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Transcript of Using Physician Extenders to Create a CKD Clinic Theresa Becker, MSN, APNP Midwest Nephrology Assoc....
![Page 1: Using Physician Extenders to Create a CKD Clinic Theresa Becker, MSN, APNP Midwest Nephrology Assoc. Chronic Kidney Disease Clinic.](https://reader035.fdocuments.net/reader035/viewer/2022062511/551a06c155034619378b4af3/html5/thumbnails/1.jpg)
Using Physician Extenders to Create a CKD Clinic
Theresa Becker, MSN, APNPMidwest Nephrology Assoc.Chronic Kidney Disease Clinic
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CKD Clinic
The ideas of:
Linking CKD Clinics & Anemia Management Programs
Using physician extenders in a multidisciplinary approach
Are not new!
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CKD Clinic
ADEPT Clinic Arizonia Disease Education Prevention &
Treatment Started as an anemia management clinic but soon
developed into a CKD Clinic Patients are referred to the Vascular Access
Program when GFRs are 25-30 mL/min.
Curtis C, Yee B. The process of implementing a CKDClinic Nephrology News & Issues. 2005;19:53-54.
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CKD Clinic
SHAPE UP Program Staging & Smoking Cessation Hypertension, Hyperglycemia, Hyperlipidemia, Hyperphosphatemia,
Hyperparathyroidism, Hyperkalemia, & Hypervolemia Anemia Proteinuria Evaluation for KRT Undo nephrotoxins Preservation of veins & Patient education
Gnanasekaran I, Kim S, Dimitrov V, Soni A. SHAPE UP-A management program for chronic kidney disease Dialysis & Transplantation. 2006;35: 294-302.
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CKD Clinic
One step further : A study by Curtis et al. suggested that even after
appropriate & timely referral to a nephrologist, there is additional value of a multidisciplinary team approach in optimizing both short and long term patient outcomes.
Curtis BM, Ravani P, Malberti F, et al. The short and long term impact of multi-disciplinary clinics in addition to standard nephrology care on patient outcomes. Nephrol Dial Transplant. 2005;20:147-154.
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CKD Clinic
CKD Care PlanCKD StagingKDOQI Guideline Follow up
CKD
EducationPatient Community Professional
Vaccination ComponentFluPneumovaxHepatitis B
Anemia Management ProgramAranesp Iron Therapy
Midwest Nephrology Associates CKD Clinic Model
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CKD Clinic
Components of the CKD Care PlanGFR < 60 ml/min. HTN Anemia Nutritional Status/DM Bone/Mineral Metabolism Neuropathy Functioning & Well-being Delaying Progression of CKD
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CKD Clinic
Components of the CKD Care PlanGFR < 30 ml/min. Review Modality Options Preparation for chosen option Transplant referralGFR < 15 ml/min. Tour Clinic Monitor for ESRD signs & symptoms
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CKD Clinic
CKD Patient Education Topics CKD and consequences; anemia and bone
disease Common medications used in CKD Avoidance of nephrotoxic agents KRT Modalities Arm Preservation for HD access, Access
placement & care of site Healthy living
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CKD Clinic
Access Teaching Pre AV access: Evaluation for appropriate
arm such as vein mapping and instruction on saving that arm.
Post AV access: Care of the site, exercising the access, and monitoring its development as well as instruction on its future use.
