US. DEPARTMENT OF HEAITH AND HUMAN SERVICES

NOTICE OF MAILING CHANGE 0 Check here ifyou wish t o

discontinue receiving this publication

US. DEPARTMENT OF HEAITH AND HUMAN SERVICES

OFFICIAL BUSINESS Penalty for Private Use, $300

The NIH Guide announces scientific initiativesand provides policy and administrative information to individuals and organizationswho need to be kept informed of opportunities, requirements, and changes in extra

'..Imural propans administered by the National Institutesof Health.

V o l . 19 , No. 30 August 17, 1990

0Check here ifyour address has changed and you wish to continue receiving this publication Make corrections below and mail this page to:

NIH Guide Printing & Reproduction Branch National Institutes of Health Room B4BN08, Building 31 Bethesda, Maryland 20892

Postages & Fees Paid PHS/NIH/OD

NIH GUIDE - Val. 19, NO. 30, August 17, 1990

NOTICES

REMINDER AND UPDATE: REQUIREMENT FOR PROGRAMS ON THE RESPONSIBLECONDUCT OF RESEARCH IN NATIONAL RESEARCH SERVICE AWARD INSTITUTIONAL WIyI

TRAINING PROGRAMS ........................................................... 1 National Institutes of Health Alcohol, Drug Abuse, and Mental Health Administration Index: NATIONAL INSTITUTES OF HEALTH

ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

NOTICES OF AVAILABILITY (RFPs AND RFAs1

ACQUISITION AND CHARACTERIZATION OF ALLOANTISERA AND MOLECULAR PROBES RECOGNIZING PUBLIC SPECIFICITIES OF THE MHC (RFP) ........................... 2 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES

PRECLINICAL PHARMACOLOGY STUDIES OF ANTI-AIDS AGENTS (RFP) .................. 2 National Cancer Institute Index: CANCER

TOXICITY STUDIES IN ANIMALS (RFP) ........................................... 3 National Institute of Environmental Health Sciences Index: ENVIRONMENTAL HEALTH SCIENCES

SPECIALIZED RESEARCH CENTER PROGRAMS OR CENTER CORE GRANTS TO SUPPORT RESEARCH IN REPRODUCTION (RFA HD-91-01) ............................. 4 National Institute of Child Health and Human DevelopmentIndex: CHILD HEALTH, HUMAN DEVELOPMENT

CHILD AND ADOLESCENT TRIAL FOR CARDIOVASCULAR HEALTH: COORDINATING 'ul'CENTER (RFA HL-90-13-P) ..................................................... 5 National Heart, Lung, and Blood Institute Index: HEART, LUNG, BLOOD

NATIONAL RESEARCH SERVICE AWARD - INSTITUTIONAL GRANTS (RFA HS-90-01) ....... 5 Agency for Health Care Policy and Research Index: AGENCY FOR HEALTH CARE POLICY AND RESEARCH

MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTERS (PA-90-24) ...... 6 National Institute of Arthritis and Musculoskeletal and Skin Diseases Index: ARTHRITIS, MUSCULOSKELETAL DISEASES, SKIN DISEASES

STUDIES OF STRUCTURAL BIOLOGY AND PROTEIN STRUCTURE-FUNCTION RELEVANT TO DIABETES, ENDOCRINOLOGY, AND GENETIC METABOLIC DISEASES (PA-90-25) ....... 7 National Institute of Diabetes and Digestive and Kidney Diseases Index: DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES

)IOTICES

W

INDER AND UPDATE : REQUIREMENT FOR PROGRAMS ON THE RESPONSIBLE CONDUCT OF RESEARCH I N NATIONAL RESEARCH SERVICE AWARD INSTITUTIONAL T R A I N I N G PROGRAMS

P.T. 44; K.W. 1014004, 1014006

Nat iona l I n s t i t u t e s o f Heal th Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion

A s s t a t e d i n t h e N I H Guide f o r Grants and Cont rac ts , V o l . 18, No. 45, December 22, 1989, admin i s t r a t ive gu ide l ines f o r t h e Nat ional Research Se rv ice Award (NRSA) i n s t i t u t i o n a l t r a i n i n g g ran t a p p l i c a t i o n s submit ted t o t h e Nat ional I n s t i t u t e s o f Heal th ( N I H ) and Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion (ADAMHA) have been r ev i sed " t o r e q u i r e t h a t a program i n t h e p r i n c i p l e s o f s c i e n t i f i c i n t e g r i t y be an i n t e g r a l p a r t o f t h e proposed r e sea rch t r a i n i n g e f f o r t " . This requirement a p p l i e s t o a l l competing t r a i n i n g g r a n t a p p l i c a t i o n s rece ived a f t e r J u l y 1 , 1990. The p r i n c i p a l goa l o f t h e NRSA gran t mechanisms is t o t r a i n s c i e n t i s t s f o r f u t u r e careers i n biomedical and behaviora l r e sea rch . An important f a c t o r i n biomedical and behaviora l r e sea rch is t h e need t o maintain t h e h ighes t l e v e l s o f i n t e g r i t y i n t h e conduct of r e sea rch . The r e sea rch t r a i n i n g environment i n t h e u n i v e r s i t y s e t t i n g provides a powerful contex t i n which t o promote r e spons ib l e r e sea rch p r a c t i c e s .

N I H and ADAMHA recognize t h a t t h e s c i e n t i f i c community is a t an e a r l y s t a g e of developing information and methods t h a t p e r t a i n s p e c i f i c a l l y t o t r a i n i n g i n r e sea rch e t h i c s f o r t r a i n e e s . Not a l l methods w i l l work i n a l l t r a i n i n g s i t u a t i o n s given t h e he t e rogene i ty among d i s c i p l i n e s and p ro fes s ions . There are no s i n g l e models or paradigms. Appreciat ion o f t h e he t e rogene i ty amongt h e biomedical and behaviora l r e sea rch components wi th in t h e i n s t i t u t i o n s cal ls f o r f l e x i b i l i t y i n approaches t o e f f e c t i v e educa t ion and t r a i n i n g models.

I n s t i t u t i o n s must accept primary r e s p o n s i b i l i t y and be allowed t o develop t h e i r own ways o f promoting r e spons ib l e conduct o f r e sea rch i n conjunct ion with t h e i r t r a i n i n g programs. S c i e n t i f i c and admin i s t r a t ive l e a d e r s o f t h e u n i v e r s i t y o r from o u t s i d e (as c o n s u l t a n t s o r speakers ) could be a v i s i b l e p a r t o f t h i s e f f o r t . Appl icants are urged t o d i s c u s s t h e development o f methods on t h i s important t o p i c with t h e i r co l leagues and a l s o look t o t h e pro fes s iona l a s s o c i a t i o n s f o r guidance as w e l l as d i scuss ions wi th N I H andADAMHA s t a f f .

