Veterinary Product Catalog - acttallergy.com · Chenopodium album LAQU Weed • • Lenscale...

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Veterinary Product Catalog

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Mission

We improve the quality of life by fi ghting the cause of allergy.

Vision

• In the global market for specifi c allergy treatment, we strengthen our leading position through our representation, acquisitions and partnerships.

• Our future is secured by a strong pipeline. We continuously launch new convenient products providing value to patients and society.

• We are driven by our customer focus and strong performance culture. We attract

and retain dynamic and business-minded employees.

Values

Progressive, Focused, United, Trustworthy.

These four values describe our corporate culture and set out the framework for our daily conduct and decisions.

At ALK, we fi ght the cause of

allergy and are in the forefront

of developing evidence- based

allergy immunotherapy treatments

for the benefi t of patients

worldwide.

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Table of ContentsIntroduction ...............................................................................................................................................................5

Farm to Pharma ..........................................................................................................................................................6

Allergen Extracts .........................................................................................................................................................7

Pollen Extracts ....................................................................................................................................................8

Molds .............................................................................................................................................................. 11

Smuts .............................................................................................................................................................. 11

Mites .............................................................................................................................................................. 12

Insects ............................................................................................................................................................ 12

Epidermals ...................................................................................................................................................... 12

Diagnostic Controls ................................................................................................................................................... 13

Ancillary Products ..................................................................................................................................................... 13

Normal Saline with Phenol (NSP) ......................................................................................................................... 13

Pumps............................................................................................................................................................. 13

Colored Caps for Vials ....................................................................................................................................... 13

Syringes .................................................................................................................................................................. 15

Trays ....................................................................................................................................................................... 15

Suggested Diagnostic Zones and Treatment Regions ..................................................................................................... 16

Cross Reactivity ........................................................................................................................................................ 18

Weight to Volume ...................................................................................................................................................... 19

Ordering Information ................................................................................................................................................. 21

Fax Order Form ......................................................................................................................................................... 22

ACTT® Allergy Program .............................................................................................................................................. 23

Contact Information ....................................................................................................................................... Back Cover

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You have a choice for your allergy products.

A pioneer in allergy immunotherapy.

Since 1923, ALK has exemplifi ed scientifi c leadership in the fi eld of allergy research and in the treatment

of allergic disease in humans. We are proud to extend our experience into the animal health industry by

supporting veterinary dermatologists in the treatment of allergic pets.

Benefits of partnering with ALK:

• Over 90 years experience of manufacturing allergenic extracts.

• Investing in allergic disease research for animals.

• Maintain dedicated Scientific Affairs team specializing in veterinary allergy to assist you with

difficult cases and dose modification in your practice.

ALK has 100% control of the extract manufacturing process and is 100% dedicated to allergic care.

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Purity� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �� Potency � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �� ! � � � � � �� " � � � � � � � � � � � � � � � � # � � � � � � � � � � � � � � � � � � � � � � � � � � � �� $ % � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �Complexity � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � & � # ' " � � � � � � � � � � � � � � � � � � � � � � � � � " � � � � � � ( � � � � � � � � � � � � � ) � � � � � � � � � � � & � � � � � � � � �� & � � � � � � � � � � � � � � � � * � � � � � � � � � � � � � � � " � � � � � � � � � � � � � � � � � � + � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � " � " � � � � � � � � � � � � � , � � � � * � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �Stability � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � - � � � � � � � � � � � � � � � � � � ! � � � � � � � � � � � � � �� + � � � � � � � � � � � � � � � � � � � � � � � � � � . � � � � � � � � � � / � � � � � � � � � � � � � 0 � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 1

Bulk Allergens for Intradermal Testing and Treatment Formulation

ALK is proud to offer bulk allergens for intradermal testing. Bulk allergens give your practice the ability and convenience

to test your patients and interpret results on the spot, without delay. ALK handles the entire manufacturing process from

the collection of raw materials, to fi nished allergy extracts.

With over one-third of the allergy immunotherapy products worldwide produced by ALK, comprehensive analyses and

quality control at all stages of the manufacturing process ensures that our products meet the highest manufacturing and

quality standards.

We are continually developing methodology to examine our extracts for their Purity, Complexity, Potency, and Stability. It

is this science-based, extract characterization process that allows us to provide you with information that supports effective

diagnosis and treatment.

ALK is the World Leader in Allergy

1. van Ree, R. J Allergy Clin Immunol. 2007 Feb; 119(2):270-7. 2. Nelson, HS. et al. J Allergy Clin Immunol. 1981; 67: 64-69.

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From Farm to Pharma

ALK controls the entire manufacturing process - from raw materials collection to packaging and distribution- to ensure

quality. Comprehensive analyses and quality control at all stages of the manufacturing process ensure that ALK’s

products meet the highest manufacturing and quality standards.

