Update of Transcatheter Closure of Ventricular Septal Defect in China Yong-wen Qin Department of...
Transcript of Update of Transcatheter Closure of Ventricular Septal Defect in China Yong-wen Qin Department of...
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Update of Transcatheter Closure of Ventricular Septal Defect in China
Yong-wen Qin
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai
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1 、 The number and quality of VSD intervention improved during past ten years
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The first pmVSD patients treated with symmetric occluder (2001.12 , 21)
The first post-MI VSD patient treated with symmetric occluder (2001.10)
The first cases of VSD intervention in our center
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Development of CHD intervention from 1990s-2011 in China
year
Patient number
*
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VSD intervention in last 3 years in China ( 394 hospitals )
2009 2010 2011
total 16045 18671 22967
ASD 5527 6793 8089
PDA 4705 5466 4075
VSD 3521 4252 5474PBPV 603 680 905
Success rate 97.24% 97.67% 98.11%
Complication 0.2% 0.17% 0.12%
Mortality 0.03% 0.05% 0.02%
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2 、 Three kind of VSD devices in
vented and clinical use in China
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Modified VSD device in China
symmetric occluder thin waist occluder asymmetric occluder
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Schematic diagram of ventricular septal defect occluder
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The classification of VSD by ventriculography
A tubular B window-like C aneurysmal D infundibular
Individualization choice of the occluder according to anatomy of VSD
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Infundibular VSD
symmetric occluder
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How to choose the occluder according to VSD
Intracristal VSD
asymmetric occluder
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Intracristal VSD
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Intracristal VSD
Symmetric device ---Aortic valve regurgitation
asymmetric device ---no aortic valve regurgitation
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Intracristal VSD
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Intracristal VSD
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Intracristal VSD
Aortic valve regurgitation--- device inclined to one side
The direction of left disk marker should be apex
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Intracristal VSD
When the marker turn to apex, aortic valve regurgitation became trace
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Intracristal VSD
No aortic valve regurgitation-- long rim direction pointed to cardiac apex
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PV
VSD
Echo: subpulmonary VSD---near PV
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VSD complicared with aortic valve prolapse
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VSD 5mm ----- 0 rim device (10mm)
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Postoperation, no aortic regurgitationHowever, occluder maybe oversized
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VSD 7mm, near aortic valve
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Echo: subpulmonary VSD---near PV
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Device 9mm (L), change to Device 11mm (R)
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no aortic valve regurgitation
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Multi-hole VSD---device choice
multi-hole VSD
thin waist occluder
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One device close three holes
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VSD2
VSD1
deviceFor VSD2
VSD1
VSD with two holes
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Two device for two holes
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Large VSD -1
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Large VSD -2
14mm A6B2 device
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Large VSD -3
No aoric valve regurgitation ,no TVR
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PDA device for large VSD
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PDA device for large VSD
20mm PDA device
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PDA device for large VSD
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Post-myocardial infarction VSD
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Postoperative residual perimembranous VSD
Transcatheter closure of postoperative residual perimembranous VSD
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PS and large VSD
VSD 17mm, device 24mm
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3 、 Conduction Block complicated with VSD
Intervention: experience in china
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anthor sample AVB% cAVB% PPM onset recovery
Song et al 328 27(8.2%) 8 0 12h-6 14-20d
Xie et al 644 16(2.5%) 6 2 3-6d 8-10dWang et al 364 20(5.5%) 4 0 3-14d NA
Zhang et al 232 17(7.3%) 12 0 4-6d 4-27d
Wu et al 112 22(19.6%) 0 0 5d 5d
Zhu et al 358 23(6.4%) 5 0 1-8d 6-10d
Liu et al 210 41(19.5) 6 1 7d 21d
Yu et al 112 37(33%) 8 0 3-9d 3-7d
Qin et al 203 11(5.4%) 1 0 2-5d 5-10d
Past Literature Review in China
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Clinial trial data of Amplatzer VSD device
Catheter Cardiovasc Interv. 2006, 68(4):620-8. (n=100)
J Am Coll Cardiol. 2006, 47(2): 319-25. (n=35)
Eur Heart J. 2007, 28: 2361. (n=430)
N: 565
Success rate 91-95 %3rd AVB 2-8 %PPM 12 (3.8 % )
death 1
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The data on VSD occluder in China from 21 centers (N=9311, 2007)
Success rate 96.45% Death 0.05% (5) Transient cAVB 0.63% (59) PPM 0.09% (8)
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2011 registry data in China
5474 cases with vsd in 394 hospital in china
PPM 1case
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The data from Changhai hospital (2001-2012)
2001-2002, 196 cases underwent percutaneous procedure (using sy
mmetry device), no cAVB
2003-2006, among 300 cases (Symmetry , Eccentric 、 thin waist de
vices), 11 cases complicated transient 3rd degree AVB, permanent
pacemaker occur in 1 case
2007-2012, sequence 550 cases with Symmetry , Eccentric,thin wai
st devices, cAVB occur 1 patient
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The possible reason of increase AVB from 2003 to 2006 ?
Patients: patients non-selected, consecutive patients admitted
Doctors: personnel stability, and operation technology maturity
Indication: increased intracristal multi-holes and aneurysm type VSD
Devices: Application of asymmetric occluder
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Device waist length and AVB
2001--2003---more than 3.5 mm---no case with AVB
2003--2006---less than 2.5mm---12/300 with AVB
2007--2012---more than 3.5mm---no case with AVB
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Chinese device shape at immediate compared with amplatzer devices
amplatzer devices Shape changeAVB
device shape at immediate
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3rd AVB
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My opinion is that device is key factor for conduction block.
Device tension---flex
Contact area with the septal
Size --- waist diameter
Length of waist
The risk factor of AVB
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Choose the proper device size Avoid oversized device
AVB seems to be fewer in symmetric occluder.
“Nice” occluder Individualized choice of occluder for pts Very experienced hands
Major success experience on prevention of AVB
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Other Risk factors for the Occurrence of AVB
Type of VSD:
perimembranous VSD
inlet VSD (behind the septal leaflet of
tricuspid valve)
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The VSD intervention is safe, effective
and an alternative method to surgery
or first choice in China
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Wire-Maintaining Technique
Using this novel technique, the reconstruction of ‘‘arteriovenous wire loop’’ could be avoided in patients requiring device replacement.
QIN, et al. CCI 75:66–71 (2010)
4 、 Useful technique in intervention of VSD
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Large VSD (22mm) Wire-Maintaining Technique
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How to choose the patient for VSD closure----TTE three views
the apical 5-chamber view LV long axis l view Aortic short axis view
Compared to TEE, TTE is enough!
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Thank youThank you