Our simple approach to proven performance

ZUKUnicompartmental Knee

ZUK Unicompartmental KneeSimply innovative

Extended posterior condyle

Angled femoral pegs

2 optimally positioned pegs

Round-on-flat articulation

Anatomic shape

3 points of tibial fixation

The ZUK design is based largely upon its predecessor M/G, a product that has been used

follow-up.1,2,3,4,5,7

Natural kinematics The ZUK Uni Knee is designed to replicate the kinematics of the natural knee with normal axial

rotation and posterior femoral rollback.4

Anatomic axis

• Femoral Peg location changes by size for

2 optimally positioned femoral pegs

Extended posterior condyle

up

• Angled femoral pegs are designed to

resistance to loosening forces during

Angled femoral pegs

• Unconstrained design intended to allow soft tissues to dictate motion of the knee

edge loading

are intended to guard against shear and rotational forces

ZUK Unicompartmental Knee

+/- 8 of varus/valgus tilt without edge loadingOrange outline indicates the M/G Uni

Patient matching Anatomically shaped tibial and femoral components are designed to provide maximum bone coverage.

Universal compatibility

• Optimal sizing designed to match patient anatomy

• 42 possible sizing combinations

Comprehensive sizing

• 7 femoral sizes and 6 tibial sizes

1mm thickness increments

Size A Size B Size C Size D Size E Size F Size G40mm 42.5mm 45mm 48mm 51.5mm 55.5mm 60mm

Size 1 Size 2 Size 3 Size 4 Size 5 Size 6 8mm 9mm 10mm 11mm 12mm 14mm

Size 1 Size 2 Size 3 Size 4 Size 5 Size 6 23mm x 41mm 25mm x 44mm 27mm x 47mm 29mm x 50mm 31mm x 53mm 33mm x 56mm

Lateral and bi-compartmental clinical solutions Freedom to perform medial, lateral and bi-compartmental procedures.

Reproducible instrumentation options

learning curve associated with UKAs

ZUK Unicompartmental High Flex Knee

Patello-femoral arthroplasty

Simply versatile

Lateral

• A study on the use in the lateral compartment showed no revisions at 12 years.5,6,8,9

3 instrument options samegreat implant

• Reproducible spacer block, extramedullary, and intramedullary instrumentation options allow surgeons to customize their surgical procedure

balancing process by linking the tibial and femoral cuts

Bi-compartmental

accommodate varying patient anatomies

• Independently oriented components allow precise alignment and rotation

Enhance precision with robotics

• The ZUK Uni Knee is compatible with Smith & Nephew’s Blue Belt robotics technology, which is designed to improve

• The ZUK implants can be implanted via Materialise’s PSI blocks

and

The ZUK Uni Knee System is based on the established implant design of the M/G Unicompartmental Knee System.Data tables from Australian Orthopaedic Association National Joint Replacement Registry Annual Report, 2015.6

Simply proven

Uni Femoral

Uni Tibial

N Revised

N Total

1 Yr 3Yrs 5 Yrs 7 Yrs 10 Yrs 14 Yrs

Allegretto Uni Allegretto Uni 283 2034 3.2 (2.5, 4.0) 5.8 (4.9, 6.9) 8.1 (6.9, 9.4) 10.3 (9.0, 11.8) 14.8 (13.2, 16.7) 20.2 (17.1, 23.9)

BalanSys Uni BalanSys Uni Fixed 17 352 1.8 (0.8, 4.0) 2.8 (1.5, 5.3) 4.1 (2.3, 7.2) 5.3 (3.1, 9.0)

Endo-Model Sled Endo-Model Sled 127 1153 1.1 (0.6, 1.9) 4.8 (3.7, 6.3) 7.8 (6.3, 9.6) 9.7 (8.0, 11.8) 15.3 (12.7, 18.4)

Freedom PKR/Active Freedom PKR/Active 224 1456 1.7 (1.1, 2.5) 7.4 (6.1, 8.9) 12.9 (11.2, 14.9) 17.3 (15.2, 19.7)

GRU GRU 204 1991 1.4 (0.9, 2.0) 4.5 (3.7, 5.5) 6.2 (5.2, 7.4) 8.5 (7.3, 9.9) 13.3 (11.6, 15.3)

Genesis Genesis 277 1864 2.7 (2.0, 3.5) 8.3 (7.1, 9.6) 10.8 (9.5, 12.4) 13.1 (11.6, 14.8) 16.6 (14.8, 18.6)

Journey Journey 14 222 0.9 (0.2, 3.7) 6.7 (3.8, 11.6) 11.0 (9.7, 12.5)

Journey Journey Deuce 7 201 2.5 (0.9, 6.5) 5.3 (2.2, 12.4)