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ALK Extracts

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Extracts

Formulation

NameLatin Name

Item #Allergen

TypeAqueous1:10 w/v

Aqueous1:20 w/v

Glycerin1:20 w/v

Aqueous 20,000 PNU

Aqueous 40,000 PNU

AcaciaAcacia dealbata

ACAC Tree •Alder, WhiteAlnus rhombifolia

ALDE Tree •AlfalfaMedicago sativa

ALFA Cul. Crop •Ash, Arizona (Velvet)Fraxinus velutina

ARAS Tree •Ash, WhiteFraxinus ameriana

ASH- Tree • •Aspen, QuakingPopulus tremuloides

QUAS Tree •Bahia GrassPaspalum notatum

BAHI Grass •BayberryMorella cerifera

BAYB Tree •Beech, AmericanFagus grandifolia

BEEC Tree •BermudaCynodon dactylon

BERM Grass •Birch, Black-SweetBetula lenta

BLBI Tree •Birch, WhiteBetula verrucosa

WHBI Tree •Box Elder Acer negundo

BOEL Tree •Brome, SmoothBromus inermis

BROM Grass •Careless WeedAmaranthus palmeri

CARE Weed •Cedar, MountainJuniperus ashei

MOCE Tree •Cedar, RedJuniperus virginiana

RECE Tree •CockleburXanthium strumarium

COCK Weed • •Cottonwood, Eastern (Common)Populus deltoides spp. monilifera

COWO Tree •Cottonwood, WesternPopulus sargentii

WECO Tree •Cypress, BaldTaxodium distichum

BACY Tree •DandelionTaraxacum offi cinale

DAND Weed • •Dock, Yellow (Curly Dock)Rumex crispus

YEDO Weed •Dock/Sorrel Mix

SODO Weed •Elm, AmericanUlmus americana

ELM- Tree • •

Product availability is subject to change without notice.

Pollens

• = Indicates outsourced product.

Custom products are available, please contact your ALK allergy consultant.

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Formulation

NameLatin Name Item #

Allergen Type

Aqueous1:10 w/v

Glycerin1:20 w/v

Aqueous 40,000 PNU

Elm, CedarUlmus crassifolia

CEEL Tree •Elm, Chinese (Siberian)Ulmus pumila

CHEL Tree •Eucalyptus (Blue Gum)Eucalyptus globulus EUCA Tree •GoldenrodSolidaga canadensis

GOLD Weed • •HackberryCeltis occidentalis

HACK Tree •Hazelnut, AmericanCorylus californica

HAZE Tree •Hickory, ShagbarkCarya ovata

HICK Tree •Hickory/Pecan Mix

HIPE Tree •Johnson GrassSorghum halepense

JOHN Grass • •Juniper, WesternJuniperus occidentalis

WEJU Tree •June (Kentucky Blue)Poa pratensis

JUNE Grass •Kochia (Mexican Firebush)Kochia scoparia

KOCH Weed • •Lamb’s QuartersChenopodium album

LAQU Weed • •LenscaleAtriplex lentiformis

LENS Weed •Maple, RedAcer saccharum

REMA Tree •Maple, SugarAcer saccharinum

MAPL Tree • •Marshelder, BurweedIva xanthifolia

BUMA Weed •Marshelder, True (Rough)Iva annua

ROMA Weed • •Meadow FescueFestuca pratensis (elatior)

