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Kala-azar : field studies on visceral leischmaniasis control in East Africa

Ritmeijer, K.J.L.

Link to publication

Citation for published version (APA):Ritmeijer, K. J. L. (2006). Kala-azar : field studies on visceral leischmaniasis control in East Africa.

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Download date: 01 Oct 2020

https://dare.uva.nl/personal/pure/en/publications/kalaazar--field-studies-on-visceral-leischmaniasis-control-in-east-africa(bfddde3e-0af0-40c0-96da-d5e01df357b4).html

754 Adult male VL patients assessed for eligibility

144 Not eligible

30 Refused

580 Randomized

6 Died 4 Defaulted 1 Discontinued 23 Failed

290 Miltefosine

100 mg / day orally x 28 Days

290SSG 20 mg/kg/day

intramuscularily x 30 Days

28 Died 6 Defaulted 2 Failed

Of 23 failures:2 Died 4 Defaulted 17 Cured

256 Initial Cure

(88.3%)

254 Initial Cure

(87.6%)

Of 2 failures:1 Cured 1 Failed

60 Lost to follow-up

273 End-of-treatment Cure

(after re-treatment of initial failures)

(94.1%)

255 End-of-treatment Cure

(after re-treatment of initial failures)

(87.9%)

53 Lost to follow-up

9 Died 30 Relapsed

213 6-month follow-up

202 6-month follow-up

6 Died 7 Relapsed

Of 30 relapses:24 Cured 3 Died 2 Defaulted 1 Failed

174 Final cure at follow-up

(60.0%)

189 Final cure at follow-up

(65.2%)

Of 7 relapses:3 Cured 3 Died 1 Failed

198 Final cure after re-treatment

of relapse

(68.3%)

192 Final cure after re-treatment

of relapse

(66.2%)

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UvA-DARE (Digital Academic Repository) Kala-azar : field ... · Kala-azar : field studies on...

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