Valvular Heart Disease - Philippe Le · PDF fileValvular Heart Disease ... • Symptoms...
Transcript of Valvular Heart Disease - Philippe Le · PDF fileValvular Heart Disease ... • Symptoms...
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Valvular Heart Disease
Principals of Physiological Support
www.philippelefevre.com
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Valvular Heart Disease
• Aortic stenosis
• Aortic regurgitation
• Mitral stenosis
• Mitral regurgitation
• Right heart
• Clinical cases
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Aortic Stenosis: Aetiology
• congenital bicuspid valve
• degenerative (calcific)
• rheumatic
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Aortic Stenosis: Pathophysiology
Left ventricular – aortic root pressure gradient ⬆
Chronic pressure overload Limited systemic pressure
Systolic failure
Concentric LVH
Diastolic failure
Pulmonary hypertension
Myocardial VO2 ⬆
Subendocardialperfusing pressure ⬇
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Aortic Stenosis: Symptoms & Outlook
• Symptoms indicate late disease
• Angina, effort syncope & SOBOE
• Without surgical correction 80 – 100% mortality within 4 years of symptoms
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Aortic Stenosis: Clinical Signs
Pulse Plateau Small volume
Blood pressure Narrow pulse pressure
Palpation
Displaced apex (late sign)Pre-systolic lift, palpable S4 Sustained basal systolic thrill Sustained heaving apex
Auscultation
Harsh systolic ejection murmur Loudest over the aortic area Radiation to the carotidsS4, S3
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Aortic Stenosis: Severity Assessment
AV Gradient (mmHg) AV Area (cm2)
Normal ~ 0 2.5 – 3.5
Mild 0 – 25 1.2 – 2.0
Moderate 25 – 50 0.8 –1.2
Severe > 50 < 0.8
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Aortic Stenosis: Principals of Physiological Support
• Full
• Normal rate
• Sinus rhythm
• Tight
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Aortic Regurgitation: Aetiology
Acute
• Bacterial endocarditis
• Aortic dissection
• Trauma
• Prosthetic valve failure
Chronic
• Marfan’s
• Rheumatic fever
• Autoimmune
• Syphilis
• Osteogenesis imperfecta
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Aortic Regurgitation: Symptoms & Outlook
• Fatigue, SOBOE & angina
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Aortic Regurgitation: Clinical Signs
Pulse Bounding & collapsing Water hammer (Corrigan’s pulse)
Blood pressure⬆ systolic ⬇ diastolic
PalpationDisplaced apex Thrusting, diffuse, non-sustained impulse
Auscultation
Soft or absent S2 Loud S3 Decrescendo diastolic murmur at the left sternal edge
Ejection systolic murmur Mid diastolic murmur at the apex (Austin Flint)
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Aortic Regurgitation: Severity Assessment
Angiography Regurgitant volume (L/min)
Normal No LV contrast ~ 0
Mild Small amounts of contrast enters the LV during diastole, cleared in systole 1 – 3
Moderate LV opacified during diastole and not cleared in systole 3 – 6
Severe LV completely opacified during diastole and remains for several beats > 6
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Aortic Stenosis: Principals of Physiological Support
• Full
• Fast
• Loose
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Mitral Stenosis: Aetiology
• Rheumatic fever
• Congenital
• Calcification
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Mitral Stenosis: Pathophysiology
Chronic left atrial pressure overload
Reversible Pulmonary Hypertension
Irreversible pulmonary hypertension
LV Filling ⬇
Cardiac output ⬇
Hypertrophic right atrial enlargement
Atrial fibrillation
Systemic thromboembolism
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Mitral Stenosis: Symptoms & Outlook
• Fatigue
• Dyspnoea, orthopnoea & paroxysmal nocturnal dyspnoea
• Recurrent respiratory infections
• Haemoptysis
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Mitral Stenosis: Clinical Signs
Pulse Atrial fibrillation
Blood pressure
Palpation Tapping apex
Auscultation
Low diastolic rumble radiating to the sternal edge Presystolic accentuation Loud S1 No S3
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Mitral Stenosis: Severity Assessment
MV Gradient (mmHg) MV Area (cm2)
Normal ~ 0 4 – 6
Mild 0 – 5 1.5 – 4
Moderate 5 – 10 1 – 2
Severe > 10 < 1
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Mitral Stenosis: Principals of Physiological Support
• Normal rate
• Full
• Loose
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Mitral Regurgitation: Aetiology
Acute
• Chordae rupture
• Bacterial endocarditis
• Trauma
• Prosthetic valve malfunction
Chronic
• Rheumatic fever
• Cardiomyopathy
• Ehlers-Danlos, Marfan’s
• Calcific annulus
• Chronic aortic regurgitation
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Mitral Regurgitation: Pathophysiology
Chronic left atrial volume overload
Reversible Pulmonary Hypertension Thin walled
right atrial dilation
Irreversible pulmonary hypertension
Hyperdynamic left ventricle ⬇
Cardiac output ⬇
Atrial fibrillation
Systemic thromboembolism
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Mitral Regurgitation: Symptoms & Outlook
• Fatigue
• Dyspnoea, orthopnoea & paroxysmal nocturnal dyspnoea
• Cardiogenic shock
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Mitral Regurgitation: Clinical Signs
Pulse Atrial fibrillation
Blood pressure
Palpation
Displaced apex Hyperdynamic “thrusting” Thrill
AuscultationApical pan-systolic murmur radiating to the axilla Soft S1 S3
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Mitral Regurgitation: Severity Assessment
Regurgitant fraction (%) Regurgitant Area (cm2)
Normal < 20 ~ 0
Mild 20 – 40
Moderate 40 – 60
Severe > 60 < 4
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Mitral Regurgitation: Principals of Support
• Normal to fast rate
• Full
• Loose
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Left Heart Summary
Murmur Optimal Heart Rate
Optimal Preload
Optimal Vascular tone
Aortic stenosis ejection systolic normal full tight
Aortic regurgitation
decrescendo diastolic fast full loose
Mitral stenosis diastolic normal full tight
Mitral regurgitation systolic fast full loose
S1 S2 S1
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Right Heart Valves
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• Mrs Davidson
• 69 years old
• Aortic stenosis with AV = 0.9 cm2 and AV gradient of 30 mmHg
• Good prior function
• RNC post lithotripsy
• Met call for hypotension
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• Mr Wells
• 58 years old
• Aortic regurgitation with regurgitant proportion of 8 L/min
• Coping at home but fatigued all the time
• Presents to ED with back pain, tingling in his arms and legs and subjective weakness in his lower limbs 2 weeks following an episode of diarrheal illness
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• Mrs Higgins
• 72 years old
• Mitral stenosis wiith AV = 1.8 cm2 and MV gradient of 8 mmHg
• Orthopnoea, PND and SOBOE on regular frusemide
• Rate controlled AF with digoxin and diltiazem
• Comes to ED in the middle of a heat wave. She is acutely confused, anuric, peripherally shut down, ventricular rate of 20 – 40 and has a lactate of 9 mmol/L