MEFE Grass •MelaleucaMelaleuca quinquenervia

MELA Tree •MesquiteProsopis julifl ora

MESQ Tree •Mugwort, CommonArtemisia vulgaris

MUGW Weed •Mulberry, RedMorus rubra

REMU Tree •Mulberry, WhiteMorus alba

WHMU Tree •Nettle, StingingUrtica dioica

NETT Weed • •Oak, Virginia LiveQuercus virginiana

VILI Tree •Oak, WhiteQuercus alba

OAK- Tree • •OliveOlea europaea

OLIV Tree •OrchardDactylis glomerata

ORCH Grass •

Pollens


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Formulation

NameLatin Name

Item # Allergen

TypeAqueous1:10 w/v

Glycerin1:20 w/v

Aqueous 10,000 PNU

Aqueous 20,000 PNU

Aqueous 40,000 PNU

Palm, QueenArecastrum romanzoffi ana

QUPA Tree •Pecan PollenCarya illinoinensis

PEPO Tree •Pepper Tree, CaliforniaSchinus molle

CAPE Tree •Pigweed, Rough RedrootAmaranthus retrofl exus

ROPI Weed •Pigweed, SpinyAmaranthus spinosus

SPPI Weed •Pine, Australian (Beefwood)Casuarina equisetifolia

AUPI Tree •Pine, YellowPinus echinata

YEPI Tree •Pine, White (Eastern)Pinus strobus

WHPI Tree •Plantain, EnglishPlantago lanceolata

ENPL Weed • • •Poplar, WhitePopulus alba

POPL Tree •PrivetLigustrum vulgare

PRIV Tree •Quack GrassElymus repens

QUGR Grass •Ragweed, False Ambrosia acanthicarpa

FARA Weed •Ragweed, ShortAmbrosia artemisiifolia

SHRA Weed •Ragweed, Giant (Tall)Ambrosia trifi da

TARA Weed •Ragweed, WesternAmbrosia psilostachya

WERA Weed •Ragweed, Mixed

MIRA Weed • • • •RedtopAgrostis alba

RETO Grass •Russian ThistleSalsola kali

RUTH Weed •Rye, PerennialLolium perenne

PERY Grass •Sagebrush, CommonArtemisia tridentata

SAGE Weed •Sheep Sorrel Rumex acetosella

SHSO Weed •Sweet VernalAnthoxanthum odoratum

STSV Grass •SweetgumLiquidambar styracifl ua

SWGU Tree •Sycamore, American (Eastern)Platanus occidentalis

SYCA Tree •TimothyPhleum pratense

TIMO Grass •Walnut, BlackJuglans nigra

BLWA Tree •Willow, BlackSalix nigra

BLWI Tree •

Pollens

Custom products are available, please contact your ALK allergy consultant.

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Formulation

Name(Alternate Name)

Item #Aqueous

(1:10 w/v)*Glycerin

(1:20 w/v)*

Alternaria alternata(Alternaria tenuis)

ALTE • •Aspergillus fumigatus

ASFU • •Aureobasidium pullulans(Pullularia pullulans)

AURE • •Bipolaris sorokiniana(Dreschslera sorokiniana)

BIPO • •Botrytis cinerea

BOTR • •Candida albicans

CAAL • •Cladosporium cladosporioides(Hormodendrum cladosporioides)

CLCL • •Epicoccum nigrum(Epicoccum purpurascens)

EPIC • •Gibberella pulicaris(Fusarium roseum)

GIBB • •Mucor plumbeus

MUCO • •Penicillium notatum

PENO • •Rhodotorula mucilaginosa(Rhodotorula rubra)

RHOD • •Saccharomyces cerevisiae (Yeast)

SACC •Sarocladium strictum(Sarocladium strictum)

SARO • •Trichophyton mentagrophytes

TRME • •

Molds & Fungi

* The PNU value for aqueous mold extracts and glycerinated mold extracts can be obtained by contacting Customer Service at 800.325.7354.

Formulation

NameLatin Name

CodeAllergen

TypeGlycerin

(1:20 w/v)*

Corn SmutUstilago maydis

COSM Smut •

Smut

Formulation

Name(Mix Components)

Item #Aqueous

(1:10 w/v)*Glycerin

(1:20 w/v)*

Mold Mix A(Alternaria, Aspergillus, Cladosporium, Penicillium)

MOMA • •Mold Mix B(Epicoccum, Gibberella, Mucor)

MOMB • •Mold Mix C(Botrytis, Candida, Rhodotorula, Trichophyton)

MOMC • •

Mold Mixes

Custom products are available, please contact your ALK allergy consultant

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Product availability is subject to change without notice.

Epidermal & Misc. Formulation

NameLatin Name/(Mix Comp.) Item #

Allergen Type

Glycerin1:10 w/v

Glycerin1:20 w/v

Aqueous 1:10 w/v

Aqueous10,000 PNU

Aqueous20,000 PNU

Cat HairFelis domesticus

STCH Epidermal •Cattle EpitheliumBos taurus

COEP Epidermal •Cotton Linters

Misc. •Dog EpitheliumCanis lupus familiaris

DOEP Epidermal • • •Feather, Mixed(Chicken, Duck, Goose)

MIFE Epidermal •Guinea Pig EpitheliumCavia porcellus

GUIN Epidermal •Horse DanderEquus caballus

HOEP Epidermal •Kapok

KAPO Misc. • •Mouse EpitheliumMus musculus

MOEP Epidermal •Rabbit EpitheliumOryctolagus cuniculus

RABB Epidermal • •Sheep Epithelium

Epidermal •Tobacco

Misc. • •

Formulation


Allergen Type

Aqueous 1:50 w/v

Aqueous5,000 PNU

Aqueous10,000 PNU

Acarus siroACSI Mite •

Dust MiteD. farinae

STDF Mite •Dust MiteD. pteronyssinus

STDP Mite •Mite, Mixed(D. farinae & D. pteronyssinus)