& a r r a y o f methods might be used a t va r ious t r a i n i n g l e v e l s . It was s t a t e d i n t h e N I H Guide for Grants and Cont rac ts , December 22, 1989 n o t i c e :

"Most u n i v e r s i t i e s and academic i n s t i t u t i o n s have p r a c t i c e s and procedures t o ensure t h e r e spons ib l e conduct o f r e sea rch . These may inc lude informal seminars and p r e s e n t a t i o n s on c o n f l i c t o f i n t e r e s t , d a t a record ing and r e t e n t i o n , p r o f e s s i o n a l s t anda rds and codes o f conduct, r e spons ib l e authorsh ip , i n s t i t u t i o n a l p o l i c i e s and procedures for handl ing a l l e g a t i o n s o f misconduct, p o l i c i e s regard ing t h e use o f human and animal s u b j e c t s , etc. or formal cour ses on b i o e t h i c s , r e sea rch conduct, t h e i d e a l s of sc ience , etc."

For t h e first 18 months o f implementation o f t h i s requirement, it is expected t h a t i n s t i t u t i o n s w i l l be given cons iderable f l e x i b i l i t y i n o rde r t o encourage innovat ion i n t h e development o f methods f o r provid ing t r a i n i n g i n s c i e n t i f i c i n t e g r i t y . However, d e s c r i p t i o n s o f formal or informal a c t i v i t i e s r e l a t e d t o i nco rpora t ion o f e f f o r t s r e l e v a n t t o t h e r e spons ib l e conduct o f r e sea rch ( i . e . , " the plan") should be e x p l i c i t as p o s s i b l e (e .g . , t o p i c s t o be covered; f a c u l t y t h a t may be involved; format; schedule , e t c . ) . No a p p l i c a t i o n w i l l be awarded u n t i l a d e s c r i p t i o n of t h e i n s t i t u t i o n ' s p l an t o provide i n s t r u c t i o n on e t h i c s i n r e sea rch t r a i n i n g is fu rn i shed .

N I H GUIDE - Vol. 19, No. 3 0 , August 17 , 1990 - Page 1

ACQUISITION AND CHARACTERIZATION OF ALLOANTISERA AND MOLEC LAR PROBESu RFP AVAILABLE: RFP-NIH-NIAID-DAIT-91-22 P.T. 34; K.W. 0710065, 1002008, 1002058, 0760053

Nat ional I n s t i t u t e o f Allergy and I n f e c t i o u s Diseases

The Div i s ion of Allergy and Immunology and Transp lan ta t ion o f t h e Nat ional I n s t i t u t e of Allergy and I n f e c t i o u s Diseases has a requirement f o r t h e a c q u i s i t i o n and c h a r a c t e r i z a t i o n of a l l o a n t i s e r a and molecular probesrecognizing complex p u b l i c spec i f ic i t ies o f t h e major h i s t o c o m p a t a b i l i t y(MHC). The a c q u i s i t i o n w i l l r e q u i r e knowledge of immunogenetics, n u c l e i c a c i d molecular b i o l o g i c a l techniques, as we l l as, a c q u i s i t i o n and c h a r a c t e r i z a t i o n o f a l l o a n t i s e r a recognizing t h e p u b l i c spec i f i t i e s o f t h e MHC.

One or more c o n t r a c t s may be awarded as a r e s u l t o f t h i s s o l i c i t a t i o n . It is expected t h a t t h e c o n t r a c t w i l l have a f ive -yea r p e r i o d o f performance. Anyr e s p o n s i b l e o f f e r o r may submit a proposal which s h a l l be considered by t h e Government.

RFP-NIH-NIAID-DAIT-91-22 w i l l be i s sued on or about August 22, 1990. Proposals w i l l be due f o r t y - f i v e days t h e r e a f t e r .

To r e c e i v e a copy o f t h i s RFP, p l e a s e supply t h i s o f f i c e with a r eques t i n w r i t i n g and two se l f - addres sed mail ing l a b e l s addressed t o t h e o f f i c e l i s t e d below:

Ms. Grace A. Bruce Contract Spec ia l i s t Contract Management Branch, N I A I D National I n s t i t u t e o f Allergy and I n f e c t i o u s Diseases West wood Bu ild ing/Room 707 5333 Westbard Avenue Bethesda, MD 20892

This advert isement does no t commit t h e Government t o make an award.

9GEN S

RFP AVAILABLE: NCI-CM-27701-27

P.T. 34; K.W. 0710100, 0740020, 0715008, 0755010

Nat ional Cancer I n s t i t u t e

The Developmental The rapeu t i c s Program (DTP), D iv i s ion o f Cancer Treatment (DCT) , Nat ional Cancer I n s t i t u t e ( N C I ) , is seeking o r g a n i z a t i o n s having t h e necessary experience, s c i en t i f i c and t e c h n i c a l personnel , and f a c i l i t i e s t o conduct a series o f p r e c l i n i c a l pharmacokinetic and o t h e r pharmacology s t u d i e s i n non-disease bea r ing animals on compounds having demonstrated ANTI-HIV a c t i v i t y and considered by DCT t o merit f u r t h e r development. The s t u d i e s t o be performed w i l l i nc lude : The development o f methodology f o r t h e q u a n t i t a t i v e measurement o f t h e compound and lo r m e t a b o l i t e s i n animal bodyf l u i d s and t i s s u e s ; s t a b i l i t y s t u d i e s o f t h e compound i n b i o l o g i c a l f l u i d s ;de t e rmina t ion o f t h e plasma concentrat ion-t ime p r o f i l e and c a l c u l a t i o n of r e l e v a n t pharmacokinetic parameters; de t e rmina t ion o f t h e most e f f e c t i v e mode o f compound a d m i n i s t r a t i o n t o achieve and maintain v i r a l i n h i b i t o r yc o n c e n t r a t i o n s i n body f l u i d s and t i s s u e s ; b i o a v a i l a b i l i t y s t u d i e s fo l lowinga d m i n i s t r a t i o n o f an agent by v a r i o u s r o u t e s ; t i s s u e d i s t r i b u t i o n and u r i n a r ye x c r e t i o n s t u d i e s ; and s t r u c t u r a l de t e rmina t ion of m e t a b o l i t e s and t r ans fo rma t ion p roduc t s of t h e pa ren t compound. The Government w i l l supplya l l animals (mice, rats, dogs) , t e s t agen t s , and r a d i o l a b e l e d tes t agen t s .Con t rac to r s w i l l be expected t o provide a l l equipment, s o l v e n t s , reagents, and animal f ac i l i t i e s needed t o conduct t h i s t y p e o f work.

