Vitamin E & K Lecture 3 BIOCHEMISTRY
-
Upload
vijaya-marakala -
Category
Health & Medicine
-
view
2.142 -
download
6
description
Transcript of Vitamin E & K Lecture 3 BIOCHEMISTRY
![Page 1: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/1.jpg)
VITAMIN EVITAMIN K
Dr. Vijay Marakala, MBBS, MD.
Assistant professor BIOCHEMISTRY SIMS & RC
![Page 2: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/2.jpg)
VITAMIN E [TOCOPHEROL]
Chemistry Sources RDA Metabolism
Functions Deficiency Toxicity
![Page 3: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/3.jpg)
VITAMIN E - CHEMISTRY
Tocopherolsα-tocopherol
β-tocopherol
γ-tocopherol
δ-tocopherol
Tocotrienolsα-tocotrienols
β-tocotrienols
γ-tocotrienols
δ-tocotrienols
![Page 4: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/4.jpg)
VITAMIN E - CHEMISTRY
![Page 5: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/5.jpg)
VITAMIN E – SOURCES
![Page 6: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/6.jpg)
VITAMIN E – RDA
RDA 8 – 10 mg/day
The daily requirement increases with increase in dietary intake of PUFA
![Page 7: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/7.jpg)
VITAMIN E – METABOLISM
Absorption
Upper SI
Along with lipids
Transport
Chylomicron
VLDL and LDL
Storage
Adipose tissue
liver
![Page 8: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/8.jpg)
VITAMIN E – FUNCTIONS
As a biological antioxidantPrevents lipid peroxidation
of biological membrane
Prevents peroxidation of vitamin A & PUFA
Reproductive functions & prevents sterility
Vitamin E
![Page 9: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/9.jpg)
VITAMIN E – FUNCTIONS
![Page 10: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/10.jpg)
VITAMIN E & SELENIUM
Selenium complements the antioxidant effects of
vitamin E and reduces the requirement of vitamin E
![Page 11: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/11.jpg)
VITAMIN E - DEFICIENCY
Causes Inadequate intake
Impaired absorption
Features Hemolytic anaemia in the new born
Muscle weakness
Spinocerebellar ataxia and impaired vision
![Page 12: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/12.jpg)
VITAMIN K
![Page 13: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/13.jpg)
VITAMIN K - CHEMISTRY
Pylloquinone
Present in plants
Vitamin K1
Menaquinone
Produced by intestinal bacteria
Vitamin K2
Menadione
Synthetic form
Vitamin K3
![Page 14: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/14.jpg)
VITAMIN K - SOURCES
![Page 15: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/15.jpg)
VITAMIN K - RDA
80µg/day
![Page 16: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/16.jpg)
VITAMIN K - METABOLISM
Absorption
Upper SI
Along with lipids
Transport
Chylomicron
LDL
Storage
Liver
![Page 17: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/17.jpg)
VITAMIN K - FUNCTIONS
Role in blood coagulation • Cofactor for gamma
carboxylation of glutamic acid in clotting factors II, VIII, IX and X
Role in bone mineralization• Cofactor for gamma
carboxylation of glutamic acid in osteocalcin
![Page 18: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/18.jpg)
![Page 19: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/19.jpg)
VITAMIN K - DEFICIENCYCauses In newborn
Impaired absorption
Sterile bacterial flora
Features
Bleeding
Prolonged prothrombin time
![Page 20: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/20.jpg)
VITAMIN K - ANTAGONIST
Dicumarol Warfarin
![Page 21: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/21.jpg)
VITAMIN K - ANTAGONIST
![Page 22: Vitamin E & K Lecture 3 BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061120/546c7212b4af9f752c8b4ffe/html5/thumbnails/22.jpg)