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CKD Clinic
Documentation
Medication List Clinical Action Plan Health Maintenance Clinic Note Surgical Referral Form Vascular Access Record Chart Label
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CKD Clinic
Surgical Referral Form
Date: __________________Surgeon: __________________________ Phone: ______________ Fax: ________________Patient: _________________________________________________ DOB: _______________Nephrologist: ________________________ Phone: ______________ Fax: _______________PCP: ______________________________ Phone: _______________This patient is being referred to you for access placement. The desired access is an AV Fistula. In the event you are not planning to place an AV Fistula in this patient, please call the nephrologist prior to placing any other access.Patient’s non-dominant are is: Right LeftPatient has been saving the following arm: Right LeftComments (ie: arm injury/mastectomy/pacemaker/previous access):Vein Mapping done pre-referral: No Yes – Date/Location: ______________________Patient is currently on dialysis:Days: ____________________________________________________________________Location/Phone: ____________________________________________________________Patient is not on dialysis at this time:Anticipated hemodialysis start date: _______________________ monthsMost recent serum creatinine: ________ mg/dL & Creatinine Clearance/GFR: ________ ml/minPatient is on Anti-Coagulant Therapy: No Yes ___________________________________Allergies: NKDA Yes _______________________________________________________The following patient information is also enclosed: Face Sheet Vein Mapping Report H & P Recent Labwork Medication List
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CKD Clinic
Vascular Access Record
Stage 4 (GFR < 30 ml/min): Surgical consult should be for ‘AVF Only’.
Instruct Patient to Preserve Veins of Non-Dominant or Appropriate Arm
Obtain Vein Mapping KDOQI Benchmark: AVF placement of > 65%
for prevalent patients.
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CKD Clinic
Surgeon ___________________ Date _______________
Right Arm _____ Left Arm _____
Direct AV Fistula: Transposition AV Fistula:
PTFE Graft:
Radial/Cephalic ____
Radial/Basilic _____ Straight _____
Brachial/Cephalic ___ Brachial/Basilic _____ Loop _____
Upper____Lower____
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CKD Clinic
Access Complication History
Date Intervention Outcome
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CKD Clinic
Save ____________________ Arm
Access Placed ___________________________________
Flu Vaccine __________________________
Pneumovax __________________________
Tetanus __________________________
Hepatitis B Vaccine #1 _______________________
Recombivax-HB X 3 #2 _______________________
Engerix-B X 4 #3 _______________________
#4 _______________________
Transplant Clinic _________________________________
Chart Label
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CKD Clinic
N=106
Non-CKD Clinic Patients N= 57
CKD Clinic Patients N= 49
AVF Used
at Start of HD
12 % 35 %
AVF Placed
at Start of HD
30 % 63 %
AVF StatisticsPatients Initiating HD
1/1/06 to 10/31/06
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CKD Clinic
N=347 N %
Flu Vaccine 231 67
Pneumovax 289 83
Hepatitis B Vaccine 109 31
Vaccination Statistics
7/1/06 to 12/31/06
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CKD Insurance Issues
CPT Office Visit Billing Codes
Low complexity visit (~ 15 min.) – 99213 Moderate complexity visit (~ 25 min.)
– 99214 High complexity visit (~ 40 min.) – 99215
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CKD Insurance Issues
ICD 9 Office Visit Billing Codes
CKD Stage 1 (GFR > 90) – 585.1 CKD Stage 2 (GFR 60-89) – 585.2 CKD Stage 3 (GFR 30-59) – 585.3 CKD Stage 4 (GFR 15-29) – 585.4 CKD Stage 5 (GFR<15) – 585.5
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CKD Insurance Issues
Office Visit Reimbursement
Commercial Insurances reimburse NPs at 100% of MD charges
Medicare only reimburses NPs at 80% of MD charges
Medicare and a secondary insurance reimburses NPs at 100% of MD charges
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Anemia Management Program
Agent Similarity to Endogenous
Erythropoietin
Estimated
T 1/2
Initial Dosing Maintenance Dosing
Epoetin alfa (Procrit)
Ortho Biotech
Identical Immunologically
~ 16 to 19 hours
50-150 units/kg TIW
Typical Dosing is 150-300 u/kg weekly
Generally weekly or QOW dosing
Darbepoetin alfa
(Aranesp)
Amgen
20% more carbohydrate content
~ 33 to 48 hours
0.45 mcg/kg/wk
Typical Dosing is 0.9 mcg/kg QOW
Generally every 2 to 4 week dosing
Erythropoietin Stimulating Agents (ESA)
Available for Stage 1 – 5 CKD Patients
McClellan, Schoolwerth A., Gehr, T. Clinical Management of Chronic Kidney Disease. Cadido, OK: Professional Communications, Inc.; 2006:185-208.
