VENTILATORY AND BLOOD GAS RESPONSE TO EXERCISE

REST TO WORK TRANSITIONS Change in pulmonary ventilation Observed below lactate threshold

REST TO WORK TRANSITIONS Transition from rest constant-load-submaximal

exercise

Arterial tensions of PCO2 and PO2 are relatively unchanged during transition during submaximal exercise

BUT: arterial PO2 decreases & PCO2 increases slight in transition from rest steady-state exercise

Therefore: at the start of exercise: Increase in ventilation is NOT as fast as increase in metabolism

REST TO WORK TRANSITIONS

At the onset of constant-load submaximal exercise: Initially, ventilation increases rapidly

Then, a slower rise toward steady-state

PO2 and PCO2 are maintainedSlight decrease in PO2 and increase in PCO2

CHANGES IN VENTILATION, PO2 AND PCO2 IN TRANSITION FROM REST TO STEADY STATE SUBMAXIMAL EXERCISE

PROLONGED EXERCISE IN A HOT ENVIRONMENT

Cool, low humidity environment = 19°C, 45% humidity

Hot, high humidity = from 28°C, 75% humidity

Hot environments hamper heat loss from the body

Increase in body temperature which directly affects respiratory control centre

= Minute ventilation increases (with increased breathing frequency)

PROLONGED EXERCISE IN A HOT ENVIRONMENT

During prolongedsub maximal exercise:

Ventilation tends to drift upwards

Little change in PCO2

Higher ventilation not due to increased PCO2

INCREMENTAL EXERCISE

Linear increase in ventilation- Up to 50 – 75% VO2max

Exponential increase beyond this point

Ventilatory threshold- Point where minute ventilation increases exponentially

VENTILATORY THRESHOLD Reflects aerobic fitness without the need to

directly measure maximal oxygen uptake Point during exercise training at which

pulmonary ventilation becomes disproportionately high with respect to oxygen consumption during an incremental exercise test

Used as a guide to determine exercise intensity

Therefore: Ventilatory threshold = intensity of exercise that shows a larger ventilation than required to do work.   

At this point, the contribution of anaerobic metabolism becomes significant to produce larger concentrations of lactic acid.   

Lactic acid accumulates, reducing pH & increasing metabolic acidosis.  

 Because one of the functions of the respiratory system is acid-base balance, respiration must increase to compensate for the increased acidosis.

   The point were ventilation deviates from linearity

is termed the ventilatory threshold (TVENT).  

VENTILATORY RESPONSE TO EXERCISE

Trained vs. Untrained:

Trained:- Decrease in arterial PO2 near exhaustion- pH maintained at a higher work rate- Ventilatory threshold occurs at higher work

rate

EFFECT OF TRAINING ON VENTILATION

Untrained: able to maintain PO2 in arteries within 10–12 mmHg of resting value

Trained: PO2 decreases by 30- 40 mmHg during heavy exercise

*low arterial PO2 vales during exercise = exercise induced hypoxemia

* Low arterial Po2 values are also seen in patients with severe lung disease

MALES VS. FEMALE ATHLETES

50% of highly trained male endurance athletes develop exercise induced hypoxemia

Females are suggested to have experience exercise induced hypoxemia more often than males

CAUSES Failure of pulmonary system?

Ventilation perfusion mismatch?Indicates matching of blood flow to ventilation Ideal: ~1.0Light exercise improvesHeavy exercise = inequality

Diffusion limitations during exercise ?Reduced amount of time that red blood cells spend in the pulmonary capillaries...caused by high cardiac outputs from athletes less time for gas equilibrium to be achieved

VENTILATORY RESPONSE TO EXERCISE: TRAINED VS. UNTRAINED

REVISION QUESTIONS

1. Describe the changes in PO2 and PCO2 with different exercises. (6)

2. What happens during prolonged sub maximal exercise? Why does this occur? (6)

3. What happens during incremental exercise? (3)4. Explain the Ventilatory Threshold (8)5. How do trained and untrained athlete’s ventilatory

responses differ? (6)6. How do male and female ventilatory responses

differ? (2)7. What is hypoxemia and how does it relate to

exercise? (4)8. What are the suggested causes to hypoxemia

in athletes? (6)