Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G....

Università degli Studi di BresciaDipartimento di Ingegneria Meccanica

Mice Drawer SystemG. Baronio, G. Falcetti, S. Uberti , V. Villa

AED Glasgowi, September 20041

Design of a facilityto host experiment mice

in space

MDS

Gabriele Baronio, Giancarlo Falcetti, Stefano Uberti, Valerio Villa

Mice Drawer System




MDS

•Device to host a colony of 6 mice in space (on board of ISS).

•Available commercial space (“rack”)with given interfaces.

•Functions: to feed, to water, administer controlled dosages of drugs, remove excrements, environmental conditioning.

•6 separate cages without contacts between mice.

•Needs: guarantee mice’s physic and psychic well-being to have realistic results in experiments.




Box: 440.1x253.2x516.1 [mm]12mm insulation, only on lateral walls.

Design targets

Max dimensions

Animals contained

6 Mice 30-40 days/mouse

Permanence in space90 day between launch

and landing

Rack Panel connectionSwitch on/off, Led, Data connector, Power connector, Air in filter, Air out filter, Water refilling connector, Food refilling opening




Needs

Air

Water

Food Dry food x 100 days 3 Kg

Reservoir (2-3l) + Pump + pipes

Filters in/out + Pump + Manifold + Vent-hole

Food tablet

LHU (Liquid Handling Unit)

Drug reservoir + Electrovalves + Metering pump

Dimensions

Vmin=650 cm^3/mouse

Consumption: 20-30% mouse’s weight/day

6 cages + denmax available surface




Climatic control

Insulation

Environment control

Cleaning Food reminder and excrements removing

Mobile camera

Filters

Management and Control Electronic unit

camera + guide + motor

Temperature

Humidity Desiccator

Heat exchanger

Decease management ?

Bacteriological in & out

Biological/microbiologicalFilters




Heat exchanger

Electronic unit

Materials

Water and food

Up/Down

Biological/micro-biological

Insulation

ContainersRack panel

Lateral walls with

insulation

Available space




Breadboard




Cages study




MDS

Cages details




Mouse’s habitat




Final cage

+

Food handling




Simple “Sandwich” type

assembling




Experiment container




Liquid handling




LHULiquid Handling Unit




Drugs and water handling




LHU can be distributed as we need, because it is pipe-connected and not rigid




Comparison between hypothesis

Building elements




Breadboard building




... thank you

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G....

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