Usually secondary to systemic or other cardiac diseases ......
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![Page 1: Usually secondary to systemic or other cardiac diseases ... lectures/Pathology/cvs9_pericardium.pdf · Usually secondary to systemic or other cardiac diseases • Pericardial fluid](https://reader033.fdocuments.net/reader033/viewer/2022051509/5ad66d887f8b9a98098b77ef/html5/thumbnails/1.jpg)
Pericardial disease
Usually secondary to systemic or other cardiac diseases
• Pericardial fluid accumulations • Pericarditis
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Pericardial Anatomy
• Two major components– visceral pericardium
mesothelial monolayerfacilitate fluid and ion exchange
– parietal pericardiumfibrocollagenous tissue
• Pericardial Fluid– 15 - 50 ml of clear plasma ultrafiltrate
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Pericardial Physiology
• Physiologic functions– limit cardiac dilatation– maintain normal ventricular compliance– reduce friction to cardiac movement – barrier to inflammation– limit cardiac displacement
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Pericardial effusion & hemopericardium
• Pericardial effusion: ↑ fluid due to non-inflammatory causes
- slow accumulation of 1000 ml can be accomodated - rapidly developing distension 200-300 ml causes
compression of thin walled atria, ventricles→ cardiac tamponade
• Hemopericardium: blood- rupture of myocardial infarct- rupture of dissecting aneurysm- bleeding diathesis- trauma
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Pericarditis
• Acute - serous- fibrinous- purulent- hemorrhagic
• Chronic - tubercular- chronic adhesive- chronic constrictive
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Serous pericarditis
• Serous effusion- 50-200ml, ↑ protein, high sp gravity• Causes - Viral- Rh fever- Rheumatoid arthritis- SLE • M/E: infiltration by some neutro, lymhos.
- fluid usually resorbs with resolution of underlying disease
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Fibrinous pericarditis
• Most common type, mixture of serous fluid and fibrinous exudate
• Causes - MI- Uremia- Rh fever• Clinically- friction rub• Morphology: normal transparent and glistening
pericardium is turned into a dull, opaque, “sandy” sac- cardiac surface covered by dry or moist, shaggy fibrinous exudate- bread & butter appearance
• Complete resorption or healing by organisation
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Purulent pericarditis
• Causes: pyogenic bacteria• Spread
- Contiguous spread: lungs, pleura, mediastinal lymph nodes, myocardium- Hematogenous spread: septicemia, toxins, neoplasm - Lymphatic spread- Traumatic or irradiation
• Gross: thick creamy pus coating the pericardial surfaces• M/E: dense infiltration by neutrophils• Does not resolve, heals by organisation
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Acute pericarditis – diagnostic clues
• History: sudden onset of anterior chest pain– more likely to be sharp and pleuritic– with coughing, inspiration, swallowing– worse by lying supine, relieved by sitting and leaning
forward• Physical exam: presence of rub
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Tuberculous pericarditis
• Incidence of pericarditis in patients with pulmonary TB ranges from 1-8%
• Occurs by either direct extension from an adjacent focus or by lymphatic spread
• Physical findings: fever, pericardial friction rub • TB skin test usually positive• Fluid smear for TB often negative• Pericardial biopsy more definitive: granulomas in
pericardial wall• Heal by fibrosis & calcification
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Chronic adhesive pericarditis
• Stage of organisation by fibrous adhesions • Formation of granulation tissue & neovascularisation• Adhesive mediastinopericarditis• Heart function remains normal, cardiac hypertrophy &
dilatation may occur
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Constrictive pericarditis
• Rare, dense fibrous or fibrocalcific thickening of pericardium→ heart fails to dilate during diastole, decreased cardiac output
• Results from preceding causes- tubercular, purulent, hemopericardium
• Idiopathic, radiotherapy, cardiac surgery, connective tissue disorders
• Morphology: heart encased in .5- 1cm thick & dense collagenous scar- heart size normal
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Dignostic evaluation
• Chest x-ray– usually requires > 200 ml of fluid– cannot distinguish between pericardial effusion
and cardiomegly• Echocardiography
– standard for diagnosing pericardial effusion– convenient, highly reliable, cost effective
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Tumors of Heart
• Primary tumors < Secondary tumors • Benign tumors:
myxoma, lipoma, fibroelastoma, rhabdomyoma, hemangioma
• Malignant:rhabdomyosarcoma, angiosarcoma, malignant mesothelioma
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Myxoma
• M/C primary tumor of heart (50%)• Gross: 90% occur in left atrium
- usually single, may be multiple- 1-10 cms D, polypoid, pedunculated, soft, hemorrhagic, resemble organised mural thrombusMicro: abundant mucoid intercellular stroma- low cellularity with stellate shaped cells- numerous capillary sized bld vs - lymphocytes, plasma cells and foci of hemorrhages
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Clinical effects:• Ball- valve obstruction, damage to valve leaflets• Embolization• Constitutional symptoms of fever d/t IL6 release• Part of Carneys syndrome
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Secondary tumors
• Hematogenous or lymphatic spread from lung, breast, lymphoma, leukemia, melanoma
• Direct extension from intrathoracic tumor
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Pathology of CV interventions
• Balloon angioplasty: dilation of stenosis of artery by a percutaneously inserted balloon catheter e.g percutaneous transluminal coronary angioplasty (PTCA)- Causes fracture of plaque, medial dissection, stretching of media of dissected segment
• Endovascular stents- are expandable tubes of mesh to preserve lumen patency: provide larger lumen, prevent mechanical vasospasm, dissections
• Vascular replacements- synthetic or autologous grafts that replace a segment of vessel or bypass diseased arteries
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• Coronary artery bypass graft surgery- Aorto coronary bypass: autologous grafts using reversed saphenous vein or internal mammary artery - Failure due to rethrombosis, intimal fibrous hyperplasia, atherosclerosis
• Cardiac transplantation