UNC’s Biomedical Imaging Research Center (BRIC) Spring2013.pdf · PDF file...

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Transcript of UNC’s Biomedical Imaging Research Center (BRIC) Spring2013.pdf · PDF file...

  • Roger Sit, Ph.D., CHP

    NCHPS Spring 2013 Meeting

    February 28, 2013

    UNC’s Biomedical Imaging

    Research Center (BRIC)

  • Outline

     Introduction

     History

     Describe capabilities of the Center developed

    over last few years

     Describe the evolution taking place presently

     Describe the capabilities that are planned

     Tie in to Health Physics or Radiation safety

     Describe some of the challenges

     Future – new imaging modalities

  • The BRIC

     Biomedical Research Imaging Center

     Established in 2005 to serve the imaging needs

    of UNC-Chapel Hill biomedical researchers and to

    advance the rapidly developing science of

    biomedical imaging. The Center enables a better

    understanding of disease, including cancer and

    neurologic diseases and studies the effects of

    genetic changes on disease development and


  • Example: Therapeutic agent for

    Ovarian Cancer

     Ho-165 (n,g) Ho-166

     Used mesopourous silica nanoparticles as carrier

     Study done in ovarian tumor-bearing mice

     Ho-166 emits low energy gamma for imaging as well

    as high energy betas for therapy

     SPECT/CT used for tissue biodistribution studies

     PET/CT used for disease progression

     Conclusion: The retention of holmium in nanoparticles during irradiation and in vivo after intraperitoneal

    administration as well as their efficacy in extending survival

    in tumor-bearing mice underscores their potential as a

    radiotherapeutic agent for ovarian cancer metastasis.

  • Truly Interdisciplinary

     Psychiatry

     Neurology

     Psychology

     Pathology

     Oncology

     Physics

     Biology

     Rheumatology

     Cardiology

     Gastroenterolo


     Public health

     Genetics

     Dentistry

     Pharmacology

     Biomedical


     Chemistry

     Bioinformatics

     Pharmacy

     Pharmacology

     Nursing

     Radiology

     And





  • Humble beginnings

  • Early Years

     Half focused on fMRI imaging of humans

     3-T Siemens Trio (whole body)

     3-T Siemens Allegra dedicated to neurological

    exams of the brain

     Half focused on research imaging of animals

     SPECT/CT

     PET/CT

     CT

     Ultrasound

     MRI

     Optical

  • Siemens Trio Siemens Allegra

  • Animal Imaging: MRI


    9.4 T



  • Animal Imaging: CT



    GE eXplore


  • Animal Imaging : CT

    Carbon Nanotube (CNT) based

    microCT Imaging System

  • Animal Imaging: SPECT/CT

    GE eXplore speCZT


  • Animal Imaging: PET/CT

    GE eXplore Vista

  • Animal Imaging: Ultrasound

    Visualsonics Vevo2100

  • Animal Imaging: Optical

    IVIS Kinetic Optical


  • Animal Imaging: Optical







  • NC Cancer Research Fund

     In 2007, the North Carolina Legislature

    established the NCCRF and began a long term

    financial commitment to research and treatment

    of cancer to improve the health and well being of

    the citizens of North Carolina.

     The fund enabled:

     highly successful recruitment of new investigators

     major expansion of research capabilities

     new buildings

  • BRIC Growth

     Addition of a 500 sq. feet enclosure

  • New Imaging Research Building

  • 2012 A Banner year

     Installed the fourth PET/MR fusion imaging

    device in the US. This is the Siemens Biograph

    mMR combining the functional imaging of PET

    with the superior soft tissue contrast of MRI


     Big advantage in having simultaneous imaging.

    PET/CT had been the best imaging technique but

    requires imaging with a PET scanner, then CT,

    then overlaying images.

     PET/MR provides better image, lower patient

    dose, and quicker scans

  • Siemens Biograph mMR

  • 2012 continued

     Installed the second dose-on-demand mini-

    cyclotron in the US. This is the ABT Biomarker


  • ABT Biomarker Generator -


  • AND

    BRIC Building

  • New Capabilities for New


     GE PETtrace 17-MeV cyclotron

     Irradiator

     Siemens 7T Full Body Scanner

     850 MHz NMR

     PET/CT Full body scanner

  • Vault for Two Cyclotrons

  • Vault Door: Plug on Rails

  • GE PETtrace Cyclotron

  • Irradiator

  • Siemens 7T Full Body Scanner

  • Bruker Ascend 850 MHz NMR

  • New Building  Sub-basement

     Cyclotron, radiochemistry, QC

     NMR Suite

     7 T MRI

     Animal facilities: 9.4 T, optical, ultrasound, PET/CT, SPECT/CT, microCT

     Basement

     Shell space for commercial partner

     Irradiator

     1st Floor

     3T MRI

     PET/MR

     PET/CT

  • IRB Sub-basement

  • IRB Basement

  • IRB First floor

  • HP Challenges  Plethora of machines and materials concerns

     Work with multiple shielding contractors

     Work with multiple equipment contractors

     Work with both branches of NC-RPS

     Bridging the knowledge gap for funding organization, architects, and /or construction management

     Integrate safety issues that may not have always been a consideration (magnetic fields, cryogenics, high rf, etc)

     Trying to convince line management that additional resources are necessary

     Working out case-by-case procedures for external research collaborators

  • Future

     X-ray Luminescence CT

     X-ray Fluorescence CT

     Cerenkov imaging

  • The End

    Thank you