UNIVERSITY SCHOOL OF PHARMACEUTICAL...

Student Handbook B.Pharm. IV Semester2015-16

UNIVERSITY SCHOOL OF PHARMACEUTICAL SCIENCES

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V.P.O. Sahauran, Tehsil Kharar, Distt. Mohali PIN – 140104 Punjab INDIA

From Dean Desk

Dear students,

Congratulations for being promoted in the next semester and to be ‘Proud Student’ of University School of Pharmaceutical Sciences

It gives me immense pleasure to extend my warm welcome to University School of

Pharmaceutical Sciences for the even semester of academic session 2014-15. USPS is one of the front runner in developing pharmaceutical education and technology with skills, attitudes and knowledge through four years Bachelor of Pharmacy (B. Pharm) program and two years of Masters of Pharmacy (M. Pharmacy) program. . The academic environment is aesthetic and oriented toward knowledge acquisition. You owe a responsibility towards nation, your career and pharmaceutical profession. The hard work, sincerity, dedication and reading - writing composure shall make your learning with us enjoyable and rewarding in every sense. I assure that the accumulation of pharmaceutical based knowledge shall stand by you throughout your career and also for your personality and a better citizen of our nation. We have a team of exceptionally brilliant and qualified faculty. Each member of the team is expert in his/her discipline and full of a enthusiasm to share knowledge with you. Their positive, dynamic, focused, cooperative and result oriented attitude is our main asset. The more you demand the more they shall deliver. We in the Institute contribute to the idea that learning is an unending process. While we teach we also learn, and many a times from our own students. Every increment in our knowledge / learning is matter of pride and joy for us.

In our institute, 100% attendance is compulsory and 25% can be relaxed in case of medical emergency or other reasons. Evaluation plan includes two mid term examination (30 marks each), end term examination (80 marks) and continuous assessment by teacher (60 marks). Teacher’s continuous Assessment is calculated on the basis of 8 assignments/subject (20 marks), 2quizzies or class-tests/subject (10 marks), 1 extempore/subject (10 marks), 1 project/subject (10 marks) and 1 seminar/syndicate/subject (10 marks). I expect you a role model for all students of the campus in discipline, behavior, personal conduct, dress habits, attendance etc. They should look at you with awe and inspiration to emulate you. This should be your first planned and organized step towards long and strenuous journey to effective leader in the field of Pharmaceutical profession. I shall be regularly interacting with you and look forward to mutually beneficial intellectual discourse, may be bouts! I once again, welcome you back to the Institute and wish you highly rewarding and enjoyable stay with us. Prof. S. L. Harikumar

Dean, USPS, RBU



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STUDY SCHEME

B.PHARM 4th SEMESTER

S. No

Subject code

Subject Name L T P Total Periods

Credits Teacher Name

1 BP2401 Pharmaceutical Analysis-II

3 0 0 3 3 Ms. Nidhi Rani

2 BP2402 Pharmaceutical Analysis-II-Lab

0 0 3 3 2 Ms. Nidhi Rani

3 BP2403 Pharmaceutical Engineering-II

3 0 0 3 3 Ms. Nirmala

4 BP2404 Pharmaceutical Engineering-II-Lab

0 0 2 2 1 Ms. Nirmala

5 BP2405 Physical Pharmaceutics 3 0 0 3 3 Ms. M. Jothi

6 BP2406 Physical Pharmaceutics-Lab

0 0 3 3 2 Ms. M. Jothi

7 BP2407 Hospital & Community Pharmacy

3 0 0 3 3 Ms. Amandeep Kaur Gill

9 BP2408 Pathophysiology 3 0 0 3 3 Mr. Hukkam Chand

10 AM2409 Pharmaceutical Statistics 3 0 0 3 3 Ms. Harpreet Kaur

11 FS2410 Soft Skill: Professional Skills

0 0 2 2 1 Dr. Shoaib Ahmad

12 IE2411 Field visit 0 0 0 0 1 Dr. Geeta Aggarwal

13 CS2412 Service Learning 0 0 0 0 1 Ms. Amandeep Kaur

Gill Total 18 0 10 28 26



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EVALUATION PROCESS • Each subject has Theory and Practical exam of 200 marks and 100 marks respectively

• Out of this 200, Sixty Marks (60) have been assigned to mid term examination (30 each), end term examination (80 marks) and continuous assessment by teacher (60 marks).

• The practical assessment includes continuous assessment by teacher of 50 marks and end term examination of 50 marks. Continuous evaluation includes viva, practical record and daily performance during practicals.

Examination Pattern for Theory Component Frequency Marks* 1st Term 1 time 30 2nd Term 1 time 30 End Term 1 time 80 Continuous Assessment* Throughout the Semester 60 Total 200 Scheme for evaluation of Continuous Evaluation for theory Component Frequency* Marks* Assignments 8 Nos. 30 Student Seminar (syndicate) 1/syndicate (8-10 student) 10 Extempore/Presentation 1/student 10 Quiz/surprise test 2 times 10 Total 60 Important:

Every student has to submit 8 assignments per subject i.e. 6 subjectsX8=48 assignment at the end of semester

Every student has to present 10 min extempore per subject i.e. 6 subjectsX10min =1h extempore during the whole semester

For the seminars, class will be divided into syndicates (6 students in 1syndicate) and every syndicate has to give one seminar per subject i.e. 6 seminars during the semester (approximately one/student).

All students have to give 2 quizzies or class test per subject i.e. 12 quizzies or class tests per semester

All students have to prepare 1 project/group/subject i.e. 6 projects during the semester.