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ESA Agents
Epoetin alfa Dose
(Units/week)
Darbepoetin alfa Dose
(mcg/week)
< 2,500 6.25
2,500 to 4,999 12.5
5,000 to 10,999 25
11,000 to 17,999 40
18,000 to 33,999 60
34,000 to 89,999 100
> 90,000 200
Aranesp Package Insert Amgen®
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ESA Agents
Side Effect Profile HTN and Headaches Myalgias DiarrheaContraindications Uncontrolled HTN Known hypersensitivity to the active substance
or any of the excipients
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ESA Agents
FDA Black Box WarningIssued 3/9/07
Use the lowest dose of ESA that will gradually increase the Hgb concentration to the lowest level sufficient to avoid the need for RBC transfusion.
ESAs increase the risk for death and serious CV events when administered to target a Hgb > 12 gm/dL.
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ESA Agents
RPARenal Physicians
Association Risks and benefits must
be on individual patient basis
Evidence based Hgb targets are helpful and should be reintroduced
May lead to unacceptably low Hgb levels
AAKPAmerican Association of
Kidney Patients Warning may be
confusing to patients & providers
Supports targeting Hgbs between 11 and 12
Lower Hgb lead to concerns regarding QOL
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ESA Agents
Epoetin alfa (Procrit)Single-Dose Preservative Free Vials 2,000 units, 3,000 units, 4,000 units,
10,000 units, 40,000 units/1 mLMulti-Dose Preserved Vials 20,000 units/1 mL 20,000 units/2 mL
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ESA Agents
Darbepoetin alfa (Aranesp)
Single-Dose Preservative Free Vials 25 mcg, 40 mcg, 60 mcg, 100 mcg, 200
mcg, 300 mcg, 500 mcg/1 mL 150 mcg/0.75 mL
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ESA Agents
Darbepoetin alfa (Aranesp)Single-Dose Prefilled Syringes 25 mcg/0.42 mL 40 mcg/0.4 mL 60 mcg/0.3 mL 100 mcg/0.5 mL 150 mcg/0.3 mL 200 mcg/0.4 mL
SingleJect Syringe
SureClick Syringe
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ESA Utilization Guidelines
Hgb Level of < 11.0 gm/dL within 30 days T. Sat. and/or Ferritin within 30 to 90 days Serum creatinine within 30 days Patient’s weight in kilograms ESA Dose per kilogram Erythropoietin level is NOT recommended
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ESA Utilization Guidelines
Target Hgb at or above 11.0 gm/dL Caution when intentionally maintaining
Hgb > 13.0 gm/dL Monitor Hgb minimum of every 30 days Target Ferritin > 100 ng/mL and T.
Saturation > 20% Monitor Iron Indices Quarterly
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ESA Utilization Guidelines
Dose Adjustments
If Hgb increases by > 2 gm/dL per 4 weeks and/or Hgb level > 12 gm/dL, decrease dose by 20 to 25%
If Hgb level is increasing < 1 gm/dL per 4 weeks, increase dose by 20 to 25%
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ESA Utilization Guidelines
Dose Adjustments
20 to 25% dose adjustments may be achieved by:
Altering the ESA dose Altering the time interval between
injections
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ESA Utilization Guidelines
Dose Adjustments Increases in dose should not be made
more frequently than once a month. Avoid holding doses to avoid marked drop
in ESA sensitive RBC precursors and the ‘seesaw’ effect of Hgb poor response pattern.
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ESA Utilization Guidelines
Dose Adjustments
More frequent Hgb &/or iron indices monitoring may be necessary when:
Recent bleeding or surgery Post hospitalization Post IV iron course Periods of ESA hypo-response
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ESA Utilization Guidelines
ESA Resistance Infection/Inflammation Blood Loss, Guiac Positive Stools Hyperparathyroidism B12, Folate Deficiencies Sickle cell, Thalacemias Multiple Myeloma/Malignancy ACE Inhibitor Use
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ESA Utilization Guidelines
Dose Adjustments
Recent data indicates Hgb levels can be maintained with every two week epoetin alfa dosing and monthly darbepoetin alfa dosing.