It is a n t i c i p a t e d t h a t t h r e e awards w i l l be made as r e s u l t of t h i s Request for Proposal (RFP), each f o r a t h r e e yea r , incrementally-funded l e v e l o f e f f o r t c o n t r a c t beginning on or about October 1 , 1991. Only one award w i l l be made t o an i n s t i t u t i o n . Th i s p r o j e c t is a recompeti t ion o f t h e work being done under c o n t r a c t numbers: N01-CM-87284 A.D. L i t t l e , I N C . , Massachusetts;N01-CM-87285 Southern Research I n s t i t u t e , Alabama; N01-CM-87286 Vermont Regional Cancer Center , Vermont.

N I H GUIDE - Vol. 19, No. 30, August 17, 1990 - Page 2

RFP No. NCI-CM-27701-27 w i l l be i ssued on o r about August 13, 1990, with a due d a t e f o r receipt o f proposa ls on October 13, 1990.

Requests f o r t h e RFP should be s e n t t o :

Johnny Jordan w Contract S p e c i a l i s t

Treatment Contract Sec t ion Research Cont rac ts Branch Nat iona l Cancer I n s t i t u t e Execut ive P laza South, Room 6031 9000 Rockvi l le Pike Bethesda, MD 20892

TOXICITY STUDIES I N ANIMALS RFP AVAILABLE: NIH-ES-90-25

P.T. 34; K.W. 1007009, 0780017

National I n s t i t u t e o f Environmental Heal th Sc iences

The purpose o f t h i s c o n t r a c t is t o conduct short-term, i n v ivo s t u d i e s t h a t w i l l assist t h e Nat iona l Toxicology Program (NTP) i n t h e t o x i c o l o g i cc h a r a c t e r i z a t i o n o f chemicals . The NTP w i l l provide a chemica l -spec i f icp ro toco l o u t l i n e f o r each chemical t o be s t u d i e d under t h i s c o n t r a c t . The c o n t r a c t s ob ta ined under t h i s s o l i c i t a t i o n s h a l l provide t h e c a p a b i l i t y t o perform s p e c i f i e d procedures f o r a s s e s s i n g t h e t o x i c i t y o f approximately 5 chemicals pe r c o n t r a c t pe r year f o r f i v e yea r s . The b a s i c c o n t r a c t award s h a l l provide f o r t h e conduct of approximately e i g h t s t u d i e s per c o n t r a c t per y e a r , The Government may, pending t h e a v a i l a b i l i t y o f funds, e x e r c i s e one op t ion i n each year o f each c o n t r a c t f o r t h e conduct o f f o u r a d d i t i o n a l s t u d i e s . Study des igns w i l l g ene ra l ly involve d a i l y (gavage o r s k i n p a i n t ) o r cont inuous (dosed fee o r water) dosing pe r iods . The types o f chemicals t o be s tud ied may inc lude , but s h a l l no t be l i m i t e d t o , i n d u s t r i a l so lven t s ,p l a s t i c i z e r s , food p r e s e r v a t i v e s and co lo ran t s , drugs, p e s t i c i d e s , and heavymeta ls . Most s t u d i e s w i l l involve rats and mice; however, some s t u d i e s mayinc lude r a b b i t s , guinea p igs , and dogs. Th i s work s h a l l be performed i n accordance wi th t h e Good Laboratory P r a c t i c e Regulat ions e s t a b l i s h e d by t h e

4 FDA f o r Noncl in ica l Laboratory S tud ie s (FDA Good Laboratory P r a c t i c e Regulat ions f o r Noncl in ica l Laboratory S tud ie s ; F i n a l Report (Fed. Reg i s t e r ,Vol. 52, t172, Friday, September 4, 1987, pp. 33768-33782; 21 CFR P a r t 58).A t least two cost-reimbursement, term form, l e v e l of e f f o r t , t a s k o rde r t ypec o n t r a c t s with an es t imated per iod o f performance o f f i v e yea r s each are contemplated as a r e s u l t o f t h i s s o l i c i t a t i o n . One award is s e t - a s i d e f o r a small bus iness concern. One o r more award(s1 w i l l be made on an opencompeti t ion b a s i s . The Government estimates t h a t approximately 1.79 s e n i o r p r o f e s s i o n a l person yea r s , 1.75 pro fes s iona l person yea r s , and 7.02 t e c h n i c a l person y e a r s w i l l be r equ i r ed on an annual b a s i s f o r each b a s i c c o n t r a c t award. An a d d i t i o n a l .98 s e n i o r p r o f e s s i o n a l person year , .90 p r o f e s s i o n a l person year, and 3.81 technical person years w i l l be r e q u i r e d on an annual b a s i s f o r each c o n t r a c t award f o r op t iona l s t u d i e s . A l l r e spons ib l e sources may submit a proposa l which s h a l l be considered by t h e Agency. Expectedrelease d a t e o f t h e RFP is August 21, 1990, with proposa ls due October 30,1990.

Requests should r e fe rence RFP NIX-ES-90-25 and should be forwarded t o :

Nat iona l I n s t i t u t e of Environmental Heal th Sc iences Contrac ts and Procurement Management Branch, OM ATTN: Marilyn B. Whaley, Contract S p e c i a l i s t 79 T.W. Alexander Drive, 4401 Bui ld ing P. 0. Box 12874 Research Tr i ang le Park, NC 27709


SPECIALIZED RESEARCH CE l ES RC JgJ N REPRODUCTION

RFA AVAILABLEr HD-91-01

P.T. 0 4 ; K.W. 0413002, 0710030

Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development

Letter o f I n t e n t Receipt Date: January 1, 1991 Appl ica t ion Receipt Date: May 6 , 1991

The Reproductive Sc iences Branch (RSB), Center f o r Populat ion Research (CPR),Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development ( N I C H D ) , suppor t sr e sea rch on reproduct ion t h a t relies on a v a r i e t y o f approaches i n biomedical s c i e n c e s . Among t h e g ran t mechanisms used t o provide r e sea rch suppor t , t h e RSB uses :

Spec ia l i zed Research Centers (P50s) which are i n t e g r a t e d groups o f r e sea rch p r o j e c t s and suppor t ing co re s e r v i c e fac i l i t i es . The r e sea rch a c t i v i t i e s included i n such p r o j e c t g r a n t s must comprise,by d e f i n i t i o n , a m u l t i d i s c i p l i n a r y approach t o biomedical problemsi n reproduct ion . Although t h e s e r e sea rch programs may have more than one theme, focus, o r emphasis, a l l o f t h e p r o j e c t s must be respons ive t o one o r more o f t h e s p e c i f i c areas o f reproduct iveresea rch which c o n s t i t u t e t h e purview o f t h e RSB, CPR, NICHD.