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Rayat Bahra University (RBU), Mohali (Academic Calendar (2016) (Even Semester Jan-Jun 2016)

S. No. Description Period 1. Registration – B.Pharm 2nd & 4th Sem, M Pharm 2nd Sem Jan 27, 2016 2. Late Registration with fine of Rs.1000/- Feb 3, 2016 3. Orientation - B.Pharm 2nd & 4th Sem, M Pharm 2nd Sem Jan 28-29, 2016 4. Commencement of Classes - B.Pharm, M Pharm 2nd Sem Feb 1, 2016 5. Guest Lecture- Industry

Feb 15-Feb 19, 2016

6. 1st Assignment Submission Feb16, 2016 7. Group Discussion Feb18, 2016 8. Competition (Fun with colors) Feb 19, 2016 9. Holiday (Ravidas Jayanthi) Feb 22, 2016 10. NSS/Club Activity/ Community Service Feb 01-Mar 31, 2016 11. Guest Lecture –Institute (B.Pharm, MPharm) Feb 22-26, 2016 12. 2nd Assignment Submission Feb 29, 2016 13. Competition (Taste & Tell) Mar 01, 2016 14. Annual Day celebrations Mar 04, 2016 15. 1st MST March 07-11, 2016 16. Guest Lecture- Industry (B.Pharm, MPharm) Mar 14-Mar 18, 2016 17. Evaluation of books and to be shown to students March 15, 2016 18. 3rd Assignment Submission March 21, 2016 19. Guest Lecture –Institute (B.Pharm, M Pharm) March 21-25, 2016 20. Industrial Trip (B.Pharm, M Pharm 2nd Sem) Feb 01-Mar 31, 2016 21. Evaluation Meeting for Academic Activities (Attendance, Syllabus Covered, Test

Results) March 16 – March 17, 2016

22. 4th Assignment Submission March31, 2016 23. Sports Meet March18, 2016 24. Poster making competition Mar 21, 2016 25. Holiday (Holi) Mar 23, 2016 26. Best out of waste competition Mar 26, 2016 27. 5th Assignment Submission

April 11, 2016 28. Holiday (Ambedkar Jayanti) April 14, 2016

29. 2nd MST April 18-22, 2016 30. Competition (Taste & Tell) April 21, 2016 31. Evaluation of books and to be shown to students April 25, 2016 32. Guest Lecture- Industry (B.Pharm, MPharm)

April 25-29, 2016

33. Guest Lecture-Institute (B.Pharm, MPharm) April 26-29, 2016 34. 6th Assignment Submission April 25, 2016 35. Evaluation Meeting for Academic Activities (Attendance, Syllabus Covered, Test

Results) April 27-29, 2016

36. Guest Lecture-Institute (B.Pharm, MPharm) April 28, 2016 37. 7th Assignment Submission May 2, 2016 38. 8th Assignment Submission May16, 2016 39. Last Day of Teaching May 31, 2016 40. End term. Practical Exams June 6-8, 2016 41. End term. Exams June 13-24, 2016 42. Evaluation of books and to be shown to students June 28,2016 43. Finalizing of Grades Meeting June 30, 2016 44. Declaration of Results July 5, 2016 45. Institutional/ Industrial Training June 25-July24, 2016 46. Summer Break June 25-July 24, 2016



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TEACHING LEARNING EVALUATION

PLAN



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TEACHING LEARNING EVALUATION PLAN Course Sub Code Sub Name L T P C

B.Pharmacy (4th Sem) BP2401 Pharmaceutical Analysis-II

3 0 0 3

Name of Subject Teacher

Ms. Nidhi Rani

Course Objectives: 1.To introduce the basic principles of Quantitative Analysis and their application in establishment of the quality of the product. 2.To establish the conventional concepts of Quantitative drug analysis used in laboratories. 3.To make them understand the principles of chromatorgraphic techniques. 4.To analyze the drugs according to the pharmaceutical industries. 5.To make the student learn the applications of these analytical methods in Quantitative Drug Analysis. Course Learning Outcome: 1.Ability to demonstrate the Quantitative Drug Analysis. 2.Ability to carry out the assay of various compounds or drugs and find out the % purity of the drugs via different types of titrations. 3.Able to learn the different types of analytical techniques and their application part. Note: A- Assignment, E-Extempore, Q- Quiz, S- Student Seminar, P- Project, T-Test

S.No

Topic/Module/Unit No. of Class

Pedagogy Unit Objectives Unit Learning Outcome No. of Activities

A E/P

Q/T

S

1 Non-Aqueous titrations: a) Titrations of acidic and basic substances in Non-aqueous solvents b) Acidimetry and Alkalimetry in non-aqueous solvents with special reference to Pharmacopoeial compounds.

08 Interactive Lectures -6 Discussion-2

To explain the Analytical chemistry on the basis of non-aqueous titrations. To introduce about the acidimetry and alkalimetry in non-aqueous solvents.

Ability to prepare the different types of standard solutions required for non-aqueous titrations. Ability to know the applications of acidimetry and alkalimetry titrations in Quality control of Pharmaceutical compounds

1 1 1 1

2 Complexometric Titrations: Theory, formation of complex and its stability, titration curves, metallochrome indicators, types of EDTA titrations, Application in assay of Magnesium sulfate, Lead nitrate & Calcium gluconate

07

Interactive

Lecture -06

Discussion-1

To explain the complexometric titrations. To introduce about the titration curves and applications in assay of Magnesium sulfate, Lead nitrate & Calcium gluconate

Ability to prepare the different types of complexometric titrations Ability to know the applications of complexometric titrations in Quality control of Pharmaceutical compounds

2 1 1 1

3 Miscellaneous method of analysis a) Diazotization titration b) Kjeldahl’s method of nitrogen estimation c) Oxygen flask combustion method

03 Lectures

Interactive –

3

To make them understand the various method of analysis such as diazotization titrations, Kjeldahl’s method of nitrogen estimation, Oxygen flask combustion method and apply the

Ability to estimate the nitrogen content. Ability to oxygen combustion method and diazotization method.

