VUOS COMPANY PROFILE PARTNER FOR COOPERATION. 2 22VUOS – PARTNER FOR COOPERATION Where you can...

VUOSCOMPANY PROFILE

PARTNER FOR COOPERATION

2

22 VUOS – PARTNER FOR COOPERATION

Where you can find us

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VUOS ownership

AGROFERTHOLDING, a.s.

SYNTHESIA, a.s.

VUOS, a.s.

100% 100%

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History

Foundation of R

esearch Laboratories

Voucher Priv

atisatio

n

New name – VUOS

Affiliatio

n of Synthesia´s R

&D

100% daughter company of S

ynthesia a.s.

19921952 200419971941

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VUOS main businesses

2. Toxicology and Analytics

1. R&D and Production of Fine Chemicals

Employees

Sales in %

70

14

106

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The Certificates of VUOS

• Certificate ČSN EN ISO 9001: 2009 (organic

chemicals - syntheses development and

manufacture)

• Decision on Compliance with Principles of Good

Manufacturing Practice in Control Laboratory

• Certificates of Good Laboratory Practice in Test

Facility (OECD GLP Principles - 1997)

• Certificate of Accredited Certification Body for

Certification of Products (EN 45011:1998)

• Certificate of Accredited Testing Laboratory (EN

ISO/IEC 17025:2005) 6 VUOS – PARTNER FOR COOPERATION

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Strong Points

• Education structure of employees

• VUOS is located in area of long-lasting chemical tradition and complete infrastructure

• Cooperation with University of Pardubice

Skilled – 25 %

Secondary – 30%

University degree – 36%

Ph.D. degree – 9%

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R&D, upscaling

• Pharmaceutical intermediates

• Intermediates for microelectronics

• Custom syntheses of chemical specialities

• Dyes and pigments for special application

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R&D, upscaling


Wide range of quantitiesGrams – in laboratory

Kilograms – in kilolab

unitMetric tons – in VUOS

production plant

Hundreds of MT –

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VUOS ’s key chemistry

VUOS ’s key technology


Adamantane derivatives

N-Heterocycles

API Building Blocks

PhosgenationHydrogenation

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VUOS ’s technology/manufactureexpertise includes:acetylationaldolisationamidationalkylationaminationamoxidationazocouplingbenzoylationchiral synthesischlorinationchlorosulfonationClaisen condensationcross coupling reaction cyclisationdecarboxylation

eliminationesterificationFriedel-Crafts reactionGrignard reactionheterocyclic synthesishydrolysis reactionsneutralisationnitrationnitriles synthesesoxidation – catalytic/chemicaloxidation in liquid phaserearrangementreduction with hydrazine and sodium borohydrideSulfonation

dehydrohalogenationdiazotisation

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Kilolab and Semi-Pilot Unit

2x reactors, 250 and 650 l

2x High performance rectification columns

Laboratory phosgenation units from 1 to 30 litres

Phosgenation

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3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200 ˚C, Hastelloy C clad

1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad

1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel

1x autoclave 1 000 l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l

Hydrogenation

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Kilolab Unit

1 x glass reactor 50 l cooled down to – 80 ˚C

1x glasslined reactor for NaH reactions (250 l)

3x glass reactors 100l for RLi, Grignard reactions

Low temperature, RLi, RMgX, NaH

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20x glass reactors, 100 l each

6x glass lined reactors (200–1 500 l)

2x evaporators 50 l / h

4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity

Multipurpose chemistry

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45x glass lined reactors, total vol. 70 000 l (500–5 000 l)

13x stainless steel reactors, total vol. 22 000 l (1 000–3,000 l)

8x High performance rectification columns

sufficient filtration capacity (nutsches, centrifuges)

computer controlled

Production Equipment


Production Unit

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Toxicology, Ecotoxicology and Analytics

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REACH and CLP Services

•Literature search

•Preparation of dossiers in IUCLID 5

•Preparation of Chemical Safety Report

•Non-testing approaches

• (Q)SAR

• Grouping/Read-across

•Preparation of SDS

•Classification of substances and mixtures

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Analytical methods•NMR Spectrometry

•Mass Spectrometry (LC/GC-MS)

•ICP-AES

•IR Spectrometry

•Chromatography (HPLC, GC)

•UV-VIS


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Toxicology, Ecotoxicology and AnalyticsToxicological tests

In vivo and in vitro tests accordingto the OECD or EU methods:

•Acute toxicity

•Skin and Eye irritation

•Sensibilisation

•Repeated dose toxicity

•Reproductive toxicity

•Carcinogenicity

•Mutagenicity

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Toxicology, Ecotoxicology and AnalyticsEcotoxicological tests

•Aquatic toxicity

•Biotic degradation

•Abiotic degradation

•Adsorption/desorption

Physico-chemical tests•Information on physicochemical

properties of substance

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Contacts

General Manager: Dr. Karel NovákPhone: +420 46 682 2550, fax: +420 46 682 2976e-mail: [email protected]

Sales Manager: Miloš Jesenský,Ph.D.Phone: +420 46 682 3300, fax: +420 46 682 2976e-mail: [email protected]

R&D: Alois Koloničný, Ph.D.Phone:+420 46 682 3156, fax: +420 46 682 3900e-mail: [email protected]

Toxicology and Analytics: Viktor Mejstřík,

Ph.D.Phone:+420 46 682 3127, fax: +420 46 682 2975e-mail: [email protected]

Process Engineering: Luboš VíšekPhone:+420 46 682 5790, fax: +420 46 682 3900e-mail:[email protected]

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VUOS COMPANY PROFILE PARTNER FOR COOPERATION. 2 22VUOS – PARTNER FOR COOPERATION Where you can...

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