STMM Mite •Tyrophagus putrescentiae

TPUT Mite • •

Mites

Formulation


Allergen Type

Aqueous 1:10 w/v

Glycerin1:20 w/v

Glycerin1:100 w/v

Ant, FireSolenopsis invicta

FIAN Insect •Cockroach, GermanBlattella germanica

GECO Insect • •MosquitoCulex pipiens

MOSQ Insect •

Insects


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Colored Caps for Vials (13 mm)

Item# Color Quantity

80405 Dark Blue 100

80415 Green 100

80425 Orange 100

80430 Pink 100

80435 Purple 100

80440 Red 100

80455 Yellow 100

Colored Caps for Vials (20 mm)

Item# Color Quantity

80432 Dark Blue 144

80416 Green 144

80426 Orange 144

80431 Pink 144

80457 Purple 144

80441 Red 144

80456 Yellow 144

Some Ancillary products are available with different color vial seals (noted below). The last letter of the part number where

color options are available determines the seal color. For instance: NSP4020S is NSP 4.0 mL with a Silver seal.

Colors available: R = red, Y = gold, G = green, O = orange, P = pink, V = purple, B = blue.

Normal Saline with Phenol (NSP)

Item# Volume Vial Size Quantity

NSP2013S 2.0 mL 13 mm x 16.5 mm 50

NSP2020S 2.0 mL 20 mm x 22 mm 25

NSP4013S 4.0 mL 13 mm x 16.5 mm 50

NSP4020S 4.0 mL 20 mm x 22 mm*Various Colors Available

25

NSP4513S 4.5 mL 13 mm x 16 mm 50


25

NSP8013S 8.0 mL 13 mm x 18.5 mm 50

NSP8020S 8.0 mL 20 mm x 22 mm 25


25

NSP30 30 mL 20 mm x 29 mm (Tall) 1

NSP50 50 mL 20 mm x 40 mm 1

NSP100 100 mL 20 mm x 52 mm 1

Labels

Item# Description

80467 Titration Labels

80230 Vial Labels, Roll of 1,000 Blue

80232 Vial Labels, Roll of 1,000 Yellow

80235 Vial Labels, Roll of 1,000 Green

80250 Vial Labels, Roll of 1,000 Red

LABELS2 Vial Labels, Roll of 1,000 White

Pump Vials

Item# Description Quantity

80158 15 mL Glass Amber Vialwith 50 uL Metered Pump

1

80159 Amber Vial (for Pump) 1

80161 Dropper Pump .05 mL 1

80162 Black Cap for Amber Vial (with Pump)

1

Ancillary Items

Item# Description Vial Size Diagnostic

DILU15 Aqueous Control 5 mL Multi-Dose Diagnostic

Diagnostic Controls*

*Contact your ALK allergy consultant for more information

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Sterile Empty Vials (SEV)

SEV Size Chart

2 mL 5 mL5 mL 10 mL 10 mL

20 mL 30 mL 50 mL 100 mL

Ancillary Items

Item# Volume Vial Size Quantity

SEV213 2.0 mL 14 mm x 13 mm 100

SEV513S 5.0 mL 13 mm x 16.5 mm*Various Colors Available

50

SEV520S 5.0 mL 20 mm x 22 mm*Various Colors Available

25

SEV1020S 10.0 mL 20 mm x 22 mm*Various Colors Available

25

SEV20 20 mL 20 mm x 30 mm 1

SEV30 30 mL 20 mm x 36.5 mm 25

SEV50 50 mL 20 mm x 40 mm 25

SEV100 100mL 20 mm x 52 mm 1

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Ancillary Items

Syringes

Item# Volume Needle Size Description Quantity Manufact Manufact Part # Manufact Packaging

SYR80345 0.5 mL 27 G x 1/2” Reg. Bevel 1,000 BD 305535 40 trays of 25

SYR80365 0.5 mL 27 G x 3/8” ID Bevel 1,000 BD 305536 40 trays of 25







SYR80405 1.0 mL 28 G x 1/2” Monoject Perm. AttachedReg. Bevel

1,000 Kendall 501236 40 trays of 25

SYR80427 1.0 mL 27 G x 1/2” Non-Saftey Allergy Tray 1,000 SOL-M 181027T 40 trays of 25

SYR80429 1.0 mL 23 G x 1/2” Mixing Tray 1,000 SOL-M 181023T 40 trays of 25

*Note - Syringes available may vary and are not exclusive to the types listed above, please call Sales Support for more information.