Center Core Grants (P30s) t h a t support Center Core fac i l i t i es designed t o enhance e x i s t i n g f e d e r a l l y supported r e sea rch p r o j e c t swi th in t h e purview o f t h e RSB, CPR, N I C H D . Such Center awards r e q u i r e a c r i t i c a l mass o f i nd iv idua l , reproduct ive-or ien ted awards whose p r o d u c t i v i t y and q u a l i t y would be increased by suppor t from c e n t r a l t e c h n i c a l f a c i l i t i e s .

A t p r e s e n t , t h e RSB suppor t s a f i x e d number of c e n t e r s wi th a commitment of f i v e y e a r s o f suppor t t h a t is compet i t ive ly renewable f o r a d d i t i o n a l f ive-year per iods . Support f o r one P50 Center and t h r e e P30 Centers ends i n FY 1992,and it is a n t i c i p a t e d t h a t t h e s e Centers w i l l submit renewal a p p l i c a t i o n s . While t h e r e are no new Center p o s i t i o n s a v a i l a b l e a t t h i s time, new groups o f i n v e s t i g a t o r s , i n a d d i t i o n t o t h e c u r r e n t awardees, are i n v i t e d t o compete f o r t h e e x i s t i n g f o u r (4)p o s i t i o n s .

P o t e n t i a l a p p l i c a n t s should con tac t t h e RSB s ta f f f o r f u r t h e r information r ega rd ing reproduct ive sc i ences c e n t e r g r a n t s (P50s and P 3 0 s ) . It is s t r o n g l y recommended, bu t n o t mandatory, t h a t p o t e n t i a l a p p l i c a n t s send a le t te r of i n t e n t t o t h e RSB s ta f f a t t h e address l i s t e d below by January I , 1991. This l e t t e r should o u t l i n e t h e o rgan iza t iona l s t r u c t u r e o f t h e proposed c e n t e r , list t h e t i t l e o f t h e r e l e v a n t r e sea rch p r o j e c t s t o be a s s o c i a t e d with it, and t h e names o f t h e r e l e v a n t p r i n c i p a l i n v e s t i g a t o r s . The le t te r o f i n t e n t should be r ece ived by t h e RSB no l a t e r than January I , 1991, but a p p l i c a n t s are encouraged t o send it as soon as they dec ide t o apply f o r t h e g r a n t so t h a t t h e RSB staff can be o f maximum a s s i s t a n c e i n t h e a p p l i c a t i o n p rocess .

Although t h i s s o l i c i t a t i o n is included i n t h e p l a n s f o r FY 1992, support f o r t h e s e c e n t e r g r a n t s is cont ingent upon t h e receipt o f funds f o r t h e s e purposes by t h e NICHD. The number o f g r a n t s t o be awarded is a l s o cont ingent upon a s u f f i c i e n t number o f a p p l i c a t i o n s r ece iv ing a h igh enough l e v e l o f m e r i t t o be cons idered f o r an award. I t is expected t h a t up t o f o u r (4) awards w i l l be made as a r e s u l t o f t h i s announcement.

Appl ica t ions f o r g r a n t s involv ing c l i n i c a l s t u d i e s should inc lude members o f minor i ty groups and women i n t h e s tudy popula t ions . Otherwise, a clear r a t i o n a l e f o r t h e i r exc lus ion must be provided i n t h e a p p l i c a t i o n .

For f u r t h e r in format ion and a copy o f t h e f u l l y descr ibed RFA, p l e a s e c o n t a c t :

J u l i a Lobotsky, M.S. Reproductive Sc iences Branch Center f o r Populat ion Research Nat iona l I n s t i t u t e o f Chi ld Heal th and Human DevelopmentNat iona l I n s t i t u t e s o f Heal th Execut ive P laza North, S u i t e 603 Bethesda, MD 20892 Telephone: (301) 496-6515


To o b t a i n cop ie s o f t h e NICHD Pol icy and Formatting Guide l ines f o r P30 and P50 c e n t e r g r a n t a p p l i c a t i o n s , p l e a s e con tac t :

Laurance Johnston, Ph.D. S c i e n t i f i c Review ProgramNational I n s t i t u t e of Chi ld Heal th and Human Development

-f Nat iona l I n s t i t u t e s of Heal th Execut ive Plaza North, S u i t e 520 Bethesda, MD 20892 Telephone: (301) 496-1696

This program is descr ibed i n t h e Catalog o f Federa l Domestic Ass i s t ance No. 13.864, Populat ion Research. Awards w i l l be made under t h e a u t h o r i t y o f t h e Pub l i c Heal th Se rv ice A c t 301 (42 USC 241) and 441 (USC 289d) and adminis te red under PHS Grant P o l i c i e s and Federal Regulat ions 42 CFR P a r t 52 and 45 CFR P a r t 74. Th i s program is no t s u b j e c t t o A-95 o r Heal th Systems Agency review.

CHILD AND ADOLESCENT TRIAL FOR CARDIOVAS C U M HEALTH: COORDINATING CENTEq

RFA AVAILABLE: HL-90-13-P

P.T. 34; K.W. 0715040, 0745035, 0755015, 0755018, 0403001

Nat iona l Heart, Lung, and Blood I n s t i t u t e

Appl ica t ion Receipt Date: November 13, 1990

The Divis ion o f Epidemiology and C l i n i c a l Appl ica t ions (DECA), Nat iona l Heart,Lung, and Blood I n s t i t u t e ( N H L B I ) , announces t h e a v a i l a b i l i t y o f a Request f o r Appl ica t ions (RFA) on t h e above s u b j e c t . Copies o f t h e RFA are a v a i l a b l e from staff o f t h e NHLBI. Competition w i l l be l i m i t e d t o domestic i n s t i t u t i o n s .