2 1 1 2



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knowledge in laboratory experiments.

4 4. Electroanalytical techniques: a) Potentiometry: Introduction, Electrochemical cells, b) Conductometry: Basic concepts, different types of conductometric titrations, apparatus used, Conductometric titrations and applications in Pharmaceutical analysis. c) Polarography and Amperometry: Basic concept, theoretical considerations, Basic instrumentation, apparatus, principles, general polarography analysis and applications in pharmaceutical analysis. Amperometric titrations with one polarized electrode, general procedure, titration curves and applications. d) Electrophoresis: Principle, instrumentation and application

12 Lectures by

PPT-8

Discussion-4

(practical

based

approaches)

To introduce electroanalytical techniques. To develop the ability to differentiate potentiometric, conductometric and amperometric techniques. To empower the knowledge about the different steps of polarography and electrophoresis.

Ability to differentiate all the different types of electroanalytical techniques and how to apply that knowledge to various experiments.

2 1 1 2

5 Chromatography: a) Introduction & classification- TLC,Paper, Column and Ion Exchange Chromatography b) Introduction to Instrumental Chromatography

07 Lectures-5

Discussion-2

(Practical

based)

To empower the knowledge about the chromatography and different types of chromatography.

Ability to demonstrate various types of chromatography techniques with their applications.

1 1 1 1

6 Instrumental Chromatography: a) High Performance Thin Layer Chromatography: Theory and Principle, instrumentation, elution techniques and pharmaceutical applications. b) High Performance Liquid Chromatography: Principle, instrumentation, solvents used, sample preparation, pre and post column derivatisation, elution techniques,

08 Lectures-7

Discussion-1

To make them understand different types of instrumental chromatography techniques. To develop their ability to use this knowledge in assay of different drugs.

Ability to understand different types of chromatography techniques and how to apply that knowledge to various experiments.

2 1 1 1



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classification of chromatographic methods based on mechanism of separation (Reverse Phase/Normal Phase chromatography), applications in Pharmacy. Introduction of UPLC. c) Gas Chromatography: Theory and principle, instrumentation and applications in Pharmacy References: Textbook:

1. Practical Pharmaceutical Analysis (Vol-II) by Beckett and Stenlake. 2. Instrumental methods of analysis by Gurdeep Chatwal. 3. Textbook of Chemical Analysis A.J. Vogel.

Reference books:

1. Textbook of Pharmaceutical Analysis by K.A. Connors. 2. Indian Pharmacopoeia Recent edition. 3. Quantitative analysis of Drugs in Pharmaceutical Formulations by P.D. Seth.



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TEACHING LEARNING EVALUATION PLAN Course Sub Code Sub Name L T P C

B.Pharmacy (4th Sem) BP2403 Pharmaceutical Engineering II

3 0 0 3


Ms. Nirmala

Course Objectives:

To make student understand and facilitate a significant step change in current pharmaceutical production,

by providing improved technologies, product design and control methodologies.

To generate the exploring ability and to develop problem solving ability among students and evaluate the

same through tests, quiz and assignments.

To study industrial processes required to convert raw material into value added pharmaceuticals such as

drugs and excipients.

Course Learning Outcome: Able to plan, conduct and report on any aspect in the design and manufacture of pharmaceutics.

Students have the ability of formulating problems and solving them.

Ability to understand the theoretical and equipment aspects relevant to the pharmaceutical industry.

Ability to demonstrate knowledge and understanding for the industrial processes which are required to

convert raw material into value added pharmaceuticals such as drugs and excipients.

A. Teaching Learning Plan: Note: A- Assignment, S- Student Seminar, P- Presentation S.No

Topic/Module/Unit No. of Class

Pedagogy

Unit Objectives Unit Learning Outcome

A S P

1 Heat transfer a)Laws of conduction, Convention and radiation, Heat transfer coefficient b)Batch heating and cooling system c) Different types of heat exchanger, double pipe, shell and tube, plate type, Spiral heat exchanger. d)Insulating material e)Mathematical problems

7 Blackborad,chalk, Seminar, Interactive lecture demo

To introduce source of heat, heat transfer, steam and electricity as heating media. To determination of requirement of amount of steam/electrical energy, steam pressure, boiler capacity, mathematical problems on heat transfer.

At the end of this chapter, students must be able to gather information regarding different types of Source of heat, heat transfer, steam and electricity as heating media.

1

2 Evaporation a)Basic concept of phase equilibrium, b)Types of evaporators, operation of evaporation units, factors affecting evaporation, single effect and multiple effect evaporators, Mathematical problems on


To introduce basic concept of phase equilibria, factor affecting evaporation, single effect and multiple effect evaporators.

It is expected that students, study different types of evaporators.

1



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evaporation. 3 Drying:

Concept of moisture content, bound and unbound moisture, critical and equilibrium moisture content, drying a batch of solid under constant drying conditions, spray dryer, drum dryer, rotating drum dryer, fluidized bed dryer and tray dryer, sublimation and freeze drying.


To describe the moisture content and mechanism of drying. To study the classification and types of freeze drying dryers. To study the behaviour of solids during drying, MC, EMC, CMC.

Better understand the mechanism as well as the classification and types of freeze drying dryers are expected in this chapter.