Trays

Item# Description Dimensions in inches (L x W x H)

80300 Vial Trays for 18 mm and 22 mm base vials, 48 holes (6x8) 10” x 7 3/4” x 1”

80301 Vial Trays for 18 mm and 22 mm base vials, 60 holes (6x10) 12” x 7 3/4” x 1”

80322 Rachman Tray, Large #202, 13 mm base vials, 84 holes



80328 Rachman Tray, Large #808, 18 holes

80185 Lucite Tray, 22 mm base vials, 5 - 10 mL, 60 holes 11” x 7” x 3/4”

80329 Syringe Tray (18 places)

80290 Rondo Tray, 13 mm base vials, 6 holes

80291 Rondo Box Only, 13 mm base vials, 6 holes

80296 Rondo Box Only, 13 mm base vials, 10 holes

Rachman Tray 303

Rachman Tray 808

Rachman Tray 404

Rachman Tray 202

Vial Trays for 18 mm & 22 mm (48 hole, 60 hole)

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Our Scientifi c Affairs department has developed these suggested zones and regions by thoroughly reviewing the indigenous allergens of each geographical area. Specifi c allergens can be ordered separately as needed. If you would like further assistance in developing or modifying your testing panel, please contact our Scientifi c Affairs department at 855-782-9323.

Suggested Diagnostic Zones and Treatment Regions

Southeast Zone Diagnostic Panel

Positive Control Red Birch Black Willow White Pine Cat Hair Aspergillus

Negative Control Eastern Cottonwood Bayberry American Sycamore Dog Epithelium Penicillium

Queen Palm American Elm Mixed Ragweed Yellow Pine Dust Mite (D. farinae) Gibberella

Timothy Grass Box Elder Lambs Quarters White Ash Dust Mite (D. pteronyssinus) Aureobasidium

Bermuda Grass Pecan (pollen) Rough Pigweed Sweetgum Cockroach, American* Bipolaris

Bahia Grass Red Maple English Plantain Red Mulberry Mouse* Rhodotorula

Johnson Grass Shagbark Hickory Mugwort Cocklebur Alternaria Mucor

White Oak Eastern Red Cedar Sheep Sorrel Rough Marshelder Cladosporium Epicoccum

Southwest Zone Diagnostic Panel

Positive Control American Sycamore Pecan (pollen) Johnson Grass Cat Hair Aspergillus

Negative Control Eastern Cottonwood Mountain Cedar Bahia Grass Dog Epithelium Penicillium

Queen Palm American Elm Mixed Ragweed White Alder Dust Mite (D. farinae) Gibberella

Perennial Rye Grass White Ash Lambs Quarters Black Willow Dust Mite (D. pteronyssinus) Aureobasidium

Bermuda Grass Black Walnut Rough Pigweed English Plantain Cockroach, American* Bipolaris

White Oak Mesquite Sagebrush Western Ragweed Mouse* Rhodotorula

Box Elder Olive (pollen) Russian Thistle Kochia Alternaria Mucor

Western Juniper Red Mulberry Sheep Sorrel Rough Marshelder Cladosporium Epicoccum

Northwest Zone Diagnostic Panel

Positive Control American Sycamore Mixed Ragweed Johnson Grass Cat Hair Aspergillus

Negative Control Eastern Cottonwood Lambs Quarters Bermuda Grass Dog Epithelium Penicillium

Queen Palm American Elm Rough Pigweed Red Mulberry Dust Mite (D. farinae) Gibberella

Timothy Grass White Ash Sagebrush White Pine Dust Mite (D. pteronyssinus) Aureobasidium

Brome Grass Black Walnut Russian Thistle Hackberry Cockroach, American* Bipolaris

White Alder Eastern Red Cedar Sheep Sorrel Black Willow Mouse* Rhodotorula

Box Elder White Birch Mugwort Rough Marshelder Alternaria Mucor

Western Juniper White Oak English Plantain Cocklebur Cladosporium Epicoccum

Northeast Zone Diagnostic Panel

Positive Control American Sycamore Black Willow Johnson Grass Cat Hair Aspergillus

Negative Control Eastern Cottonwood White Pine Privet Dog Epithelium Penicillium

Queen Palm American Elm Rough Pigweed Red Mulberry Dust Mite (D. farinae) Gibberella

Timothy Grass White Ash Mixed Ragweed Black Walnut Dust Mite (D. pteronyssinus) Aureobasidium

Bermuda Grass Shagbark Hickory Lambs Quarters White Pine Cockroach, American* Bipolaris

White Birch Red Cedar Sheep Sorrel Russian Thistle Mouse* Rhodotorula

Box Elder American Beech Mugwort Rough Marshelder Alternaria Mucor

White Oak Red Maple* English Plantain Cocklebur Cladosporium Epicoccum

* Only available in Glycerin

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Northwest Zones

Pacifi c Northwest

Western High Plains

Northern Rocky Mountains

Great Plains

Southwest Zones

Central California Coast

Desert Southwest

South Central Texas

Northeast Zones

Atlantic Northeast

Eastern Mountains

Mid-Atlantic Seaboard

Midwest Great Lakes

Southeast Zones

Gulf Coast

Midwest Mississippi Valley

Subtropical Florida

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Pacifi c Northwest • • • • • • • • • • • • • • • • • •

