UNIVERSI TY OF THE PUNJ AB●・

° ° ° °・・ ・

・

● ● 0 0 0 00● ● ● ● ● ● ● ●.

Second Prof. A/2015 :Examination : Doctor of Pharmacv (pharm. D.) i *:lr.r:::...: ...

: ..,.: ...:

;; ;:.j.. ;SuЦ eCt : Pharmacol ogy&Therapeut i cs_I~PAPER: 2 TIME ALLOWED: 3 brs.

MAX. MARKS: 100NOTE: Attempt any FIW questions. All questions corry equal marks.

Q.# I Define the fbllowing terms:

Pharmacokinetics and pharmacodynamics. 5

Agonist, antagonist and partial agonist. 5

5Volume of distribution and clearance of drug.

- Drug receptor and mechanism of action of drug. 5

Q. # 2 What is biotransformation? Discurss phase 1 and phase II metabolic reactions. 20;

Q.# 3. Classify antimuscarinic clrugs. Discuss ATROPINE with respect to its mechanism of 20

action, et-tecls orr diftbrent organ/systems and toxicity.

Q.# 4. Classity antihyperlipidemic drurgs. Discuss the pharmacology ol'SIMVASI'ATIN. 20

Q. # 5. Classity anti-ulcer drugs. Discuss the mechanism of action, therapeutic uses and side 20

effbcts of PROTON PUMP INHIBITOS.

Q. # 6. Classify beta adrenergic blockers. Discuss the mechanisms of action, therapeutic uses,20

side effects and contra-indications of PROPRANOLOL.

Q. #7. Wri t ea.

b.

C.

shot notes on:

Digoxin.

Prostaglandians.

Irritant purgatives.

776

UNIVERSI TY OF THE PUNJ ABSecond Prof. A/2016 :

|)

aa a a a a a a a aa a a aa a aaa a a a a a aa

Subject: Pharmacology & Therapeutics-I

ヨAPER12( Ol d&New COurseNorE: Attempt any FrvE questions. All questions corry equal *o*r.

Q. # 1 What are the different classes of receptors. Discuss G-Protein Coupled Receptors

(cPCRs) in detail. Z0

Q- # 2 What is bioavailability? What factors can modify the bioavailability of the drug. ZO

Q. # 3 Classify diuretics. Describe mechanism of action, effects on renal hemodym.amics,

adverse effects and therapeutic uses of Spironolactone. ZO

Q. # 4 Classify antimuscarinic drugs. Discuss mechanism of action, pharmacological

properties, toxicity and therapeutic uses of Atropine . ZO

Q.# 5 What is asthma? Classify Anti-Asthmatic drugs and discuss pharmacology of

Leukotriene antagonist and IgE antibodies in detail. ZO

Q- # 6 Classify direct acting sympathomimetics. Discuss Epinephrine with respect to its

mechanism of action, effects on different organ\system, toxicity and contraindication. 20

Q. # 7 Write notes on:

a. Nitroglycerine

b. Lritant laxatives

TIME ALLOWED: 3 hrs.MAX, MARKS: 100

０

　

０

Exami nat i on: DoctOr of Pharmacv f Pharm. D。 ) l Rol l No. … . . … …… ……… :八　´、

去

UNIVERSI TY OF THE PUNJ AB●・ ・

・

・ ・ ・

・

・

° 0 0 0 0 。 ● ● ● ● ● ● ● ● 0 0。

Second Pro■ 2nd A/2016 : :Exami nat i on: Doct or of Pharmacv( Pharm. D。 ) : 。 191N91∵ : ∵ : ∵ : 1・ : ∵ : ∵ : 1l F

ヽSubject: Pharmacology & Therapeutics-I TIME ALLOWED: 3 hrs.PAPER 2( Ol d&New Course) ___ MAXo MARKS: 100

ハЙ9EE「 И` ` cη

′ ″

“ッF1/Eα

“ι sJ l i θ

“s. ∠ J J g“ ω J l i ο ″ sc″ rry ι α″ αJ ″ αrたs. ´ ‐

e. # 1 Describe biotransformation of drugs and discuss phase I and phase II reactions.

e.#ZDescribe main classes of receptors and discuss ligand-gated ion channels thoroughly.

e.# 3 Classify p- adrenergic blockers. Discuss mechanism of action, therapeutic uses, side

eft-ects and contraindicati ons of Propranoio I'

e. # 4 Classify muscarinic receptor agonists. Describe mechanism of action therapeutic uses

and adverse effects ofthese agents. 20

e. # 5 Define autacoids ? Give in detail the effects of histamine and antihistamine on different.