1 1

4 Distillation : Raoult’s law, phase diagrams, volatility; simple steam and flash distillations, principles of rectification, Calculation of number of theoretical plates, Azeotropic and extractive distillation. Mathematical problems on distillation.


To describe the Raoult’s law, phase diagrams, volatility. To study the simple steam and flash distillations. A clear understanding azeotropic and extractive distillation.

Students must be well versed in the various law, phase diagrams, volatility and Simple steam and flash distillations with a clear understanding azeotropic and extractive distillation.

1 1

5 Extraction Techniques: Liquid-liquid extraction, separation of mixtures by extraction. Distribution law. Successive & multiple extraction [Craig method], continuous counter current extraction. Effect of temperature & pH on extraction. Inert solute, associate ion pair formation, emulsion problem in extractions. Applications in pharmacy.

5 Presentations Interactive lecture

To isolate one or more components from a mixture by using extraction techniques and obtain a purify product. To understand the principle of the equilibrium distribution of a substance.

Students able to obtain pure product by using simple or multiple extraction techniques

6 Refrigeration and Air Conditioning : Principles and applications of refrigeration and air conditioning.

3 Projects Presentations Interactive lecture demo

To study the characteristics and engineering design of heating, ventilating, air conditioning and refrigeration systems. To enable students to achieve effective and efficient design solutions

Students have ability to describe major design considerations of air-side, water-side, ventilation and refrigeration systems. To evaluate applications and design calculations of HVAC&R systems.

7 Dehumidification and 5 Projec To understand the Ability to



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Humidity Control: Basic concepts and definition, wet bulb and adiabatic saturation temperatures, Psychrometric chart and measurement of humidity, application of humidity measurement in pharmacy, equipments for dehumidification operations.

ts Presentations Interactive lecture demo

use of humidity chart and to interpret the humidity, dew point and humidity at adiabatic saturation

preserve the pharmaceuticals using humidification and dehumidification principle.

8 Industrial hazards and Safety Precautions: Engineering controls for safe management, MSDS, Mechanical, Chemical, Electrical, fire and dust hazards. Industrial dermatitis, Accident records etc.

2 Projects Presentations Interactive lecture demo

In-depth understanding of industrial hazards like mechanical, chemical electrical and fire hazards and how these can be prevented.

Ability to understand reasons behind the industry hazards and these hazards can be controlled.

References: 1. Text Books:

CVS Subrahmanyam, Pharmaceutical engineering, vallabh prakashan.

K Sambamurthy, Pharmaceutical engineering, new age international publisher.

2. Reference books: 1. Carter SJ.“Cooper & Gunn’s Tutorial Pharmacy”,6th edition,CBSPublishers&Distributors, New Delhi. 2. Badger WL, Banchero JT. “Introduction to Chemical Engineering”. McGraw Hill International Book Co., London. 3. Perry RH, Green DW. “Chemical Engineers Handbook”, 7th edition, 1998, McGraw Hill, International Editors Ltd, London. 4. Subramanyam CVS, Setty JT, Suresh S, Devi VK.” Pharmaceutical Engineering- Principles & practices”, 1st edition, 2002, Vallabh Prakashan , Delhi. 5. Subramanyam CVS, Setty JT, Suresh S, Devi VK.” Practical Pharmaceutical Engineering”, 1st edition, 2002, Vallabh Prakashan , Delhi. 6. Sudakar Reddy, Pharmaceutical Engineering: Practical Manual (Unit Operations), PharmaMed Press.



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TEACHING LEARNING EVALUATION PLAN

Course Sub Code Sub Name L T P C B.Pharmacy (4th Sem) BP2405 Physical

Pharmaceutics 3 0 0 3


Ms. M. Jothi

Course Objectives: 1. Physical pharmaceutics is a fundamental course that leads to proper understanding of subsequent courses in Pharmaceutics and pharmaceutical technology. 2. To understand the Physical pharmaceutics integrates knowledge of mathematics, physics and chemistry and applies them to the pharmaceutical dosage form development. 3. To develop the concepts of applying knowledge of physicochemical properties of material in development of stable and effective dosage form. 4. To enable the pharmacist to make rational decisions on scientific basis concerning the art and technology of solutions, suspensions, emulsions, etc. Course Learning Outcome: 1. Ability to understand the basic fundamental course that leads to proper understanding of subsequent courses in Pharmaceutics and pharmaceutical technology. 2. Ability to demonstrate Particle-particle interaction and particle behaviour, Controlled flocculation, sedimentation concepts of suspension. 3. Ability to demonstrate different type’s apparatus. A. Teaching Learning Plan: Note: A- Assignment, E-Extempore, Q- Quiz, S- Student Seminar.

S.No

Topic/Module/Unit Pedagogy Unit Objectives

Unit Learning Outcome

No. of Class

NO. of Activities

A E Q S 1 Rheology:

Newtonian systems, non-Newtonian systems,determination of viscometers.

Blackboard teaching. (4) Discussion (or) Quizzes (1).

To make students understand the basic concepts of Rheology.

Students should have the ability to interpret the basic knowledge of Rheology.

5 1 1 1 1

2 Surface-active agents: a) Classification based on chemical nature and HLB scale, Determination, Mechanism of action, Factors influencing CMC. b) Micelles solubilisation: Factors, Mechanism of solubilisation, Ternary phase diagram in the formulation of solubilised systems.

Blackboard teaching. (4) Tutorial in the practical class with special problems.

To make students understand the basic knowledge of Surface-active agents.

Ability to understand the basic knowledge of Surface-active agents.