This award w i l l suppor t a coord ina t ing c e n t e r t o p a r t i c i p a t e wi th f i e l d c e n t e r s and t h e NHLBI i n a c o l l a b o r a t i v e s tudy e n t i t l e d "Child and Adolescent T r i a l f o r Cardiovascular Health" (CATCH). The o v e r a l l o b j e c t i v e o f t h e t r i a l is t o assess t h e effects o f a school-based i n t e r v e n t i o n f o r promoting h e a l t h f u l behavior i n e lementary school c h i l d r e n t o reduce t h e i r subsequent ca rd iovascu la r d i s e a s e r i s k . CATCH is c u r r e n t l y i n t h e l a s t year o f a 3.5 year f e a s i b i l i t y s tudy t h a t involves p ro toco l w r i t i n g and developmental work

-eand t e s t i n g i n e lementary schools a t f o u r F i e l d Centers a c r o s s t h e count ry .The a s s i s t a n c e mechanism used t o support t h e c u r r e n t f e a s i b i l i t y s tudy and t h e proposed main t r i a l f o r t h e CATCH Study is t h e coopera t ive agreement which is similar t o t h e t r a d i t i o n a l N I H r e sea rch g r a n t . The a d m i n i s t r a t i v e and fundingmechanism f o r t h i s t r i a l w i l l con t inue t o be a coopera t ive agreement. I t d i f f e r s from a r e sea rch g r a n t p r i n c i p a l l y i n t h e e x t e n t and n a t u r e o f NHLBI s taff involvement.

Requests f o r cop ie s o f t h e RFA may be addressed t o :

E la ine J . Stone, Ph.D. Prevention and Demonstration Research Branch Divis ion o f Epidemiology and C l i n i c a l Appl ica t ionsNational Heart, Lung, and Blood I n s t i t u t e Federal Bui lding, Room 604A Bethesda, MD 20892 Telephone8 (301) 496-3503 FAX : (301) 402-0517

NATI ONAL RESEARCH SERVICE AWARD -INSTITUTIONAL GRANTS

RFA AVAILABLE8 HS-90-01

P.T. 44; K.W. 0720005, 0730050

Agency f o r Heal th Care Pol icy and Research

Appl ica t ion Receipt Date: October 15, 1990

AUTHORITY AND PURPOSE

Under a u t h o r i t y o f Sec t ion 487 o f t h e Publ ic Heal th Se rv ice (PHS) A c t as amended (42 USC 2881, t h e Agency f o r Heal th Care Po l i cy and Research (AHCPR)is awarding Nat ional Research Se rv ice Award (NRSA) i n s t i t u t i o n a l g r a n t s (T32)t o e l i g i b l e i n s t i t u t i o n s t o develop or enhance r e sea rch t r a i n i n g o p p o r t u n i t i e sf o r q u a l i f i e d i n d i v i d u a l s o f t h e i n s t i t u t i o n ' s s e l e c t i o n who seek t o preparefor careers i n h e a l t h s e r v i c e s r e sea rch . Th i s Request for Appl ica t ions (RFA)


announces t h e a p p l i c a t i o n receipt date f o r t h i s program (October 1, 1990) and i d e n t i f i e s t h e t r a i n i n g areas o f special i n t e r e s t .

The purpose o f t h e NRSA program is t o he lp ensure t h a t h i g h l y t r a i n e d s c i e n t i f i c personnel w i l l be a v a i l a b l e i n adequate numbers and i n t h e a p p r o p r i a t e r e s e a r c h areas and f i e l d s t o maintain t h e n a t i o n ’ s h e a l t h s e r v i c e s r e s e a r c h agenda. T i t l e 42 of t h e Code o f Federal Regulat ions, P a r t 66, is a p p l i c a b l e t o t h i s program as is t h e fol lowing Catalog o f Federal Domestic c

Ass i s t ance number: 13.226.

APPLICANT ELIGIBILITY REQUIREMENTS

Domestic n o n p r o f i t p r i v a t e o r p u b l i c i n s t i t u t i o n s may apply f o r g r a n t s t o support r e s e a r c h t r a i n i n g programs. The a p p l i c a n t i n s t i t u t i o n must have t h e s t a f f and f ac i l i t i e s r e q u i r e d for t h e proposed program. The t r a i n i n g programd i r e c t o r a t t h e i n s t i t u t i o n w i l l be r e s p o n s i b l e f o r t h e s e l e c t i o n and appointment o f t r a i n e e s and f o r t h e o v e r a l l d i r e c t i o n o f t h e program.

REVIEW SCHEDULE

The schedule ( i n d i c a t e d below) is designed t o a l low Program D i r e c t o r s t i m e t o r e c r u i t cand ida te s du r ing t h e f a l l / w i n t e r o f t h e academic yea r (1991) f o r appointments t o begin t h e fol lowing summer.

Appl i ca t ion I n i t i a l Review Council Earliest Receipt Date Meeting Meeting Award

October 15 February May/ June J u l y 1990 1991 1991 1991

ADDITIONAL INFORMATION

The AHCPR suppor t s t r a i n i n g i n a l l a r e a s of h e a l t h s e r v i c e s r e s e a r c h . The AHCPR expec t s t o fund approximately f i v e new and/or renewal i n s t i t u t i o n a l t r a i n i n g awards i n response t o t h i s RFA.

Complete d e t a i l s on t h e p o l i c y and g u i d e l i n e s , t h e mechanism o f t h e award,a p p l i c a t i o n procedure, review cr i ter ia , and cop ie s o f t h e RFA may be obtained from:

M r . Hoke S . Glover Parklawn Building, Room 18-1 2 5600 F i s h e r s Lane Rockvil le , MD 20857 Telephoner (301) 443-3091

O N G O I N G PROGRAM ANNOUNCEMENIS

WJLTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTERS PAX PA-90-24

P.T. 04; K.W. 0715010, 0715136, 0785055, 0710030, 0730050

National I n s t i t u t e o f A r t h r i t i s and Musculoskeletal and Skin Diseases

The Nat ional I n s t i t u t e o f A r t h r i t i s and Musculoskeletal and Skin Diseases (NIAMS) uses a v a r i e t y of award mechanisms t o accomplish i t s re sea rch mission. Among t h e s e mechanisms is t h e P60 award f o r a multipurpose a r t h r i t i s and musculoskeletal d i s e a s e s c e n t e r .

The a p p l i c a t i o n g u i d e l i n e s f o r t h e multipurpose a r t h r i t i s and musculoskeletal d i s e a s e s c e n t e r s have been r e v i s e d and are i n effect f o r a l l a p p l i c a t i o n srece ived on o r after June 1, 1990.