Western High Plains • • • • • • • • • • • • • • • •

Northern Rocky Mountains

• • • • • • • • • • • • • • • • •

Great Plains • • • • • • • • • • • • • • •

Central California Coast

• • • • • • • • • • • • • •

Desert Southwest • • • • • • • • • • • •

South Central Texas • • • • • • • • • • • • • • •

Atlantic Northeast • • • • • • • • • • • • • • •

Mid-Atlantic Seaboard

• • • • • • • • • • • • • •

Eastern Mountains • • • • • • • • • • • • • •

Midwest Great Lakes

• • • • • • • • • • • • • •

Midwest Mississippi Valley

• • • • • • • • • • • • • • • •

Gulf Coast • • • • • • • • • • • • • • • •

Subtropical Florida • • • • • • • • • • • • • • •

U.S. Pollen Prevalence

800-325-7354 18

Cross Reactivity

The term cross-reactivity refers to two distinct antigens that are recognized by the same antibody, thereby eliciting a

similar immune response. Cross-reactivity in allergic reactions occurs when the proteins in one allergen are similar to

the proteins found in other allergen.

Typically, cross-reactivity occurs between species in the same taxonomic genus or family. For example:

Our Scientifi c Affairs Department is available for all of your science questions

Email: [email protected]

Science Hotline: 855-782-9323 (Option 4)

Online helpdesk: https://alkinc.freshdesk.com

ALK strives to improve the scientifi c knowledge base for allergy in the veterinary fi eld.

Many cross-reactivity relationships have been established in the scientifi c literature for human immunotherapy, and

our Scientifi c Affairs department can provide substitution options available for ALK allergens as well as cross-reactivity

charts by request.

TREES

Members of the Betula genus (e.g. White Birch, Red Birch and Black Birch)

are cross-reactive.

WEEDS

Ragweed species (Ambrosia genus) are highly cross-reactive, and exhibit

moderate cross-reactivity with other members of the Asteraceae family (e.g

Mugwort, Marhshelder, and Cocklebur).

GRASSES

Timothy grass is expected to be cross-reactive with Pooideae subfamily,

including Orchard, Sweet Vernal, and Perennial Rye grasses.

MOLDS

Molds containing the same genus name (e.g. Aspergillus niger and

Aspergillus fumigatus) are considered cross-reactive, and these molds can

be readily substituted for one another.

800-325-7354 19

Weight to Volume

Allergenic extracts are available commercially in multiple formulations as well as concentrations. All extracts are

initially generated by combining source material (e.g., pollen, mold, etc.) with set volumes of solutions designed

to extract allergenic proteins. Weight-to-volume (w/v) is a manufacturer’s designation that identifi es the amount of

source material and extraction buffer used to make the product. Additionally, w/v extracts may be diluted to a certain

Protein Nitrogen Unit (PNU) and sold at specifi c concentrations. Each formulation has unique advantages, and both

are successfully utilized for immunotherapy nationwide. In order to determine which formulation is best for your

specifi c practice, we have outlined the differences between PNU and w/v extracts below.

Weight-to-Volume (w/v)

Most w/v extracts are generated at the 1:10 w/v aqueous strength. This formulation serves as the mother lot from

which most other extract formulations are derived. Glycerin extracts may be generated two ways: 1) addition of equal

parts of 100% glycerin to the aqueous mother lot, yielding a 1:20 w/v extract; 2) direct extraction using 50% glycerin

solutions. The concentration of w/v extracts is typically much higher than diluted PNU formulations, conferring greater

protein stability for long-term storage. This equates to more stable potency over the lifespan of the product.

Protein Nitrogen Unit (PNU)

PNU was one of the fi rst measurements used to describe extract strength and indicates the concentration of total

protein in a vial. PNU identifi es the total nitrogen present in a sample measured by the Kjeldahl assay, as specifi ed

by the FDA. Nearly all aqueous extracts are subjected to PNU determination as part of FDA-required quality control

measures, therefore this measurement is also used to dilute extracts to specifi c PNU concentrations (i.e. 10,000,

20,000, and 40,000 PNU/mL). These dilutions are useful for formulating immunotherapy dosage by PNU.

There are a few issues to note when using PNU for immunotherapy applications. Not all of the components identifi ed

by the Kjeldahl assay are relevant allergenic proteins, therefore the PNU concentration on the label may overstate

the actual amount of true allergen in the vial. To further complicate the issue, studies have shown that in some cases

not all of an allergen protein is identifi ed by Kjeldahl assay, causing PNU to understate allergenic content. May et al.

reported that only half of the short ragweed in solution was captured by Nitrogen determination1. Because of this, the

FDA does not recognize PNU as a potency measurement and therefore is not a reliable parameter for standardization.