Benefits include increased staff productivity and patient satisfaction/compliance.
Moore T., Chookie S. Extended dosing od darbepoetin alfa in patients with chronic kidney disease not on dialysis: A review of recent data. Journal of ANNA 2005;32:399-407.
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ESA Utilization Guidelines
Medicare considers doses exceeding 90,000 units per week for epoetin alfa or 200 mcg per week for darbepoetin alfa to be rarely reasonable and necessary. Medical justification for doses exceeding these amounts should be documented in the patient’s record.
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ESA Utilization GuidelinesName ________________________________ DOB __________
Access____________________________ Weight ________
Date ESADose
Lot # Site Hgb BP HR Comments
Signature _________ Iron Studies
Iron Ferritin TIBC T. Sat.
Date
DateESA Flowsheet
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Hemoglobin Monitoring
HemoCue vs. Lab Draw
HemoCue Analyzer utilizes an optical measuring microcuvette. It provides nearly instantaneous Hgb results with very good accuracy.
Traditional Lab Draw may be used. However, it will require another appointment or extended patient visit while awaiting lab results.
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Hemoglobin Monitoring
HemoCue AnalyzerHemoCue Inc.40 Empire DriveLake Forest, CA 92630Phone: 1800.881.1611 Fax: 1800.333.7043www.hemocue.com
HemoCue machines require a CLIA (Clinical Laboratory Improvement Amendment) Certificate of Waiverwww.cms.hhs.gov/clia/
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ESA Insurance Issues
CPT ESA Billing Codes
Epoetin alfa – J0885 (Standard unit 1,000 units) Darbepoetin alfa - J0881 (Standard unit 1 mcg) Injection – 90772 HemoCue Lab – 85018QW
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ESA Insurance Issues
ICD 9 ESA Billing Codes
Anemia – 285.9 CKD Stage 1 (GFR > 90) – 585.1 CKD Stage 2 (GFR 60-89) – 585.2 CKD Stage 3 (GFR 30-59) – 585.3 CKD Stage 4 (GFR 15-29) – 585.4 CKD Stage 5 (GFR<15) – 585.5
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ESA Insurance Issues
Benefit Determination
Billing Office Review of Patient’s Insurance Procit – PROCRITline
1800.553.3851 or www.procritline.com
Aranesp – Amgen Reimbursement Connection1800.272.9376 or www.reimbursementconnection.com
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ESA Insurance Issues
Benefit Assistance
HealthWell FoundationP.O. Box 4133
Gaithersburg, MD 20885-4133
Phone: 1800.675.8416
Fax: 1800.282.7692
www.healthwellfoundation.org
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ESA Insurance Issues
Drug Assistance
Drug company vouchers which generally allow one month supply of ESA
ESA samples may be available
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ESA Self Administration
Initial Teaching
ESA script must include Anemia & CKD Stage ICD 9 codes
Instruct patient on storage, handling, and observe administration of ESA
Office visit charge
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ESA Self Administration
Monitoring
Monthly HemoCue lab charge vs. traditional lab draw
Office visit charge
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New Agents
Mircera Developed by Roche First and only Continuous Erythropoietin
Receptor Activator (C.E.R.A.) Twice monthly dosing schedule, however
generally will be able to administer monthly yet maintain stable Hgb levels
IV/SC administration May be used in CKD & dialysis patients
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IV Iron
Iron Sucrose (Venofer) 100 mg/1 mL vial Administer 200 mg slow IV infusion over 2 to 5
minutes on 5 different occasions within a 14 day period. Typically dosed weekly for 5 weeks.
Generally administered when Ferritin < 100 ng/mL and/or T. Saturation < 20%
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IV Iron Insurance Issues
CPT Iron Billing Code Iron Sucrose – J1786 (Standard unit 1 mg) IV Infusion – 90765 Office charge, high complexity visit - 99215
ICD 9 Iron Billing Code Iron Deficiency Anemia – 280.9
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Questions