Fourteen c e n t e r s are c u r r e n t l y funded by NIAMS. Organizat ions no t c u r r e n t l yfunded are encouraged t o cons ide r applying �or t h i s program. E l i g i b l eo r g a n i z a t i o n a l e n t i t i e s are major medical complexes i n t h e United S t a t e s with a base o f m e r i t o r i o u s biomedical r e sea rch r e l a t e d t o a r t h r i t i s and musculoskeletal d i s e a s e s . I n s t i t u t i o n a l programs i n educat ion, epidemiology,and/or h e a l t h s e r v i c e s t h a t can be r e l a t e d to a r t h r i t i s and musculoskeletal d i s e a s e s should a l s o be p r e s e n t . The c e n t e r f o s t e r s a m u l t i d i s c i p l i n a r yr e s e a r c h approach t o t h e manifold problems o f a r t h r i t i s and musculoskeletald i s e a s e s . The c e n t e r g r a n t is not intended t o provide t o t a l funding f o r a l l .FI.

of t h e s e a c t i v i t i e s , bu t t o provide funds f o r development o f new c a p a b i l i t i e sf o r r e sea rch and r e l a t e d a c t i v i t i e s .


wrrl

A mult ipurpose a r t h r i t i s and musculoskeletal d i s e a s e s c e n t e r has two majorresearch coord ina t ing components: biomedical r e sea rch and r e sea rch i n educat ion, epidemiology, and h e a l t h s e r v i c e s . An a d m i n i s t r a t i v e u n i t p rovides over s igh t . The i n t e r a c t i o n s a f forded by t h e a d m i n i s t r a t i v e u n i t and two r e sea rch components provide o p p o r t u n i t i e s t o promote new re sea rch d i r e c t i o n s through developmental and f e a s i b i l i t y p r o j e c t s and through c o r e u n i t s . I n add i t ion , r e sea rch p r o j e c t s i n educat ion, epidemiology, and/or h e a l t h s e r v i c e s a r e supported. The N I H u rges a p p l i c a n t s f o r g r a n t s t o g ive added a t t e n t i o n (where f e a s i b l e and a p p r o p r i a t e ) t o t h e i n c l u s i o n o f minor i ty groups and women i n t h e s tudy popula t ions f o r r e sea rch .

APPLICATION AND REVIEW PROCEDURES

Appl ica t ions i n response t o t h i s announcement w i l l be reviewed i n accordance with s t anda rd N I H peer review procedures f o r r e sea rch c e n t e r g r a n t s . Review c r i t e r i a inc lude s i g n i f i c a n c e and o r i g i n a l i t y o f t h e r e sea rch goa l s and approaches; f e a s i b i l i t y o f t h e r e sea rch and adequacy o f t h e experimental design; t r a i n i n g , r e sea rch competence, and ded ica t ion of t h e i n v e s t i g a t o r s ; adequacy o f a v a i l a b l e f ac i l i t i e s ; and p rov i s ion f o r t h e humane care o f animals and appropr i a t e use o f human s u b j e c t s . Funding d e c i s i o n s w i l l be based on pee r review group and Nat iona l Advisory Council recommendations. Appl ica t ions should be submit ted on form PHS-398 ( r e v . 10/88), a v a i l a b l e i n t h e bus iness or g r a n t s o f f i c e a t most academic r e sea rch i n s t i t u t i o n s , or from t h e N I H Divis ion of Research Grants . Appl ica t ions w i l l be accepted i n accordance wi th t h e submission d a t e s f o r new and competing c e n t e r g ran t a p p l i c a t i o n s on a cont inuing b a s i s :

February 1, June I , October 1

The phrase "RESPONSE TO NIAMS PROGRAM ANNOUNCEMENT: MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTER, PA-90-24" should be typed on l i n e 2 of t h e face page o f t h e a p p l i c a t i o n . The o r i g i n a l and s i x cop ie s should be s e n t or de l ive red t o :

Grant Appl ica t ion Receipt Office Divis ion of Research Grants Westwood Building, Room 240 National I n s t i t u t e s o f Health Bethesda, MD 20892-45OOXX

Because o f t h e l i m i t a t i o n s and t h e s p e c i a l n a t u r e o f t h e program, p o t e n t i a l a p p l i c a n t s are s t r o n g l y encouraged t o con tac t NIAMS s ta f f t o d i s c u s s t h e scope, con ten t , s i z e , and t iming of any a p p l i c a t i o n s f o r t h i s program.I n i t i a l i n q u i r i e s and r e q u e s t s f o r t h e r e v i s e d g u i d e l i n e s and a d d i t i o n a l information should be d i r e c t e d t o :

J u l i a B. Freeman, Ph.D. Centers Program Di rec to r National I n s t i t u t e o f A r t h r i t i s and Musculoskeletal and Skin Diseases Westwood Building, Room 403 Bethesda, MD 20892 Telephone: ( 3 0 1 ) 496-7495

This program is descr ibed i n t h e Catalog of Federa l Domestic Ass is tance No. 13.846, A r t h r i t i s , Musculoskeletal and Skin Diseases Research. Awards w i l l be made under t h e a u t h o r i t y of t h e Pub l i c Heal th Se rv ice A c t , adminis te red under PHS g r a n t p o l i c i e s and Federal Regulat ions 42 CFR P a r t 52 and 45 CFR P a r t 74. This program is no t s u b j e c t t o t h e intergovernmental review requirements o f Execut ive Order 12372 or Heal th Systems Agency.

STUDIES OF STRUCTURAL BIOLOGY AND PROTEIN STRUCTURE-FUNCTION RELEVANT TO DIABETES, ENDOCRINOLOGY, AND GENETI C METABOLIC DISEASES

PA: PA-90-25

P.T. 34; K.W. 0790000, 0760060, 0760070, 1002004, 1002008, 1002019, 0710070

National I n s t i t u t e o f Diabetes and Diges t ive and Kidney Diseases

PURPOSE

This announcement is intended t o encourage t h e submission of a p p l i c a t i o n s proposing r e sea rch r e l e v a n t t o understanding t h e r e l a t i o n s h i p s between s t r u c t u r e and func t ion o f pep t ides and/or p r o t e i n s and t h e r o l e they p l ay i n normal and d i s e a s e - r e l a t e d processes . Such understanding should a l s o l e a d t o t h e design, s y n t h e s i s , or engineer ing of new, b i o l o g i c a l l y a c t i v e


p e p t i d e s l p r o t e i n s wi th t h e r a p e u t i c p o t e n t i a l i n d i a b e t e s , endocrine d i s o r d e r s ,and g e n e t i c metabol ic d i s e a s e s .