4 1 1 1 1

3 Colloidal dispersions: a) Classification of dispersed systems and colloids particles, their general characteristics, size and shapes of colloidal particles. b) Properties of Colloids: Optical and Kinetic properties and their applications in determining molecular weight of polymers. Electrical properties: Electro kinetic

Presentations (1),Black board & Chalk,(5) Seminar.(1)

To understand the benefits and know the main types of dispersed systems and colloids particles.

Ability to interpret/apply the basic knowledge of Properties of Colloid and Stability of Colloidal Systems.

7 1 1 1 1



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phenomena, Donnan membrane equilibrium. c) Stability of Colloidal Systems: Mechanism, Effect of electrolytes, Co-acervation, Peptization and protective action.

4 Emulsions: a) Definition, Thermodynamic consideration, Classification, Transparent emulsions, Pharmaceutical applications. b) Emulsion types: Empirical rules governing emulsion types, Methods for determination of type of emulsions (only principle) and their limitations c) Mechanisms of Emulsion (droplet) stabilization: Monomolecular and particulate orientation, Mixed emulsifiers, Critical HLB concept. d) Theories of Emulsifications: Non-electrical and electrical theories, Detailed account of non-electrical theories and advanced electrical theories like Schulman and Cockbain molecular complex formation, DLVO and Davies theories. e)Stability of Emulsions: Factors influencing stability of emulsions f) Factors influencing rheological properties of emulsions.

Blackboard & Chalk(7), Extempore(1), Seminar (1). Tutorial in the practical class with special problems.

To provide basic information of different types of Emulsion, Classification, Mechanisms, Theories, Factors, Stability of Emulsions.

Ability to understand the basic knowledge of Classification, types, Mechanisms, Theories, Factors, Stability of Emulsions.

9 2 1 1 1

5 Suspensions: a)Definition, Application & solid content. b)Theoretical concepts in the formulation of suspensions: Wetting and Dispersion, Particle-particle interaction and particle behaviour, Controlled flocculation, sedimentation concepts, Rheological considerations, and Formulation in structure vehicle.

Blackboard &Chalk, (4) Student syndicate seminar along with Interactive session (1).

To discuss the basic concepts of Suspensions, Rheological considerations, and Formulation in structure of vehicle.

Ability to interpret/ understand the basic knowledge of Suspensions.

5 1 1 1 1

6 Powder Micromeritics: a)Introduction: Definition, Applications, and Classification of properties of powders. b)Fundamental Properties of Powders: (i) Particle size and size distribution-Equivalent spherical diameters, Average particle size, size-frequency distribution, Number and weight distribution, Particle number, Determination of particle size. (ii)Particle shape,

Blackboard & Chalk(7), Extempore(1), Seminar (1),Discussion (or) Quizzes (1). Tutorial in the practical class with special problems.

To make students understand the basic concepts of Powder Micromeritics:

Ability to interpret/ understand the basic knowledge of Fundamental Properties of Powders.

10 1 1 1 1



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References: 1. Text Books: 1. Gaud and Gupta “ Practical Physical Pharmacy”, I edition, reprint 2008, CBS Publisher and Distributor, New Delhi 2. Subhramanyam CVS. “Textbook of Physical Pharmaceutics”, 2nd edition , 2007, Vallabh Prakashan, New Delhi.

3.Carter SJ. “Cooper & Gunn’s Tutorial Pharmacy”, 6th edition, 200, CBS Publishers & Distributors, New Delhi. 2. Reference books:

1. Sinko PJ.”Martin’s Physical pharmacy & Pharmaceutical sciences”, 5th edition, 2006, B.I. Publications Pvt Ltd, New Delhi.

2. Remington’s The Science & Practice of Pharmacy Mack Publishing Co. Easton, PA 3.Ansel's Pharmaceutical Dosage Forms & Drug Delivery Systems, Eighth Edition, L.V.Allen, Jr. N.G. Popovich and H.C. Ansel (Eds), Lippincott Williams & Wilkins 2005

surface area and its measurement. (iii) Derived Properties of Powders: Packing arrangements, Densities and Porosities, Bulkness, Flow properties and their influence on processing of solid dosage forms.

7 Complexation Classification of complexes, methods of preparation and analysis, applications.

Blackboard & Chalk(3).

To make students understand the basic concepts of Complexation.

Ability to interpret/ the different types of Complexation.

3 1 1 1 1

8 Drug Stability:

Physical and Chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, Ionic strength, Dielectric constant, specific & general acid base Catalysis light.

Stabilization of medicinal agents against common reactions like hydrolysis & Oxidation.

Accelerated stability testing in dating of Pharmaceutical dosage forms.

Blackboard & Chalk(5), Extempore(1), Seminar (1).

To make students understand the basic concepts of Drug Stability.

Ability to interpret/ understand the basic knowledge of Drug Stability.

7 1 1 1 1



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Course Sub Code Sub Name L T P C B.Pharmacy (4th Sem) BP2407 Hospital and community

Pharmacy 3 0 0 3


Ms. Amandeep Kaur Gill

Course Objectives: To provide knowledge of structure, functions of hospital pharmacy and responsibilities

and requirements of pharmacist in hospitals. To impart knowledge on basic principles of Purchase and Inventory Control. To acquire knowledge on dispensing and distribution of drugs. To make them understand the sterilization facilities, Equipments & Methods. To impart knowledge on radiopharmaceuticals and radiation hazards. To make them understand the fundamental and regulatory requirement to start the

wholesale or retail drug store and role of community pharmacist. Course Learning Outcome:

Ability to demonstrate knowledge on organization and function of hospital Pharmacy. Ability to calculate Inventory Turnover & Inventory Control. Ability to dispense and distribute drugs to patients. Ability to demonstrate sterilizing equipments and methods used in sterile unit of

hospitals. Ability to understand use of radiopharmaceuticals and prevention and control of

radiation hazards. Ability to apply knowledge of fundamental and regulatory requirement to start the

wholesale or retail drug store and role of pharmacist in hospitals and as a community pharmacist. A. Teaching Learning Plan: Note: A- Assignment, E-Extempore, Q- Quiz, S- Student Seminar, P- Presentation- T- Test

S.No Topic/Module/Unit Noof Class

Pedagogy

Unit Objectives Unit Learning Outcome

No. of

A E Q/T

S P

1 Fundamentals a. Definition, Goals & Advantages, and b. Detailed Study with respects to: Hospital Pharmacy Organization- Organizational Structure of Hospital Pharmacy, and Responsibilities of various Divisions of Hospital Pharmacy. c. Hospital Pharmacy Policies. d.Hospital Pharmacy Personnels- Determination of Requirements of Hospital e. Pharmacy Personnel, Abilities Required of Hospital Pharmacists, and Responsibilities of Personnel. f. Hospital Pharmacy Facilities. g. Hospital Formulary. h. Pharmacy & Therapeutic Committee.

9 Lecture by using black board (2) ppt (3),Discussion(2) ,presentation & Group Seminar (1)

1.To make them understand the structure and functions of hospitals and hospital pharmacy 2.To provide them knowledge of responsibilities of pharmacist 3.To acquire the knowledge of contents, preparation and revision of hospital formulary 4. To impart the knowledge of composition and role of PTC

Ability to demonstrate knowledge on organization and function of hospital Pharmacy. Ability to take the responsibilities of pharmacist. Ability to conceptualize the knowledge of contents, preparation and revision of hospital formulary. Ability to explain knowledge on composition and functions of PTC.

1 1 1 1

2 PURCHASE & INVENTORY 6 Lecture 1.To acquire the Ability to apply 1 1 1 1



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CONTRO L a. Modes of Drug Purchases. b. Procedures of Drug Purchases by Hospital Pharmacy. c. Control of Purchases : Calculations of Reorder Quantity Level, Economic Order Quantity, and Inventory Turnover & Inventory Control ( Annual and Perpetual)

by using ppt (2), Discussion (2) Extempore (1) & Quiz (1)

Knowledge of basic principles of Purchase and Inventory Control

knowledge on Procedures of Drug Purchases by Hospital Pharmacy and to control them.

3 DISPENSING OF MEDICATIONS & Their Distribution w.r.t. : a. In – patients, b. Ambulatory, c. Out – Patients, and d. Controlled Drugs.

6 Lecture

by using

black

board(1),

ppt(2),Di

scussion(

1)Present

ation (1)

& Quiz

(1)

1. To provide the knowledge of dispensing of medications to inpatient, outpatient and ambulatory patients. To acquire knowledge on distribution of controlled drugs.

Ability to demonstrate knowledge on dispensing of medications to inpatient, outpatient, ambulatory patients and distribution of controlled drugs.

1 1 1 1

4 CENTRAL STERILE UNIT & its MANAGEMENT: a. Types of Materials for Sterilization. b. Packaging of Materials prior to Sterilization. c. Sterilization Facilities, Equipments & Methods. d. Distribution of Sterile Materials.

6 Lecture by using black board (1),ppt (2), Discussion (1) Extempore (1) & Quiz (1)

1. To make them understand the various types of materials to be sterilized. 2. To demonstrate them sterilization equipments and methods.

Ability to apply knowledge of sterilizing equipments and methods used in sterile unit of hospitals.

1 1 1 1

5 HOSPITAL PHARMACY LAY-OUT

5 Lecture by using black board (1), ppt (1), Discussion (1), seminar (1) & Extempore (1)

1. To acquire the knowledge of location and layout of hospital pharmacy, drug store, O.P.D, central sterile supply unit.

To make them understand the location and layout of hospital pharmacy, drug store, O.P.D, central sterile supply unit.

1 1 1 1

6. RADIO PHARMACEUTICALS: Introduction to Radio pharmaceuticals, radio-active half life, Units of radio-activity Production of radio-pharmaceuticals, Permissible radiation dose level, Radiation hazards and their prevention, specifications for radio-active laboratory

6 Lecture

by using

black

board

(2),ppt

(2),

seminar

(1)

Extempo

1.To make them understand the radio-Pharmaceuticals, Permissible radiation dose level 3. To impart knowledge on Radiation hazards and its prevention.

Ability to demonstrate the knowledge on Radio pharmaceuticals, Permissible radiation dose level, Radiation hazards and their prevention.

1 1 1 1



18

re (1)

7. COMMUNITY PHARMACY: Organization and structure of retail and wholesale drug store types of drug store and design, legal requirements for establishment, maintenance and drug store, dispensing of proprietary products, maintenance of records of retail and wholesale, patient counselling on rational use of drugs, role of pharmacist in community healthcare & education.

7 Lecture

by using

black

board

(3),ppt

(2),

seminar

(1) &

presentat

ion (1)

To make them understand the fundamental and regulatory requirement to start the wholesale or retail drug store. To impart knowledge of maintenance of records. To make them understand the role of pharmacist in community healthcare & education.

Ability to explain the Fundamental and regulatory requirements to start the wholesale or retail drug store. Ability to prepare records of maintenance of wholesale or retail drug store. Ability to counsel the patient regarding the use of drugs. Ability to understand the role of pharmacist in community healthcare & education.