20organs.

e. # 6 Classify anti-ulcer drugs and enumerate detailed pharmacology of these dugs. Z0

Q. # 7 Write short notes on:

a. Prazosin

b. Digoxin

一　

２０

　

２０

20

０

　

　

０

■ム

UNIVERSI TY OF THE PUNJ AB

Exi ni i i a酬: ■ l t r i hi t t Lhari l : D: 〕 : 取Iド9: ∵|: : ∵|: : ∵ : ∵i : : :

Subject: Pharmacology & Therapeutics-I TIME ALLOWED33 hrs.

ヽ

PAPER32 New Course 峰 100

NOfh Afiempt any FIW questions, All questions carry equal morks,

Q. I What is biotransformation of drug. Discuss Phase I and Phase II reactions

with examples.

Q. 2 Classify Parasympathomimetics. Give mechanism of action, therapeutic uses and

toxicity of Physostigmine.

Q. 3 Classify receptors. Give detailed account of Ligand-gated ion channels.

Q. 4 (a) Define emesis. Give the mechanism of action and therapeutic uses of

antiemetic drugs.

(b) Write down the pharmacology of proton pump intribitors.

Q. 5 Classify anti-asthmatic drugs. Give the pharmacology of leukotriene receptor antagonists.20

Q. 6 Ctassify Sympathomimetics. Give the pharmacology of Epinephrine.

Q. 7 (a) Describe the mechanism of action and therapeutic uses of Amiodarone.

(b) Discuss the pharmacology of Captopril.

20

20

20

10

10

20

姫

炒

UNIVERSI TY OF THE PUNJ ABSecond Prof: 2nd Annual - 2017

Examination: Doctor of Pharmacv (pharm.D.)

Subject: Pharmacotogy & Therapeutics-I

.a taf a ta aa t toaa la af t a a iaaa

aaaO

! Rou No. ..................... :'aaaaaat aoa a t ta a o ooa r r lol!

TIME ALLOWED: 3 hrs.

MAX. MARKS: 100New CourseNorE: Attempt any FIVE questions. All questions carry equal marks,

Q. L Discuss G-Protein coupled receptors in details.

Q' 2 What is drug absorption? Discuss different ways by which drug can be transported zO

across the membranes.

Q' 3 classify antimuscarinc drugs. Give mechanism of action, therapeutic uses and toxicity zo

of Atropine.

Q' 4 classify sympatholytic drugs. Discuss propranolol in detail.

a. 5 (a) Discuss H2 receptor antagonists.

(b) Give the pharmacology of anti-diarrheal drugs.

Q. 6 what is congestive heart fairure. Give the pharmacology of Digoxin.

Q. 7 Write note on the following:

(a) Potassium sparing diuretics

(b) Salbutamol

20

20

20

・０

　

・０

０

　

０

１

　

１

‘）

2'

UNIVERSI TY OF THE PUNJ 俎●・・ ・ ・ ・ ・ ・ ・・

● ● ● ● ● ● ● ● ● ● ● ● ● ● ●.

Second Prot t Annual … 2018 : :Exami nat i or Doct or of Pharmacv f Pharm. D。 ヽ l RouNo. … … … … … . :

● ● 00● ● ● 000● ● ● ● ● ● ● 0● ● ● 00°

\ Subjecfi Pharmacology & Therapeutics-I (New Course) TrME ALLowED: 2 rrrs. & 30 min.

PAPER:2(Part-I! 雌 。MARKS: 80

Attempt this Paper on Separate Answer Sheet provided.

Attempt anv Four questions. Each question,carrr equal marks.

Q.No.2.Define Angina Pectoris? Explain in detail the mechanism ofaction of Antianginal drugs? (20)

Q.No.3.what do you understand by Cardiac Arrhythmias? Discussvarious kinds of Arrhythmias? Explain Anti arrhythmic drugs indetail? (20)

Q.No.4.Describe the main classes of receptors. Discuss ligand-gatedion channels. (20)

Q.No.S.what are the diff'erent classes of receptors. Discuss GProtein Coupled Receptors (GpCRs). (20)

Q.No-6.classify bronchodilators? Discuss in detail pharmacology ofbeta 2 agonists and methylxanthines? (20)