M/G M/G 228 2135 1.6 (1.1, 2.2) 4.1 (3.4, 5.1) 5.3 (2.2, 12.4) 8.2 (7.0, 9.4) 10.5 (9.1, 12.0)

Oxford Oxford 3 9 656 1.1 (0.5, 2.5) 1.9 (0.9, 3.9)

Oxford 3 Oxford 115 2485 3.1 (2.5, 4.0) 5.2 (4.2, 6.3) 7.8 (6.3, 9.7)

Oxford 3 Oxford 3 1558 12003 2.2 (2.0, 2.5) 5.9 (5.5, 6.4) 8.6 (8.1, 9.1) 11.2 (10.6, 11.8) 15.0 (14.2, 15.7) 20.5 (19.0, 22.0)

Preservation Preservation Fixed 330 2318 2.4 (1.9, 3.1) 7.1 (6.1, 8.2) 9.5 (8.3, 10.7) 11.8 (10.5, 13.2) 15.4 (13.8, 17.1)

Preservation Preservation Mobile 117 400 5.3 (3.5, 7.9) 15.5 (12.3, 19.5) 19.1 (15.6, 23.3) 21.7 (17.9, 26.1) 27.1 (23.0, 31.9)

Repicci II Repicci II 461 2980 1.6 (1.2, 2.2) 4.5 (3.8, 5.4) 7.5 (6.6, 8.6) 10.7 (9.6, 11.9) 17.7 (16.2, 19.4)

Sigma HP Sigma HP 19 571 1.2 (0.5, 2.7) 3.6 (2.1, 5.9) 5.1 (3.1, 8.4)

Uniglide Uniglide 117 737 4.9 (3.6, 6.8) 10.9 (8.8, 13.4) 13.0 (10.7, 15.7) 16.0 (13.4, 19.1) 19.5 (16.3, 23.2)

Unix Unix 335 3682 2.4 (2.0, 3.0) 5.4 (4.7, 6.2) 7.2 (6.4, 8.1) 9.1 (8.1, 10.2) 12.1 (10.8, 13.6)

ZUK ZUK 177 4494 1.4 (1.1, 1.8) 3.7 (3.1, 4.3) 4.8 (4.1, 5.6) 5.6 (4.8, 6.6)

Other (30) 255 1809 3.6 (2.8, 4.6) 8.6 (7.3, 10.0) 11.1 (9.7, 12.8) 15.0 (13.2, 17.0) 20.2 (17.8, 22.9)

TOTAL 4874 43534

Note: Only combinations with over 200 procedures have been listed.

Knee Class N Revised

N Total

1 Yr 3Yrs 5 Yrs 7 Yrs 10 Yrs 14 Yrs

Unicompartmental 4816 43087 2.2 (2.1, 2.4) 5.8 (5.6, 6.1) 8.3 (8.0, 8.6) 10.7 (10.4, 11.1) 20.5 (19.5, 21.6)

TOTAL 4816 43087

N Model N Model N Model N Model N Model

1366 Oxford 3 514 ZUK 490 ZUK 576 ZUK 660 ZUK

444 Repicci II 513 Oxford 3 419 Oxford 492 Oxford 650 Oxford

373 Preservation Fixed 371 Oxford 390 Oxford 3 388 Oxford 3 376 Oxford 3

353 M/G 291 Unix 208 Unix 167 Unix 128 Sigma HP

336 Allegretto Uni 108 Sigma HP 90 Repicci II 96 Sigma HP 92 Unix

321 GRU 75 Freedom PKR/Active 69 Sigma HP 67 Repicci II 52 Journey Deuce

275 Genesis 72 Repicci II 68 Freedom PKR/Active 64 Journey Deuce 50 Freedom PKR/Active

260 Unix 71 Journey 64 Journey Deuce 63 Freedom PKR/Active 45 Endo-Model Sled

121 Preservation Mobile 69 GRU 55 GRU 37 Endo-Model Sled 33 Repicci II

101 Endo-Model Sled 61 Genesis 46 Journey 36 BalanSys Uni Fixed 28 BalanSys Uni Fixed

10 Most Used3950 (10) 96.1% 2145 (10) 89.0% 1899 (10) 88.6% 1986 (10) 93.2% 2114 (10) 94.8%

Remainder159 (7) 3.9% 265 (10) 11.0% 245 (12) 11.4% 145 (9) 6.8% 115 (10) 5.2%

TOTAL4109 (17) 100.0% 2410 (20) 100.0% 2144 (22) 100.0% 2131 (19) 100.0% 2229 (20) 100.0%

pp

2003 2011 2012 2013 2014

Table KP11: 10 Most Used Tibial Prostheses in Primary Unicompartmental Knee Replacement