DISCIPLINES AND EXPERTISE

I n t e r d i s c i p l i n a r y approaches may be needed f o r t h e proposed s t u d i e s . E x p e r t i s e r e q u i r e d could span t h e fol lowing r e s e a r c h areas: biophysics ,computer-based s t r u c t u r a l a n a l y s i s , biochemistry, c e l l and molecular biology,immunology, g e n e t i c s , and g e n e t i c o r p r o t e i n eng inee r ing . I n t e g r a t i o n of b a s i c r e s e a r c h approaches and development of t echn iques is encouraged.

BACKGROUND

The Div i s ion o f Diabetes , Endocrinology and Metabolic Diseases (DDEM) suppor t sb a s i c and c l i n i c a l r e s e a r c h and r e s e a r c h t r a i n i n g r e l a t e d t o d i a b e t e s m e l l i t u s and i t s compl i ca t ions r t o endocrinology and a v a r i e t y o f endocrine d i s e a s e s ,and t o metabolism and va r ious g e n e t i c metabol ic d i s e a s e s . S t u d i e s on s t r u c t u r a l biology, e s p e c i a l l y p e p t i d e l p r o t e i n s t r u c t u r e - f u n c t i o n , are o f s i g n i f i c a n t r e l evance t o t h e DDEM. Recent no tab le advances i n t h i s area include: development o f area d e t e c t o r s t h a t f ac i l i t a t e macromolecular X-rayc r y s t a l d i f f r a c t i o n d a t a c o l l e c t i o n and a n a l y s i s ; a v a i l a b i l i t y o f neutron s c a t t e r i n g f ac i l i t i e s and o t h e r new b iophys ica l approaches t o macromolecular s t r u c t u r a l a n a l y s i s ; development o f new approaches t o computerizedr e p r e s e n t a t i o n , manipulation, and a n a l y s i s o f three-dimensional s t r u c t u r e s ;and development o f novel gene manipulation t echn iques inc lud ing s i t e - d i r e c t e d mutagenesis. These t echn iques allow t h e i n i t i a t i o n o f a broad v a r i e t y of new s t u d i e s r e l e v a n t t o understanding p e p t i d e l p r o t e i n s t r u c t u r e - f u n c t i o n .

OBJECTIVE AND SCOPE

The r e s e a r c h p r o j e c t g r a n t ( R o l l and FIRST g r a n t (R29) a p p l i c a t i o n s submitted i n response t o t h i s announcement could propose s t u d i e s on8

Development of manual, semiautomated, and automated t echn iques f o r t h e p u r i f i c a t i o n and c r y s t a l l i z a t i o n of s o l u b l e ,membrane-associated, o r i n t e g r a l membrane p e p t i d e s and/or p r o t e i n s .

Analysis o f c r y s t a l l i z e d p e p t i d e o r p r o t e i n s t r u c t u r e s by X-ray and neutron d i f f r a c t i o n , image r e c o n s t r u c t i o n , and o t h e r s t a t e - o f - t h e - a r t t echno log ie s .

Development o f new approaches f o r t h e p r e d i c t i o n of three-dimensional s t r u c t u r e s of p e p t i d e s and p r o t e i n s i n s o l u t i o n ,l i p i d - b i l a y e r s , and membranes, i nc lud ing t h e p r e d i c t i o n of surface p r o b a b i l i t y p r o f i l e s and p r o t e i n backbone s t r u c t u r e s .

Development o f new so f tware a lgo r i thms and improvement of e x i s t i n gmethods t h a t w i l l accelerate p rogres s i n t h e f i e l d o f macromolecular s imula t ions i n s t r u c t u r a l biology.

Enhancement of t r a n s c r i p t i o n a l and t r a n s l a t i o n a l e f f i c i e n c y for over-expression o f p r o t e i n s from genes of i n t e r e s t , both endogenousand f o r e i g n , i n euka ryo t i c o r model p roka ryo t i c systems.

E l u c i d a t i o n o f mechanisms for p e p t i d e l p r o t e i n i n s e r t i o n and/ort r a n s l o c a t i o n a c r o s s membranes.

Design, s y n t h e s i s , and engineer ing o f new pharmacologically-activep e p t i d e s and/or p r o t e i n s .

S t r u c t u r e - a c t i v i t y s t u d i e s of p e p t i d e s and/or p r o t e i n s t h a t i n t e g r a t e s e v e r a l o f t h e above approaches.

The r e s e a r c h areas exemplif ied above are not intended t o be a l l i n c l u s i v e . There are, however, some s p e c i f i c l i m i t a t i o n s t o t h e scope o f t h i s announcement. Thust

1. Pep t ides and/or p r o t e i n s s e l e c t e d f o r s tudy should be o f mammalian o r o t h e r v e r t e b r a t e o r i g i n . Pep t ides and/or p r o t e i n s o f p r o k a r y o t i c o r i g i n , o r o f lower euka ryo t i c o r i g i n such as d rosoph i l a o r y e a s t , should be proposed only as models f o r mammalian systems when information on t h e l a t t e r is no t a v a i l a b l e . S t u d i e s proposed i n t h e s e model systems should f ac i l i t a t e understanding of p e p t i d e l p r o t e i n s t r u c t u r e - f u n c t i o n i n mammalian systems.


2. The pep t ides or p r o t e i n s t o be s t u d i e d should have s p e c i f i cre levance t o one o f t h e fo l lowing programmatic areas: carbohydratemetabolism and i t s hormonal con t ro l ; d i a b e t e s m e l l i t u s ; pep t idehormones, hormone r ecep to r s , and s i g n a l t ransmiss ion; endocrine d i so rde r s ; normal and abnormal processes o f l i p i d , p r o t e i n , amino a c i d , u rea , pur ine , pyrimidine, metal ion , and s t e r o i d metabolism;g e n e t i c metabol ic d i so rde r s , e . g . , lysosomal s t o r a g e d i seases ,d i s e a s e s o f peroxisomal metabolism, d i s e a s e s o f t r a n s p o r t , d i s e a s e s o f amino and o t h e r organic a c i d metabolism, d i s e a s e s o f carbohydrate metabolism ( o t h e r t han d i a b e t e s m e l l i t u s ) , d i s e a s e s o f pur ine and pyrimidine metabolism, etc.