Q. No. 7。 Gi ve t he mechani sm Of act i on, t herapeut i c uses and adverseef f ect s Of t he f o110wi ngs( 5+5+5+5)

I. Prazosine

II. Dobutamine

III. Succinylcholine

IV. Ephedrine

氏

ヘ

UNIVERSI TY OF THE PUNJ AB` ｀ヽ、、l RonNo.Second Prot t Annual - 2018

｀`、、

Exami nat i on3 Doct or of Pharmacv f Pharm. D. ) ｀ヽ、、

SuЦ eCt 8 Pharmacol ogy&Therapeut i cs‐ I σ ew CO■ rse)PAPER82 Part― I ( Compul sOryp

TIME ALLOWED: 30 mi n。 、`、暉 。MARKS: 20 、`

Attempt this Paper on this Ouestion Sheet oqlv.

Please encircle the correct ontion. Each MCO carries 1 Mark This Paner will be collected back

aftpr expiry of time limit mentioned above.

Q.NO.I Select the best Option (20)

1.As an Antiepileptic drug, Phenytoin is most similar in action to which one of the followingdrugs?

(A) Digoxin' (B) Propafenone

(C) Lidocaine(D) Sotalol

2.The following drugs when combined with ACE inhibitors may produce troublesomeproblems EXCEPT

a. Theophylline

b. Potassium supplements

c. Spironolactone

d. Lithium

,

f.Wlnicn of the following calcium channel blockers is excreted predominanfly in the faeces?

a. Nifedipineb. Felodipine

c. Diltiazem

d. Nimodipine

4.Which of the following increases the risk of digoxin induced arrhythmias?

a. Hyperkalaemia

b. Hypercalcaemia

c. Hypermagnesaemia

d. Hyperuricaemia

5.The nitrates

a. Have an antianginal effect via vasodilation of arterioles onlyb. Serve to increase preload

c. Have a direct effect on cardiac muscle to cause a decrease in anginal symptomsd. Are contraindicated in the presence of increased intracranial pre-ssure

- ^

6.The following include major actions of digoxin on cardiac electrical functions EXCEPT

a. Decreased PR interval on ECG

b. Decreased conduction velocity at the AV node

c. Increased automaticity of the atrial muscle

d. D ecreased_effective refractory period in purkinj e system/ventri cles

Page 1 of3

>5

7. Receptors are usually

A) lipids

B) proteins

C) DNAD) Carbohydrates

8.Factors that may cause variation in drug responsiveness

A) changes in the number or function of receptorsB) tachyphylaxis

C) idiosyncratic drug responsesD) hypersensitivity reaction sE) all of the above

g.Major role of receptors is to

A) determine rate of drug eliminationB) {etermine drug action selectivityC) provide a means of drug distributionD) act as drug storage sites

l0.Ligand gated ion channel receptors include all of the folrorving ExcEpr

A) GABAB) Glycine

C) Glutamate

D) Muscarinic

ll.Which of the following acts on intracellular receptors

A) Serotonin

B) Corticosteroids

C) GABAD) Insulin

l2.Machanism of action of Acarbos

A. Inhibition of alpha-glucosidase enzymeB. Decrease insulin resistance

C. Activate AMp-activated protein kinase enzymeD. Modulate p-cell insulin release

13. What is the relative receptor affinity of Dobutamine

A. pl= p2

B. B2>p1C. pl > 02>>>oD. p2 > Fl>>>o

Page 2 of 3

しι

ユ）

tl.Wtri"t one of the following drugs facilitate cessation of cigarette smokingA. Dobutamine

B. Clonidine

C. Ephedrine

D. Tizanidine

lS.Propranolol is contraindicated inA. Pregnancy

B. Asthma

C. Liver cirrhosis

D. Renal disease

l6.Spinephrine causes

A. Incrcase systolic and decrease diastolic B.P

B. Increase both systolic and diastolic B.P

C. Decrease cardiac out put

D. Decrease stroke volume

17. The characteristic of organophosphate drugs is

A. water soluble

B. Lipid insoluble

C. Highly lipid soluble

D. Water insoluble

l8.Which of the following class of the drugs is NOT a bronchodilator

A.Beta 2 agonists

B.Leukotriene receptor antagonist

C.Mast cell stabilizers

D.Corticosteroids

l9.Proton pump inhibitors block one of the following receptors in parietal cell

A.H*-K* ATpase pump

B.Na*-K" ATpase pump

C.Na*-Cl- ATpase pump

D.H*- Na* ATPase pump

2O.which of the following anti-emetic inhibits dopamine receptors

A.Omeprazole

B.Ranitidine

C.Metoclopramide

D.Ondansetron

Page 3 of3

J

I INI VERSI TY OF TⅡE PUNJ ABSecond Pro■ 2nd An■ ■ol - 2018

Ex3mi nat i on: Doct or of Pharmacv□ barm. D. )