1 1 1 1

RECOMMENDED BOOKS 1. Owunwonne Handbook of Radio pharmaceuticals. Narosa Publishing House, New Delhi. 2. Hassan, William E. Hospital Pharmacy. Lea & Febiger, Philadelphia. 3. Remington‟s The Science & Practice of Pharmacy Mack Publishing Co. Easton, PA 4. Turco. S, and King, R.E. Sterile Dosage Forms. Lea & Febiger, Philadelphia.



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Course Sub Code Sub Name L T P C

B.Pharmacy (4th Sem) BP2408 Pathophysiology of Common Diseases

3 0 0 3


Mr. Hukkam Chand

Course Objectives: To enable the students:

To understand the Basic Principles of Cell Injury and Adaptation, Basic Mechanisms involved in the process of inflammation and repair, Physiology of Inflammatory Diseases.

To understand the Pathophysiology of cardiac Disorders, renal diseases, metabolic disorders, respiratory and digestive disorders.

To understand the Pathophysiology of CNS Disorders, Pathophysiology of common diseases and pathophysiology of microbial diseases. Also understand the pathogenesis of cancer and leukemia.

Course Learning Outcome: 1. To know the better, recent, suitable methods and techniques for easy understanding of physiology and pathophysiology of common and chronic diseases. 2. They will learn about the flow diagrams of pathophysiology which will use for better understanding the signalling mechanisms of various diseases. A. Teaching Learning Plan: Note: A- Assignment, E-Extempore, Q- Quiz, S- Student Seminar, P- Project

S. No

Topic/Module/Unit No. of Classes

Pedagogy Unit Objectives Unit Learning Outcome

No. of

A E Q S P

1 Basic Principles of Cell Injury and Adaptation * Causes of Cellular injury * Pathogenesis and morphology of cell injury. * Intercellular alterations in lipids, proteins and carbohydrates * Cellular adaptation atrophy, hypertrophy, hyperplasia, metastasis

7 Lectures (4) Presentations (2) Discussion (1)

To learn about Cause of cellular injury, pathogenesis and mechanism of cellular injury. To understand the intercellular alterations in lipids proteins and carbohydrates. Understanding the various cellular adaptation mechanisms and cellular death

After completion of the unit Students should learn about cell injury, types and causes of cell injury, Intracellular alterations and cellular adaption mechanisms, cellular death etc.

1 1 1 1

2 Basic Mechanisms involved in the process of inflammation and repair * Alterations in vascular permeability and blood flow * Migration of WBCs, acute and chronic inflammation * Mediators of inflammation * Brief outline of the process of repair

6 Presentations (3) Discussion (1) Lecture (3)

To study about the basic mechanism of inflammation, basic concept of alterations in blood flow and migration of WBCs at injury site. To understand the general principles of acute and chronic inflammation, inflammatory mediators Understanding the basic mechanism of cellular repair.

Make the student to learn about new strategies involved in inflammation, various processes at injury site and process of repair.

1 1 1 1



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3 Pathophysiology of

Inflammatory Diseases Understanding the basic mechanism behind common inflammatory disorders of joints * Rheumatoid arthritis * Gout

3 Presentations (1) Lecture (2)

To study about the physiology of joints and various pathophysiological pathways involved in the pathogenesis of Rheumatoid arthritis and gout rheumatoid arthritis and gout.

Make students to understand about the physiology of inflammatory diseases with the help of flow diagram and pathophysiological pathways

1 1 1 1

4 Pathophysiology of Central Nervous System Disorders: Basic understanding of CNS and Pathophysiology of * Epilepsy * Psychosis * Depression * Mania

4 Presentations (2) Lectures (2)

To study in detail about the pathophysiology of CNS and CNS related disorders. To study the pathophysiological role of various neurotransmitters in pathogenesis of seizures, psychosis, depression bipolar disorders.

To make the student to understand the basic physiology of Neurotransmitters regulations and their pathophysiological role in the genesis of CNS disorders.

1 1 1 1

5 Pathophysiology of cardiac Disorders: * Hypertension, * Angina, * Congestive heart failure * Atherosclerosis * Myocardial infarction * Arrhythmia

6 Presentations (3) Discussion (1) Lectures (2)

To study about the cardiac functions, regulation of B.P, heart rate, vessel tune by various neurohormonal substances. To understand pathophysiology of hypertension, angina and CHF, atherosclerosis, myocardial infarction and arrhythmia.

After completion of the chapter student should able to understand about various physiological pathways involves in normal functioning of heard and vessel tone. Also student should understand the pathophysiological role of lipids, cholesterol and other pathophysiological markers in the pathogenesis of cardiac disorders.

1 1 1 1 1

6 Pathophysiology of Endocrine System * Diabetes

2 Presentation (2)

To study about the mechanisms/processes involved in regulation of blood glucose level. Also understand the pathophysiological role of insulin and pancreatic cell in the pathogenesis of metabolic disorders.

Student should understand about basic regulation of glucose in body and pathophysiological markers involved in the development of diabetes.

1 1 1 1 1

7 Pathophysiology of Respiratory Disorders: * Pathophysiology of

2 Lecture (1) Presentation (1)

To understand the physiological roles of various receptors in

Make student to learn about the pathophysiologica

1 1 1 1 1



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Asthma airways and study the various pathophysiological pathways involved in the pathogenesis of Asthma

l role of adrenoreceptors, mast cell and various inflammatory mediators involved in the pathogenesis of Asthma.

8 Pathophysiology of Digestive and hepatic Disorders * Peptic ulcer * Ulcerative colitis * Jaundice * Viral hepatitis * Cirrhosis and * Hepatocellular carcinoma

7 Presentations (2) Discussion (1) Lectures (4)

To study the pathophysiology of gastric disorders, various types of Hepatitis and cancer of liver. To study the role of gastric acid production, various receptors, and inflammatory markers involved in the pathogenesis of peptic ulcer and ulcerative colitis.