Nevertheless, knowledge of PNU concentration does provide some useful information, and is often utilized as a unit

for therapeutic dosing.

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800-325-7354 20

Converting between PNU and w/v Extracts

Transitioning between PNU and w/v extracts is a relatively straight-forward process, but does require two simple

calculations. Before getting started, acquire the PNU value of the w/v extract that will be diluted; identify the desired

(diluted) PNU concentration, and determine the total volume of diluted extract that will be created. Most aqueous

extracts state the PNU concentration on the vial label. For glycerin extracts or those extracts without a labeled PNU

concentration, contact ALK customer service at 800-444-2370 for the historical PNU concentration.

It is important to note that when the desired PNU concentration is greater than the w/v extract PNU concentration,

a dilution cannot be made. For instance, Mountain Cedar 1:10 W/V typically has a PNU concentration below 10,000.

Therefore a 20,000PNU/mL vial cannot be formulated. When issues such as these arise, feel free to contact Medical

Scientifi c Affairs for advice on extract formulation.

ALK Commitment

ALK is committed to helping our customers maintain uniformity of care for their patients. Please do not hesitate to

contact Scientifi c Affairs Team at 855-782-9293 should you have additional questions or concerns regarding a transition

between ALK products.

References

1. May, et.al JACI 63:89 (1979)

To create a specifi c PNU concentration from a w/v product:

Volume of W/V extract needed = (desired PNU ÷ PNU of W/V extract) X Total vial volume

Divide the desired PNU concentration by the PNU concentration of the w/v extract; multiply the resulting number by the total volume of diluted extract needed.

Example : (10,000PNU/mL desired ÷ 80,000PNU/mL w/v extract) X 10mL = 1.25mL of w/v extract needed

Next, determine how much diluent is needed to dilute the extract above in a new vial:

Volume of diluent needed = Total vial volume – Volume of w/v extract needed (determined above)

Subtract the volume of w/v extract needed (answer from previous calculation) from the total vial volume that will be created (i.e. 10mL in above example).

Example: 10mL – 1.25mL = 8.75mL of diluent

Finally, use the two numbers from the formulas above to create a diluted extract in a sterile empty vial by

combining the w/v extract with diluent

*PNU calculators are available, please contact your ALK allergy consultant

800-325-7354 21

Terms and ConditionsConfi rmation

A confi rmation number will be issued for all telephone orders. Fax and email orders will be confi rmed by the corresponding method within 24 hours.

If you send a written confi rmation of your telephone order, you must indicate Confi rming Phone Order to prevent duplication of your order. No credit

will be issued for duplication resulting from customer errors in ordering.

Shipping

To provide the best service and to safeguard the integrity of our products, allergen extracts are shipped to arrive the next day. Allergenic extracts

are normally shipped Monday, Tuesday, Wednesday and Thursday only to avoid weekend delays. Other products are shipped daily by ground

delivery service. Freight charges are calculated by weight of package rounded to the nearest full pound.

Terms

F.O.B. Round Rock, TX or Port Washington, NY. Net 30 days. All prices are subject to change without notice.

Return Policy

Please contact Sales Support at 800-325-7354 for all product return and/or credit issues. Allergenic extracts and sterile products may not be

returned unless shipped by an ALK, Inc. error. All shipping errors must be reported to Sales Support within 10 days of invoice date. Returns are

permitted ONLY with prior authorization from the Sales Support Department. If, for any reason you are dissatisfi ed with the quality of the product,

these returns will not be subject to the stated 10-day time period, but will be subject to our investigation and approval process. Product return

requests initiated in response to customer order errors will be subject to a 15% processing charge, provided that the item is eligible for restocking

per the ALK, Inc. Restocking Policy. Per the Restocking Policy, we are not able to restock allergy extracts. You will be notifi ed as to the results of all

return investigations within 5 – 10 business days. Upon investigation and approval of your return claim, a credit will be issued to your account and/

or replacement product will be shipped to you, when deemed necessary. A revised invoice will not be sent; however, a copy of the credit memo will

be sent and/or faxed to the number or address on record.

Product Quality

If you have any concerns with product quality, please contact our Sales Support department at 800-325-7354. The 10-day call limitation does not

apply to product quality issues, but will be subject to our investigation and approval process.

Errors

Errors in order entry or shipping should be reported immediately but no later than ten (10) days from date shipped (invoice date).

Minimum Order

A minimum order of $50 is required. Please combine orders to achieve these minimums. A service charge of not more than $10 will be applied to

orders of less than $50.