Subject: Pharmecolory & Therapeutics-IPAPER: 2 P● I t― Ⅱ Courre'

0°° ° °・

° ° ° ° 0● ● ● ● ● C● ● ● ● 00● ●.

l 119り1191∵ : ∵ : =: ∵ : =: ∵ : 1. 1は TIME: 2 Hrs. 30 Mi n.こヽA】C MARKS: 80

NOTEI ATTEMPT ANY FOUR OWSTIONS EACH OaESTION CARRIES EOUAL It{ARKl.

Q.No.2.What do you understand by Hypertension? Classify

.,intihypertensive Drugs? Explain Calcium Channel blockers &

ACE Inhibitors in detail? (20)

Q.No.3 (A) rvhat do you understand by cardiac Failure? Explain

Digitalis Glycosides in detail? (10)

6lOiscuss the mechanism of action of Class I & Class IIAntiarrhythmic drugs? (l-0)

Q.No.4 (A) Discuss the pharmacology of Proton pump inhibitors?

(10)

(B) Classify the drugs used in

agents in detail? (10)

constipation and discuss prokinetic

Q.No.5.Defi ne pharmacokinetics.

State the factors lvhich can affect

Describe the absorPtion of drugs.

the absorption ofdrugs. (20)

Q.No.6.Discussreceptors. Give

the structure and signaling of kinase-linked

examples. (20)

the mechanism of action, therapeutic uses and adverse

lbllowings(5+5+5+5)

Physostigmine

Phenoxybenzamine

PilocarpineIV.Reserpine

Q.No.7.Giveeffects ofthe

I.II.

IU.IV.

At t EMPT TⅢS( SI I BJ ECTI VEヽ ON TI I E SEPARATE ANSWER SHEET PROVI IDED

UNIVERSI TY OF TⅡE PUNJ ABSecond Pro彙 2・

. Anmual ‐ 2018Ex3mi nat i on: Doct or of Pharmacv f Pharm. D。 )

. RollNo. inFig.

\r Roll No. in lYords.

\^............"'

Mi n卜、20 ｀ヽSubjoct Pharmacology & Therapeutics'I

PAPER:2 Part-I (Compulsory) (Nem Courre)

雌 TIME830耐 . MARKS8 \.slgnature of SuPdt:

At t empt t ht t PaDer On t hi s O■ est i on Sheet on市 .

Q.1. Encircle the right answer cutting ond ovelvriting is not allowed.

I.Which of rhe following calcium channel blockers is excreted preclominantly i, tn" faeccs?

A. Nifedipine

B. Felodipine

C. Diltiazem

D. Nimodipine

2.Which of the.following increases the risk of digoxin induced arrhythmias?

A. Hyperkalaemia

B. Hypercalcaemia

C. Hypermagnesaemia

D. Hyperuricaemia

3.f'he nitrates

A. Have an antianginal effect via vasodilation of arterioles only

B. Serve to increase preload

C. Have a direct effect oh cardiac muscle to cause a decrease in anginal slmptoms

D. Are contraindicated in the presence of increased intracranial pressure

4.The following include major actions of digoxin on cardiac electrical functions EXCEPT

A. Decreased PR interval on ECG

B. Decreased condttction velocity at tlrc A\r node

C. Increased automaticity of the atrial muscle

D. Decreased eft-ective refractory period in purkinje system/ventricles

S.Methyl dopa

A. Lowers the heart rate and cardiac outPut more than clonidine does

B. Causes reduction in renal vascular resistance

C. Has rninimal CNS Side effects.

D Has 80% bioavailability

6.An examplc of a receptor which is a structural protein

A) NaiK ATPase

B) Acetl'lcholineqterase

C) tubulin

D) phospholipase C

T.Example(s) of second messenger effect(s)

A) Increases in cAMP intracellular concentration

B) Changes in intracellular calcium concentration

C) Phosphoinositide effects

D) AII the above .