Make student to understand the basic physiology and pathophysiological role of gastric HCl, H. pylori, role of proton pump along with other receptors in the pathogenesis of gastric disorders. Also, student may know about the pathophysiological role of virus and inflammatory mediators involved in the hepatitis.

1 1 1 1 1

9 Pathophysiology of renal diseases Acute and chronic renal failure

3 Presentation (1) Lectures (2)

To study about the basic functioning of nephron and understanding the pathophysiology of acute as well as chronic renal failure.

Make student to learn about the GFR, urine formation processes and make them to understand the various pathophysiological pathways in the pathogenesis of acute and chronic renal failure

1 1 1 1

10

Pathophysiology of common diseases caused by microbes * Tuberculosis * Urinary Tract Infections (UTI) * Sexually transmitted Diseases Pathophysiological of Endemic Diseases * Common types of neoplasm * Carcinoma of lung * Carcinoma of Skin Cancer * Carcinoma of Cervix * Leukemia

9 Presentations (4) Discussions (2) Lectures (3)

To study the common diseases caused by microbes, their pathophysiology and mode of infections. To understand various pathophysiological pathways involved in the pathogenesis of TB, STD, UTI and cancer and leukemia.

Make student to learn about the various causative organisms, their mode of infections & transmission. Also make the student to understand the various pathophysiological pathways involved in the pathogenesis of Cancer of lung, skin, cervix, Leukemia, and tuberculosis.

1 1 1 1 1



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References: 1. Text Books: Recommended Textbook: 1. Cotran, R.S., Kumar, V., Collins, T. Robbins Pathological Basis of Disease. 7th edt.2003 W.B. Saunders Co.New York 2. J.T. Dipiro, R.L. Talbert, , G.C. Yee, G.R. Matzke, B.G. Wells, L. Michael Posey (eds.),Pharmacotherapy : A Pathophysiologic Approach, 6th ed.., The McGraw Hill Companies,Inc.,2005. 3. E.T. Herfindal and D.R Gourley, Text Book of Therapeutics: Drug and DiseaseManagement, 7th ed., Lippincott Williams & Wilkins, USA, 2000. 4. Dennis L. Kasper, Eugene Braunwald, Anthony S. Fauci, Stephen L. Hauser, Dan L. Longo,J. Larry Jameson, and Kurt J. Isselbacher, (Eds.), Harrison's Principles of Internal Medicine,16th ed., The McGraw Hill Companies, Inc., 2004



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B.Pharm IV Semester Syllabus

Course Sub Code Sub Name L T P C B.Pharmacy (4th Sem) AM2409 Pharmaceutical Statistics 3 0 0 3 Name of Subject Teacher

Ms. Harpreet Kaur

1. Basic Definitions and Concepts: Variables and variation [continuous variables and discrete variables], sample and population [population parameters and sample statistics, random sampling], precision, accuracy and bias; significant figures. Mean, Median, Mode 2. Probability Distributions: Discrete and continuous random variables, probability distribution functions, expectation of random variables, mean, variance and moments of random variables, Binomial, Poisson, Normal, beta distribution functions, Chi-square distribution, F-distribution, Joint distributions, notion of covariance. 3. Sampling distribution, Point and interval estimations of mean, variance and proportion of single and multiple samples. 4. Hypothesis testing: Inferences concerning mean, variance and proportions, Chi-square test, goodness of fit. 5. Regression and Correlation: Linear regression and Correlation 6.ANOVA: One-way and two way ANOVA tests. 7. Parametric & Non Parametric tests: student t-test, chi-square test, f-test, Sign test, Rank sum test, Wilcoxon and Kruskal-Vallis test. Books Recommended 1. Pharmaceutical Statistics: Practical and Clinical Applications, Sanford Bolton, Charles Bon, Marcel Dekker 2. Pharmaceutical Statistics, David Jones, Pharmaceutical Press UK 3. Statistics Methods , S. P. Gupta, S. Chand & Co.



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Course Sub Code Sub Name L T P C B.Pharmacy (4th Sem) FS 2410 Soft Skill: Professional

Skills 0 0 2 1


Dr. Shoaib Ahmad

1. Organisation behaviour

a) Goal setting b) Individual goals c) Organisational goals

2. Professional skills a) Personality development b) Interpersonal skills c) Time management skills d) People management skills e) Strategic thinking f) Creative thinking g) Listening skills h) Quick learning skills i) Responsibility and Reliability j) Risk taking k) Diplomacy skills l) Situation based conversation

3. One minute talk 4. Group discussion 5. Value based role plays 6. News sharing and news interpretation



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Course Sub Code Sub Name L T P C B.Pharmacy (4th Sem) IE2411 Field Visit 0 0 0

1


Ms. Amandeep Kaur Gill

1. Industrial Visit of the students should be organized during the semester 2. Syndicate consists of minimum 20 students should be formed during the visit. Students in different syndicates may visit Pharmaceutical Industry, Punjab & Haryana Test Laboratory, Hospital Pharmacy (PGI or CMC), Punjab Drug Controller Office or Botanical Garden 3. Observations and learning outcome of the visit should be submitted by the syndicate in the prescribed format. 4. The submitted report should be evaluated by the committee formed for this purpose. 5. The said syndicate of students should present the summary of the visit and the learning outcome before the committee. 6. The committee should evaluate the report and the presentation for the purpose of final grading 7. Evaluation on the basis of the following parameters:. Field Visit Report 25 50 Student Presentation 25

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