Table KP14: Cumulative Percent Revision of Primary Unicompartmental Knee Replacement by Prosthesis Type

Table KP15: Cumulative Percent Revision of Primary Unicompartmental Knee Replacement (Primary Diagnosis OA)

1987

2004

ZUK

M/G Uni Knee

M/G Unicompartmental Knee survivorship

10 Years

13 Years

15 Years

98%1

95%2

95%3

St

udy

(Yea

r)

Sa

mpl

e si

ze (K

nees

)

M

ean

Pre-

Op

KSS

Clin

ical

Sco

re

M

ean

Post

-Op

KSS

Clin

ical

Sco

re

M

ean

Pre-

Op

KSS

Fu

ncti

on S

core

M

ean

Post

-Op

KSS

Fu

ncti

on S

core

M

ean

Pre-

Op

Rang

e

of M

otio

n (D

egre

es)

M

ean

Post

-Op

Ra

nge

of M

otio

n

(Deg

rees

)

Pooled Weighted Means

6.3(338)

48.8 93.2 51.0 89.0 113.1 126.6

Biswas et al., 201311 85 49.0 95.1 NR NR 120.0 124.0

Geller et al., 201110 30 45.9 88.7 47.4 83.9 110.9 123.6

Mochizuki et al., 201413 17 55.6 93.0 42.6 89.1 NR NR

Takayama et al., 201514 30 47.4 92.4 47.5 92.2 NR NR

Thienpoint et al., 201415 51 NR NR 58.0 90.0 NR NR

Abbreviations: NR = Not Reported

Clinical outcomes of ZUK7

Geller et al. 2011; n= 3089.7% survivorship at 2 years*10

*This study did not clearly identify the endpoint for measuring survivorship. In all other studies, survivorship was calculated as “revision for any reason.”

Vasso et al. 2015; n=12598.4% survivorship at 6.8 years12

Biswas et al. 2013; n=8596.5% survivorship at 10 years11

Kap

lan-

Mei

er S

urvi

vors

hip

Mean Follow-up (Years)

20%

80%

100%

60%

40%

0%0 2 4 6 8 10 12 14 16 18 20

Kaplan-Meier survivorship estimates of ZUK7

References:

1. Galante et al. The Progression of Patellofemoral Arthrosis after Medial Unicompartmental Replacement: CORR 2004 2. Argenson JN, Blanc G, Aubaniac JM, Parratte S. Modern unicompartmental knee arthroplasty with cement: a concise follow-up, at a mean of twenty years, of a previous report. J Bone Joint Surg Am. 2013;95(10):905–909.3. Galante et al. Results of Unicompartmental Knee Arthroplasty at a Minimum of Ten Years of Follow-up. JBJS 2005 4. Akizuki et al. In Vivo Determination of Kinematics for Subjects having a Zimmer Unicompartmental High Flex Knee system. Journal of Arthroplasty. 2009.5. Pennington et al. Lateral Unicompartmental Knee Arthroplasty. The Journal of Arthroplasty. 2006.6. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide: AOA; 2015. Table KP 11, page 141; KP 14, page 143; KP 15, page 144.7. Phillips M, Sprague S, Bhandari M, Watson J. The ZUK Unicompartmental Knee: a systematic literature review of clinical outcomes and a supplementary analysis of its predecessor device. Bone&Joint Outcome. 2015;2(3):1–26. Lit no: 042348. Marson B, Prasad N, Jenkins R, Lewis M. Lateral unicompartmental knee replacements: early results from a District General Hospital. Eur J Orthop Surg Traumatol. Aug 2014;24(6):987–991.9. Volpi P, Marinoni L, Bait C, Galli M, Denti M. Lateral unicompartimental knee arthroplasty: indications, technique and short-medium term results Knee Surg Sports Traumatol Arthrosc. 2007;15(8):1028–1034.

comparison at 2 years. J Arthroplasty. 2011;26(8):1468–1474.11. Biswas D, Van Thiel GS, Wetters NG, Pack BJ, Berger RA, Della Valle CJ. Medial unicompartmental knee arthroplasty in patients less than 55 years old: minimum of two years of follow-up. J Arthroplasty. 2014;29(1):101–105.12. Vasso M, Del Regno C, D’Amelio A, Viggiano D, Corona K, Panni AS. Minor varus alignment provides better results than neutral alignment in medial UKA. Knee. 2015;22(2):117–121.

Sports Traumatol Arthrosc. 2014:1–7.14. Takayama K, Matsumoto T, Muratsu H, et al. Joint gap assessment with a tensor is useful for the selection of insert thickness in unicompartmental knee arthroplasty. Clin Biomech (Bristol, Avon). 2015;30(1):95–99.

J Arthroplasty. 2014;29(1):48–51.

Instructions for Use (IFU) prior to use.

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