E.EC56 mainly reflexs a drug's

A) Maximal effect

B) Potencl

C) Lethality

D) Ease of eiimination

E) Safety

9. Pharmacokinetic does include

A) N4echanism ofactionB) New drug developmenl

C) Study oftherapeutic effects

D) Study of metabolism and excretion of drugs

oOxl =20)

Page 1 of3

I

J

10. Main mechanism of the most drugs' absorption in GI tract is

A) Active Transport

B) l-iitration

C) Endocytosis

D) Passive diffusion

11. What kind of substances can't permeate membranes by passive diffusion?

A) I{ydrophilic substances

B) Hydrophobic substances

C) Lipid soiuble

D) Non-ionized substances

12.The characteristic of organophosphate drugs is

A.water soluble

tl. Lipid insolrble

Cl.Higlrty lipid soluble

D.Water insoiuble

13. Duration of action of Pyridostigmine is

A.5-15minutesB4-6hoursC.15 - 20 hour

D.100 hours

I4. Muscarinic M3 rcceptors are located in

A.Myocardium srnooth musole

B.Brain

C.Skeletal muscles

D.Glands

15. a2 - receptors are located on

A.Platelets

B.Lipocytes smooth muscles

C.Presynapti c adrenergic nerve terminal

D.AU of the above

L6.Glaucoma is treated with

A.AtropineB.Cholinesterase inhibitor

C.B-receptor blockers

D.Both B and C

lT.Beta 2 agonists increase the concentration of .......'.... in the cell of the smooth muscle

of bronchi

A.Cyclic AMP

B,Cyclic GMP

C.Nitrous oxide

D.Adenosine Page 2 of3

18.One of the following is a prominent side effect of Cimetidine

A At ri al f l bri l l at i on

B」 l cers .・ ィ C, Gynecomast l a苺 D. Esophagi t i S

l9'MisoProstol is a congener of

. A.Prostaglandin I

B.Prostaglandin E

C.Prostaglandin G

D.None of the above

2O.Montelukast blocks

A'LiPooxYgenase

B.Prostagiandins

' C.Leukotirene recePtors

D'Arachidonic acid

（　　　ィ

Page 3 of3

^n^ UNI\{ERSITY OF THE PUNJAB1*( Second Prof: 2od Annurt - 201s

W Exemination: Doctgr of Phermrcv (PFarm.D.)

Subiecfi Pharmacolory & Therapeutics-I (Old Coune)PAPER:2

aaaa aa aaaaa r aaaaaa a a aaaa aa

r'll

! RollNo.....................' !'laorl taa aaaa a ao a a a aoo"'-

MAtr. TIME:3 Hrs.

MA)t MARKS: 100

^4J

Attempt thls Paper on Separute Answet Sheel provided

Q.No.l.Describe the biotransfo.-"tiori of drugs. Discuss phase I and IIreactions. (20)

Q .No.2 .Define pharmacokinetics. Describe the absorption of drugs. State the

factors which can affect the absorption of drugs. (20)

Q.No.3.Define Angina Pectoris? Explain in detail the mechanism of action of

Antianginal drugs? (20)

Q.No.4.What do you understand by Cardiac Arrhythmias? Discuss various

kinds of Arrhythmias? Explain Anti arrhythmic drugs in detail? (20)

Q.No.S.(A) Define emesis? Discuss the pharmacology of 5HT3 receptor :

antagonist.(10)(B) Classify anti-histamines and discuss their pharmacology? (10)

Q.No.6 .(A) Give the therapeutic uses of drugs affecting parasympathetic

nervous system. (10)

(B) Discuss the pharmacological actions, therapeutic uses and toxicity ofatropine. (10)

Q.No.7.Write short Notes on the followings (5+5+5+5)

I. Prazosine

II. Dobutamine

IIL SuccinylcholineIV. Ephedrine

DUNJ AB ｀`き

‖ No. h Fi g. … …… …………

Prof : Annual … 2019 、`、Ro: : No. i n Words. . . . . ¨ ・・̈・・

■mα 30 ⅢL M“ ka 20」…………………O`i gnat ure of Supdt . :

Q.1. Encircle the correct oPtion.

of the following agents?

a. Physostigmine

c. PilocarPine

c. Stable Angina

vii. Effectiveanti-anginaldrug(s):a. ProPranolol

c. Esmolol

viii. Half life of Nitric Oxide is:

a. About 5 Sec

c. Ten Min

ix. Cardio selective beta blocker is:

a. ProPranolol

c. Nadolol

vi. Angina associated with coronary vasospasm:

a. Exertional angina b'