Ordering Information

800-325-7354 22

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800-325-7354 23

ACTT® Allergy Program

800-325-7354 24

ALK enables the veterinary dermatologist and general practitioner alike to manage allergic patients with confi dence

and success. We provide complete allergy management, offering allergy testing and treatment solutions that suit the

needs of your patients and your practice. Our commitment is to help you bring allergy relief to your patients, and to

provide you with the resources to grow your allergy practice.

Allergenic Extracts

• ALK handles the entire manufacturing process from the collection of raw materials to fi nished allergy extracts

• ALK provides over one-third of the allergy immunotherapy products worldwide

• Comprehensive analyses and quality control at all stages of the manufacturing process

In addition to providing allergenic extracts, ALK also provides the ACTT® Allergy Program, with serum allergy testing

and custom -made, allergen specifi c treatment.

ACTT® Allergy Test

• Supplement for skin testing

• In vitro serum IgE testing for allergen identifi cation

• No steroid or antihistamine interference

• Accurate and reproducible results

• Canine, feline, and equine

• Comprehensive: weeds, trees, grasses, molds, mites, insects, foods, fl eas, and culicoides. ACTT® also offers

testing for Staphylococcus and Malassezia.

Patient Specifi c Treatment Sets

• Customized treatment sets based on your dosing and formulation protocols in both subcutaneous and

sublingual

• ACTT® formulations available following fi ve different protocols; specifi c to the patient’s species, age, weight,

breed and clinical history

• USDA approved sublingual treatments

• Strict quality control and sterility standards in production

Allergy ProgramCountless Pet Allergies. One Solution.

ALK and the ACTT® Allergy Program

800-325-7354 25

ACTT® Serum Testing

Proven TechnologyThe ACTT® ELISA technology identifi es allergen-specifi c IgE with precision and accuracy. Our affi nity purifi ed,

anti-IgE antibody detects IgE only; it does not bind to IgG. Test scores are not subject to miss-identifi cation or

false-positive due to IgG interference. Our laboratory employs rigorous quality control methods to ensure accurate and

reproducible test results for each patient.

No Steroid InterferenceACTT® Allergy Test results are not affected by steroid use. Your patient does not need to be withdrawn from steroid

or anti-histamine therapy prior to serum allergy testing, making this modality a safe and accurate testing alternative to

intradermal testing.

ACTT® Allergy Testing Services

Successful allergy management begins by identifying all aspects of the animal’s allergy exposure. The ACTT® Allergy Test

offers a comprehensive list of testing options:

The ACTT® ELISA test results are the foundation for a successful immunotherapy treatment program.

Immunotherapy is the only treatment that can change the course of allergic disease, and is a safe, all- natural treatment

modality. Immunotherapy is available in allergy shots and allergy drops.

ACTT® Allergy Test

800-325-7354 26 800-325-7354 26

ACTT® Treatment

For more information about testing and treatment, please call 800-444-2370

to speak with our allergy specialists.

Allergen-Specifi c Immunotherapy Treatment

Immunotherapy is the only allergy treatment that actually reverses the natural course of allergic disease, thereby

reducing the body’s sensitivity to allergens. Because every allergy case is unique, we custom-formulate treatment

for each animal, based on species, age, weight, breed and clinical history. This unique feature separates ALK from

other laboratories. Benefi ts of custom treatment include:

• Fewer patient reactions to injections and drops

• Quicker improvement of the patient’s symptoms

• Increased owner compliance

Distinguishing Features of ACTT® Immunotherapy

Careful Allergen Selection

ALK focuses on treating immuno-dominant allergens, which provide cross protection for any allergens in related

families. Allergen cross-reactivity occurs within grass, tree, weed, mold, dust mite and insect families.

Separation of Molds, Mites and Insects

ALK follows the recommendations of the AAAAI for allergen groupings when formulating immunotherapy treat-

ment.

Custom Treatment Protocols

Immunotherapy protocols are custom-formulated according to the species, age, weight, breed and clinical history

of each animal.

Save staff resources, minimize inventory, and reduce necessary mixing space - ALK can customize your treatment sets.

800-325-7354 27 80 80 80 80 80 80 80 800-30-30-30-30-30-30-30-30-30-30-325-25-25-25-25-25-25-25-25-25-25-7357357357357357357357357357357354 4 4 4 4 4 4 27

800-325-7354 28

Visit Us Onlinewww.alk.net/us www.ACTTallergy.com

Order Online 24 hours a day.myalkus.com

Email [email protected]

Telephone Orders800-325-73547:30 am - 5:30 pm CST Mon-Wed7:30 am - 5:00 pm CST Thurs - Fri

Serum Testing and Treatment Telephone Orders800-444-2370

Fax Orders888-329-2551

ALK USA • 1700 Royston Ln • Round Rock, TX 78664

VET-US-18-000009-000

ALK products are available to licensed veterinarians only.

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