.com/
A wiki is a website that can be edited by anyone who is granted permission.
It is simple and powerful knowledge sharing and
collaboration online tool that solves problems of Document management for a Team Project Management in an enterprise.
Other advantages of wiki: cheap or free, simple enough for non-technical employees to use.
Detailed instructions on how to create a wiki page are available at http://www.umich.edu/~umctdocs/Wiki.html
Wikis
Wiki Examples:
Wikipedia: http://en.wikipedia.org/wiki/Main_Page
WRNMMC ICEBERG: http://nnmcresearch.wikispaces.com/
2011 Research Course 61
WikisWiki at WRNMMC• ICEBERG (Interdepartmental Collaborative Bethesda Research
Group) http://nnmcresearch.wikispaces.com/
2011 Research Course 62
2011 Research Course 63
Google Docs https://www.docs.google.com
GoogleDocs is a free web-based collaborative software. It has applications of word processors, spreadsheet and presentations that are similar to Word, Excel and PowerPoint.
Several useful functions are: autosave, revision history and rename of the files.
It allows users to create
and edit documents online
while collaborating in
real-time with other users.
2011 Research Course 64
References: Hulley, S. et al.(2007), Designing Clinical Research, 2nd ed. Lippincott Williams &
Wilkins
On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition. (2009). Committee on Science, Engineering, and Public Policy,
National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. http://www.nap.edu/catalog/12192.html
• Goodnoe, E. (2005). How To Use Wikis For Business. The InformationWeek Business Technology Network. Retrieved March 11, 2010, from http://www.informationweek.com/news/management/showArticle.jhtml?articleID=167600331
• Pfeifer, S. (March 11, 2008). Wikis and Blogs. Presented at Administrative and
Instructional Uses of Technology, ED.851.609 (91) lecture at Johns Hopkins University.
• Riedel, C. (2008). Turnitin Integrates Plagiarism Tool into New Online Writing Service. Retrieved March 10, 2010, from http://campustechnology.com/articles/2008/09/turnitin-integrates-plagiarism-tool-into-new-online-writing-service.aspx
• Auga, N. (2006). Developing wikis to foster web-based learning communities: an iterative approach, International Journal of Web Based Communities (IJWBC), Vol.2, No.3. Retrieved March 12, 2010, from http://www.inderscience.com/offer.php?id=11761
Questions?
2011 Research Course 65
Research Course 66Research Course 66
Thank You!My Contact Information:Marina Borovok, PhD
Head of Research EducationDepartment of Research ProgramsDirectorate for Professional EducationWalter Reed National Military Medical Center8901 Wisconsin Avenue,Bldg. 1, Rm. 4372,Bethesda, MD 20889
Phone: 301-295-2876Fax: 301-295-1490E-mail: [email protected]
2011