( 20Xl =20)

i. A drug that stimulates p 1 and B 2adreneceptors can be expected to cause:

a. Decrease in heart rate

b. A decrease in total peripheral resistance

c. A constriction of airway smooth muscle resistance

d. A decrease in renin release

ii. Which of the following Oiug. ""n

be used to reduce intraocular pressure in the

trealment of glaucoma?

a. PilocaiPine b Acetazolamide

;. Neostigmine d' All of the above

iii. clonidine and-alpha-methyldopa act as agonists at alpha2-adrenoceptors to cause:

a. A sustained increase in mean arterial pressure

b. An increase in intestinal motility

c. A CNS-mediated decrease in blood pressure

d. An increase in myocardial contractility

iv. Which of the fof fo*ing diugt i. ine snortest acting acetylcholinesterase inhibitor?

,. Neostigmine b' PhYsostigmine

;. EdroPtionium d EchothioPhate

v. Poisoning with Malathion insecticide is best managed by administration of which one

b. Bethanechol

d. AtroPine

dPri nzmet ars angi naA‖ of t heSe

b Ti mo! old A‖ of t heSe

Har Mi nAbOut an HOur

b. MetoProlol

d. None of these

ｂ

ｄ

x. Most common symptom of heart failure:

a.- -

facnYc"rAia' b' Oligouria

c. DysPnea d' HePatomegalY ..

xi. n Orug ttiai binds to a cell receptor and causes a response is called an:

a. Agonist b' Antagonist

;- R6ceptor blocker d' lnverse agonist

P. T. 0.

xii. Receptors fora. Steroidsc. Retinoids

a. Emollient laxatives

c. Fiber

are DNA-binding proteins

b. Vitamin D

d. All the above

xiii. Drugs interact with their receptors sites by forming.

a. lonic bonds

c. Van der Waals bond

xiv. The rate of drug absorption is greatest in

a. The small intestine

c. The stomachxv. An antagonist has:

a. lntrinsic activity and no affinityb. Only intrinsic activity and no affinity

c. No intrinsic activity and no affinity

d. Affinity same as agonist and devoid of intrinsic activity

xvi. Which of the following has overdose toxicity that includes insomnia, arrhythmias, and

convulsions?a. Aminophylinec. Epinephrine

xvii. Drugs that can dilate bronchi during an acute asthmatic attack include all of the

following except.

a. Epinephrine

c. Nedocromil

xviii. A drug administered by inhalation of powder as a prophylactic for asthma is:

a. Ephedrine b. Disodium cromolync. lsoproterenol d. Epinephrine

xix. Which of the following is most effective in the treatment of peptic ulcer disease?

a, Bromocriptine b Ci mel di nec. Ergotamine d. lpratropium

xx. All of the following agents are considered close to ideal laxatives except:

b. Hydrogen bonds

d. All the above

b. The large intestine

b. Cromolynd. lpratropium

b. Terbutaline

d. Theophyline

b. Bulk-forming laxatives

d. Stimulant laxatives

UNIVERSI TY OF THE PUNJ ABDoctor of Pharmacy (Pharm.D.) Second Prof: Annual-2019

Subi eCt : Pharmacoi ogy&Therapeut i cs‐ : ( New Course)Paper: 2 Part― : l Ti me: 2 Hrs. 30 Mi n. Marks: 80

ATTEMPT THIS (SUBJECTIVE) ON THE SEPARATE ANSWER SHEET PROVIDED

Note: Attempt any FOUR questions. Each question caries equal marks.

Q.2. What is biotransformation of a drug. Discuss Phase I and ll reactions of (20)

metabolism of drugs.

Q.3. Classify anti-asthma drugs. Write in detail pharmacology of theophylline. (20)

Q.4. Describe types of cholinergic receptors, their distribution and signal (20)

transduction pathways. Classify antimuscarinic drugs and explain their

therapeutic uses and adverse effects.

Q.5. Define Angina Pectoris. What are the major types of Angina? Classify (20)

Anti-anginal drugs and discuss the Nitrates in detail.

Q.6. a) Classify adrenergic receptors. steps of their signal transduction pathways, (10), distribution of adrenergic receptors in body and therapeutic uses of

adrenergic agonists and antagonists.

b) lllustrate and explain mechanism of control of pupil diameter, (10)

accommodation and intraocular pressure. Also describe ocularpharmacology of cholinergic and adrenergic drugs.

Q.7. a) Classify receptors, Give a comprehensive account of ionotropic receptors. (10)

b) Give the classification of diuretics. Explain mechanism of action, uses. (10)

adverse effects and toxicity of Furosemide.