MECHANISM OF SUPPORT

The mechanism o f suppor t f o r t h i s program w i l l be t h e regular r e sea rch p r o j e c tand FIRST g r a n t s (R01 and R29). The r e g u l a t i o n s (Code o f Federa l Regulat ion,T i t l e 42, P a r t 52 and, as app l i cab le t o t h e s ta te and l o c a l governments, T i t l e 45, P a r t 74) and p o l i c i e s which govern t h e r e sea rch g r a n t s programs of t h e Nat ional I n s t i t u t e s of Health w i l l p r e v a i l . S ince a v a r i e t y of approacheswould r ep resen t v a l i d responses t o t h i s s o l i c i t a t i o n , it is a n t i c i p a t e d t h a t t h e r e w i l l be a range o f c o s t s among ind iv idua l g r a n t s awarded. With respectt o pos t award admin i s t r a t ion , t h e c u r r e n t p o l i c i e s and requirements t h a t govern t h e r e g u l a r r e sea rch g r a n t programs of t h e N I H w i l l p r e v a i l .

REVIEW PROCEDURES AND CRITERIA

Assignment of Appl ica t ion

Appl ica t ions w i l l be rece ived by t h e N I H , Div is ion o f Research Grants (DRG) ,r e f e r r e d t o an appropr i a t e I n i t i a l Review Group ( I R G ) f o r s c i e n t i f i c merit review, and t h e usua l DRG referral gu ide l ines w i l l be followed i n assignmento f a p p l i c a t i o n s . Referral d e c i s i o n s w i l l be governed by normal programmaticcons ide ra t ions as s p e c i f i e d i n t h e Referral Guidel ines of t h e N I H , DRG. Some a p p l i c a t i o n s may r e c e i v e a dual assignment.

Review Procedures

Appl ica t ions submit ted i n response t o t h i s s o l i c i t a t i o n w i l l be reviewed on a nationwide b a s i s i n accord wi th t h e usua l N I H peer review procedures .Appl ica t ions w i l l f i rst be reviewed f o r s c i e n t i f i c and t e c h n i c a l merit by an I R G composed p r i m a r i l y of non-federal s c i e n t i f i c consu l t an t s , and then by t h e* National Advisory Council of t h e appropr i a t e I n s t i t u t e ( s 1 . The review c r i t e r i a cus tomar i ly employed by t h e N I H w i l l p r e v a i l .

Review Criteria

The f a c t o r s t o be considered i n t h e eva lua t ion o f t h e s c i e n t i f i c merit o f each a p p l i c a t i o n w i l l be t h o s e used i n t h e review of t r a d i t i o n a l r e sea rch p r o j e c tg ran t a p p l i c a t i o n s , i nc lud ing t h e novel ty , o r i g i n a l i t y , and f e a s i b i l i t y o f t h e approach; t h e t r a i n i n g experience and r e sea rch competence o f t h e i n v e s t i g a t o r ( s 1 ; t h e adequacy o f t h e experimental design; and t h e s u i t a b i l i t yof t h e f a c i l i t i e s . The appropr i a t eness of the reques ted budget t o t h e work proposed w i l l a l s o be a s ses sed .

METHOD OF APPLYING:

Format f o r Appl ica t ion

Appl ica t ions should be submit ted on form PHS 398 ( r ev . 10/88), which is a v a i l a b l e from t h e a p p l i c a n t i n s t i t u t i o n ' s Office o f Sponsored Research or from t h e N I H Div is ion of Research Grants . U s e t h e convent ional format f o r r e sea rch p r o j e c t g r a n t a p p l i c a t i o n s and ensure t h a t t h e p o i n t s i d e n t i f i e d i n t h i s Program Announcement (PA), i n t h e s e c t i o n on "Review Procedures and Criteria", are f u l f i l l e d . To i d e n t i f y t h e a p p l i c a t i o n as a response t o t h i s PA, check "Yes" on i t e m two o f page one o f t h e a p p l i c a t i o n and e n t e r t h e t i t l e "NIDDK: S t r u c t u r a l Biology i n DEMD, PA-90-25."

Dead1i n e

Appl ica t ions w i l l be accepted i n accordance with t h e announced r e c e i p t d a t e s f o r new a p p l i c a t i o n s (see r e c e i p t d a t e s and review schedule i n a p p l i c a t i o nkits). This is an open-ended program which in t ends t o provide i n t e r e s t e d a p p l i c a n t s t h e maximum f l e x i b i l i t y t hey need t o develop appropr i a t e r e sea rch a p p l i c a t i o n s .


Appl i ca t ion Procedure

The o r i g i n a l and s i x cop ie s of t h e a p p l i c a t i o n should be s e n t or d e l i v e r e d t o :

Appl i ca t ion Receipt Div i s ion of Research Grants National I n s t i t u t e s of Heal th YI-

Westwood Building, Room 240 Bethesda, MD 20892XX

I n q u i r i e s

Before submi t t i ng an a p p l i c a t i o n , and f o r f u r t h e r information, i n v e s t i g a t o r s are s t r o n g l y encouraged t o c o n t a c t t h e a p p r o p r i a t e program s taff l i s t e d below:

For t h e Endocrinology, Metabolic Diseases, and Cys t i c F i b r o s i s Research Programs :

Robert Katz, Ph.D. Deputy Chief , Endocrinology and Metabolic Diseases Research Programs Branch,DDEM, N I D D K , N I H Westwood Building, Room 607 Bethesda, MD 20892 Telephone: (301) 496-7997

For t h e Diabetes Research Programs:

Joan T . Harmon, Ph.D. Executive D i r e c t o r , Diabetes Research ProgramDDEM, N I D D K , N I H Westwood Building, Room 622 Bethesda, MD 20892 Telephone: (301) 496-7731

This program is desc r ibed i n t h e Catalog of Federal Domestic Ass i s t ance , No. 13.847, Diabetes , Endocrinology, and Metabolic Diseases. Awards w i l l be made under t h e a u t h o r i t y of t h e Pub l i c Heal th Se rv ice A c t , T i t l e 111, Sec t ion 301,( P u b l i c Law 78-410, as amended; 42 USC 241) and adminis tered under PHS g r a n t p o l i c i e s and Federal Regulat ions, most s p e c i f i c a l l y a t 42 CFR and CFR P a r t 74. This program is no t s u b j e c t t o t h e intergovernmental review requirements o f Executive Order 12372 or Health Systems Agency review.

**THE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF I N THE WESTWOOD B U I L D I N G I S THE CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD B U I L D I N G IS:

5333 Westbard Avenue Bethesda, Maryland 20816

QU. S.GOVERNMENT P R I N T I N G O F F I C E : 1 9 9 0 - 2 6 1 - 1 3 8 : 200 I O

N I H G U I D E - Vol. 19, No. 30, August 17, 1990 - Page 10

US. DEPARTMENT OF HEAITH AND HUMAN SERVICES

Documents

Transcript of US. DEPARTMENT OF HEAITH AND HUMAN SERVICES